Dairy Foods and Prevention of Colon Cancer: Human Studies

Journal of the American College of Nutrition

Volumn 18, Issue , 1999, Pages 379S-391S

  Holt, Peter R ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

Calcium; Chemoprevention; Colon cancer; Dairy products; Vitamin D

Indexed keywords

BILE ACID; BIOLOGICAL MARKER; CALCIUM; FATTY ACID; VITAMIN D;

ACID PRECIPITATION; ARTICLE; CALCIUM INTAKE; CANCER INCIDENCE; CANCER MORTALITY; CANCER RISK; CELL PROLIFERATION; COLON CANCER; COLON POLYP; CYTOTOXICITY; DAIRY PRODUCT; DIET SUPPLEMENTATION; HUMAN; SUN EXPOSURE; VITAMIN INTAKE;

CALCIUM, DIETARY; CELL DIVISION; COLON; COLONIC NEOPLASMS; DAIRY PRODUCTS; FECES; HUMANS; RECTUM; TUMOR CELLS, CULTURED; VITAMIN D;

EID: 0032880858     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.1999.10718902     Document Type: Article

References (128)

1. Distler P, Holt PR: Are right-and left-sided colon neoplasms distinct tumors? Dig Dis 15: 302-311, 1997.
2. Haenszel W, Berg JW, Segi M et al.: Large bowel cancer in Hawaiian Japanese. JNCI 51: 1765-1779, 1973.
3. Winawer SJ, Fletcher RH, Miller L et al.: Colorectal cancer screening: clinical guidelines and rationale. Gastroenterology 112: 594-642, 1997.
4. Mandell JS, Bond JH, Church TR et al.: Reducing mortality from colorectal cancer by screening for fecal occult blood. N Engl J Med 328: 1365-1371, 1993.
5. Winawer SJ, Zauber AG, Ho MN et al.: Prevention of colorectal cancer by colonoscopic polypectomy. N Engl J Med 329: 1977-1981, 1993.
6. Muller AD, Sonnenberg A: Prevention of colorectal cancer by flexible endoscopy and polypectomy. A case-control study of 32,702 veterans. Ann Intern Med 123: 904-910, 1995.
7. Boring CC, Squires TS, Tong T: Cancer statistics. CA Cancer J Clin 41: 19-51, 1991.
8. Parker SL, Tong T, Bolden S, Wingo PA: Cancer statistics. CA Cancer J Clin 47: 5-27, 1997.
9. Lipkin M: Application of intermediate biomarkers to studies of cancer prevention in the gastrointestinal tract: introduction and perspective. Am J Clin Nutr 54: 188S-192S, 1991.
10. Kelloff GJ, Boone CW, Crowell JA, Steele VE, Lubet R, Doody LA: Surrogate endpoint biomarkers for phase II cancer chemoprevention trials. J Cell Biochem 19: 1-9, 1994.
11. Eaton SB, Shostak M, Konner M: “The Paleolithic Prescription.” New York: Harper and Row, 1988.
12. Newmark H, Wargovich M, Bruce R: Colon cancer and dietary fat, phosphate and calcium-a hypothesis. J Natl Canc Inst 72: 1323-1325, 1984.
13. Potter JD, Slattery ML, Bostick RM, Gapstur SM: Colon cancer: a review of the epidemiology. Epidemiol Rev 15: 499-545, 1993.
14. Garland C, Barrett-Connor E, Rossof AH, Shekelle RB, Criqui MH, Paul O: Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet 307-309, 1985.
15. Slattery ML, Sorenson AW, Ford MH: Dietary calcium intake as a mitigating factor in colon cancer. Am J Epidemiol 128: 504-514, 1988.
16. Kune S, Kune GA, Watson LF: Case-control study of dietary etiological factors: the Melbourne colorectal cancer study. Nutr Cancer 9: 21-42, 1987.
17. Sorenson AW, Slattery ML, Ford MH: Calcium and colon cancer: a review. Nutr Cancer 11: 135-145, 1988.
18. Lipkin M, Newmark H: Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer. N Engl J Med 313: 1381-1384, 1985.
19. Bostick RM: Human studies of calcium supplementation and colorectal epithelial cell proliferation. Cancer Epidemiol Biomark Prev 6: 971-980, 1997.
20. Garland CF, Garland FC: Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 9: 227-231, 1980.
21. Garland CF, Garland FC, Shaw EK, Comstock GS, Helsing KJ, Gorham ED: Serum 25-hydroxyvitamin D and colon cancer: Eight-year prospective study. Lancet 1176-1178, 1989.
