Obesity and hypertension

Progress in Cardiovascular Diseases

Volumn 42, Issue 1, 1999, Pages 39-58

  Mikhail, N ^a   Golub, M S ^a   Tuck, M L ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD PRESSURE REGULATION; CORRELATION FUNCTION; HUMAN; HYPERTENSION; INSULIN METABOLISM; OBESITY; REVIEW; RISK FACTOR; RISK MANAGEMENT; SODIUM BALANCE; WEIGHT REDUCTION;

EID: 0032871537     PISSN: 00330620     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0033-0620(99)70008-3     Document Type: Article

References (152)

1. RJ Kuczmarski KM Flegal SM Campbell Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991 JAMA 272 1994 205 211
2. VL Burt P Whelton EJ Roccella Prevalence of hypertension in the US adult population. Results from the third National Health and Nutrition Examination Survey, 1988-1991 Hypertension 25 1995 305 313
3. DR Krieger L Landsberg Obesity and Hypertension ed 2 JH Laragh BM Brenner Hypertension: Pathophysiology, Diagnosis, Management 1995 Raven Press New York, NY 2367 2388
4. ML Tuck Obesity JD Swales Textbook of Hypertension. 1994 Blackwell Scientific Publications, Cambridge, MA 572 592
5. HB Hubert M Feinleib PM McNamara Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart study Circulation 72 1983 53 60
6. N Ruderman D Chisholm X Pi-Sunyer The metabolically obese, normal-weight individual revisited Am J Clin Nutr 34 1998 1617 1621
7. National Institute of Health Consensus development Panel on the health implications of obesity Consensus Conference Statement Ann Intern Med 103 1985 1073 1077
8. ND Ernst E Obarzanek MB Clark Cardiovascular health risks related to overweight J Am Diet Assoc 97 suppl 1997 S47 S51
9. WB Kannel M Brand J Skinner The relation of adiposity to blood pressure and development of hypertension. The Framingham study Ann Intern Med 67 1967 48 59
10. JF Caro Insulin resistance in obese and nonobese man J Clin Endocrinol Metab 73 1991 691 695
11. J Vague The degree of masculine differentiation of obesities: A factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease Am J Clin Nutr 4 1956 20 34
12. M Ashwell TJ Cole AK Dixon Obesity: New insight into the anthropometric classification of fat distribution shown by computed tomography BMJ 290 1985 1692 1694
13. PT William SP Fortmann RB Terry Associations of dietary fat, regional adiposity, and blood pressure in men JAMA 257 1987 3251 3256
14. JM Raison AM Achimastos ME Safar Sex-difference of body fat distribution in patients with obesity and hypertension Clin Exp Hypertens 14 1992 505 525
15. L Lapidus C Bengtsson BO Larsson Distribution of adipose tissue and risk of cardiovascular disease and death: A 12 year follow up of participants in the population study of women of Gothenburg, Sweden BMJ 289 1984 1257 1261
16. B Larsson K Svardsudd L Welin Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of men born in 1913 BMJ 288 1984 1401 1404
17. MJ Vanhala TK Pitkajarvi EA Kumpusalo Obesity type and clustering of insulin resistance-associated cardiovascular risk factors in middle-aged men and women Int J Obes 22 1998 369 374
18. AH Kissebah N Vydelingum M Murray Relation of body fat distribution to metabolic complications of obesity J Clin Endocrinol Metab 54 1982 254 260
19. P Randle P Garland C Hales The glucose fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus Lancet 1 1963 785 789
20. JG Spangler R Bell JH Summerson Hyperinsulinemia in hypertension. Associations with race, abdominal obesity, and hyperlipidemia Arch Fam Med 7 1998 53 56
21. R Stamler J Stamler WF Riedlinger Weight and blood pressure. Findings in hypertension screening of 1 million Americans JAMA 240 1978 1607 1610
22. RS Paffenbarger Jr MC Thorne WL Alvin Chronic disease in former college students. VIII. Characteristics in youth predisposing to hypertension in later years Am J Epidemiol 88 1968 25 32
