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Volumn 6, Issue 4, 1999, Pages 235-240

Homocysteine and risk of stroke

Author keywords

Epidemiological study; Homocysteine; Stroke

Indexed keywords

HOMOCYSTEINE; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CREATININE;

EID: 0032874965     PISSN: 13506277     EISSN: None     Source Type: Journal    
DOI: 10.1177/204748739900600408     Document Type: Review
Times cited : (36)

References (37)
  • 1
    • 0021894152 scopus 로고
    • The natural history of homocystinuria due to cystathionine beta-synthase deficiency
    • Mudd SH, Skovby F, Levy HL, Pettigrew KD, Wilcken B, Pyeritz RE, et al. The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 1985; 37:1-31. A classic paper on natural history of severe congenital homocysteinuria.
    • (1985) Am J Hum Genet , vol.37 , pp. 1-31
    • Mudd, S.H.1    Skovby, F.2    Levy, H.L.3    Pettigrew, K.D.4    Wilcken, B.5    Pyeritz, R.E.6
  • 3
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinaemia in an elderly population
    • 6 as key determinants of hyperhomocysteinaomia among the elderly. Compliance with current nutritional guidelines for this age-group is not necessarily associated with normal levels of homocysteine.
    • (1993) JAMA , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jaque, P.F.2    Wilson, P.W.F.3    Rush, D.4    Rosenberg, J.H.5
  • 4
    • 0028918123 scopus 로고
    • Can lowering homocysteine levels reduce cardiovascular disease risk?
    • Stampfer MJ, Malinow MR. Can lowering homocysteine levels reduce cardiovascular disease risk? N Engl J Med 1995; 332:328-329.
    • (1995) N Engl J Med , vol.332 , pp. 328-329
    • Stampfer, M.J.1    Malinow, M.R.2
  • 6
    • 0029066299 scopus 로고
    • A quantative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SAA, Omenn GS, Motolsky AG. A quantative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995; 274:1049-1057. A definitive meta-analysis of studies, published up to June 1994, addressing associations between homocysteine and coronary artery disease, cerebrovascular disease and peripheral vascular disease. It includes a good discussion of public health implications of the findings, with particular reference to folate supplementation.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.A.2    Omenn, G.S.3    Motolsky, A.G.4
  • 8
    • 0009673527 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia
    • Cattaneo M. Hyperhomocysteinaemia. Vessels 1997; 3:16-21.
    • (1997) Vessels , vol.3 , pp. 16-21
    • Cattaneo, M.1
  • 9
    • 0023696435 scopus 로고
    • Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate roductase
    • Kang S-S, Zhou J, Wong PWK, Kowalisyn J, Storkosch G. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate roductase. Am J Hum Genet 1988; 42:414-421.
    • (1988) Am J Hum Genet , vol.42 , pp. 414-421
    • Kang, S.-S.1    Zhou, J.2    Wong, P.W.K.3    Kowalisyn, J.4    Storkosch, G.5
  • 10
    • 0029806746 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
    • Ma JSM, Hennekens CH, Frosst P, Selhub J, Horsford J, Malinow MR, et al. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation 1996; 94:2410-2416.
    • (1996) Circulation , vol.94 , pp. 2410-2416
    • Ma, J.S.M.1    Hennekens, C.H.2    Frosst, P.3    Selhub, J.4    Horsford, J.5    Malinow, M.R.6
  • 11
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenotetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenotetrahydrofolate reductase [letter]. Nat Genet 1995; 10:111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3    Goyette, P.4    Sheppard, C.A.5    Matthews, R.G.6
  • 12
    • 0028600627 scopus 로고
    • Homocysteine and cysteine: Determinants of plasma levels in middle-aged and elderly subjects
