Inhibitory effect of Ginkgo biloba extract on the expression of inducible nitric oxide synthase in endothelial cells

Biochemical Pharmacology

Volumn 58, Issue 10, 1999, Pages 1665-1673

  Cheung, Filly ^a   Siow, Yaw L ^a   Chen, Wei Z ^b   Karmin, O ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Endothelial cells; Ginkgo biloba leaf extracts; Nitric oxide

Indexed keywords

GINKGO BILOBA EXTRACT; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL;

CELL LINE; DNA; ENDOTHELIUM, VASCULAR; GINKGO BILOBA; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PLANTS, MEDICINAL; RNA, MESSENGER;

EID: 0032833272     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00255-5     Document Type: Article

References (49)

1. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide Physiology, pathophysiology and pharmacology . Pharmacol Rev. 43:1991;109-142.
2. Bredt D.S., Snyder S.H. Nitric oxide A physiologic messenger molecule . Annu Rev Biochem. 63:1994;175-195.
3. Knowles R.G., Moncada S. Nitric oxide synthases in mammals. Biochem J. 298:1994;249-258.
4. Fleming I., Bauersachs J., Busse R. Calcium-dependent and calcium-independent activation of the endothelial NO synthase. J Vasc Res. 34:1997;165-174.
5. Wever R.M., Luscher T.F., Cosentino F., Rabelink T.J. Atherosclerosis and the two faces of endothelial nitric oxide synthase. Circulation. 97:1998;108-112.
6. Nathan C., Xie Q.W. Regulation of biosynthesis of nitric oxide. J Biol Chem. 269:1994;13725-13728.
7. Bredt D.S., Snyder S.H. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA. 87:1990;682-685.
8. Lamas S., Marsden P.A., Li G.K., Tempst P., Michel T. Endothelial nitric oxide synthase Molecular cloning and characterization of a distinctive constitutive enzyme isoform . Proc Natl Acad Sci USA. 89:1992;6348-6352.
9. Garthwaite J., Boulton C.L. Nitric oxide signaling in the central nervous system. Annu Rev Physiol. 57:1995;683-706.
10. Stuehr D.J., Marletta M.A. Mammalian nitrate biosynthesis Mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide . Proc Natl Acad Sci USA. 82:1985;7738-7742.
11. Nathan C. Inducible nitric oxide synthase What difference does it make? J Clin Invest. 100:1997;2417-2423.
12. Iwashina M., Hirata Y., Imai T., Sato K., Marumo F. Molecular cloning of endothelial, inducible nitric oxide synthase gene from rat aortic endothelial cell. Eur J Biochem. 237:1996;668-673.
13. Igarashi J, Nishida M, Hoshida S, Yamashita N, Kosaka H, Hori M, Kuzuya T and Tada M, Inducible nitric oxide synthase augments injury elicited by oxidative stress in rat cardiac myocytes. Am J Physiol 274: C245-C252, 1998.
14. Marczin N., Jilling T., Papapetropoulos A., Go C., Catravas J.D. Cytoskeleton-dependent activation of the inducible nitric oxide synthase in cultured aortic smooth muscle cells. Br J Pharmacol. 118:1996;1085-1094.
15. Geller D.A., Lowenstein C.J., Shapiro R.A., Nussler A.K., Di Silvio M., Wang S.C., Nakayama D.K., Simmons R.L., Snyder S.H., Billiar T.R. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci USA. 90:1993;3491-3495.
16. Shultz P.J., Archer S.L., Rosenberg M.K. Inducible nitric oxide synthase mRNA and activity in glomerular mesangial cells. Kidney Int. 46:1994;683-689.
17. Ohara Y., Peterson T.E., Harrison D.G. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest. 91:1993;2546-2551.
18. Buttery L.D., Springall D.R., Chester A.H., Evans T.J., Standfield E.N., Parums D.V., Yacoub M.H., Polak J.M. Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite. Lab Invest. 75:1996;77-85.
19. Xie Q.W., Cho H.J., Calaycay J., Mumford R.A., Swiderek K.M., Lee T.D., Ding A., Troso T., Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science. 256:1992;225-228.
20. Wang Y., Marsden P.A. Nitric oxide synthase Biochemical and molecular regulation . Curr Opin Nephrol Hypertens. 4:1995;12-22.
21. Pfeilschifter J., Eberhardt W., Hummel R., Kunz D., Muhl H., Nitsch D., Pluss C., Walker G. Therapeutic strategies for the inhibition of inducible nitric oxide synthase - Potential for a novel class of anti-inflammatory agents. Cell Biol Int. 20:1996;51-58.
22. Fukuto J.M., Chaudhuri G. Inhibition of constitutive and inducible nitric oxide synthase Potential selective inhibition . Annu Rev Pharmacol Toxicol. 35:1995;165-194.
23. Garvey E.P., Oplinger J.A., Tanoury G.J., Sherman P.A., Fowler M., Marshall S., Harmon M.F., Paith J.E., Furfine E.S. Potent and selective inhibition of human nitric oxide synthase. J Biol Chem. 269:1994;26669-26676.
