Regulation of human IgE synthesis

Annals of the New York Academy of Sciences

Volumn 796, Issue , 1996, Pages 59-71

  Bonnefoy, Jean Yves ^a   Gauchat, Jean Francois ^a   Lecoanet Henchoz, Sybille ^a   Graber, Pierre ^a   Aubry, Jean Pierre ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD23 ANTIGEN; CD40 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; IMMUNOGLOBULIN E; INTERLEUKIN 4;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; NONHUMAN; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALIA;

EID: 0029826813     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb32567.x     Document Type: Conference Paper

References (91)

1. PENE, J., F. ROUSSET, F. BRIERE, I. CHRÉTIEN, J. Y. BONNEFOY, H. SPITS, T. YOKOTA, N. ARAI, K. ARAI & J. BANCHEREAU. 1988. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by intereferons g and a and prostaglandin E2. Proc. Natl. Acad. Sci. U.S.A. 85(18): 6880-6884.
2. GAUCHAT, J. F., D. A. LEBMAN, R. L. COFFMAN, H. GASCAN & J. E. DE VRIES. 1990. Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production. J. Exp. Med. 172(2): 463-473.
3. PUNNONEN, J., G. AVERSA, B. G. COCKS, A. N. MCKENZIE, S. MENON, G. ZURAWSKI, R. DE WAAL MALEFYT & J. E. DE VRIES. 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. U.S.A. 90(8): 3730-3734.
4. BONNEFOY, J. Y. & R. NOELLE. 1994. The CD40-CD40L interaction - All things to all immunologists. Res. Immunol. 145(3): 199-240.
5. KOPF, M., G. LE GROS, M. BACHMANN, M. C. LAMERS, H. BLUETHMANN & G. KOHLER. 1993. Disruption of the murine II-4 gene blocks Tg2 cytokine responses. Nature 362(6417): 245-248.
6. GASCAN, H., J. F. GAUCHAT, G. AVERSA, P. VAN VLASSELAER & J. E. DE VRIES. 1991. Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways. J. Immunol. 147(1): 8-13.
7. CHENG, G., A. M. CLEARY, Z. S. YE, D. I. HONG, S. LEDERMAN & D. BALTIMORE. 1994. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267(5203): 1494-1498.
8. KOTANIDES, H. & N. C. REICH. 1993. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 262(5137): 1265-1267.
9. HOU, J., U. SCHINDLER, W. J. HENZEL & T. C. HO. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265(5179): 1701-1706.
10. JOHNSTON, J. A., M KAWAMURA, R. A. KIRKEN, Y. Q. CHEN, T. B. BLAKE, K. SHIBUYA, J. R. ORTALDO, D. W. MCVICAR & J. J. O'SHEA. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370(6485): 151-153.
11. MIYAZAKI, T. A. KAWAHARA, H. FUJII, Y. NAKAGAWA, Y. MINAMI, Z. J. LIU, I. OISHI, O. SILVENNOINEN, B. A. WITTHUHN & J. N. IHLE. 1994. Functional activation of Jak-1 and Jak-3 by selective association with IL-2 receptor subunits. Science 266(5187): 1045-1047.
12. HELDIN, C. H. 1995. Dimerization of cell surface receptors in signal transduction. Cell 80(2): 213-223.
13. KLINGMULLER, U., U. LORENZ, L. C. CANTLEY, B. G. NEEL & H. F. LODISH. 1995. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80(5): 729-738.
14. D'AMBROSIO, D., K. L. HIPPEN, S. A. MINSKOFF, I. MELLMAN, G. PANI, K. A. SIMINOVITCH & J. C. GAMBIER. 1995. Science 268(5208): 293-297.
15. HU, M. H., K. O'ROURKE, M. S. BOGUSKI & V. M. DIXIT. 1994. A novel RING finger protein interacts with the cytoplasmic domain of CD40. J. Biol. Chem. 269(48): 30069-30072.
16. SATO, T., S. IRIE & J. C. REED. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. 1995. FEBS 358(2): 113-118.
17. MOSIALOS, G., M. BIRKENBACH, R. YALAMANCHILI, T. VANARSDALE, C. WARE & E. KIEFF. 1995. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. 1995. Cell 80(3): 389-399.