    • Brattstrom L, Lindgren A, Israelsson B, Andersson A, Hultberg B. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med 1994; 236:633-641.
    • (1994) J Intern Med , vol.236 , pp. 633-641
    • Brattstrom, L.1    Lindgren, A.2    Israelsson, B.3    Andersson, A.4    Hultberg, B.5
  • 13
    • 0028788020 scopus 로고
    • Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study
    • Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 1995; 274:1526-1533. Large cross-sectional study, providing good data on associations between homocysteine and established cardiovascular disease risk factors.
    • (1995) JAMA , vol.274 , pp. 1526-1533
    • Nygard, O.1    Vollset, S.E.2    Refsum, H.3    Stensvold, I.4    Tverdal, A.5    Nordrehaug, J.E.6
  • 14
    • 2642676850 scopus 로고    scopus 로고
    • Major lifestyle determinants of plasma total homocysteine distribution: The hordaland homocysteine study
    • Nygard O, Refsum H, Ueland PM, Vollset SE. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr 1998; 67:263-270.
    • (1998) Am J Clin Nutr , vol.67 , pp. 263-270
    • Nygard, O.1    Refsum, H.2    Ueland, P.M.3    Vollset, S.E.4
  • 15
    • 0025924025 scopus 로고
    • How independent are "independent" effects? Relative risk estimation when correlated exposures are measured imprecisely
    • Phillips AN, Smith GD. How independent are "independent" effects? Relative risk estimation when correlated exposures are measured imprecisely. J Clin Epidemiol 1991; 44:1223-1231.
    • (1991) J Clin Epidemiol , vol.44 , pp. 1223-1231
    • Phillips, A.N.1    Smith, G.D.2
  • 16
    • 0027963429 scopus 로고
    • Hyperhomocysteinemia: A newly recognised risk factor for vascular disease
    • Boers GHJ. Hyperhomocysteinemia: a newly recognised risk factor for vascular disease. Neth J Med 1994; 45:34-41.
    • (1994) Neth J Med , vol.45 , pp. 34-41
    • Boers, G.H.J.1
  • 17
    • 0030797307 scopus 로고    scopus 로고
    • Hyperhomocysteinemia as a risk factor for arterial and venous disease. A review of evidence and relevance
    • Boers GH. Hyperhomocysteinemia as a risk factor for arterial and venous disease. A review of evidence and relevance. Thromb Haemost 1997; 78:520-522.
    • (1997) Thromb Haemost , vol.78 , pp. 520-522
    • Boers, G.H.1
  • 18
    • 1842331509 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for vascular disease. The European concerted action project
    • Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA 1997; 277:1775-1781. Major case-control study from the European Concerted Action project. The study was based in 19 centres in nine European countries and recruited a total of 750 cases of atherosclerotic vascular disease (cardiac cerebral and peripheral) and 800 controls of both sexes, younger than 60 years. The study reports positive findings on associations between homocysteine and vascular end-points and provides detailed exploration of interactions between homocysteine and established risk factors.
    • (1997) JAMA , vol.277 , pp. 1775-1781
    • Graham, I.M.1    Daly, L.E.2    Refsum, H.M.3    Robinson, K.4    Brattstrom, L.E.5    Ueland, P.M.6
  • 19
    • 0028219672 scopus 로고
    • Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study
    • Alfthan G, Pekkanen J, Jauhiainen M, Pitkaniemi J, Karvonen M, Tuomilehto J, et al. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis 1994; 106:9-19.
    • (1994) Atherosclerosis , vol.106 , pp. 9-19
    • Alfthan, G.1    Pekkanen, J.2    Jauhiainen, M.3    Pitkaniemi, J.4    Karvonen, M.5    Tuomilehto, J.6
  • 21
    • 0032501963 scopus 로고    scopus 로고
    • Low circulating folate and vitamin B6 concentrations: Risk factors for stroke, peripheral vascular disease, and coronary artery disease