22. Glass AR, Kikendall JW, Sobin LH, Bowen PE: Serum 25-hydroxyvitamin D concentrations in colonic neoplasia. Horm Metab Res 25: 397-398, 1993.
23. Pritchard RS, Baron JA, Gerhardsson de Verdier M: Dietary calcium, vitamin D, and the risk of colorectal cancer in Stockholm, Sweden. Cancer Epidem Biomark Prev 5: 897-900, 1996.
24. White E, Shannon JS, Patterson RE: Relationship between vitamin and calcium supplement use and colon cancer. Cancer Epidem Biomark Prev 6: 769-774, 1997.
25. Willett W: The search for the causes of breast and colon cancer. Nature 338: 389-394, 1989.
26. Weisburger JH: Causes, relevant mechanisms, and prevention of large bowel cancer. Semin Oncol 18: 316-336, 1991.
27. Burkitt DP, Walker ARP, Painter NS: Effect of dietary fiber on stools and transit-times, and its role in the causation of disease. Lancet ii: 1408-1411, 1972.
28. Phillips RL, Garfinkel L, Kuzma JW, Beeson WL, Lotz T, Brin B: Mortality among California Seventh-Day Adventists for selected cancer sites. J Natl Cancer Inst 65: 1097-1107, 1980.
29. Alberts DS, Einspahr J, Ritenbaugh C et al.: The effect of wheat bran fiber and calcium supplementation on rectal mucosal proliferation rates in patients with resected adenomatous colorectal polyps. Cancer Epidem Biomark Prev 6: 161-169, 1997.
30. de Cosse JJ, Miller HH, Lesser ML: Effective wheat fiber and vitamins C and E on rectal polyps in patients with familial adenomatous polyposis. J Natl Cancer Inst 81: 1290-1297, 1989.
31. McKeown-Eyssen GE, Bright-See E: Dietary factors in colon cancer: international relationships. Nutr Cancer 6: 160-170, 1984.
32. MacLennan R, McCrae F, Bain C et al.: The Australian Polyp Prevention Project. Randomized trial of fat, fiber and b carotene to prevent colorectal adenomas. J Natl Cancer Inst 87: 1760-1767, 1995.
33. Ingles SA, Bird CL, Shikany JM, Frankl HD, Lee ER, Haile RW: Plasma tocopherol and prevalence of colorectal adenomas in a multiethnic population. Cancer Res 58: 661-666, 1998.
34. Greenberg ER, Baron JA, Tosteson TD et al.: A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med 331: 141-147, 1994.
35. Clark LC, Combs G, Turnbull BW et al.: Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. JAMA 276: 1957-1963, 1996.
36. Garland CF, Garland FC, Shaw EK, Comstock GW, Helsing KJ, Gorham ED: Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet 1176-1178, 1989.
37. MacLennan WJ, Hamilton JC: Vitamin D supplements and 25-hydroxyvitamin D in the elderly. Br Med J ii: 859-861, 1997.
38. Jacques PF, Felson DT, Tucker KL et al.: Plasma 25-hydroxyvitamin D and its determinants in an elderly population sample. Am J Clin Nutr 66: 929-936, 1997.
39. Pence BC, Buddingh F: Inhibition of dietary fat-promoted colon carcinogenesis in rats by supplemental calcium or vitamin D3. Carcinogenesis 9: 187-190, 1988.
40. Sitrin MD, Halline AG, Abrahams C, Brasitus TA: Dietary calcium and vitamin D modulate 1,2-dimethylhydrazine-induced colonic carcinogenesis in the rat. Cancer Res 51: 5608-5613, 1991.
41. Kinywmu HK, Gallagher JC, Knezetic JA, DeLuca HF, Prahl JM, Lanspa SJ: Effect of vitamin D receptor genotypes on calcium absorption, duodenal vitamin D receptor concentration, and serum 1,25 dihydroxyvitamin D levels in normal women. Calcif Tissue Int 60: 491-495, 1997.
42. Morrison NA, Qi JC, Tokita A et al.: Prediction of bone density from vitamin-D-receptor alleles. Nature 367: 284-287, 1994.
43. Spector TD, Keen RW, Arden NK et al.: Influence of vitamin-D-receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain. Br Med J 310: 1357-1360, 1995.
