Calcium in milk products precipitates intestinal fatty acids and secondary bile acids and thus inhibits colonic cytotoxicity in humans

Cancer Research

Volumn 56, Issue 14, 1996, Pages 3270-3275

  Govers, Mirjam J A P ^a   Termont, Denise S M L ^a   Lapré, John A ^a   Kleibeuker, Jan H ^b   Vonk, Roel J ^b   Van Der Meer, Roelof ^a  

^a NIZO FOOD RESEARCH   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CALCIUM; DEOXYCHOLIC ACID; FATTY ACID; LITHOCHOLIC ACID; LONG CHAIN FATTY ACID; PHOSPHOLIPID; STEROL;

ADULT; ARTICLE; CALCIUM INTAKE; CANCER RISK; CLINICAL PROTOCOL; CLINICAL TRIAL; COLON CARCINOMA; COLON MUCOSA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FOOD COMPOSITION; HUMAN; HUMAN EXPERIMENT; MALE; MILK; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; ANIMALS; BILE ACIDS AND SALTS; CALCIUM; CELL MEMBRANE PERMEABILITY; CYTOTOXINS; DIET; ERYTHROCYTES; FATTY ACIDS; FECES; HUMANS; MALE; MILK; PHOSPHATES; PRECIPITATION; WATER;