23. SM Haffner BD Mitchell RA Valdez Eight-year incidence of hypertension in Mexican-Americans and non-Hispanic whites. The San Antonio study Am J Hypertens 5 1992 147 153
24. ML Tuck J Sowers L Dornfeld The effect of weight reduction on blood pressure, Plasma renin activity, and plasma aldosterone levels in obese patients N Engl J Med 304 1981 930 933
25. GL Burke PJ Savage JM Sprafka Relation of risk factor levels in young adulthood to parental history of disease. The CARDIA study Am J Hypertens 7 1994 242 248
26. BR Widgren H Herlitz J Wikstrand Increased waist/hip ratio, metabolic disturbances, and family history of hypertension Hypertension 20 1992 563 568
27. Q Qiao U Rajala S Keinanen-kiukaanniemi Hypertension, hyperinsulinemia, and obesity in middle-aged Finns with impaired glucose tolerance J Hum Hypertens 12 1998 265 269
28. AW Voors LS Webber RR Frerichs Body height and body mass as determinants of basal blood pressure in children. The Bogalusa Heart Study Am J Epidemiol 106 1977 101 108
29. TB Van Itallie The problem of obesity: Health implications of overweight and obesity in the United States Ann Intern Med 103 1985 983 988
30. S Julius K Jamerson A Mejia The association of borderline hypertension with target organ changes and higher coronary risk: Tecumseh Blood Pressure Study JAMA 264 1990 354 358
31. P Arroyo V Fernandez Avila-Rosas: Overweight and hypertension. Data from the 1992-1993 Mexican Survey Hypertension 30 1997 646 649
32. Y Chen DC Rennie BA Reeder Age-related association between body mass index and blood pressure: The Humboldt Study Int J Obes Relat Metab Disord 19 1995 825 831
33. R Chakraborty RE Ferrell MP Stern Relationship of prevalence of non-insulin dependent diabetes mellitus with Amerindian admixture in the Mexican Americans of San Antonio, Texas Genet Epidemiol 3 1986 435 454
34. National Center for Health Statistics Blood pressure levels and hypertension in persons aged 6-74 years: United States, 1976-80 1987 US Government Printing Office Washington, DC Advance Data from Vital and Health Statistics, No. 84, US Department of Health and Human Services, Publications No. (PHS) 82-1250
35. KD Ward D Sparrow L Landsberg Influence of insulin, sympathetic nervous system activity and obesity on blood pressure: The Normative Aging Study J Hypertens 14 1996 301 308
36. LA Sechi A Melis A Pala Serum insulin, insulin sensitivity, and erythrocyte sodium metabolis in normotensive and essential hypertensive subjects with and without overweight Clin Exp Hypertens 13 1991 261 276
37. V Manicardi L Camellini G Bellodi Evidence for an association of high blood pressure and hyperinsulinemia in obese man J Clin Endocrinol Metab 62 1986 1302 1304
38. H Kanai Y Matsuzawa K Tokunaga Hypertension in obese children: Fasting serum insulin levels are closely correlated with blood pressure Int J Obes 14 1990 1047 1056
39. M Modan H Halkin S Almog Hyperinsulinemia: A link between hypertension, obesity, and glucose intolerance J Clin Invest 75 1985 809 817
40. E Ferrannini G Buzzigoli R Bonadonna Insulin resistance in essential hypertension N Engl J Med 317 1987 350 356
41. JC Mbanya R Wilkinson TH Thomas Hypertension and hyperinsulinemia: A relation in diabetes but not essential hypertension Lancet 1 1988 733 734
42. R Bonadooona L Groop N Kraemer Obesity and insulin resistance: A dose-response study Metabolism 39 1990 452 459
43. JM Olefsky Decreased insulin binding to adipocytes and circulating monocytes from obese subjects J Clin Invest 57 1976 1165 1172
44. TP Ciaraldi OG Koltermann JM Olefsky Mechanism of the post-receptor defect in insulin action in human obesity. Decrease in glucose transport system activity J Clin Invest 68 1981 875 880
45. NW Istfan CS Plaisted BR Bistrian Insulin resistance versus insulin secretion in the hypertension of obesity Hypertension 19 1992 385 392
46. M Maxwell D Heber AU Waks Role of insulin and epinephrine in the hypertension of obesity Am J Hypertens 7 1994 402 408