44. Lore F, Di Cairano G, Di Perri G: Vitamin D status in the extreme age of life. Ann Med Int 137: 209-211, 1986.
45. Brehier A and Tomassett M: Human colon cell line HT-29: characterization of 1,25-dihydroxyvitamin D3 receptors in established human cancer cell lines in culture. Cancer Res 42: 1116-1119, 1982.
46. Lointier P, Wargovich MJ, Saez S, Levin B, Wildrick D et al.: The role of vitamin D3 in the proliferation of a human colon cancer cell line in vitro. Anticancer Res 7: 817-822, 1987.
47. Shabahang M, Buras RR, Davoodi F, Schumaker LM, Nauta RJ, Evans SRT: 1,25-dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition. Cancer Res 53: 3712-3728, 1993.
48. Wali RK, Bissonnette M, Khare S, Hart J, Sitrin MD, Brasitus TA: 1a,15-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, a non-calcemic analogue of 1a25-dihydroxyvitamin D3, inhibits azoxymethane-induced colonic carcinogenesis. Cancer Res 55: 3050-3054, 1995.
49. Wali RK, Baum CL, Sitrin MD, Bolt MJG, Dudeja PK, Brasitus TA: Effect of vitamin D status on the rapid actions of 1,25-dihydroxy-cholecalciferol in rat colonic membranes. Am J Physiol 262: 945-953, 1992.
50. Bissonnette M, Tien X-Y, Niedziela SM et al.: 1,25(OH)2 vitamin D3 activates PKC-a in Caco-2 cells: a mechanism to limit secosteroid-induced rise in [Ca21]i. Am J Physiol 267: 465-475, 1994.
51. Bolt MJG, Bissonnette BM, Wali RK, Hartmann SC, Brasitus TA, Sitrin MD: Characterization of phosphoinositide-specific phospholipase C in rat colonocyte membranes. Biochem J 292: 271-276, 1993.
52. Khare S, Bolt MJG, Wali RK et al.: 1,25 dihydroxyvitamin D3 stimulates phospholipase c in rat colonocytes: Role of c-Src in PLC-g activation. J Clin Invest 99(8): 1831-1841, 1997.
53. Gupta AK, Sexton RC, Rudney H: Effect of vitamin D3 derivatives on cholesterol s synthesis and HMG-CoA reductase activity in cultured cells. J Lipid Res 30: 379-386, 1989.
54. Brenner BM, Russell N, Albrecht S, Davies RJ: The effect of dietary vitamin D3 on the Intracellular calcium gradient in mammalian colonic crypts. Cancer Lett 127: 43-53, 1998.
55. Thomas MG, Tebbutt S, Williamson RN: Vitamin D and its metabolites inhibit cell proliferation in human rectal mucosa and a colon cancer cell line. Gut 33: 1660-1663, 1992.
56. Thomas MG, Brown GR, Alison MR, Williamson RCN: Divergent effects of epidermal growth factor and calcipotriol on human rectal cell proliferation. Gut 35: 1742-1746, 1994.
57. Thomas MG, Nugent KP, Forbes A, Williamson RCN: Calcipotriol inhibits rectal epithelial cell proliferation in ulcerative proctocolitis. Gut 35: 1718-1720, 1994.
58. Winawer SJ, Zauber AG, O'Brien MJ et al.: Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps. N Engl J Med 328: 901-906, 1993.
59. Rex DK, Cutler CS, Lemel T et al.: Colonoscopic miss rates of adenomas determined by back-to-back colonoscopies. Gastroenterology 112: 24-28, 1997.
60. Hyman J, Baron JA, Dain BJ et al.: Dietary and supplemental calcium and the recurrence of colorectal adenomas. Canc Epidem Biomark Prevent 7: 291-295, 1998.
61. Lipkin M: Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects. Cancer Res 48: 235-245, 1988.
62. Lipkin M, Uehara K, Winawer S et al.: Seventh-Day Adventist vegetarians have a quiescent proliferative activity in colonic mucosa. Cancer Lett 26: 139-144, 1985.
63. Yang K, Cohen L, Lipkin M: Lectin soybean agglutinin: measurements in colonic epithelial cells of human subjects following supplemental dietary calcium. Cancer Lett 56: 65-69, 1991.
64. Filipe MI, Branfoot AC: Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma. Cancer 34: 282-290, 1974.