18. FLORES-ROMO, L., J. F. GAUCHAT, P. GRABER, J. P. AUBRY & J. Y. BONNEFOY. The role of surface molecules in the control of human IgE synthesis. In Molecular Analysis of IgE-Mediated Hypersensitivity and Strategies for Immunological Intervention, A. M. Roberts, Ed. Wiley. London. In press.
19. YOKOTA, A., H. KIKUTANI, T. TANAKA, R. SATO, E. L. BASUMIAN, M. SUEMURA & T. KISHIMOTO. 1988. Two species of human FcERII (CD23): Tissue-specific and IL-4-specific regulation of gene expression. Cell. 55(4): 611-618.
20. SARFATI, M., E. RECTOR, K. WONG, M. RUBIO-TRUJILLO, A. H. SEHON & G. DELESPESSE. 1984. In vitro synthesis of IgE by human B lymphocytes. II. Enhancement of the spontaneous IgE synthesis by IgE-binding factors secreted by RPMI 8866 lymphoblastoid B cells. Immunol. 53(2): 197-214.
21. SARFATI, M. & G. DELESPESSE. 1988. Possible role of human lymphocyte receptorfor IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE. J. Immunol. 141(7): 2195-2199.
22. THOMPSON, L. F., H. L. SPIEGELBERG & R. H. BUCKLEY. 1985. IgE Fc receptor positive T and B lymphocytes in patients with the Hyper IgE syndrome. Clin. Exp. Immunol. 59(1): 77-84.
23. NAGAI, T., M. ADACHI, N. NORO, J. YODO & H. UCHINO. 1985. T and B lymphocytes with Immunoglobulin E Fc receptors (FcER) in patients with nonallergic Hyperimmunoglobulinemia E: Demonstration using a monoclonal antibody against FcER-associated antigen. Clin. Immunol. Immunopathol. 35(3): 261-275.
24. YANAGIHARA, Y., M. SARFATI, D. MARSH, T. NUTMAN & G. DELESPESSE. 1990. Serum levels of IgE-binding factor (soluble CD23) in diseases associated with elevated IgE. Clin. Exp. Allergy 20(4): 395-401.
25. BENGTSSON, M., J. GORDON, L. FLORES-ROMO, J. A. CAIRNS, B. SMEDMYR, G. OBERG, B. SIMONSSON & T. H. TOTTERMAN. 1989. B cell reconstitution after autologous bone marrow transplantation: Increase in serum CD23 precedes IgE and B cell regeneration. Blood 73(8): 2139-2144.
26. DEFRANCE, T, J. P. AUBRY, F. ROUSSET, B. VANBERVLIETET, J. Y. BONNEFOY, N. ARAI, Y. TAKEBE, J. YOKOTA, F. LEE & K. ARAI 1987. Human recombinant interleukin 4 induces FcER (CD23) on normal B lymphocytes. J. Exp. Med. 165(6): 1459-1467.
27. BONNEFOY, J. Y., J. J. MERMOD & J. SHIELDS. 1990. Inhibition of human IL-4 induced IgE synthesis by a subset of anti-CD23/FcERII monoclonal antibodies. Eur. J. Immunol. 20(1): 139-144.
28. FLORES-ROMO, L.,G. D. JOHNSON, A. A. GHATDERI, D. R. STANWORTH, A. VERONESI & J. GORDON. 1990. Functional implication for the topographical association between MHC class II and the low affinity receptor for IgE: Occupancy of CD23 blocks the ability of B cells to present alloantigen to T cells. Eur. J. Immunol. 20(1): 2465-2469.
29. WANG, F., C. D. GREGORY, M. ROWE, A. B. RICKINSON, D. WANG, M. BIRKENBACH, H. KIKUTANI, J. KISHIMOTO & E. KIEFF. 1987. Epstein-Barr virus nuclear antigen-2 specifically induces expression of the B cell activation antigen CD23. Proc. Natl. Acad. Sci. U.S.A. 84(10): 3452-3456.
30. BJORCK, P., C. ELENSTROM-MAGNUSSON, A. ROSEN, E. SEVERINSON & S. PAULIE. 1993. CD23 and CD21 function as adhesion molecules in homotypic aggregation of human B lymphocytes. Eur. J. Immunol. 23(6): 1771-1775.
31. VERCELLI, D., H. H. JABARA, K. I. ARAI & R. S. GEHA. 1989. Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC Class II antigens. J. Exp. Med. 169(4): 1295-1307.
