Betulinic acid: A new chemotherapeutic agent in the treatment of neuroectodermal tumors

Klinische Padiatrie

Volumn 211, Issue 4, 1999, Pages 319-322

  Fulda, S ^a   Jeremias, I ^a,b   Pietsch, T ^c   Debatin, Klaus Michael ^a,b  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Apoptosis; Betulinic acid; Cytotoxic drugs; Mitochondria

Indexed keywords

BETULIC ACID; CYTOCHROME C; DOXORUBICIN; FAS ANTIGEN; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN P53;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BRAIN MITOCHONDRION; CLINICAL ARTICLE; CYTOTOXICITY; EWING SARCOMA; FLUORESCENCE ACTIVATED CELL SORTER; GLIOBLASTOMA; HUMAN; HUMAN CELL; MEDULLOBLASTOMA; MEMBRANE POTENTIAL; NEUROBLASTOMA; NEUROECTODERM TUMOR; NONHUMAN; PROTEIN EXPRESSION;

EID: 0032856644     PISSN: 03008630     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1043808     Document Type: Article

References (25)

1. 1 Fisher, D. E.: Apoptosis in cancer therapy: crossing the threshold. Cell 78 (1994) 539-542
2. 2 Debatin, K.-M.: Anticancer drugs, programmed cell death and the immune system: defining new roles in an old play. J. Natl. Cancer Inst. 89 (1997) 750-751
3. 3 Fulda, S., C. Friesen, K.-M. Debatin: Molecular determinants of apoptosis induced by cytotoxic drugs, Klin. Paediatr. 210 (1998) 148-152
4. 4 Nagata, S.: Apoptosis by death factor. Cell 88 (1997) 355-365
5. 5 Trauth, B. C., C. Klas, A. M. J. Peter, S. Matz, P. Möller, W. Falk, K.-M. Debatin, P. H. Krammer: Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245 (1989) 301-305
6. 6 Peter, M. E, P. H. Krammer. Mechanisms of CD95 (Apo-1/Fas)-mediated apoptosis. Curr. Opinion Immunol. 10 (1998) 545-551
7. 7 Kroemer, G., N. Zamzami, S. A. Susin. Mitochondrial control of apoptosis. Immunol. Today 18 (1997) 44-51
8. 8 Friesen, C., I. Herr, P. H. Krammer, K.-M. Debatin: Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med. 2 (1996) 574-577
9. 9 Fulda, S., H. Sieverts, C. Friesen, I. Herr, K.-M. Debatin: The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells. Cancer Res. 57 (1997) 3823-3829
10. 10 Fulda, S., M. Los, C. Friesen, K.-M. Debatin: Chemosensitivity of solid tumor cells is related to activation of the CD95 system. Int. J. Cancer 76 (1998) 105-114
11. 11 Fulda, S., C. Scaffidi, T. Pietsch, P.H. Krammer, M.E. Peter, K.-M. Debatin: Activation of the CD95 (APO-1/Fas) pathway in drug-and γ-irradiation-induced apoptosis of brain tumor cells. Cell Death Differ. 5 (1998) 884-893
12. 12 Fulda, S., S.A. Susin, G. Kroemer, K.-M. Debatin. Molecular ordering of drug-induced apoptosis in neuroblastoma cells. Cancer Res. 58 (1998) 4453-4460
13. 13 Fulda, S., W. Lutz, M. Schwab, K.-M. Debatin. MycN sensitizes neuroblastoma cells for drug-induced apoptosis. Oncogene 18 (1999) 1479-1486
14. 14 Lutz, W., S. Fulda, I. Jeremias, K.-M. Debatin, M. Schwab. MycN and IFNγ cooperate in apoptosis of human neuroblastoma cells. Oncogene 17 (1998) 339-346
15. 15 Friesen, C., S. Fulda, K.-M. Debatin: Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells. Leukemia 11 (1997) 1833-1841
16. 16 Scaffidi, C., S. Fulda, F. Li, C. Friesen, A. Srinivasan, K.J. Tomaselli, K.-M. Debatin, P.H. Krammer, M.E. Peter. Two CD95 signaling pathways. EMBO J. 17 (1998) 1675-1687
17. 17 Los, M., I. Herr, C. Friesen, S. Fulda, K. Schulize-Osthoff, K.-M. Debatin: Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases). Blood 8 (1997) 3118-3129
18. 18 Müller, M., S. Strand, H. Hug, E.-M. Heinemann, H. Walczak, W. J. Hofmann, W. Stremmel, P. H. Krammer, P. R. Galle: Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J. Clin. Invest. 99 (1997) 403-413
19. 19 Kroemer, G.: The protooncogene Bcl-2 and its role in regulating apoptosis. Nat. Med. 3 (1997) 614-620
20. 20 Li, P., D. Nijhawan, I. Budihardjo, S. Srinivasula, M. Ahmad, A.S. Alnemri, X. Wang. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-189
21. 21 Pisha, E., H. Chai, I. S. Lee, T. E. Chagwedera, N. R. Farnsworth, G. A. Cordell, C. W. Beecher, H. H. Fong, A. D. Kinghorn, D. M. Brown, M. C. Wani, M. E. Wall, T. J. Hieken, T. K. Das Gupta, J. M. Pezzuto. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat. Med. 1 (1995) 1046-1051
22. 22 Fulda, S., C. Friesen, M. Los, C. Scaffidi, W. Mier, M. Benedict, G. Nunez, P. H. Krammer, M. E. Peter, K.-M. Debatin: Betulinic acid triggers CD95 (APO-1/Fas)-and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res. 57 (1997) 4956-4964
23. 23 Fulda, S., C. Scaffidi, S.A. Susin, P.H. Krammer, G. Kroemer, M.E. Peter, K.-M. Debatin. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J. Biol. Chem. 273 (1998) 33942-33948
24. 24 Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, C. Riccardi: A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139 (1991) 271-279
25. 25 Scaffidi, C., J.P. Medema, P.H. Krammer, M.E. Peter: FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. J. Biol. Chem. 272 (1997) 26953-26958