65. Garin-Chesa P, Rettig WJ, Melamed MR: Expression of cytokeratins in normal and neoplastic colonic epithelial cells. Implications for cellular differentiation and carcinogenesis. Am J Surg Path 10: 829-835, 1986.
66. Moorehead RJ, Hoper M, McKelvey STD: Assessment of ornithine decarboxylase activity in rectal mucosa as a marker for colorectal adenomas and carcinomas. Br J Surg 74: 364-365, 1987.
67. Lans JI, Jaszewski R, Arlow FL, Tureaud J, Luk GD, Majumdar APN: Supplemental calcium suppresses colonic mucosal ornithine decarboxylase activity in elderly patients with adenomatous polyps. Cancer Res 51: 3416-3419, 1991.
68. Wargovich ML, Allnut D, Palmer C, Anaya P, Stephens LC: Inhibition of the promotional phase of azoxymethane-induced colon carcinogenesis in the F344 rat by calcium lactate: effect of simulating two human nutrient density levels. Cancer Lett 53: 17-25, 1990.
69. Yang K, Fan K, Newmark H et al.: Cytokeratin, lectin, and acidic mucin modulation in differentiating colonic epithelial cells of mice after feeding Western-style diets. Cancer Res 56: 4644-4648, 1996.
70. Oshima H, Oshima M, Kobayashi M, Tsutsumi M, Taketo MM: Morphological and molecular processes of polyp formation in ApcD716. Cancer Res 57: 1644-1649, 1997.
71. Lipkin M, Enker WE, Winawer SJ: Tritiated-thymidine labeling of rectal epithelial cells in ‘non-prep' biopsies of individuals at increased risk for colonic neoplasia. Cancer Lett 87: 153-161, 1987.
72. Richter F, Richter A, Yang K, Lipkin M: Cell proliferation in rat colon measured with bromodeoxyuridine, proliferating cell nuclear antigen, and [3H]thymidine. Cancer Epidemiol Biomark Prev 1: 561-566, 1992.
73. Bostick RM, Fosdick L, Tamera JL et al.: Methodological findings and considerations in measuring colorectal epithelial cell proliferation in humans. Cancer Epidemiol Biomark Prev 6: 931-942, 1997.
74. Holt PR, Moss SF, Kapetanakis AM et al.: Is Ki-67 a better proliferative marker in the colon than proliferating cell nuclear antigen? Cancer Epidemiol Biomark Prev 6: 131-135, 1997.
75. Terpstra OT, Blankenstein M, Dees J, Eilers GAM: Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer. Gastroenterology 92: 704-708, 1987.
76. Gregoire R, Yeung KS, Stadler J et al.: Effect of high fat and low-fibre meals on the cell proliferation activity of colorectal mucosa. Nutr Cancer 15: 21-26, 1991.
77. Lieberman V, Nyska A, Kashtan H, Zajicek G, Lubin F and Rozen P: Differing proliferative responses in proximal and distal colons of growing rats fed food eaten by adenoma patients. Dig Dis Sci 41: 1057-1064, 1996.
78. Bostick RM, Fosdick L, Grandits GA et al.: Colorectal epithelial cell proliferative kinetics and risk factors for colon cancer in sporadic adenoma patients. Cancer Epidemiol Biomark Prev 6: 1011-1019, 1997.
79. Lipkin M, Friedman E, Winawer SJ, Newmark H: Colonic epithelial cell proliferation in responders and nonresponders to supplemental dietary calcium. Cancer Res 49: 248-254, 1989.
80. Rozen P, Fireman A, Fine N, Wax Y, Ron E: Oral calcium suppresses increased rectal epithelial proliferation of persons at risk for colorectal cancer. Gut 30: 650-655, 1989.
81. Baron JA, Tosteson TD, Wargovich MJ et al.: Calcium supplementation and rectal mucosal proliferation: a randomized controlled trial. J Natl Cancer Inst 87: 1303-1307, 1995.
82. Bostick R, Potter JD, Fosdick L et al.: Calcium and colorectal epithelial cell proliferation: a preliminary randomized, doubleblinded, placebo-controlled clinical trial. J Natl Cancer Inst 85: 132-141, 1993.
83. Baron JA, Beach M: A randomized trial of calcium supplementation to prevent colorectal adenomas [abstract]. Gastroenterology 114: 563, 1998.
