A repeat polymorphism in interleukin-4 gene is highly associated with specific clinical phenotypes of asthma

International Archives of Allergy and Immunology

Volumn 120, Issue 1, 1999, Pages 50-55

  Chouchane, Lotfi ^a,f   Sfar, I ^a   Bousaffara, R ^b   Kamel, A El ^c   Sfar, M T ^b   Ismail A ^a,d  

^a UNIVERSITY OF MONASTIR   (Tunisia)

^b Tahar Sfar University Hospital   (Tunisia)

^c FATTOUMA BOURGUIBA UNIVERSITY HOSPITAL   (Tunisia)

^d

^e Tunisia

^f Fac de Meacute d de Monastir   (Tunisia)

Author keywords

Asthma; Clinical phenotypes; Genetic predisposition; IL 4; Intron 2 polymorphism

Indexed keywords

INTERLEUKIN 4; REPETITIVE DNA;

ADOLESCENT; ADULT; ALLELE; ALLERGIC ASTHMA; ARTICLE; ASTHMA; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE SEVERITY; DISEASE TRANSMISSION; FAMILY STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HIGH RISK POPULATION; HUMAN; HUMAN CELL; INHERITANCE; INTRON; MAJOR CLINICAL STUDY; MALE; MARKER GENE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCHOOL CHILD; STATISTICAL ANALYSIS; TUNISIA;

ADOLESCENT; ADULT; ALLELES; ASTHMA; BASE SEQUENCE; CASE-CONTROL STUDIES; CHILD; DNA PRIMERS; FEMALE; GENOTYPE; HUMANS; INTERLEUKIN-4; INTRONS; MALE; PEDIGREE; PHENOTYPE; POLYMORPHISM, GENETIC; REPETITIVE SEQUENCES, NUCLEIC ACID; RISK FACTORS; TUNISIA;

EID: 0032878961     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024219     Document Type: Article

References (31)