32. AUBRY, J. P., J. C. SHIELDS, K. U. JANSEN & J. Y. BONNEFOY. 1993. A multiparameter flow cytometric method to study surface molecules involved in interactions between subpopulations of cells. J. Immunol. Methods 159(1-2): 161-171.
33. BEVILACQUA, M. P., S. STENGELIN, M. A. GIMBRONE & B. SEED. 1989. Endothelial leukocyte adhesion molecule-1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243(4895): 1160-1165.
34. BETTLER, B., R. MAIER, D. RUEGG & H. HOFSTETTER. 1989. Binding site of IgE of the human low affinity receptor (FcERII/CD23) is confined to the domain homologous with animal lectins. Proc. Natl. Acad. Sci. U.S.A. 86(15): 7118-7122.
35. AUBRY, J. P., S. POCHON, P. GRABER, K. U. JANSEN & J. Y. BONNEFOY. 1992. CD21 is a ligand for CD23 and regulates IgE production. Nature 358(6386): 505-507.
36. POCHON, S., P. GRABER, M. YAEGER, K. JANSEN, A. R. BERNARD, J. P. AUBRY & J. Y. BONNEFOY. 1992. Demonstration of a second ligand for the low affinity receptor for IgE (CD23) using recombinant CD23 reconstituted into fluorescent liposomes. J. Exp. Med. 176(2): 389-397.
37. GORDON, J., L. FLORES-ROMO, J. CAIRNS, M. J. MILLSUM, P. J. LANE, G. D. JOHNSON & I. C. MACLENNAN. 1989. CD23: A multi-functional receptor/lymphokine? Immunol. Today 10: 153-157.
38. LIU, Y. J., J. A. CAIRNS, M. HOLDER, S. D. ABBOT, K. U. JANSEN, J. Y. BONNEFOY, J. GORDON & I. C. MACLENNAN. 1991. Recombinant 25 kDa CD23 and interleukin-1 promote the survival of germinal center B cells: Evidence for bifurcation in the development of centrocytes rescued from apoptosis. Eur. J. Immunol. 21(5): 1107-1114.
39. MOSSALAYI, M. D., J. C. LECRON, A. H. DALLOUL, M. SARFATI, J. M. BERTHO, G. DELESPESSE & P. DEBRÉ. 1990. Soluble CD23 (FcERII) and interleukin-1 synergistically induce early human thymocyte maturation. J. Exp. Med. 171(3): 959-964.
40. MOSSALAYI, M. D., M. AROCK, J. M. BERTHO, C. BLANC, A. H. DALLOUL, H. HOFSTETTER, M. SARFATI, G. DELESPESSE & P. DEBRÉ. 1990. Proliferation of early human myeloid precursors induced by interleukin-1 and recombinant soluble CD23. Blood 75(10): 1924-1927.
41. CAPRON, A., J. P. DESSAINT, M. CAPRON, M. JOSEPH, J. C. AMEISEN & A. B. TONNEL. 1986. From parasites to allergy: A second receptor for IgE. Immunol. Today 7: 15-18.
42. KEHRY, M. R. & L. C. YAMASHITA. 1989. FcERII (CD23) function on mouse B cells: Role in IgE dependent antigen focusing. Proc. Natl. Acad. Sci. U.S.A. 86(19): 7556-7560.
43. PIRRON, U., T. SCHLUNCK, J. C. PRINZ & E. P. RIEBER. 1990. IgE-dependent antigen focusing by human B lymphocytes is mediated by the low affinity receptor for IgE. Eur. J. Immunol. 20(7): 1547-1551.
44. GROSJEAN, I., A. LACHAUX, C. BELLA, J. P. AUBRY, J. Y. BONNEFOY & D. KAISERLAN. 1994. CD23/CD21 interaction is required for presentation of soluble protein antigen by lymphoblastoid B cell lines to specific CD4+ T cell clones. Eur. J. Immunol. 24(12): 2982-2986.
45. TEXIDO, G., H. EIBEL, G. LE GROS & H. VAN DER PUTTEN. 1994. Transgene CD23 expression on lymphoid cells modulates IgE and IgG1 responses. J. Immunol. 153(7): 3028-3042.
46. FUJIWARA, H., H. KIKUTANI, S. SUEMATSU, T. NAKA, K. YOSHIDA, T. TANAKA, M. SUEMURA, N. MATSUMOTO & S. KOJIMA. 1994. The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 91(15): 6835-6839.
