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Volumn 9, Issue 5, 1999, Pages 571-577

Topics in prion cell biology

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ION; MUTANT PROTEIN; PRION PROTEIN;

EID: 0032843918     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(99)00016-1     Document Type: Review
Times cited : (28)

References (65)
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    • Newnam GP, Wegrzyn RD, Lindquist SL, Chernoff YO Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing. Mol Cell Biol. 19:1999;1325-1333. Reports that maintenance of the prion state depends on the interplay of two different chaperones. This represents a significant step towards identifying intermolecular interactions that are critical for maintenance.
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    • Translation termination efficiency can be regulated in saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism
    • Explores the interrelation of prion state and stress tolerance for [PSI+]. The authors favour models based on alterations in translation termination efficiency and subsequent effects on the stress response. Provides an important additional perspective on the prion phenotype.
    • Eaglestone SS, Cox BS, Tuite MF Translation termination efficiency can be regulated in saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism. EMBO J. 18:1999;1974-1981. Explores the interrelation of prion state and stress tolerance for [PSI+]. The authors favour models based on alterations in translation termination efficiency and subsequent effects on the stress response. Provides an important additional perspective on the prion phenotype.
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    • Prion domain initiation of amyloid formation in vitro from native Ure2p
    • Demonstrates that Ure2p prion domain can polymerise to amyloid filaments and recruit native Ure2p. Filaments are congophilic and have high β-sheet content. See also [53].
    • Taylor KL, Cheng N, Williams RW, Steven AC, Wickner RB Prion domain initiation of amyloid formation in vitro from native Ure2p. Science. 283:1999;1339-1343. Demonstrates that Ure2p prion domain can polymerise to amyloid filaments and recruit native Ure2p. Filaments are congophilic and have high β-sheet content. See also [53].
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    • The [URE3] prion is an aggregated form of Ure2p that can be cured by overexpression of Ure2p fragments
    • Reports the detection of Ure2p-GFP aggregates in [URE3], but also provides evidence that various Ure2p fragments can cure prion aggregates. This could be the basis for a therapeutic strategy.
    • Edskes HK, Gray VT, Wickner RB The [URE3] prion is an aggregated form of Ure2p that can be cured by overexpression of Ure2p fragments. Proc Natl Acad Sci USA. 96:1999;1498-1503. Reports the detection of Ure2p-GFP aggregates in [URE3], but also provides evidence that various Ure2p fragments can cure prion aggregates. This could be the basis for a therapeutic strategy.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1498-1503
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    • Two prion-inducing regions of Ure2p are nonoverlapping
    • This progressive deletion analysis of Ure2p reveals a number of regions promoting or inhibiting prion formation. The idea that the amino-terminal domain is sufficient as well as necessary in this context appears too simplistic.
    • Maddelein ML, Wickner RB Two prion-inducing regions of Ure2p are nonoverlapping. Mol Cell Biol. 19:1999;4516-4524. This progressive deletion analysis of Ure2p reveals a number of regions promoting or inhibiting prion formation. The idea that the amino-terminal domain is sufficient as well as necessary in this context appears too simplistic.
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    • Non-conventional infectious elements in filamentous fungi
    • Presents analysis of potential prion phenomena in filamentous fungi. Particularly valuable for analysis of older literature on modifications of hyphal morphology which propagate through cultures.
    • Silar P, Daboussi MJ Non-conventional infectious elements in filamentous fungi. Trends Genet. 15:1999;141-145. Presents analysis of potential prion phenomena in filamentous fungi. Particularly valuable for analysis of older literature on modifications of hyphal morphology which propagate through cultures.
    • (1999) Trends Genet , vol.15 , pp. 141-145
    • Silar, P.1    Daboussi, M.J.2
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