Estrogen increases cGMP in selected brain regions and in cerebral microvessels

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 11, 1998, Pages 1248-1252

  Palmon, Sally C ^a   Williams, Megan J ^a   Littleton Kearney, Marguerite T ^a   Traystman, Richard J ^a   Kosk Kosicka, Danuta ^a   Hurn, Patricia D ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Cerebral microvessels; CGMP; Estrogen; Stroke

Indexed keywords

CYCLIC GMP; ESTRADIOL; ESTROGEN; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CORTEX; BRAIN HOMOGENATE; BRAIN ISCHEMIA; BRAIN REGION; CAUDATE NUCLEUS; CEREBELLUM; CONTROLLED STUDY; DOSE RESPONSE; ESTROGEN THERAPY; FEMALE; HIPPOCAMPUS; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SIGNAL TRANSDUCTION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031771364     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199811000-00011     Document Type: Article

References (44)

1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD (1998) Gender-linked brain injury in experimental stroke. Stroke 29:159-165
2. Barret-Connor E, Bush TL (1991) Estrogen and coronary heart disease in women. JAMA 265:1896-1967
3. Berman KF, Schmidt PJ, Rubinow DR, Danaceau MA, Van Horn JD, Esposito G, Ostrem JL, Weinberger DR (1997) Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography on women. Proc Natl Acad Sci USA 94: 8836-8841
4. Bredt DS, Snyder SH (1989) Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 86:9030-9033
5. Dharmarajan AM, Zanagnolo VL, Dasko LM, Zirkin BR, Ewing LL, Wallach EE (1991) Estradiol regulation of the rabbit corpus luteum: in vivo and in vitro studies. Endocrinology 128:2678-2684
6. East SJ, Garthwaite J (1991) NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway. Neurosci Lett 123:17-19
7. Fisher CM, Gore I, Okabe N, White PD (1965) Atherosclerosis of the carotid and vertebral arteries - extracranial and intracranial. J Neuropathol Exp Neurol 24:455-476
8. 2+-transporting ATPase in neuronal and erythrocyte plasma membranes. Anesthesiology 84:1189-1195
9. Ford G, Toole J, Frye J (1985) Gender, TIA's, and asymptomatic carotid bruits. Stroke 16:148-154
10. + channels in rat arterioles. Am J Physiol 270:F69-F81
11. Goldman H, Skelley EB, Sandman CA (1976) Hormones and regional brain blood flow. Pharmacol Biochem Behav 5:165-169
12. Hall ED, Pazara KE, Linseman KL (1991) Sex differences in postischemic neuronal necrosis in gerbils. J Cereb Blood Flow Metab 11:292-298
13. 2+ calmodulin dependent mechanism. Biochem Biophys Res Comm 203:1013-1019
14. Hurn PD, Littleton-Kearney M, Kirsch JR, Dharmarajan AM, Traystman RJ (1995) Postischemic cerebral blood flow recovery in the female: effect of 17β-estradiol. J Cereb Blood Flow Metab 15: 666-672
15. Hull AD, Long DM, Longo LD, Pearce WJ (1992) Pregnancy-induced changes in ovine cerebral arteries. Am J Physiol 262:R137-R143
16. Luo D, Leung E, Vincent SR (1994) Nitric oxide-dependent efflux of cGMP in rat cerebellar cortex: an in vivo microdialysis study. J Neurosci 14:263-271
17. Magness RR, Rosenfeld CR, Shaul PW (1991) Role of endothelium in the control of cAMP and cGMP production by uterine artery vascular smooth muscle in ovine pregnancy. Proc Soc Gynecol Invest 265
18. McEwen BS, Alves SE, Bullock K, Weiland NG (1997) Ovarian steroids and the brain: implications for cognition and aging. Neurology 48:S8-S15
19. Mendelsohn ME, Karas RH (1994) Estrogen and the blood vessel wall. Curr Opin Cardiol 9:619-626
20. Ohkura T, Teshima Y, Isse K, Matsuda H, Inoue T, Sakai Y, Iwasaki N, Yaoi Y (1995) Estrogen increases cerebral and cerebellar blood flow in postmenopausal women. Menopause 2:13-18