47. MORRIS, S. C., A. LEES, J. M. HOLMES, R. D. JEFFRIES & F. D. FINKELMAN. 1994. Induction of B cell and T cell tolerance in vivo by anti-CD23 mAb. J. Immunol. 152(8): 3768-3776.
48. STIEF, A., G. TEXIDO, G. SANSIG, H. EIBEL, G. LE GROS & H. VAN DER PUTTEN. 1994. Mice deficient in CD23 reveal its modulatory role in IgE production but no role in T and B cell development. J. Immunol. 152(7): 3378-3390.
49. YU, P., M. KOSCO-VILBOIS, M. RICHARDS, G. KOHLER & M. C. LAMERS. 1994. Negative feedback regulation of IgE synthesis by murine CD23. Nature 369(6483): 753-756.
50. FLORES-ROMO, L., J. SHIELDS, Y. HUMBERT, P. GRABER, J. P. AUBRY, J. F. GAUCHAT, G. AYALA, B. ALLET, M. CHAVEZ, H. BAZIN & J-Y. Bonnefoy. 1993. Inhibition of an in vivo antigen-specific IgE response by antibodies to CD23. Science 261(5124): 1038-1041.
51. BONNEFOY, J. Y., O. GUILLOT, H. SPITS, D. BLANCHARD, K. ISHIZAKA & J. BANCHEREAU. 1988. The low affinity receptor of IgE (CD23) on B lymphocytes is spatially associated with HLA-DR antigens. J. Exp. Med. 167(1): 57-72.
52. MOSSALAYI, D. M., M. AROCK, G. DELESPESSE, H. HOFSTETTER, B. BETTLER, A. H. DALLOUL, E. KILCHHERR, F. QUAAZ, P. DEBRE & M. SARFATI. 1992. Cytokine effects of CD23 are mediated by an epitope distinct from the IgE binding site. EMBO J. 11(12): 4323-4328.
53. THYPHRONITIS, G., G. C. TSOKOS, C. H. JUNE, A. D. LEVINE & F. D. FINKELMAN. 1989. IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon g. Proc. Natl. Acad. Sci. U.S.A. 86(14): 5580-5584.
54. AUBRY, J. P., S. POCHON, J. F. GAUCHAT, A. NUEDA-MARIN, V. M. HOLERS, P. GRABER, C. SIEGFRIED & J. Y. BONNEFOY. 1994. CD23 interacts with a new functional extracytoplasmic domain involving N-linked Oligosaccharides on CD21. J. Immunol. 152(12): 5806-5813.
55. HENCHOZ-LECOANET, S., P. JEANNIN, J. P. AUBRY, P. GRABER, C. G. BRADSHAW, S. POCHON & J. Y. BONNEFOY. 1996. The Epstein Barr virus-binding site on CD21 is involved in CD23 binding and IL-4 induced IgE and IgG4 production by human B cells. Immunology 88: 35-39.
56. GAGRO, A. & S. RABATIC. 1994. Allergen-induced CD23 on CD4+ T lymphocytes and CD21 on B lymphocytes in patients with allergic asthma: Evidence and regulation. Eur. J. Immunol. 24(5): 1109-1114.
57. GAGRO, A., S. RABATIC, A. TRESCEC, D. DEKARIS & M. MEDAR-LASIC. 1993. Expression of lymphocytes Fc epsilon RII/CD23 in allergic children undergoing hyposensitization. Int. Arch. Allergy Appl. Immunol. 101(2): 203-208.
58. LECOANET-HENCHOZ, S., J. F. GAUCHAT, J. P. AUBRY, P. GRABER, P. LIFE, N. PAUL-EUGÈNE, B. FERRUA, A. L. CORBI, B. DUGAS, C. PLATER-ZYBERK & J. Y. BONNEFOY. 1995. CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b/CD18 and CD11c/CD18. Immunity 3: 119-125.
59. TAKIGAWA, M., T. TAMAMORI, D. HORIGUCHI, T. SAKAMOTO, M. YAMADA, A. YOSHIOKA, K. TODA, S. IMAMURA & J. YODOI. 1991. FcER II/CD23 positive lymphocytes in atopic dermatitis. I. The proportion of FcERII + lymphocytes correlates with the extent of skin lesion. Clin. Exp. Immunol. 84(2): 275-282.
60. ARMITAGE, R. J., L. K. GOFF & P. C. L. BEVERLEY. 1989. Expression and functional role of CD23 on T cells. Eur. J. Immunol. 19(1): 31-35.
