Effects of the sulphydryl donor N-acetyl-L-cysteine on nerve conduction, perfusion, maturation and regeneration following freeze damage in diabetic rats

European Journal of Clinical Investigation

Volumn 26, Issue 8, 1996, Pages 698-706

  Love, A ^a   Cotter, M A ^a   Cameron, N E ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Anti oxidant; Diabetic rat; Endoneurial blood flow; Free radicals; Ischaemia; Nerve neuropathy; Regeneration; Vascular

Indexed keywords

ACETYLCYSTEINE; FREE RADICAL; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CELL MATURATION; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; MALE; NERVE CONDUCTION; NERVE INJURY; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM;

EID: 0029780545     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2362.1996.tb02156.x     Document Type: Article

References (49)

1. Cameron NE, Cotter MA. The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications. Diabetes Metab Rev 1994;10:189-224.
2. Cameron NE, Cotter MA, Low PA. Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits. Am J Physiol 1991; 261:E1-8.
3. Cameron NE, Cotter MA. Effects of chronic treatment with a nitric oxide donor on nerve conduction abnormalities and endoneurial blood flow in streptozotocin-diabetic rats. Eur J Clin Invest 1995;25:19-24.
4. 2+ antagonist, nimodipine, ameliorates an existing neuropathy in the streptozotocin-induced diabetic model. Br J Pharmacol 1993;108:780-5.
5. Greene DA, De Jesus PV Jr, Winegrad AI. Effects of insulin and dietary myo-inositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes. J Clin Invest 1975;55:1326-36.
6. Cameron NE, Cotter MA, Archibald V, Dines KC, Maxfield EK. Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats. Diabetologia 1994;37:449-59.
7. Bravenboer B, Kapelle AC, Hamers FPT, Van Buren T, Erkelens DW, Gispen WH. Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat. Diabetologia 1992;35:813-7.
8. Cameron NE, Cotter MA, Dines KC, Maxfield EK, Carey F, Mirrlees DJ. Aldose reductase inhibition, nerve perfusion, oxygenation and function in streptozotocin-diabetic rats: dose-response considerations and independence from a myo-inositol mechanism. Diabetologia 1994;37:651-63.
9. Calcutt NA, Mizisin AP, Kalichman MW. Aldose reductase inhibition, Doppler flux and conduction in diabetic rat nerve. Eur J Pharmacol 1994;251:27-33.
10. Hotta N, Kaskuta H, Fukasawa H et al. Effect of a potent new aldose reductase inhibitor (5-(3-thienyl)tetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats. Diabetes Res Clin Pract 1995;27:107-17.
11. Kihara M, Schmelzer JD, Poduslo JF, Curran FF, Nickander KK, Low PA. Aminoguanidine effect on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals. Proc Natl Acad Sci USA 1991;88:6107-11.
12. Dines KC, Cotter MA, Cameron NE. Comparison of the effects of evening primrose oil and triglycerides containing γ-linolenic acid on nerve conduction and blood flow in diabetic rats. J Pharmacol Exp Ther 1995;273:49-55.
13. Boulton AJM, Levin S, Comstock J. A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy. Diabetologia 1990;33:431-7.
14. Keen H, Payan J, Allawi J et al. Treatment of diabetic neuropathy with γ-linolenic acid. Diabetes Care 1993;16:8-15.
15. Reja A, Tesfaye S, Harris ND, Ward JD. Is ACE inhibition with lisinopril helpful in diabetic neuropathy? Diabetic Med 1995;12:307-9.
16. Tesfaye S, Malik R, Ward JD. Vascular factors in diabetic neuropathy. Diabetologia 1994;37:847-54.
17. Cameron NE, Cotter MA. Neurovascular dysfunction in diabetic rats: potential contribution of autoxidation and free radicals examined using transition metal chelating agents. J Clin Invest 1995;96:1159-63.
18. Cameron NE, Cotter MA, Maxfield EK. Antioxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats. Diabetologia 1993;36:299-304.
19. Cotter MA, Love A, Watt MJ, Cameron NE, Dines KC. Effects of natural free radical scavengers on peripheral nerve and neurovascular function in diabetic rats. Diabetologia 1995;38:1284-94.
20. Nickander KK, Schmelzer JD, Rohwer DA, Low PA. Effects of α-tocopherol deficiency on indices of oxidative stress in normal and diabetic peripheral nerve. J Neurol Sci 1994;126:6-14.
21. 2 in human umbilical vein endothelial cells cultured in high glucose medium. Diabetologia 1994;37:264-9.
22. Sharma AK, Bajada S, Thomas PK. Influence of streptozotocin-induced diabetes on myelinated nerve fibre maturation and integrity and on body growth in the rat. Acta Neuropathol 1981;53:257-65.
