메뉴 건너뛰기




Volumn 11, Issue 5, 1999, Pages 394-400

Molecular advances in gynecologic oncology

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE; PROTEIN P53;

EID: 0032843636     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-199909000-00013     Document Type: Review
Times cited : (4)

References (42)
  • 2
    • 0002746249 scopus 로고    scopus 로고
    • Basic biology and biochemistry of gynecologic cancer
    • Edited by Hoskins W, Perez C, Young R. Philadelphia: Lippincott-Raven
    • Parker MF, Sausville EA, Birrer MJ: Basic biology and biochemistry of gynecologic cancer. In Principles and Practice of Gynecologic Oncology, edn 2. Edited by Hoskins W, Perez C, Young R. Philadelphia: Lippincott-Raven. 1997:61-86.
    • (1997) Principles and Practice of Gynecologic Oncology, Edn 2 , pp. 61-86
    • Parker, M.F.1    Sausville, E.A.2    Birrer, M.J.3
  • 3
    • 0033082311 scopus 로고    scopus 로고
    • Altered expression of transforming growth factor beta (TGF-β) ligands and receptors in primary and recurrent ovarian carcinomas
    • Bristow RE, Baldwin RL, Yamada SD, Korc M, Karlan BY: Altered expression of transforming growth factor beta (TGF-β) ligands and receptors in primary and recurrent ovarian carcinomas. Cancer 1999, 85:658-668.
    • (1999) Cancer , vol.85 , pp. 658-668
    • Bristow, R.E.1    Baldwin, R.L.2    Yamada, S.D.3    Korc, M.4    Karlan, B.Y.5
  • 4
    • 0031776537 scopus 로고    scopus 로고
    • The biology of ovarian cancer
    • Auersperg N, Edelson MI, Mok SC, Johnson SW, Hamilton TC: The biology of ovarian cancer. Semin Oncol 1998, 25:281-304. A comprehensive summary of current biologic understanding of ovarian carcino-genesis and drug resistance.
    • (1998) Semin Oncol , vol.25 , pp. 281-304
    • Auersperg, N.1    Edelson, M.I.2    Mok, S.C.3    Johnson, S.W.4    Hamilton, T.C.5
  • 5
    • 0029962038 scopus 로고    scopus 로고
    • The role of HER-2/neu oncogene in gynecologic cancers
    • Cirisano FD, Karlan BY: The role of HER-2/neu oncogene in gynecologic cancers. J Soc Gynecol Invest 1996, 3:99-105.
    • (1996) J Soc Gynecol Invest , vol.3 , pp. 99-105
    • Cirisano, F.D.1    Karlan, B.Y.2
  • 6
  • 7
    • 0031903646 scopus 로고    scopus 로고
    • Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185 HER-2/neu monoclonal antibody plus cisplatin in patients with HER-2/neu overexpressing metastatic breast cancer refractory to chemotherapy treatment
    • Pegram MD, Lipton A, Hayes DF, Weber BL, Baselga JM, Tripathy D, et al.: Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185 HER-2/neu monoclonal antibody plus cisplatin in patients with HER-2/neu overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 1998, 16:2659-2671. An important phase II trial that demonstrates that gene therapy with HER 2/neu is well tolerated and has promising results in patients with breast cancer.
    • (1998) J Clin Oncol , vol.16 , pp. 2659-2671
    • Pegram, M.D.1    Lipton, A.2    Hayes, D.F.3    Weber, B.L.4    Baselga, J.M.5    Tripathy, D.6
  • 9
    • 0032527913 scopus 로고    scopus 로고
    • AKT2, a member of the protein kinase B family, is activated by growth factors, v-Haras and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells
    • Liu A, Testa JR, Hamilton TC, Jove R, Nicosia SV, Cheng JO: AKT2, a member of the protein kinase B family, is activated by growth factors, v-Haras and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells. Cancer Res 1998, 58:2973-2977.
    • (1998) Cancer Res , vol.58 , pp. 2973-2977
    • Liu, A.1    Testa, J.R.2    Hamilton, T.C.3    Jove, R.4    Nicosia, S.V.5    Cheng, J.O.6
  • 11
    • 0032590011 scopus 로고    scopus 로고
    • PIK3CA is implicated as an oncogene in ovarian cancer
    • Shayesteh L, Lu Y, Kuo W, Baldocci R, Godfrey T, Collins C, et al.: PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999, 21:99-102. This article provides a model for establishing that a candidate gene is an oncogene through experiments that demonstrate increased expression and the functional significance of, gene product in cancer cells.