61. PRINZ, J. C., X. BAUR, G. MAZUR & E. P. RIEBER. 1990. Allergen-directed expression of Fc receptors for IgE (CD23) on human T lymphocytes is modulated by interleukin 4 and interferon g. Eur. J. Immunol. 20(6): 1259-1264.
62. YAMAOKA, K. A., S. TSUKIDATE, M. HIGAKI, N. MRYASAKA & K. FUJITA. 1991. Induction of FcERII/CD23 on human T cells by excretory and secretory antigen of Dirofilaria immitis. Int. Arch. Allergy Appl. Immunol. 95(1): 92-93.
63. BONNEFOY, J. Y., S. HENCHOZ, D. HARDIE, M. J. HOLDER & J. GORDON. 1993. A subset of anti-CD21 antibodies promote the rescue of germinal center B cells from apoptosis. Eur. J. Immunol. 23(4): 969-972.
64. MAEDA, K., G. F. BURTON, D. A. PADGETT, D. H. CONRAD, T. F. HUFF, A. MASUDA & A. K. SZAKAL. 1992. Murine follicular dendritic cells and low affinity Fc receptors for IgE (FcERII). J. Immunol. 148(8): 2340-2347.
65. MITANI, S., K. TAKAGI, T. OKA & S. MORI. 1988. Increased Immunoglobulin E Fc receptor bearing cells in germinal centers of hyperimmunoglobulinemia E patients. Int. Arch. Allergy Appl. Immunol. 87(1): 63-69.
66. OKUMURA, K. & T. TADA. 1971. Regulation of homocytotropic antibody formation in the rat. III. Effect of thymectomy and splenectomy. J. Immunol. 106: 1019-1025.
67. JABARA, H. H., S. M. FU, R. S. GEHA & D. VERCELLI. 1990. CD40 and IgE: Synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J. Exp. Med. 172(6): 1861-1864.
68. STAMENKOVIC, I., E. A. CLARK & B. SEED. 1989. A B lymphocyte activation molecule related to nerve growth factor receptor and induced by cytokines. EMBO J. 8(5): 1403-1410.
69. GORDON, J., M. J. MILLSUM, G. R. GUY & J. A. LEDBETTER. 1988. Resting B lymphocytes can be triggered directly through the CDW40 (Bp50) antigen. J. Immunol. 140(5): 1425-1430.
70. BARRETT, T. B., G. SHU & E. A. CLARK. CD40 signalling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells. J. Immunol. 146(6): 1722-1729.
71. FLORES-ROMO, L., D. ESTOPPEY & K. B. BACON. 1993. Anti-CD40 antibody stimulates the VLA-4-dependent adhesion of normal and LFA-1-deficient B cells to endothelium. Immunology. In press.
72. LIU, Y. J., D. E. JOSHUA, G. T. WILLIAMS, C. A. SMITH, G. GORDON & I. C. MACLENNAN. 1989. Mechanism of antigen-driven selection in germinal centers. Nature 342(6252): 929-931.
73. BANCHEREAU, J., P. DE PAOLI, A. VALLE, E. GARCIA & F. ROUSSET. 1991. Long-term growth of human B cell lines dependent on interleukin 4 and antibody to CD40. Science 251(4989): 70-72.
74. SHAPIRA, S. K., D. VERCELLI, H. H. JABARA, S. M. FU & R. S. GEHA. 1992. Molecular analysis of the induction of immunoglobulin IgE synthesis in human B cells by interleukin 4 and engagement of CD40 antigen. J. Exp. Med. 175(1): 289-292.
75. GAUCHAT, J. F., G. AVERSA, H. GASCAN & J. E. DE VRIES. 1992. Modulation of IL-4 induced germline e RNA synthesis in human B cells by tumor necrosis factor a, anti-CD40 monoclonal antibodies or transforming growth factor b correlates with levels of IgE production. Int. Immunol. 4(3): 397-406.
76. ARMITAGE, R. J., W. C. FANSLOW, L. STROCKBINE, T. A. SATO, K. N. CLIFFORD, B. M. MACDUFF, D. M. ANDERSON, S. D. GIMPEL, T. DAVIS-SMITH & C. R. MALISZEWSKI. 1992. Molecular and biological characterization of a murine ligand for CD40. Nature 357(6373): 80-82.