    • European COMAC Group
    • Robinson K, Arheart K, Refsum H, Brattstrom L, Boers G, Ueland P, et al. Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group. Circulation 1998; 97:437-443.
    • (1998) Circulation , vol.97 , pp. 437-443
    • Robinson, K.1    Arheart, K.2    Refsum, H.3    Brattstrom, L.4    Boers, G.5    Ueland, P.6
  • 22
    • 0027523674 scopus 로고
    • Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis risk in communities study
    • Malinow MR, Nieto FJ, Szklo M, Chambless LE, Bond G. Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study. Circulation 1993; 87:1107-1113.
    • (1993) Circulation , vol.87 , pp. 1107-1113
    • Malinow, M.R.1    Nieto, F.J.2    Szklo, M.3    Chambless, L.E.4    Bond, G.5
  • 23
    • 0030698745 scopus 로고    scopus 로고
    • Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly: The Rotterdam study
    • Bots ML, Launer LJ, Lindemans J, Hofman A, Grobbee DE. Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly: The Rotterdam Study. J Intern Med 1997; 242:339-347.
    • (1997) J Intern Med , vol.242 , pp. 339-347
    • Bots, M.L.1    Launer, L.J.2    Lindemans, J.3    Hofman, A.4    Grobbee, D.E.5
  • 24
    • 0028966321 scopus 로고
    • Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis
    • Selhub J, Jacques PF, Bostom AG, D'Agostino RB, Wilson PW, Belanger AJ, et al. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 1995; 332:286-291. This study provides data suggesting a continuous graded association between plasma homocysteine concentrations and carotid artery disease.
    • (1995) N Engl J Med , vol.332 , pp. 286-291
    • Selhub, J.1    Jacques, P.F.2    Bostom, A.G.3    D'Agostino, R.B.4    Wilson, P.W.5    Belanger, A.J.6
  • 25
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
    • Perry I, Refsum H, Morris R, Ebrahim S, Ueland P, Shaper A. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 1995; 346:1395-1398. A nested case-control study within the British Regional Heart Study cohort, addressing the association between serum total homocysteine and risk of stroke. The findings suggest a continuous association between serum homocysteine and risk of stroke without an obvious threshold.
    • (1995) Lancet , vol.346 , pp. 1395-1398
    • Perry, I.1    Refsum, H.2    Morris, R.3    Ebrahim, S.4    Ueland, P.5    Shaper, A.6
  • 26
    • 0029800912 scopus 로고    scopus 로고
    • Serum total homocysteine concentration and risk of stroke
    • Perry IJ. Serum total homocysteine concentration and risk of stroke [letter]. Lancet 1996; 348:1526.
    • (1996) Lancet , vol.348 , pp. 1526
    • Perry, I.J.1
  • 27
    • 0000972816 scopus 로고    scopus 로고
    • Homocysteine and risk of cardiovascular disease in the elderly. The Rotterdam study
    • Bots ML, Witteman JCM, Hoes AW, Koudstaal PJ, Grobbee DE. Homocysteine and risk of cardiovascular disease in the elderly. The Rotterdam Study [abstract]. Can J Cardiol 1997; 13 (suppl B): 150B.
    • (1997) Can J Cardiol , vol.13 , Issue.SUPPL. B
    • Bots, M.L.1    Witteman, J.C.M.2    Hoes, A.W.3    Koudstaal, P.J.4    Grobbee, D.E.5
  • 28
    • 0029012077 scopus 로고
    • Serum folate and risk for ischemic stroke. First national health and nutrition examination survey epidemiologic follow-up study
    • Giles WH, Kittner SJ, Anda RF, Croft JB, Casper ML. Serum folate and risk for ischemic stroke. First National Health and Nutrition Examination Survey epidemiologic follow-up study. Stroke 1995; 26:1166-1170.
    • (1995) Stroke , vol.26 , pp. 1166-1170
    • Giles, W.H.1    Kittner, S.J.2    Anda, R.F.3    Croft, J.B.4    Casper, M.L.5
  • 29
    • 0028670786 scopus 로고
    • Homocyst(e)ine and arterial occlusive diseases