    • (1999) Nat Genet , vol.21 , pp. 99-102
    • Shayesteh, L.1    Lu, Y.2    Kuo, W.3    Baldocci, R.4    Godfrey, T.5    Collins, C.6
  • 12
    • 0032898972 scopus 로고    scopus 로고
    • A molecular blueprint for targeting cancer?
    • Tlsty TD: A molecular blueprint for targeting cancer? Nat Genet 1999, 21:64-65.
    • (1999) Nat Genet , vol.21 , pp. 64-65
    • Tlsty, T.D.1
  • 15
    • 0029919109 scopus 로고    scopus 로고
    • Hereditary cancer: Two hits revisited
    • Knudson AG: Hereditary cancer: two hits revisited. J Cancer Res Clin Oncol 1996, 122:135-140.
    • (1996) J Cancer Res Clin Oncol , vol.122 , pp. 135-140
    • Knudson, A.G.1
  • 18
    • 0032542697 scopus 로고    scopus 로고
    • Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: Association with human papilloma virus type
    • Muller CY, O'Boyle JD, Fong KM, Wistuba II, Biesterveld E, Ahmedian M, et al.: Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papilloma virus type. J Natl Cancer Inst 1998, 90:433-439. A good model for how to critically evaluate whether the FHIT gene may be a tumor-suppressor gene in cervical cancer.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 433-439
    • Muller, C.Y.1    O'Boyle, J.D.2    Fong, K.M.3    Wistuba, I.I.4    Biesterveld, E.5    Ahmedian, M.6
  • 19
    • 0032422644 scopus 로고    scopus 로고
    • PTEN mutations mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics
    • Risinger JI, Hayes K, Maxwell GL, Carney ME, Dodge RK, Barret JC, Berchuck A: PTEN mutations mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics. Clin Cancer Res 1998, 4:3005-3010.
    • (1998) Clin Cancer Res , vol.4 , pp. 3005-3010
    • Risinger, J.I.1    Hayes, K.2    Maxwell, G.L.3    Carney, M.E.4    Dodge, R.K.5    Barret, J.C.6    Berchuck, A.7
  • 20
    • 0029783835 scopus 로고    scopus 로고
    • Mutations of MSH3 in endometrial cancer and evidence for its role in heteroduplex repair
    • Risinger JI, Umar A, Boyd J, Berchuck A, Knukel TA, Barrett JC: Mutations of MSH3 in endometrial cancer and evidence for its role in heteroduplex repair. Nat Genet 1996, 14:102-105.
    • (1996) Nat Genet , vol.14 , pp. 102-105
    • Risinger, J.I.1    Umar, A.2    Boyd, J.3    Berchuck, A.4    Knukel, T.A.5    Barrett, J.C.6
  • 22
    • 0032529467 scopus 로고    scopus 로고
    • The role of hMLH1, hMSH3 and hMSH6 defects in cisplatin and oxaliplatin resistance: Correlation with replicative bypass of platinum-DNA adducts
    • Vaisman A, Varchenko M, Umar A, Kunkel TA, Risinger JI, Barrett C, et al.: The role of hMLH1, hMSH3 and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts. Cancer Res 1998, 58:3579-3585.
    • (1998) Cancer Res , vol.58 , pp. 3579-3585
    • Vaisman, A.1    Varchenko, M.2    Umar, A.3    Kunkel, T.A.4    Risinger, J.I.5    Barrett, C.6
  • 23
    • 0030846212 scopus 로고    scopus 로고
    • Alterations in DNA methylation: A fundamental aspect of neoplasia
    • Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP: Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 1998, 72:141-196. A comprehensive review of DNA methylation and its potential role in carcinogenesis.