47. E Bonora RC Bonadonna SD Prato In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension Diabetes 42 1993 764 772
48. IM O'Shaughnessy TJ Myers K Stepniakowski Glucose metabolism in abdominally obese hypertensive and normotensive subjects Hypertension 26 1995 186 192
49. L Landsberg JB Young Fasting, feeding and regulation of the sympathetic nervous system N Engl J Med 298 1978 1295 1301
50. JR Sowers LA Whitfield RA Catania Role of the sympathetic nervous system in blood pressure maintenance in obesity J Clin Endocrinol Metab 54 1982 1181 1186
51. ML Tuck JR Sowers L Dornfeld Reductions in plasma catecholamines and blood pressure during weight loss in obese subjects Acta Endocrinol (Copenh) 102 1983 252 257
52. JB Young IA Macdonald Sympathoadrenal activity in human obesity: Heterogeneity of findings since 1980 Int J Obes 16 1992 959 967
53. T Kushiro F Kobayashi H Osada Role of sympathetic activity in blood pressure reduction with low calorie regimen Hypertension 17 1991 965 968
54. B Anderson M Elam BG Wallin Effect of energy-restricted diet on sympathetic muscle nerve activity in obese women Hypertension 18 1991 783 789
55. K Masuo H Mikami T Ogihara Sympathetic nerve hyperactivity and blood pressure elevation in a young, nonobese Japanese population Am J Hypertens 10 1997 77 83
56. M Hausberg CA Sinkey A Mark Sympathetic nerve activity and insulin sensitivity in normotensive offspring of hypertensive parents Am J Hypertens 11 1998 1312 1320
57. L Landsberg Hyperinsulinemia: Possible role in obesity-induced hypertension Hypertension 19 suppl 1 1992 161 166
58. JW Rowe JB Young KL Minaker Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man Diabetes 30 1981 219 225
59. ROB Gans L Toor HJG Bilo Renal and cardiovascular effects of exogenous insulin in healthy volunteers Clin Sci 80 1991 219 225
60. G Lembo R Napoli B Capaldo Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension J Clin Invest 90 1992 24 29
61. EA Anderson CA Sinkey WJ Lawton Elevated sympathetic nerve activity in borderline hypertensive humans: Evidence from direct intraneuronal recordings Hypertension 14 1989 177 183
62. JA O'Hare KL Minaker GS Meneilly Effect of insulin on plasma norepinephrine and 3, 4 dihydroxyphenylalanine in obese men Metabolism 38 1989 322 329
63. EA Anderson RP Hoffman TW Balon Hyperinsulinemia produces both sympathetic neural activation and vasodilatation in normal humans J Clin Invest 87 1991 2246 2252
64. HA Frandsen S Snitker NJ Christensen Effects of insulin on muscle sympathetic nerve activity during euglycemia and hypoglycemia Circulation 84 suppl 2 1991 II267 abstr
65. C Berne J Fagius T Pollare The sympathetic response to euglycemic hyperinsulinemia Diabetologia 35 1992 873 879
66. M Laasko SV Edelman G Brechtal Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance J Clin Invest 87 1990 1844 1852
67. A Natali G Buzzigoli S Taddei Effects of insulin on hemodynamics and metabolism in human forearm Diabetes 39 1990 490 500
68. JM Neathring K Stepniakowski AS Greene Insulin does not reduce forearm α-vasoreactivity in obese hypertensive or lean normotensive men Hypertension 22 1993 584 590
69. Y Zhang R Proenca M Maffei Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425 432
70. RV Considine MK Sinha ML Heiman Serum immunoreactive-leptin concentrations in normal-weight and obese humans N Engl J Med 334 1996 292 295
71. JL Halaas KS Gajiwala M Maffei Weight-reducing effect of the plasma protein encoded by the obese gene Science 269 1995 543 546
72. WG Haynes WI Sivitz DA Morgan Sympathetic and cardiorenal actions of leptin Hypertension 30 1997 619 623
73. EK Jackson P Li Human leptin may function as a diuretic/natriuretic hormone Hypertension 28 1996 517 (abstr)
74. G Reams D Villarreal A Taraben Renal effects of leptin in normotensive and spontaneously hypertensive rats FASEB J 11 1997 A528 (abstr)