84. Welberg JWM, Monkelbaan JF, de Vries EGE et al.: Effects of supplemental dietary calcium on quantitative and qualitative fecal fat excretion in man. Ann Nutr Metab 38: 285-291, 1994.
85. Denke MA, Fox MM, Schulte MC: Short-term dietary calcium fortification increases fecal saturated fat content and reduces serum lipids in men. J Nutr 123: 1047-1053, 1993.
86. Alder RJ, McKeown-Eyssen G, Bright-See E: Randomized trial of the effect of calcium supplementation of fecal risk factors for colorectal cancer. Am J Epidemiol 138: 804-814, 1993.
87. Van der Werf SDJ, Nagengast FM, Van Berg Henegouwen GP, Huijbregts AWN, Van Tongeren JHM: Colonic absorption of secondary bile acids in patients with adenomatous polyps and in matched controls. Lancet 1: 759-762, 1982.
88. Moorehead RJ, Campbell GR, Donaldson JD, McKelvey STD: Relationship between duodenal bile acids and colorectal neoplasia. Gut 28: 1454-1459, 1987.
89. Wargovich MJ, Eng VWS, Newmark HL, Bruce WR: Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium. Carcinogenesis 4: 1205-1207, 1983.
90. Wargovich MJ, Eng VWS, Newmark HL: Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett 23: 253-258, 1984.
91. Van der Meer R, Welberg JWM, Kuipers F et al.: Effects of supplemental dietary calcium on the intestinal association of calcium, phosphate, and bile acids. Gastroenterology 99: 1653-1659, 1990.
92. Lapre JA, De Vries HT, Termont DSML, Kleibeuker JH, De Vries EGE, Van der Meer R: Mechanism of the protective effect of supplemental dietary calcium on cytolytic activity of fecal water. Cancer Res 53: 248-253, 1993.
93. Govers MJAP, Termont DSML, Van der Meer R: Mechanism of the antiproliferative effect of milk mineral and other calcium supplements on colonic epithelium. Cancer Res 54: 95-100, 1994.
94. Govers MJAP, Termont DSML, Lapre JA, Kleibeuker JH, Vonk RJ, Van der Meer R: Calcium in milk products precipitates intestinal fatty acids and secondary bile acids and thus inhibits colonic cytotoxicity in humans. Cancer Res 56: 3270-3275, 1996.
95. Glinghammar B, Venturi M, Rowland IR, Rafter JJ: Shift from a dairy product-rich to a dairy product-free diet: influence on cytotoxicity and genotoxicity of fecal water-potential risk factors for colon cancer. Am J Clin Nutr 66: 1277-1282, 1997.
96. Govers MJAP, Van der Meer R: Effects of dietary calcium and phosphate on the intestinal interactions between calcium, phosphate, fatty acids and bile acids. Gut 34: 365-370, 1993.
97. Newmark HL, Holt PR: Shift from a dairy product-rich to a dairy product-free diet: influence on cytotoxicity and genotoxicity of fecal water-potential risk factors for colon cancer. Letter Am J Clin Nutr (in press), 1998.
98. Van der Meer R, De Vries HT: Differential binding of glycineand taurine-conjugated bile acids to insoluble calcium phosphate. Biochem J 229: 265-268, 1985.
99. Van der Meer R, Termont DSML, De Vries HT: Differential effects of calcium ions and calcium phosphate on cytotoxicity of bile acids. Am J Physiol 260: G142-G147, 1991.
100. Lapre JA, Termont DSML, Groen AK et al.: Lytic effects of mixed micelles of fatty acids and bile acids. Am J Physiol 263: G333-G337, 1992.
101. Lapre JA, De Vries HT, Van der Meer R: Dietary calcium phosphate inhibits cytotoxicity of fecal water. Am J Physiol 261: G907-G912, 1991.
102. Welberg JWM, Kleibeuker JH, Van der Meer R et al.: Effects of oral calcium supplementation on intestinal bile acids and cytolytic activity of fecal water in patients with adenomatous polyps of the colon. Eur J Clin Invest 23: 63-68, 1993.