    • (1998) Adv Cancer Res , vol.72 , pp. 141-196
    • Baylin, S.B.1    Herman, J.G.2    Graff, J.R.3    Vertino, P.M.4    Issa, J.P.5
  • 24
    • 13144266670 scopus 로고    scopus 로고
    • Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    • Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, et al.: Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 1998, 95:6870-6875. This article provides strong evidence that hypermethylation can inactivate tumor-suppressor genes through a series of experiments that demonstrate that hypermethylation of hMLH1 occurs frequently, and that the reversal of methylation restores hMLH1 expression and function in colon cancer cell lines.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6870-6875
    • Herman, J.G.1    Umar, A.2    Polyak, K.3    Graff, J.R.4    Ahuja, N.5    Issa, J.P.6
  • 25
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones PA, Laird PW: Cancer epigenetics comes of age. Nat Genet 1999, 21:163-167. A review of how epigenetic mechanisms of gene inactivation, including DNA methylation, can contribute to cancer.
    • (1999) Nat Genet , vol.21 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 26
    • 0033557918 scopus 로고    scopus 로고
    • Frequent silencing of the GPC3 gene in ovarian cancer cell lines
    • Lin H, Huber R, Schlessinger D, Morin PJ: Frequent silencing of the GPC3 gene in ovarian cancer cell lines. Cancer Res 1999, 59:807-810.
    • (1999) Cancer Res , vol.59 , pp. 807-810
    • Lin, H.1    Huber, R.2    Schlessinger, D.3    Morin, P.J.4
  • 28
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane DP: p53, guardian of the genome. Nature 1992, 358:15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 29
    • 0031819661 scopus 로고    scopus 로고
    • Studies on the molecular mechanism of growth inhibition with p53 adenoviral construct in human ovarian cancer
    • Mujoo K, Catino JJ, Maneval DC, Gutterman JU: Studies on the molecular mechanism of growth inhibition with p53 adenoviral construct in human ovarian cancer. Int J Gynecol Cancer 1998, 8:233-241.
    • (1998) Int J Gynecol Cancer , vol.8 , pp. 233-241
    • Mujoo, K.1    Catino, J.J.2    Maneval, D.C.3    Gutterman, J.U.4
  • 30
    • 0031942278 scopus 로고    scopus 로고
    • Li-Fraumeni syndrome and the role of p53 tumor suppressor gene in cancer susceptibility
    • Akashi M, Koeffler HP: Li-Fraumeni syndrome and the role of p53 tumor suppressor gene in cancer susceptibility. Clin Obstet Gynecol 1998, 41:172-199.
    • (1998) Clin Obstet Gynecol , vol.41 , pp. 172-199
    • Akashi, M.1    Koeffler, H.P.2
  • 31
    • 0032171323 scopus 로고    scopus 로고
    • Correlation of TP53 mutations and p53 expression in ovarian tumors
    • DiCioccio RA, Werness BA, Peng R, Allen HJ, Piver MS: Correlation of TP53 mutations and p53 expression in ovarian tumors. Cancer Genet Cytogenet 1998, 105:93-102. A good summary of the methods of detection and heterogeneity of p53 mutations in ovarian cancers.
    • (1998) Cancer Genet Cytogenet , vol.105 , pp. 93-102
    • Dicioccio, R.A.1    Werness, B.A.2    Peng, R.3    Allen, H.J.4    Piver, M.S.5
  • 32
    • 0029857892 scopus 로고    scopus 로고
    • DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies
    • Casey G, Lopez ME, Ramos JC, Plummer SJ, Arboleda MJ, Shaughnessy M, et al.: DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies. Oncogene 1996, 13:1971-1981.
    • (1996) Oncogene , vol.13 , pp. 1971-1981
    • Casey, G.1    Lopez, M.E.2    Ramos, J.C.3    Plummer, S.J.4    Arboleda, M.J.5    Shaughnessy, M.6
  • 33
    • 0001235002 scopus 로고    scopus 로고
    • Relationship between p53 mutation, p53 overexpression and survival in advanced stage ovarian cancers treated on Gynecologic Oncology Group protocols 114 and 132
    • Havirlesky L, Berchuck A, Hamdan H, Walsh K, Leon J: Relationship between p53 mutation, p53 overexpression and survival in advanced stage ovarian cancers treated on Gynecologic Oncology Group protocols 114 and 132. Gynecol Oncol 1999, 72:445.