1. National Heart, Lung, and Blood Institute: Guidelines for the diagnosis and management of asthma. National Asthma Education Program. J Allergy Clin Immunol 1991;88:425-534.
2. Sporik R, Holgate ST, Plans-Mills TAE, Cogswell JJ: Exposure to house-dust mite allergen (Der p I) and the development of asthma in chilhood: A prospective study. N Engl J Med 1990;323:502-507.
3. Young RP, Hart BJ, Merrett TG, Read AF, Hopkin JM: House dust mite sensitivity: Interaction of genetics and allergen dosage. Clin Exp Allergy 1992;22:205-211.
4. Zeiger RS: Development and prevention of allergic disease in childhood; in Middleton E Jr, Reed CE, Ellis EF, Adkinson NF Jr, Yunginger JW, Busse WW (eds): Allergy: Principles and Practice, ed 4. St. Louis, Mosby-Year Book, 1993, vol 2, pp 1137-1171.
5. Huang SK, Marsh DG: Genetics of allergy. Ann Allergy 1993;70:347-358.
6. Panhuysen CIM, Meyers DA, Postma DS, Bleeker ER: The genetics of asthma and atopy. Allergy 1995;50:863-869
7. Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley A, Corrigan C, Durham S, Kay AB: Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
8. Robinson DS, Hamid Q, Bentley A, Ying S, Kay AB, Durham S: Activation of CD4+ T cells, increased Th2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993;313-324.
9. Holgate ST, Church MK, Howarth PH, Morton NE, Frew AJ, Djukanovic R: Genetic and environmental influences on airway inflammation. Int Arch Allergy Immunol 1995;107:29-33.
10. Bleeker ER, Postma DS, Meyers DA: Evidence for multiple genetic susceptibility loci for asthma. Am J Respir Crit Care Med 1997; 156:S113-S116.
11. Meyers DA, Postma DS, Panhuysen CIM, Xu J, Amelung PJ, Levitt RC, Bleeker ER: Evidence for a locus regulating total serum IgE level mapping to chromosome 5. Genomics 1994;23:464-470.
12. Postma DS, Bleeker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CIM, Meyers DA, Levin RC: Genetic susceptibility to asthma: bronchial hyperresponsiveness coinhireted with a major gene of for atopy. N Engl J Med 1995; 333:894-900.
13. Bleeker ER, Scott AF, Xu J, Panhuysen CIM, Postma DS, Meyers DA. Fine mapping of asthma susceptibility locus to 5q31-33. Am J Hum Genet 1996;59:A213.
14. Doull IJM, Lawrence S, Watson M, Begishvili T, Beasley RW, Lampe F, Holgate ST, Morton NE: Allelic association of gene markers on chromosome 5q and 11q with atopy and bronchial hyperresponsiveness. Am J Respir Crit Care Med 1996;153:1280-1284.
15. Sandford A, Weir T, Pare P: The genetics of asthma. AmJ Respir Crit Care Med 1996;153: 1749-1765.
16. Ismaïl A, Bousaffara R, Kaziz J, Zili J, El Kamel A, Sfar MT, Remadi S, Chouchane L. Polymorphism in transporter antigen peptides gene (TAPI) associated with atopy in Tunisians. J Allergy Clin Immunol 1997;99: 216-223.
17. Marsh DG: Genetics of atopy and IgE; in Frank MM, Austen KF, Claman HN, Unanue ER, Samter US (eds): Immunological Diseases, ed 5. Boston, Little, Brown and Company, 1994, pp 1257-1272.
18. Marsh DG, Hsu SH, Roebber M, Ehrlich-Kautzky E, Freidhoff LR, Meyers DA, Pollard MK, Bias WB: HLA-Dw2: A genetic marker for human immune response to short ragweed pollen allergen Ra5. I. Response resulting primarily from natural antigenic exposure. J Exp Med 1982;155:1439-1451.
19. Shirakawa T, Li A, Dubowitz M, Dekker JW, Shaw AE, Faux JA, Ra C, Cookson WO, Hopkin JM: Association between atopy and variants of the beta subunit of the high affinity immunoglobulin E receptor. Nat Genet 1994;7: 125-129.
20. Marsh DG, Neely JD, Breazeale DR, Gosh B, Freidhoff LR, Ehrlich-Kautzky E, Schou C, Krishnaswamy G, Beaty TH: Linkage analysis of IL-4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994;264:1152-1156.
21. Boonefoy JY, Gauchat JF, Lecoanet-Henchoz S, Graber P, Aubry JP: Regulation of human IgE synthesis. Ann N Y Acad Sci 1996;796: 59-71.
22. Stavnezer J: Antibody class switching. Adv Immunol 1996;61:79-146.
23. Paul WE, Seder RA: Lymphocyte responses and cytokines. Cell 1994;76:241-251.
24. Olerup O, Zetterquist H: HLA-DR typing by PCR amplification with sequence specific primers (PCR-SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 1992;39:225-235.
25. Dyer P, Warrens A: Design and interpretation of studies of the major histocompatibility complex in disease: in Lechler R (ed): HLA and Disease. London, Academic Press, 1994, pp 93-121.
26. Kleinbaum N, Kupper S, Morgensten N: Principles and quantitative methods. In: Epidemiologic Research. London, Lifetime Learning Publications, 1982.
27. Collaborative Study of the Genetics of Asthma (CSGA): A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 1997;15:389-397.
28. Genome Data Base. Welch Library, the Johns Hopkins University, Baltimore, 21287.
29. Rosenwasser LJ, Klemm DJ, Dresback JK, Inamura H, Mascali JJ, Klinnert M, Borish L: Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995;25:74-78.
30. Walley AJ, Cookson WO. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. J Med Genet 1996;33:689-692.
31. Henkel G, Weiss DL, McCoy R, Deloughery T, Tara D, Brown MA: A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer. J Immunol 1992;149:3239.