75. EW Shek MW Brands J Hall Chronic leptin infusion increases arterial blood pressure Hypertension 31 1998 409 414
76. LK Dahl L Silver RW Christie The role of salt in the fall of blood pressure accompanying reduction in obesity N Engl J Med 258 1958 1186 1192
77. E Reisin R Abel M Modan Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients N Engl J Med 298 1978 1 6
78. AP Rocchini V Katch J Anderson Blood pressure in obese adolescents: Effect of weight loss Pediatrics 82 1988 16 23
79. AP Rocchini J Key Bondie Diane The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents N Engl J Med 321 1989 580 585
80. JE Dimsdale M Ziegler P Mills Prediction of salt sensitivity Am J Hypertens 3 1990 429 435
81. AC Guyton TG Coleman AW Cowely Jr Arterial pressure regulation: Overriding dominance of the kidneys in long-term regulation and in hypertension Am J Med 52 1972 585 594
82. CD Saudek PR Boulter RH Knopp Sodium retention accompanying insulin treatment of diabetes mellitus Diabetes 23 1974 240 246
83. RA De Fronzo Insulin and renal sodium handling: Clinical implications Int J Obes 5 suppl 1 1981 93 104
84. HE Eliahou J Laufer A Blau Effect of low-calorie diets on the sympathetic nervous system, body weight, and plasma insulin in overweight hypertension Am J Clin Nutr 56 suppl 1 1992 175S 178S
85. + transport in cultured kidney cells (A6) Endocrinology 115 1984 1171 1178
86. N Stern ML Tuck Mechanisms of hypertension in diabetes mellitus JH Laragh BM Brenner Hypertension: Pathophysiology, Diagnosis, and Management. 1990 Raven Press New York, NY 1689 1702
87. RE Katholi RM Carey CR Ayers Production of sustained hypertension by chronic intrarenal norepinephrine infusion in conscious dogs Circ Res 40 suppl 1 1977 I 118 I 126
88. JCS Kleinjans JFM Smits CM Kasbergen Blood pressure response to chronic low dose intra-renal infusion in conscious rats Clin Sci 65 1983 111 116
89. G Licata M Volpe R Scaglione Salt-retaining hormones in young normotensive obese subjects. Effects of saline load Hypertension 23 1994 120 124
90. RW McMurray Jr DL Vesely Weight reduction decreases atrial natriuretic factor and blood pressure in obese patients Metabolism 38 1989 1231 1237
91. JE Hall MW Brands JR Henegar Abnormal kidney function as a cause and a consequence of obesity hypertension Clin Exp Pharmacol Physiol 25 1998 58 64
92. J Ribstein J du Cailar A Mimran Combined renal effects of overweight and hypertension Hypertension 26 1995 610 615
93. DE Wesson NA Kurtzman JP Prommer Massive obesity and nephrotic proteinuria with a normal renal biopsy Nephron 40 1985 235 237
94. RR Verani Obesity-associated focal segmental glomerulosclerosis: Pathological features of the lesion and relationship with cardiomegaly and hyperlipidemia Am J Kidney Dis 20 1992 629 634
95. Bl Kasiske JT Crosson Renal disease in patients with massive obesity Arch Intern Med 146 1986 1105 1109
96. DB Corry ML Tuck Hypertension and diabetes Semin Nephrol 5 1991 561 570
97. SK Mujais RC Tarazi HP Dustan Hypertension in obese patients: Hemodynamic and volume studies Hypertension 4 1982 84 92
98. FH Messerli K Sundgaard-Riise E Reisin Disparate cardiovascular effects of obesity and hypertension Am J Med 74 1983 808 812
99. E Reisin FH Messerli HO Ventura Renal hemodynamics in obese and lean essential hypertensive patients FH Messerli Kidney in Essential Hypertension. 1983 Martinus Nijhoff Boston, MA 125 130
100. HO Ventura MR Johnson B Grusk Cardiac adaptation to obesity and hypertension after heart transplantation J Am Coll Cardiol 19 1992 55 59
101. RC Tarazi Hemodynamics of hypertension ed 2 J Genest O Kuchel P Hamet Hypertension: Physiopathology and Treatment 1983 McGraw-Hill New York, NY 15
102. FH Messerli K Sundgaard-Riise E Reisin Dimorphic cardiac adaptation to obesity and arterial hypertension Ann Intern Med 99 1983 757 761