EID: 0030002173     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Potter, J. D , Slattery, M. L , Bostick, R. M , and Gapstur, S. M. Colon cancer review of epidemiology Epidemiol. Rev , 15: 499-545, 1993.
2. Willett, W C., Stampfer, M. J., Colditz, G. A., Rosner, B. A., and Speizer, F E. Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women N. Engl. J. Med , 323: 1664-1672, 1990.
3. Sorenson, A. W., Slattery, M. L., and Ford, M. H. Calcium and colon cancer: a review. Nutr. Cancer, 11: 135-145, 1988.
4. Bruce, W. R Recent hypotheses for the origin of colon cancer. Cancer Res., 47: 4237-4242, 1987.
5. Wargovich, M. J., Eng, V. W. S Newmark, H L , and Bruce, W R Calcium ameliorates the toxic effects of deoxycholic acid on colonic epithelium. Carcinogenesis (Lond.), 4: 1205-1207, 1983.
6. Wargovich, M J , Eng, V. W. S., and Newmark, H. L. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett., 23: 253-258, 1984.
7. Lipkin, M. Biomarkers of increased susceptibility to gastrointestinal cancer: new application to studies of cancer prevention in human subjects. Cancer Res., 48: 235-245, 1988.
8. Newmark, H. L , Wargovich, M. J., and Bruce, W R. Colon cancer and dietary fat, phosphate, and calcium: a hypothesis. J Natl. Cancer Inst., 72 1323-1325, 1984.
9. Newmark, H. L., Wargovich, M J., Bruce, W. R., Boynton, A. L., Kleine, L. P., Whitfield, J. F., Jansson B , and Cameron, I. L. Ions and neoplastic development In: A. J. Mastromarino and M. G. Brattain (eds), Large Bowel Cancer, pp. 102-130. New York: Praeger Publishers, 1985
10. Govers, M J. A. P , Termont, D S. M. L., Van Aken, G. A., and Van der Meer, R. Characterization of the adsorption of conjugated and unconjugated bile acids to insoluble, amorphous calcium phosphate. J. Lipid Res , 35: 714-748, 1994
11. Van der Meer, R., Termont, D. S. M. L , and De Vries, H. T Differential effects of calcium ions and calcium phosphate on cytotoxicity of bile acids. Am. J. Physiol., 260: G142-G147, 1991
12. Buset, M., Galand, P., Lipkin, M , Winawer, S , and Friedman, E. Injury induced by fatty acids or bile acids in isolated human colonocytes prevented by calcium. Cancer Lett , 50: 221-226, 1990
13. Lapré, J. A., De Vries, H. T., and Van der Meer, R. Dietary calcium phosphate inhibits cytotoxicity of fecal water Am J. Physiol., 261: G907-G913, 1991.
14. Lapré, J. A., De Vries, H T , Koeman, J. H., and Van der Meer, R The antiproliferative effect of dietary calcium on colonic epithelium is mediated by luminal surfactants and dependent on the type of dietary fat. Cancer Res., 53: 784-789, 1993
15. Govers, M. J. A. P , and Van der Meer, R. Effects of dietary calcium and phosphate on the intestinal interactions between calcium, phosphate, fatty acids and bile acids Gut, 34: 365-370, 1993.
16. Lipkin, M. Application of intermediate biomarkers to studies of cancer prevention in the gastrointestinal tract: introduction and perspective. Am. J. Clin. Nutr., 54, 188S-192S, 1991.
17. Zimmerman, J. Does dietary calcium supplementation reduce the risk of colon cancer? Nutr. Rev , 51: 109-112, 1993
18. Steinbach, G , Lupton, J., Reddy, B. S., Kral, J. G , and Holt, P R. Effect of calcium supplementation on rectal epithelial hyperproliferation in intestinal bypass subjects Gastroenterology, 106 1162-1167, 1994.
19. Barsoum, G. H., Hendrickse, C., Winslet, M. C., Youngs, D., Donovan, I. A , Neoptolemos, J. P , and Keighley, M. R. B. Reduction of mucosal crypt cell proliferation in patients with colorectal adenomatous polyps by dietary calcium supplementation Br J. Surg., 79 581-583, 1992.
20. Welberg, J. W M., Kleibeuker, J. H , Van der Meer, R , Kuipers, F., Cats, A., Van Rijsbergen, H , Termont, D. S. M. L., Boersma-Van Ek, W , Vonk, R J , Mulder, N. H , and De Vries, E. G. E. Effects of oral calcium supplementation on intestinal bile acids and cytolytic activity of fecal water in patients with adenomatous polyps of the colon Eur J Clin. Invest., 23: 63-68, 1993.
21. Lapré, J. A., De Vries, H T., Termont, D. S. M L , Kleibeuker, J. H , De Vries, E. G. E , and Van der Meer, R. Mechanism of the protective effect of supplemental dietary calcium on cytolytic activity of fecal water Cancer Res , 53: 248-253, 1993
22. Govers, M J. A. P., Termont, D. S. M. L , and Van der Meer, R Mechanism of the antiproliferative effect of milk mineral and other calcium supplements on colonic epithelium. Cancer Res., 54: 95-100, 1994
23. De Jong, E A M , Klomp, H., Ellen, G., and Van Hemert, H. Evaluation of a segmented-flow method for the routine determination of urea in milk. Neth. Milk Dairy J., 46: 115-122, 1992.
24. Fiske, C. H., and Subbarow, Y The colorimetric determination of phosphorus J. Biol Chem , 66: 375-400, 1925.
25. Henry, R. J., Cannon, D C , and Winkelman, J. W. Clinical Chemistry, Principles and Techniques, pp. 1481-1483 New York: Harper and Row, 1974.
26. Van der Meer, R , Welberg, J. W. M., Kuipers, F., Kleibeuker, J H., Mulder, N. H., Termont, D. S. M. L., Vonk, R. J , De Vries, H. T., and De Vries, E. G. E Effects of supplemental dietary calcium on the intestinal association of calcium, phosphate, and bile acids. Gastroenterology, 99: 1653-1659, 1990.
27. Bligh, E. G., and Dyer, W. J. A rapid method of total lipid extraction and purification. Can. J Biochem. Physiol., 37: 911-917, 1959.
28. Chen, P. S., Toribara, T. Y., and Warner, H Microdetermination of phosphorus. Anal Chem., 28: 1756-1758, 1956
29. Lapré, J. A., Termont, D. S. M. L., Groen, A K., and Van der Meer, R. Lytic effects of mixed micelles of fatty acids and bile acids. Am. J. Physiol., 263: G333-G337, 1992.
30. Lewis, N. M., Marcus, M. S. K., Behling, A. R., and Greger, J L. Calcium supplements and milk: effects on acid-base balance and on retention of calcium, magnesium, and phosphorus Am. J. Clin. Nutr , 49: 527-533, 1989
31. Gregoire, R. C., Stern, H. S., Yeung, K. S., Stadler, J., Langley, S , Furrer, R., and Bruce, W. R. Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer. Gut, 30: 376-382, 1989.
32. Rémésy, C., Levrat, M A., Gamet, L., and Demigné, C. Cecal fermentations in rats fed oligosaccharides (inulin) are modulated by dietary calcium level. Am. J. Physiol., 264: G855-G862, 1993.
33. Richards, J. F., and Carroll, K. K. Studies on calcium phosphate fatty acid salts occurring in fecal lipids. Can. J Biochem. Physiol., 37: 725-730, 1959.
34. Saunders, D., Sillery, J., and Chapman, R Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis. Sci., 33: 409-413, 1988.
35. Welberg, J. W. M., Monkelbaan, J. F., De Vries, E G. E., Muskiet, F. A. J , Cats, A , Oremus, E. T. H G. J , Boersma-Van Ek, W , Van Rijsbergen, H., Van der Meer, R , Mulder, N. H., and Kleibeuker, J. H The effects of supplemental dietary calcium on quantitative and qualitative fecal fat excretion in man. Ann. Nutr & Metab., 38: 185-191, 1994
36. Bayerdörffer, E , Mannes, G E , Richter, W. O , Ochsenkühn, T , Wiebecke, B., Köpcke, W , and Paumgartner, G. Increased serum deoxycholic acid levels in men with colorectal adenomas. Gastroenterology, 104: 145-151, 1993.
37. Van der Werf, S. D. J., Nagengast, F. M., Van Berge Henegouwen, G. P., Huijbregts, A. W. M., and Van Tongeren, J. H. M. Colonic absorption of secondary bile acids in patients with adenomatous polyps and in matched controls. Lancet, 1: 759-762, 1982.
38. DeRubertis, F. R , Craven, P A., and Saito, R. Bile salt stimulation of colonic epithelial proliferation. Evidence for involvement of lipoxygenase products. J Clin. Invest., 74: 1614-1624, 1984.
39. Craven, P A., Pfanstiel, J , and DeRuberus, F. R. Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids J Clin. Invest., 79: 532-541, 1987.
40. Payne, C M , Bernstein, H , Bernstein, C., and Garewal, H. Role of apoptosis in biology and pathology: resistance to apoptosis in colon carcinogenesis. Ultrastruct. Pathol., 19: 221-248, 1995
41. Velardi, A. L. M., Groen, A. K., Oude Elferink, R. P. J., Van der Meer, R , Palasciano, G , and Tytgat, G. N. J. Cell type dependent effect of phospholipid and cholesterol on bile salt cytotoxicity. Gastroenterology, 101: 457-464, 1991.
42. Lapré, J A , and Van der Meer, R. Diet-induced increase of colonic bile acids stimulates lytic activity of fecal water and proliferation of colonic cells. Carcinogenesis (Lond.), 13: 41-44, 1992.
43. Lapré, J. A , De Vries, H. T., and Van der Meer, R The hyperproliferative effect of increasing amounts of dietary fat is inhibited by calcium (Abstract). Gastroenterology, 104: A419, 1993.