21. Paterno R, Faraci FM, Heistad DD (1996) Role of Ca(2+)-dependent K+ channels in cerebral vasodilatation induced by increases in cyclic GMP and cyclic AMP in the rat. Stroke 27:1603-1607
22. Pearce WJ, Hull AD, Long DM, Longo LD (1991) Developmental changes in ovine cerebral artery composition and reactivity. Am J Physiol 261:R458-R465
23. Pelligrino DA, Wang Q, Baughman VL (1996) Estrogen, nitric oxide, and cerebral blood flow changes during transient forebrain ischemia in the female rat [abstract]. FASEB J 10:A29
24. Rahimian R, Van Breeman C, Ruscko J, Li L, Bolzen B, Dube G, Laher I (1996) Greater stimulated and basal release of nitric oxide in the presence of estradiol [abstract]. FASEB J 10:A706
25. Reis SE, Gloth ST, Blumenthal RS, Resar RR, Zacur HA, Gerstenblith G, Brinker JA (1994) Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in postmenopausal women. Circulation 89:52-60
26. Rodriguez G, Warkentin S, Risberg J (1988) Sex differences in regional blood flow. J Cereb Blood Flow Metab 8:783-789
27. Rosenfeld CR, Cox BE, Roy T (1996) Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation. J Clin Invest 98:2158-2166
28. Rusa R, Crain B, Traystman R, Klaus J, Hurn P (1998) Neuroprotective effect of 17β estradiol in experimental stroke (abstract). Stroke 29:330
29. Shaw TG, Mortel KF, Meyer JS, Rogers RL, Hardenberg J, Cutaia MM (1984) Cerebral blood flow changes in benign aging and cerebrovascular disease. Neurology 34:855-862
30. Simerly RB, Chang C, Muramatsu M, Swanson LW (1990) Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J Comp Neurol 294: 76-95
31. Sivenius J, Laakso M, Penttila IM, Smets P, Lowenthal A, Riekkinen PJ, et al (1991) The European Stroke Prevention study: results according to sex. Neurology 41:1189-1192
32. Stumpf WE (1968) Estradiol concentrating neurons. Science 162: 1001-1003
33. Vallebuona F, Raiteri M (1994) Extracellular cGMP in the hippocampus of freely moving rats as an index of nitric oxide (NO) synthase activity. J Neurosci 14:134-139
34. Venema RC, Nishida K, Alexander RW, Harrison DG, Murphy TJ (1994) Organization of the bovine gene encoding the endothelial nitric oxide synthase. Biochim Biophys Acta 1218:413-420
35. Weiland NG, Orikasa C, Hayashi S (1996) Localization of estrogen receptors in the hippocampus of male and female. Soc Neurosci Abstr 22:618
36. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S (1994) Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA 91:5212-5216
37. Wellman GC, Bonev AD, Nelson MT, Brayden JE (1996) Gender differences in coronary artery diameter involve estrogen, nitric oxide and Ca2+ dependent K+ channels. Circ Res 79:1024-1030
38. White RE, Darkow DJ, Falvo Lang JLF (1995) Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism. Circ Res 77:936-942
39. Williams JK, Kim YD, Adams MR, Chen MF, Myers AK, Ramwell PW (1994) Effects of estrogen on cardiovascular responses of premenopausal monkeys. J Pharmacol Exp Ther 271:671-676
40. Wolf PA, Kannel WB, Cupples LA, D'Agostino RB (1987) Risk factor interaction in cardiovascular and cerebrovascular disease. In: Furlan AJ (ed) The Heart and Stroke, London, Springer-Verlag, 331-355
41. Woolley CS, McEwen BS (1992) Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci 12:2549-2554
42. Woolley CS, Weiland NG, McEwen BS, Schwartzdroin PA (1997) Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci 17:1848-1859
43. Wu CH, Blasco L, Flickinger GL, Mikhail G (1977) Ovarian function in the preovulatory rabbit. Biol Reprod 17:304-308
44. Yu J, Zhang W, Jansen-Olesen I, Edvinsson L (1995) Relation between cyclic GMP generation and cerebrovascular reactivity: modulation by NPY and alpha-trinositol. Pharmacol Toxicol 77:48-56