103. HL Smith FA Willius Adiposity of the heart: A clinical pathologic study of one hundred and thirty-six obese patients Arch Intern Med 52 1933 910 931
104. JG Kral Morbid obesity and related health risks Ann Intern Med 103 1985 1043 1047
105. E Barrett-Connor KT Khaw Is hypertension more benign when associated with obesity? Circulation 72 1985 53 60
106. F Cambien JM Chretien P Ducimetiere Is the relationship between blood pressure and cardiovascular risk dependent on body mass index? Am J Epidemiol 122 1985 434 442
107. GA Perera A Damon Height, weight, and their ratio in the accelerated form of hypertension Arch Intern Med 100 1956 263 265
108. E Ferrannini Physiological and metabolic consequences of obesity Metabolism 44 suppl 3 1995 15 17
109. JK Rockstroph RE Schmeider H Schachinger Stress response pattern in obesity and systemic hypertension Am J Cardiol 70 1992 1035 1039
110. AP Rocchini C Moorehead V Katch Forearm resistance vessel abnormalities and insulin resistance in obese adolescents Hypertension 19 1992 615 620
111. P Eggena JR Sowers MH Maxwell Hormonal correlates of weight loss associated with blood pressure reduction Clin Exp Hypertens A13 1991 147 1456
112. E Reisin ED Frolich FH Messerli Cardiovascular changes after weight reduction in obesity hypertension Ann Intern Med 98 1983 315 319
113. SW MacMahon DEL Wilcken GJ MacDonald The effect of weight reduction on left ventricular mass: A randomized controlled trial in young, overweight hypertensive patients N Engl J Med 314 1986 334 339
114. Multiple Risk Factor Intervention Trial Research Group (MRFIT) A national study of primary prevention of coronary artery disease JAMA 235 1976 825 827
115. E Reisin ED Frohlich Effects of weight reduction on arterial pressure J Chronic Dis 35 1982 887 891
116. DE Schotte AJ Stunkard The effects of weight reduction on blood pressure in 301 obese patients Arch Intern Med 150 1990 1701 1704
117. N Cohen W Flamenbaum Obesity and hypertension: Demonstration of a “floor” effect Am J Med 80 1986 177 181
118. LP Dornfeld MH Maxwell AU Waks Obesity and hypertension: Long-term effects of weight reduction on blood pressure Int J Obes 9 1985 381 389
119. RL Weinsier LD James BE Darnell Obesity-related hypertension: Evaluation of the separate effects of energy restriction and weight reduction on hemodynamic and neuroendocrine status Am J Med 90 1991 460 468
120. M Modan S Almog Z Fuchs Obesity, glucose intolerance hyperinsulinemia, and response to antihypertensive drugs Hypertension 17 1991 565 573
121. R Stamler J Stamler R Grimm Nutritional therapy for high blood pressure. Final report of a four-year randomized controlled trial—The Hypertension Control Program JAMA 257 1987 1484 1491
122. P Whelton LJ Appel MA Espeland Sodium reduction and weight loss in the treatment of hypertension in older persons. A Randomized Controlled Trial of Nonpharmacologic Interventions in the Elderly (TONE) JAMA 279 1998 839 846
123. R Stamler J Stamler F Gosch Primary prevention of hypertension by nutritional-hygienic means. Final report of a randomized, controlled trial JAMA 262 1989 1801 1807
124. The Trials of Hypertension Prevention Collaborative Research Group Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high blood pressure. The Trials of Hypertension Prevention, Phase II Arch Intern Med 157 1997 657 667
125. ML Tuck Obesity, the sympathetic nervous system, and essential hypertension Hypertension 19 suppl I 1992 I-67 I-77
126. CR Lake MG Ziegler MD Coleman Hydrochlorotiazide-induced sympathetic hyperactivity in hypertensive patients Clin Pharmacol Ther 26 1979 428 432
127. ED Frolich HW Schnaper IM Wison Hemodynamic alterations in hypertensive patients due chlorothiazide N Engl J Med 262 1960 1261 1263
128. T Pollare H Lithell C Berne A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension N Engl J Med 321 1989 868 873