24. Griffith M.J.D., Messent M., MacAllister R.J., Evans T.W. Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol. 110:1993;963-968.
25. DeFeudis FV, Ginkgo biloba Extract (EGb761): Pharmacological Activities and Clinical Applications. Elsevier, Paris, 1991.
26. Mouren X., Caillard P., Schwartz F. Study of the antiischemic action of EGb761 in the treatment of peripheral arterial occlusive disease by TcPo2 determination. Angiology. 45:1994;413-417.
27. Yan L.J., Droy-Lefaix M.T., Packer L. Ginkgo biloba extract (EGb761) protects human low density lipoproteins against oxidative modification mediated by copper. Biochem Biophys Res Commun. 212:1995;360-366.
28. Oyama Y., Chikahisa L., Ueha T., Kanemaru K., Noda K. Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide. Brain Res. 712:1996;349-352.
29. Rong Y., Geng Z., Lau B.H. Ginkgo biloba attenuates oxidative stress in macrophages and endothelial cells. Free Radic Biol Med. 20:1996;121-127.
30. Kobuchi H., Droy-Lefaix M.T., Christen Y., Packer L. Ginkgo biloba extract (EGb761) Inhibitory effect on nitric oxide production in the macrophage cell line RAW 264.7 . Biochem Pharmacol. 53:1997;897-903.
31. Shen J., Wang J., Zhao B., Hou J., Gao T., Xin W. Effects of EGb 761 on nitric oxide and oxygen free radicals, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo. Biochim Biophys Acta. 1406:1998;228-236.
32. Wheller S.K., Perretti M. Dexamethasone inhibits cytokine-induced intercellular adhesion molecule-1 up-regulation on endothelial cell lines. Eur J Pharmacol. 331:1997;65-71.
33. Abedi H., Zachary I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem. 272:1997;15442-15451.
34. 2+ from intracellular stores in ECV304 endothelial cells. Cell Calcium. 21:1997;461-467.
35. Zhang Y.N., Zhang J., Huang G.Q., Gu C.Y., Chen W.Z. Protective effects of extract of Ginkgo biloba (EGb) on lysophosphatidylcholine induced damages of vascular endothelial cells in vitro. Acta Pharm Sin. 32:1997;737-739.
36. Chen J.X., Chen W.Z., Huang H.L., Chen L.X., Xie Z.Z., Zhu B.Y. Protective effects of Ginkgo biloba extract against lysophosphatidylcholine-induced vascular endothelial cell damage. Acta Pharmacol Sin. 19:1998;359-363.
37. Yates M.T., Lambert L.E., Whitten P.J., McDonald I., Mano M., Ku G., Mao S.J.T. A protective role for nitric oxide in the oxidative modification of low density lipoproteins by mouse macrophages. FEBS Lett. 309:1992;135-138.
38. Hogg N., Kalyanaraman B., Joseph J., Struck A., Parthasarathy S. Inhibition of low-density lipoprotein oxidation by nitric oxide Potential role in atherogenesis . FEBS Lett. 334:1993;170-174.
39. Frohlich J. Role of lecithin:cholesterol acyltransferase and apolipoprotein A-I in cholesterol esterification in lipoprotein-X in vitro. J Lipid Res. 36:1995;2344-2354.
40. Liao J.K., Shin W.S., Lee W.Y., Clark S.L. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem. 270:1995;319-324.
41. Lynn E.G., Choy P.C., Magil A. and O K, Uptake and metabolism of lipoprotein-X in mesangial cells. Mol Cell Biochem. 175:1997;187-194.
42. Yang X.Y., Cai B., Sciacca R.P., Cannon P.J. Inhibition of inducible nitric oxide synthase in macrophages by oxidized low-density lipoproteins. Circ Res. 74:1994;318-328.
43. Vodovotz Y., Bodgan C., Paik J., Xie Q.W., Nathan C. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β J Exp Med. 178:1993;605-613.
44. Amri H., Drieu K., Papadopoulos V. Ex vivo regulation of adrenal cortical cell steroid and protein synthesis, in response to adrenocorticotropic hormone stimulation, by the Ginkgo biloba extract EGb 761 and the isolated ginkgolide B. Endocrinology. 138:1997;5415-5426.
45. Itil T., Martorano D. Natural substances in psychiatry (Ginkgo biloba in dementia). Psychopharmacol Bull. 31:1995;147-158.
46. Kanowski S., Herrmann W.M., Stephan K., Wierich W., Horr R. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry. 29:1996;47-56.
47. Le Bars P.L., Katz M.M., Berman N., Itil T.M., Freedman A.M., Schatzberg A.F. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA. 278:1997;1327-1332.
48. Maurer K., Ihl R., Dierks T., Frolich L. Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type. J Psychiatr Res. 31:1997;645-655.
49. Dorheim M.A., Tracey W.R., Pollock J.S., Grammas P. Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease. Biochem Biophys Res Commun. 205:1994;659-665.