    • Malinow MR. Homocyst(e)ine and arterial occlusive diseases. J Intern Med 1994; 236:603-617.
    • (1994) J Intern Med , vol.236 , pp. 603-617
    • Malinow, M.R.1
  • 31
    • 0032499024 scopus 로고    scopus 로고
    • Homocysteine and atherothrombosis
    • Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998; 338:1042-1050. Good review of recent work on homocysteine and vascular disease, with a short, but comprehensive overview of current hypotheses on the pathophysiological mechanisms of hyperhomocysteinaemia.
    • (1998) N Engl J Med , vol.338 , pp. 1042-1050
    • Welch, G.N.1    Loscalzo, J.2
  • 32
    • 0031979737 scopus 로고    scopus 로고
    • A methylenetetrahydrofolate reductase gene polymorphism in ischaemic stroke and in carotid artery stenosis
    • Kostulas K, Crisby M, Huang WX, Lannfelt L, Hagenfeldt L, Eggertsen G, et al. A methylenetetrahydrofolate reductase gene polymorphism in ischaemic stroke and in carotid artery stenosis. Eur J Clin Invest 1998; 28:285-289.
    • (1998) Eur J Clin Invest , vol.28 , pp. 285-289
    • Kostulas, K.1    Crisby, M.2    Huang, W.X.3    Lannfelt, L.4    Hagenfeldt, L.5    Eggertsen, G.6
  • 33
    • 0030880665 scopus 로고    scopus 로고
    • A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease
    • Markus HS, Ali N, Swaminathan R, Sankaralingam A, Molloy J, Powell J. A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease. Stroke 1997; 28:1739-1743.
    • (1997) Stroke , vol.28 , pp. 1739-1743
    • Markus, H.S.1    Ali, N.2    Swaminathan, R.3    Sankaralingam, A.4    Molloy, J.5    Powell, J.6
  • 34
    • 0030775334 scopus 로고    scopus 로고
    • Common mutation in the methylenetetrahydrofolate reductase gene offers no support for mild hyperhomocysteinemia being a causal risk factor for cardiovascular disease
    • Brattstrom L. Common mutation in the methylenetetrahydrofolate reductase gene offers no support for mild hyperhomocysteinemia being a causal risk factor for cardiovascular disease [letter]. Circulation 1997; 96:3805-3807.
    • (1997) Circulation , vol.96 , pp. 3805-3807
    • Brattstrom, L.1
  • 35
    • 0006725517 scopus 로고    scopus 로고
    • A common mutation in the methylinetetrahydrofolate reductase gene (C6771) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V: Q506)
    • Cattaneo MTM, Bucciarelli P, Taioli E, Zighetti ML, Bignell M, Mannucci PM. A common mutation in the methylinetetrahydrofolate reductase gene (C6771) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V: Q506) [abstract]. Blood 1996; 10 (suppl 1):285a.
    • (1996) Blood , vol.10 , Issue.SUPPL. 1
    • Cattaneo, M.T.M.1    Bucciarelli, P.2    Taioli, E.3    Zighetti, M.L.4    Bignell, M.5    Mannucci, P.M.6
  • 36
    • 0031464710 scopus 로고    scopus 로고
    • Myocardial infarction in a 35- year-old man with homocysteinemia, high plasminogen activator inhibitor activity, and resistance to activated protein C
    • Glueck CJ, Fontaine RN, Gupta A, Alasmi M. Myocardial infarction in a 35- year-old man with homocysteinemia, high plasminogen activator inhibitor activity, and resistance to activated protein C. Metabolism 1997; 46:1470-1472.
    • (1997) Metabolism , vol.46 , pp. 1470-1472
    • Glueck, C.J.1    Fontaine, R.N.2    Gupta, A.3    Alasmi, M.4
  • 37
    • 0031911582 scopus 로고    scopus 로고
    • A cost-benefit analysis of a cardiovascular disease prevention trial, using folate supplementation as an example
    • Hornberger J. A cost-benefit analysis of a cardiovascular disease prevention trial, using folate supplementation as an example. Am J Public Health 1998; 88:61-67.
    • (1998) Am J Public Health , vol.88 , pp. 61-67
    • Hornberger, J.1


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