    • (1999) Gynecol Oncol , vol.72 , pp. 445
    • Havirlesky, L.1    Berchuck, A.2    Hamdan, H.3    Walsh, K.4    Leon, J.5
  • 34
    • 0029960147 scopus 로고    scopus 로고
    • Adenoviral-mediated p53 tumor suppressor gene therapy of human ovarian carcinoma
    • Mujoo K, Maneval DC, Anderson SC, Gutterman JU: Adenoviral-mediated p53 tumor suppressor gene therapy of human ovarian carcinoma. Oncogene 1996, 12:1617-1623.
    • (1996) Oncogene , vol.12 , pp. 1617-1623
    • Mujoo, K.1    Maneval, D.C.2    Anderson, S.C.3    Gutterman, J.U.4
  • 35
    • 0000132837 scopus 로고    scopus 로고
    • A phase I/II trial of recombinant adenoviral human p53 (SCH58500) intraperitoneal (ip) gene therapy in recurrent ovarian cancer
    • Buller R, Pegram M, Runnebaum I, Horowitz JA, Buekers R, Salko TP, et al.: A phase I/II trial of recombinant adenoviral human p53 (SCH58500) intraperitoneal (ip) gene therapy in recurrent ovarian cancer. Gynecol Oncol 1999, 72:453.
    • (1999) Gynecol Oncol , vol.72 , pp. 453
    • Buller, R.1    Pegram, M.2    Runnebaum, I.3    Horowitz, J.A.4    Buekers, R.5    Salko, T.P.6
  • 37
    • 7144250518 scopus 로고    scopus 로고
    • Role of p53 polymorphism in the development of human papillomavirus-associated cancer
    • Storey A, Thomas M, Kalita A, Harwood C, Gardiol D, Mantovani F, et al.: Role of p53 polymorphism in the development of human papillomavirus-associated cancer. Nature 1998, 393:229-234.
    • (1998) Nature , vol.393 , pp. 229-234
    • Storey, A.1    Thomas, M.2    Kalita, A.3    Harwood, C.4    Gardiol, D.5    Mantovani, F.6
  • 38
    • 0032517478 scopus 로고    scopus 로고
    • p53 polymorphism and risk of cervical cancer
    • Lanham S, Campbell I, Watt P, Gornall R: p53 polymorphism and risk of cervical cancer. Lancet 1998, 352:1631.
    • (1998) Lancet , vol.352 , pp. 1631
    • Lanham, S.1    Campbell, I.2    Watt, P.3    Gornall, R.4
  • 40
    • 17344365851 scopus 로고    scopus 로고
    • Genetic heterogeneity and penetrance analysis of BRCA1 and BRCA2 genes in breast cancer families
    • Ford D, Easton DF, Bishop DT, Narod SA, Goldgar DE: Genetic heterogeneity and penetrance analysis of BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet 1998, 62:676-689.
    • (1998) Am J Hum Genet , vol.62 , pp. 676-689
    • Ford, D.1    Easton, D.F.2    Bishop, D.T.3    Narod, S.A.4    Goldgar, D.E.5
  • 41
    • 0031832736 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: From molecular genetics to clinical medicine
    • Blackwood MA, Weber BL: BRCA1 and BRCA2: from molecular genetics to clinical medicine. J Clin Oncol 1998, 16:1969-1977. A comprehensive description of the incidence of mutations in BRCA1 and BRCA2 and their function in both normal and cancer cells.
    • (1998) J Clin Oncol , vol.16 , pp. 1969-1977
    • Blackwood, M.A.1    Weber, B.L.2
  • 42
    • 0032521537 scopus 로고    scopus 로고
    • BRCA1 up-regulation is associated with repair mediated resistance to cis-diamminechloroplatinum (ii)
    • Husain A, He G, Venkatraman ES, Spriggs DR: BRCA1 up-regulation is associated with repair mediated resistance to cis-diamminechloroplatinum (ii). Cancer Res 1998, 58:1120-1123. The investigators begin with the interesting observation that BRCA1 is up-regulated in cisplatin-resistant cell lines and then demonstrate its role in DNA damage repair, thereby elucidating a possible function of BRCA1 in ovarian cancer.
    • (1998) Cancer Res , vol.58 , pp. 1120-1123
    • Husain, A.1    He, G.2    Venkatraman, E.S.3    Spriggs, D.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.