FGF-2/fibroblast growth factor receptor/heparin-like glycosaminoglycan interactions: A compensation model for FGF-2 signaling

FASEB Journal

Volumn 13, Issue 13, 1999, Pages 1677-1687

  Padera, Robert ^a,b   Venkataraman, Ganesh ^b   Berry, David ^c   Godavarti, Ranga ^c,d   Sasisekharan, Ram ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d PFIZER INC   (United States)

Author keywords

Extracellular matrix; FGF receptor; Thermodynamic parameters

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR; GLYCOSAMINOGLYCAN; HEPARIN DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING SITE; BIOLOGICAL MODEL; CELL PROLIFERATION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BINDING;

ANIMALIA;

EID: 0032850597     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.13.13.1677     Document Type: Article

References (35)

1. Basilico, C., and Moscatelli, D. (1992) The FGF family of growth factors and oncogenes. Adv. Cancer Res. 59, 115-165
2. Sporn, M. B., and Roberts, A. B. (1990) Peptide Growth Factors and Their Receptors, Springer-Verlag, Berlin
3. Klein, S., Roghani, M., and Rifkin, D. B. (1997). Fibroblast growth factors as angiogenesis factors: new insights into their mechanism of action. Exper. Suppl. (Basel) 79, 159-192
4. Conrad, E., (1998) Heparin Binding Proteins, pp. 301-348, Academic Press, New York
5. Rapraeger, A. C. (1993) The coordinated regulation of heparan sulfate, syndecans and cell behavior. Curr. Opin. Cell Biol. 5, 844-853
6. Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., and Goldfarb, M. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271, 15292-15297
7. Givol, D., and Yayon, A. (1992) Complexity of FGF receptors: genetic basis for structural diversity and functional specificity. FASEB J. 6, 3362-3369
8. Sasisekharan, R., Ernst, S., and Venkataraman, G. (1997) On the regulation of fibroblast growth factor activity by heparin-like glycosaminoglycans. Angiogenesis 1, 45-54
9. Ornitz, D. M., Yayon, A., Flanagan, J. G., Svahn, C. M., Levi, E., and Leder, P. (1992) Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Mol. Cell. Biol. 12, 240-247
10. Rapraeger, A. C., Krufka, A., and Olwin, B. B. (1991) Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation. Science 252, 1705-1708
11. Klagsbrun, M., and Baird, A. (1991). A dual receptor system is required for basic fibroblast growth factor activity. Cell 67 229-231
12. Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., and Ornitz, D. M. (1991) Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 64, 841-848
13. Kato, M., Wang, H., Kainulainen, V., Fitzgerald, M. L., Ledbetter, S., Ornitz, D. M., and Bernfield, M. (1998) Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat. Med. 4, 691-697
14. Aviezer, D., Hecht, D., Safran, M., Eisinger, M., David, G., and Yayon, A. (1994) Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Cell 79, 1005-1013
15. Vlodavsky, I., Miao, H.-Q., Medalion, B., Danagher, P., and Ron, D. (1996) Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor. Cancer Metast. Rev. 15, 177-186
16. Folkman, J., Klagsbrun, M., Sasse, J., Wadzinski, M., Ingber, D., and Vlodavsky, I. (1988) A heparin-binding angiogenic protein - basic fibroblast growth factor - is stored within basement membrane. Am. J. Pathol. 130, 393-400
17. Schlessinger, J., Lax, I., and Lemon, M. (1995). Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors? Cell 83, 357-360
18. Venkataraman, G., Sasisekharan, V., Herr, A. B., Ornitz, D. M., Waksman, G., Cooney, C. L., Langer, R., and Sasisekharan, R. (1996) Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation. Proc. Natl. Acad. Sci., USA93, 845-580
19. Waksman, G., and Herr, A. B. (1998). New insights into heparin-induced FGF oligomerization. Nature Struct. Biol. 5, 527-530
20. Kan, M., Wang, F., Xu, J., Crabb, J. W., Hou, J., and McKeehan, W. L. (1993) An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science 259, 19918-19921
21. Bikfalvi, A., Klein, S., Pintucci, G., and Rifkin, D. B. (1997) Biological roles of fibroblast growth factor-2. Endocr. Rev. 18, 26-45
22. Basilico, C., and Moscatelli, D. (1992) The FGF family of growth factors and oncogenes. Adv. Cancer Res. 59, 115-165
23. Roghani, M., Mansukhani, A., Dell'Era, P., Bellosta, P., Basilico, C., Rifkin, D. B., and Moscatelli, D. (1994) Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding. J. Biol. Chem. 269, 3976-3984
24. Fannon, M., and Nugent, M. A. (1996) Basic fibroblast growth factor binds its receptors, is internalized, and stimulates DNA synthesis in Balb/c3T3 cells in the absence of heparan sulfate. J. Biol. Chem. 271, 17949-17956
25. Filla, M. S., Dam, P., and Rapraeger, A. C. (1998) The cell surface proteoglycan syndecan-1 mediates fibroblast growth factor-2 binding and activity. J. Cell. Physiol. 174, 310-321
26. Forsten, K. E., Courant, N. A., and Nugent, M. A. (1997) Endothelial proteoglycans inhibit bFGF binding and mitogenesis. J. Cell. Physiol. 172, 209-220
27. Higuchi, R. (1990) in PCR Protocols: A guide to Methods and Applications (Innis, M. A., Gelfand, D. H., Sninsky, J. J., and White, T. J., eds) Academic Press, San Diego, California
28. Thompson, L. D., Pantoliano, M. W., and Springer, B. A. (1994). Energetic characterization of the basic fibroblast growth factor-heparin interaction: identification of the heparin binding domain. Biochemistry 33, 3831-3840
29. Li, L.-Y., Safran, M., Aveizer, D., Böhlen, P., and Yayon, A. (1994). Diminished heparin binding of a basic fibroblast growth factor mutant is associated with reduced receptor binding, mitogenesis, plasminogen activator induction, and in vitro angiogenesis. Biochemistry 34, 731-736
30. Springer, B. A., Pantoliano, M. W., Barbera, F. A., Gunyuzlu, P. L., Thompson, L. D., Herblin, W. F., Rosenfeld, S. A., and Book, G. W. (1994). Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis. J. Biol. Chem. 269, 26879-26884
31. Faham, S., Hileman, R. W., Fromm, J. R., Linhardt, R. J., and Rees, D. C. (1996). Heparin structure and interactions with basic fibroblast growth factor. Science 271, 1116-1120
32. Nugent, M. A., and Edelman, E. R. (1992). Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: a mechanism for cooperativity. Biochemistry 31, 8876-8883
33. Sperinde, G. V., and Nugent, M. A. (1998). Heparan sulfate proteoglycans control intracellular processing of bFGF in vascular smooth muscle cells. Biochemistry 37, 13153-13164
34. Larrain J., Alvarez J., Hassell J. R., and Brandan E. (1997). Expression of perlecan, a proteoglycan that binds myogenic inhibitory basic fibroblast growth factor, is down regulated during skeletal muscle differentiation. Exp. Cell Res. 234, 405-412
35. Bikfalvi, A., Savona, C., Perollet, C., and Javerzat, S. ( 1997). New insights in the biology of fibroblast growth factor-2. Angiogenesis 1, 155-173