103. Buset M, Lipkin M, Winawer S, Swaroop S, Friedman E: Inhibition of human colonic epithelial cell proliferation in vivo and in vitro by calcium. Cancer Res 46: 5426-5430, 1986.
104. Scalmati A, Lipkin M, Newmark H: Calcium, vitamin D, and colon cancer. Clin Appl Nutr 2: 67-74, 1992.
105. Chang W-CL, Chapkin RS, Lupton JR: Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis. Carcinogenesis 18: 721-730, 1997.
106. Whitfield JF, Boynton AL, MacManus JP et al.: The regulation of cell proliferation by calcium and cyclin AMP. Mol Cell Biochem 27: 155, 1979.
107. Hennings H, Michael D, Cheng C et al.: Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19: 245, 1980.
108. Babcock MS, Marino MR, Gunning WE III et al.: Clonal growth and serial propagation of rat esophageal epithelial cells. In Vitro 19: 403, 1983.
109. McGrath M, Soule HD: Calcium regulation of normal mammary epithelial cell growth in culture. In Vitro 20: 652, 1984.
110. Soule HD, McGrath CM: A simplified method for passage and long-term growth of human mammary epithelial cell. In Vitro 22: 6, 1985.
111. Boffa LC, Mariani MR, Newmark H et al.: Calcium as a modulator of nucleosomal histones acetylation in cultured cells. Proc Am Assoc Cancer Res 30: 8, 1989.
112. Optimal calcium intake. NIH Consensus Statement 12: 1-31, 1994.
113. Curhan GC, Willett WC, Rimm EB, Stampfer MJ: A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med 328: 833-838, 1993.
114. Cook JD, Dassenko SA, Whittaker P: Calcium supplementation: effect on iron absorption. Am J Clin Nutr 53: 106-111, 1991.
115. Hallberg L: Brune M, Erlandsson M et al.: Calcium: effect of different amounts on nonheme-and heme-iron absorption in humans. Am J Clin Nutr 53: 112-119, 1991.
116. Hallberg L: Does calcium interfere with iron absorption? Am J Clin Nutr 68: 3-4, 1998.
117. Whiting SJ: Safety of some calcium supplements questioned. Nutr Rev 52: 95-97, 1994.
118. Evron E, Goland S, von der Walde J, Schattner A, Sthoeger ZM: Idiopathic calcitriol-induced hypercalcemia. A new disease entity? Arch Intern Med 157: 2142-2145, 1997.
119. Kune S, Kune GA, Watson LF: Case-control study of dietary etiological factors: the Melbourne colorectal cancer study. Nutr Cancer 9: 21-42, 1987.
120. Macquart-Moulin G, Riboli E, Cornee J, Charnay B, Berthezene P, Day N: Case-control study on colorectal cancer and diet in Marseilles. Int J Cancer 38: 183-191, 1986.
121. Negri E, La Vecchia C, D'Avanzo B, Franceschi S: Calcium, dairy products, and colorectal cancer. Nutr Cancer 13: 255-262, 1990.
122. Jensen OM, MacLennan R, Wahrendorf J: Diet, bowel function, fecal characteristics, and large bowel cancer in Denmark and Finland. Nutr Cancer 4: 5-19, 1982.
123. Jensen OM, MacLennan R: Dietary factors and colorectal cancer in Scandinavia. Israel J Med Sci 15: 329, 1979.
124. Stemmermann GN, Nomura A, Chyou P-H: The influence of dairy and nondairy calcium on subsite large-bowel cancer risk. Dis Col & Rect 33: 190-194, 1990.
125. Rosen M, Nystrom L, Wall S: Diet and cancer mortality in the counties of Sweden. Am J Epideiol 127: 42-49, 1988.
126. Peters RK, Pike MC, Garabrant D, Mack TM: Diet and colon cancer in Los Angeles County, California. Cancer Causes & Control 3: 457-473, 1992.
127. Nelson RL, Tanure JC, Andrianopoulos G: The effect of dietary milk and calcium on experimental colorectal carcinogenesis. Dis Colon Rectum 30: 947-949, 1987.
128. Holt PR, Atillasoy EO, Gilman J, Guss J, Moss SF, Newmark H, Fan K, Yang K, Lipkin M: Modulation of abnormal colon epithelial cell proliferation and differentiation by low-fat dairy foods: a randomized controlled trial. JAMA 280(12): 1074-1079, September 23/30, 1998.