77. HOLLENBAUGH, D., L. S. GROSMAIRE, C. D. KULLAS, N. J. CHALUPNY, S. BRAESCHANDERSEN, R. J. NOELLE, I. STAMENKOVIC, J. A. LEDBETTER & A. ARUFFO. 1992. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: Expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J. 12(11): 4313-4321.
78. GRAF, D., U. KORTHAUER, H. W. MAGES, G. SENGER & R. A. KROCZEK. 1992. Cloning of TRAP, a ligand for CD40 on human T cells. Eur. J. Immunol. 22(12): 3191-3194.
79. SPRIGGS, M. K., R. J. ARMITAGE, L. STROCKBINE, K. N. CLIFFORD, B. M. MACDUFF, T. A. SATO, C. R. MALISZEWSKI & W. C. FANSLOW. 1992. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J. Exp. Med. 176(6): 1543-1550.
80. GAUCHAT, J. F., J. P. AUBRY, G. MAZZEI, P. LIFE, T. JOMOTTE, G. ELSON & J. Y. BONNEFOY. 1993. Human CD40-ligand: Molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production. FEBS Lett. 315(3): 259-266.
81. DISANTO, J. P., J. Y. BONNEFOY, J. F. GAUCHAT, A. FISCHER & G. DE SAINT BASILE. 1993. CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM. Nature 361(6412): 541-543.
82. KORTHAUER, U., D. GRAF, H. W. MAGES, F. BRIERE, M. PADAYACHEE, S. MALCOLM, A. G. UGAZIO, L. D. NOTARANGELO, R. J. LEVINSKY & R. A. KROCZEK. 1993. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 361(6412): 539-541.
83. ARUFFO, A., M. FARRINGTON, D. HOLLENBAUGH, X. LI, A. MILATOVICH, S. NONOYAMA, J. BAJORATH, L. S. GROSMAIRE, R. STENKAMP & M. NAUBAUER. 1993. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell 72(2): 291-300.
84. ALLEN, R. C., R. J. ARMITAGE, M. E. CONLEY, H. ROSENBLATT, N. A. JENKINS, N. G. COPELAND, M. A. BEDELL, S. EDELHOFF, C. M. DISTECHE & D. K. SIMONEAUX. 1993. CD40 ligand defects responsible for X-linked hyper-IgM syndrome. Science 259(5097): 990-993.
85. FULEIHAN, R., N. RAMESH, R. LOH, H. JABARA, R. S. ROSEN, T. CHATILA, S. M. FU, I. STAMENKOVIC & R. S. GEHA. 1993. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc. Natl. Acad. Sci. U.S.A. 90(6): 2170-2173.
86. GAUCHAT, J. F., S. HENCHOZ, G. MAZZEI, J. P. AUBRY, T. BRUNNER, H. BLASEY, P. LIFE, D. TALABOT, L. FLORES-ROMO, J. THOMPSON, K. KISHI, J. BUTTERFIELD, C. DAHINDEN & J. Y. BONNEFOY. 1993. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 365(6444): 340-343.
87. GAUCHAT, J. F., S. HENCHOZ, D. FATTAH, G. MAZZEI, J. P. AUBRY, T. JOMOTTE, L. DASH, K. PAGE, R. SOLARI, D. ALDEBERT, M. CAPRON, C. DAHINDEN & J. Y. BONNEFOY. 1995. CD40 ligand is functionally expressed on human eosinophils. Eur. J. Immunol. 25(3): 863-865.
88. PICCINNI, M. P., D. MACCHIA, P. PARRONCHI, M. G. GIUDIZI, D. BANI, R. ALTERNI, A. GROSSI, M. RICCI, E. MAGGI & S. ROMAGNANI. 1991. Human bone marrow non-B, non-T cells produce interleukin 4 in responses to cross-linkage of Fce and Fcg receptors. Proc. Natl. Acad. Sci. U.S.A. 88(19): 8656-8660.
89. BRUNNER, T., C. H. HEUSSER & C. A. DAHINDEN. 1993. Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation. J. Exp. Med. 177(3): 605-611.
90. BROWN, M. A., J. H. PIERCE, C. J. WATSON, J. FALCO, J. N. IHLE & W. E. PAUL. 1987. B Cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Cell 50(5): 809-818.
91. LEDERMAN, F., C. HEUSSER, C. SCHLEINGER & G. LE GROS. 1992. Interleukin 3-treated non-B, non-T cells switch activated B cells to IgG1/IgE synthesis. Eur. J. Immunol. 22(11): 2783-2787.