In stroke, complement will get you nowhere

Nature Medicine

Volumn 5, Issue 9, 1999, Pages 995-996

  Del Zoppo, Gregory J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN ISCHEMIA; COMPLEMENT SYSTEM; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NERVE CELL LESION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SHORT SURVEY; STROKE;

ANIMALS; BRAIN ISCHEMIA; COMPLEMENT SYSTEM PROTEINS; HUMANS; INFLAMMATION; MICE; NEURONS;

EID: 0032869793     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/12431     Document Type: Short Survey

References (15)

1. Reid, D.M., Perry, V. H., Andersson, P.B. & Gordon, S. Mitosis and apoptosis of microglia in vivo induced by an anti-CR3 antibody which crosses the blood-brain barrier. Neuroscience 56, 529-533 (1993).
2. Yasojima, K., Schwab, C., McGeer, E.G. & McGeer, P.L. Up-regulated production and activation of the complement system in Alzheimer's disease brain. Am. J. Pathol. 154, 927-936 (1999).
3. Compston, D.A. et al. Immunocytochemical localization of the terminal complement complex in multiple sclerosis. Neuropathol, Appl. Neurobiol. 15, 307-316 (1989).
4. Huang, J. et al. Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Science 285, 595-599 (1999).
5. Okada Y. et al. P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion. Stroke 25, 202-211 (1994).
6. Haring, H-P., Berg, E.L., Tsurushita, N., Tagaya, M. & del Zoppo, G.J. E-selectin appears in non-is-chemic tissue during experimental focal cerebral ischemia. Stroke 27, 1386-1391 (1996).
7. Del Zoppo, G.J., Schmid-Schinbein, G.W., Mori, E., Copeland, B.R. & Chang, C.-M. Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 22, 1276-1283 (1991).
8. Okada, Y., Copeland, B.K., Tung, M-M. & del Zoppo, G.J. Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion. Stroke 25, 1847-1853 (1994).
9. Kaczorowski, S.L., Schiding, J.K., Toth, C.A. & Kochanek, P. M. Effect of soluble complement receptor-1 on neutrophil accumulation after traumatic brain injury in rats. J. Cereb. Blood Flow Metab. 15, 860-864 (1995).
10. Rittershaus, C.W. et al. Recombinant glycoproteins that inhibit complement activation and also bind the selectin adhesion molecules. J. Biol. Chem. 274, 11237-11244 (1999).
11. Kato H., Kogure K., Liu X.H., Araki T. & Itoyama Y. Progressive expression of immunomolecules on activated microglia and invading leukocytes following focal cerebral ischemia in the rat. Brain Res. 734, 203-212 (1999).
12. Afagh, A., Cummings, B.J., Cribbs, D.H., Cotman, C.W. & Tenner, A.J. Localization and cell association of C1q in Alzheimer's disease brain. Exp. Neurol. 138, 22-32 (1996).
13. Casque, P., Singhrao, S.K., Neal, J.W., Gotze, O. & Morgan, B.P. Expression of the receptor for complement CSa (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system. Am. J. Pathol. 150, 31-41 (1997).
14. Du, C., Hu R., Csernansky, C.A., Hsu, C.Y. & Choi, D.W. Very delayed infarction after mild focal cerebral ischemia: A role for apoptosis? J. Cereb. Blood Flow Metab. 16, 195-201 (1996).
15. Endres M. et al. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the Caspase family. J. Cereb. Blood Flow Metab. 18, 238-247 (1998).