129. GM Reaven C Clinkingbeard J Jeppesen Comparison of the hemodynamic and metabolic effects of low-dose hydrochlorothiazide and lisinopril treatment in obese patients with high blood pressure Am J Hypertens 8 1995 461 466
130. E Reisin MR Weir B Falkner Lisinopril versus hydrochlorothiazide in obese hypertensive patients. A multicenter placebo-controlled trial Hypertension 30 1997 140 145
131. E Reisin SG Weed The treatment of obese hypertensive black women: A comparative study of chlorthalidone versus clonidine J Hypertens 10 1992 489 493
132. BR Davis A Oberman D Blaufax Effect of antihypertensive therapy on weight loss Hypertension 19 1992 393 399
133. ND Vlachakis L Aledort Hypertension and propranolol therapy: Effect on blood pressure, plasma catecholamines and platelet aggregation Am J Cardiol 45 1980 321 325
134. G Sundolf BG Wallin E Stromgren Acute effects of metoprolol on muscle sympathetic activity in hypertensive humans Hypertension 5 1983 749 757
135. T Pollare H Lithell I Selinus Sensitivity to insulin during treatment with atenolol and metoprolol: A randomized, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients BMJ 298 1989 1152 1157
136. SW MacMahon GJ MacDonald L Bernstein Comparison of weight reduction with metoprolol in treatment of hypertension in young overweight patients Lancet 1 1985 1233 1236
137. B Fagerberg A Berglund OK Andersson Cardiovascular effects of weight reduction vs antihypertensive drug treatment: A comparative, randomized, 1-year study of obese men with mild hypertension J Hypertens 9 1991 431 439
138. RE Schmieder C Gatzka H Schachinger Obesity as a determinant for response to antihypertensive treatment BMJ 307 1993 537 540
139. B Jarrot EL Conway C Maccarrone Clonidine: Understanding its disposition, sites and mechanism of action Clin Exp Pharmacol Physiol 14 1987 471 479
140. VM Campese M Romoff N Teffer Role of sympathetic nerve inhibition and body-sodium volume state in the antihypertensive action of clonidine in essential hypertension Kidney Int 18 1980 351 357
141. The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure Arch Intern Med 157 1997 2413 2446
142. T Pollare H Lithell I Selinus Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension Diabetologia 31 1988 415 420
143. IG Crozier R Teoh R Kay Sympathetic nervous system during converting enzyme inhibition Am J Med 87 1989 S29 S32
144. ML Tuck Metabolic considerations in hypertension Am J Hypertens 3 1990 S355 S365
145. FH Messerli UR Kaesser CJ Losem Effect of antihypertensive therapy on hypertensive heart disease Circulation 80 suppl 4 1989 IV 145 IV 150
146. BL Kasiske RSN Kalil JZ Ma Effect of antihypertensive therapy on the kidney in patients with diabetes: A metaregression analysis Ann Intern Med 118 1990 129 138
147. A Moan T Risanger I Eide The effect of angiotensin II receptor blockade on insulin sensitivity and sympathetic nervous system activity in primary hypertension Blood Press 3 1994 185 188
148. ML Tuck EL Bravo LR Krakoff Endocrine and renal effects of nifedipine gastrointestinal system therapeutic system in patients with essential hypertension: Results of a multicenter trial. The Modern Approach to the Treatment of Hypertension Study Group Am J Hypertens 3 1990 S333 S341
149. P Valensi B Uzzann JR Attali Effects of nifedipine and nitredipine on insulin secretion in obese patients J Cardiovasc Pharmacol 18 suppl 1 1991 S91 S93
150. T Pollare H Lithell C Morlin Metabolic effects of diltiazem and atenolol: Results from a randomized, double-blind study with parallel groups J Hypertens 7 1989 551 559
151. PP Stein HR Black Drug treatment of hypertension in patients with diabetes mellitus Diabetes Care 14 1991 425 448
152. CD Furberg BM Psaty JV: Meyer Nifedipine. Dose-related increase in mortality in patients with coronary heart disease Circulation 92 1995 1326 1331