A novel, nongenomic action of estrogen on the cardiovascular system

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 7, 1998, Pages 2313-2316

  Komesaroff, Paul A ^a   Black, Catherine V S ^a   Westerman, Roderick A ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CONJUGATED ESTROGEN; ESTRADIOL; NICOTINE; NITROPRUSSIDE SODIUM;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; ESTROGEN BLOOD LEVEL; HEART PROTECTION; HORMONE ACTION; HORMONE RESPONSE; HUMAN; HUMAN EXPERIMENT; MALE; MICROVASCULATURE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN BLOOD FLOW;

EID: 0031787445     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.83.7.4945     Document Type: Article

References (23)

1. Stampfer MJ, Colditz GA, Willett WC, et al. 1991 Postmenopausal estrogen therapy and cardiovascular disease. N Engl J Med. 325:756-762.
2. White MM, Zamudio S, Stevens T, et al. 1995 Estrogen, progesterone and vascular reactivity: potential cellular mechanisms. Endocr Rev. 16: 739-751.
3. Gilligan DM, Badar DM, Panza JA, Quyyumi AA, Cannon RA. 1994 Acute vascular effects of estrogen in postmenopasual women. Circulation. 90:786-791.
4. Chien YW, Siddiqui O, Shi WM, Lelawpngs P, Liu JC. 1989 Direct current iontophoretic transdermal delivery of peptide and protein drugs. J Pharm Sci. 78:376-383.
5. Westerman RA, Widdop RE, Hannford J, et al. 1988 Laser Doppler velocimetry in the measurement of neurovascular function. Aust Phys Eng Sci Med. 11:53-66.
6. Morris SJ, Shore AC, Tooke JE. 1995 Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM. Diabetologia. 38:1337-1344.
7. Sudhir K, Jennings GL, Funder JW, Komesaroff PA. 1996 Estrogen enhances basal nitric oxide release in the forearm vasculature in perimenopausal women. Hypertension. 28:330-335.
8. Izumi H, Karita K. 1992 Axon flare evoked by nicotine in human skin. Jpn J Physiol. 42:721-730.
9. Anderson RR, Parrish JA. 1981 Optical properties of human skin. In: Marks R, Payne PA, eds. Bioengineering and the skin. Lancaster, Boston; MTP Press: 147-194.
10. Ryan TJ. 1992 Cutaneous circulation. In: Goldsmith LA, ed. Biochemistry, physiology and molecular biology of the skin, 2nd ed. London: Oxford University Press; 1019-1083.
11. Sarrel PM, Poole-Wilson PA, Collins P. 1993 Beneficial effect of oestrogen on exercise-induced myocardial ischaemia in women with coronary artery disease. Lancet. 342:133-135.
12. Gilligan DM. 1994 Effects of physiological levels of estrogen on coronary vasomotor function. Circulation. 89:2545-2551.
13. Bartelink ML, Wollersheim H, Theeuwes D, Thien T. 1990 Changes in skin blood flow during the menstrual cycle. Clin Sci (Lond). 78:527-532.
14. Gorski J, Welshons WV, Sakai D, et al. 1986 Evolution of a model of estrogen action. Recent Prog Horm Res. 42:297-321.
15. Wehling M, Kasmayr J, Theisen K. 1991 Rapid effects of mineralocorticoids on sodium-proton exchanger: genomic or nongenomic pathway? Am J Physiol 260:E719-E726.
16. McEwen BS. 1991 nongenomic and genomic effects of steroids on neural activity. Trends Pharmacol Sci. 12:141-147.
17. Mueck AO, Seeger H, Lippert TH. 1996 Calcium antagonistic effect of natural and synthetic estrogens - investigations on a nongenomic mechanism of vascular action, Int J Clin Pharmacol Ther. 34:424-426.
18. Sudhir K, Chou TM, Mullen WL, et al. 1995 Mechanisms of estrogen-induced vasodilation: in vivo studies in canine coronary conductance and resistance arteries. J Am Coll Cardiol. 26:807-814.
19. Reis SE, Cloth ST, Blumenthal RS, et al. 1994 Ethinyl estradiol acutely attenuates abnormal coronary vasomotor responses to acetylcholine in post-menopausal women. Circulation. 89:52-60.
20. Morris SJ, Shore AC. 1996 Skin blood flow responses to the iontophoresis of acetylcholine and sodium nitroprusside in man: possible mechanisms. J Physiol. 496:531-542.
21. Carlsson I, Sollevi A, Wennmalm A. 1987 The role of myogenic relaxation, adenosine and prostaglandins in human forearm reactive hyperaemia. J Physiol. 389:147-161.
22. Sagach VF, Tkachenko MN. 1991 On the mechanisms nf the involvement of endothelium in reactive hyperemia. Experientia. 47:828-830.
23. Sudhir S, Chou TM, Messina LM, et al. 1997 Endothelial dysfunction in a man with disruptive mutation in oestrogen-receptor gene. Lancet. 347: 1146-1147.