23. Cameron NE, Leonard MB, Ross I, Whiting P. The effects of Sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin diabetic rat. Diabetologia 1986;29:168-74.
24. Longo FM, Powell HC, LeBeau J, Gerrero MR, Heckman BS, Myers RR. Delayed nerve regeneration in streptozotocin diabetic rats. Muscle Nerve 1986;9:385-93.
25. Vinik AI, Newlon PG, Lauterio TJ et al. Nerve survival and regeneration in diabetes. Diabetes Rev 1995;3:139-57.
26. Shupeck M, Ward KK, Schmelzer JD, Low PA. Comparison of nerve regeneration in vascularized and conventional grafts: nerve electrophysiology, norepinephrine, prostacyclin, malondialdehyde, and the blood nerve barrier. Brain Res 1989;493:225-30.
27. Loven DH, Schedl H, Wilson H et al. Effects of insulin and oral glutathione on glutathione levels and superoxide dismutase activities in organs of rats with streptozotocin-induced diabetes. Diabetes 1986;35:503-7.
28. Low PA, Lagerlund TD, McManis PG. Nerve blood flow and oxygen delivery in normal, diabetic and ischemic neuropathy. Int Rev Neurobiol 1989;31:355-438.
29. Bondoux-Jahan M, Sebille A. Conditioning lesion effects on rat sciatic nerve regeneration are influenced by electrical stimulation delivered to denervated muscles. Brain Res 1989;490:350-4.
30. Cameron NE, Love A, Cotter MA. Ciliary neuronotrophic factor improves nerve conduction and regeneration in experimental diabetes. Diabetologia 1995;38(Suppl. 1):A233.
31. 9-analogue Org 2766 can improve existing neuropathy in streptozotocin-induced diabetic rats. Acta Diabetol 1993;30:21-4.
32. Cameron NE, Cotter MA, Archibald V. Chronic N-acetyl-L-cysteine treatment prevents impaired endothelium-dependent relaxation and improves peripheral nerve blood flow and conduction in diabetic rats. Eur J Clin Invest 1995;25(Suppl. 2):A9.
33. Cameron NE, Cotter MA. Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: role of polyol pathway activity. Diabetologia 1992;35:1011-19.
34. Cotter MA, Archibald V, Cameron NE. Effects of anti-oxidant and aminoguanidine treatments on in vitro relaxation and contraction of aorta from diabetic rats. J Physiol 1995;487:85P.
35. Cameron NE, Cotter MA, Hohman TC. Interactions between essential fatly acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats. Diabetologia 1996;39:172-82.
36. Cameron NH, Cotter MA, Dines KC, Maxfield EK. Pharmacological manipulation of vascular endothelium in non-diabetic and streptozotocin-diabetic rats: effects on nerve conduction, hypoxic resistance and endoneurial capillarization. Diabetologia 1993;36:516-22.
37. +)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat. J Clin Invest 1994;94:853-9.
38. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620-4.
39. Hyslop PA, Hinshaw DB, Halsey WA Jr et al. Mechanism of oxidant-mediated cell injury: the glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J Biol Chem 1988;263:1665-75.
40. Evensen SA, Galdal KS, Nilsen E. LDL-induced cytotoxicity and its inhibition by anti-oxidant treatment in cultured human endothelial cells and fibroblasts. Atherosclerosis 1983;49:23-30.
41. Ceriello A. Coagulation activation in diabetes mellitus: the role of hyperglycaemia and therapeutic prospects. Diabelologia 1993;36:1119-25.
42. Ekström PAR, Tomlinson DR. Impaired nerve regeneration in streptozotocin-diabetic rats. Effect of treatment with an aldose reductase inhibitor. J Neurol Sci 1989;93:231-7.
43. 1 receptor antagonist. Am J Physiol 1995;269:E530-7.
44. Nukudu H. Post-traumatic neovascularization and nerve regeneration: a morphological study. Brain Res 1988;449:89-96.
45. Kamijo M, Cherian PV, Merry A, Sima AAF. Nerve fiber regeneration and nodal maturation in diabetic BB/W-rats following axotomy and the effect of ARI-treatment, Muscle Nerve 1994;17(Suppl. 1):S194.
46. Love A, Cotter MA, Cameron NE. Impaired myelinated fiber regeneration following freeze-injury in rats with streptozotocin-induced diabetes: involvement of the polyol pathway. Brain Res 1995;105-10.
47. Apfel SC, Arezzo JC, Brownlee M, Federolf H, Kessler JA. Nerve growth factor administration protects against experimental diabetic sensory neuropathy. Brain Res 1994;634:7-12.
48. Diemel LT, Brewster WJ, Fernyhough P, Tomlinson DR. Expression of neuropeptides in experimental diabetes: effects of treatment with nerve growth factor or brain derived neurotrophic factor. Mol Brain Res 1994;21:171-5.
49. Ceriello A, Guigliano D, Quatraro A, Lelebvre PJ. Anti-oxidants show an anti-hypertensive effect in diabetic and hypertensive subjects. Clin Sci 1991;81:739-42.