Ex vivo regulation of adrenal cortical cell steroid and protein synthesis, in response to adrenocorticotropic hormone stimulation, by the Ginkgo biloba extract EGb 761 and isolated ginkgolide B

Endocrinology

Volumn 138, Issue 12, 1997, Pages 5415-5426

  Amri, Hakima ^a   Drieu, Katy ^b   Papadopoulos, Vassilios ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b Institut Henri Beaufour   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE RECEPTOR; CORTICOSTERONE; CORTICOTROPIN; GINKGO BILOBA EXTRACT; GINKGOLIDE B; REGULATOR PROTEIN; STEROID;

ADRENAL CORTEX CELL; ANIMAL CELL; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; HORMONAL REGULATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RAT; STEROIDOGENESIS;

EID: 0030690197     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.12.5604     Document Type: Article

References (53)

1. Simpson ER, Waterman MR 1983 Regulation by ACTH of steroid hormone biosynthesis in the adrenal cortex. Can J Biochem Cell Biol 61:692-707
2. scc in steroid hormone synthesis. J Steroid Biochem Mol Biol 43:751-767
3. Papadopoulos V 1993 Peripheial-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr Rev 14:222-240
4. Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversat JL, Bernassau JM, Drieu K 1997 Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids 62:21-28
5. Anholt RRH, Pedersen PL, DeSouza EB, Snyder SH 1986 The peripheral-type benzodiazepine receptor: localization to the mitochondrial outer membrane. J Biol Chem 261:576-583
6. Sprengel R, Werner P, Seeburg PH, Mukhin AG, Santi MR, Grayson DR, Guidotti A, Krueger KE 1989 Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor. J Biol Chem 264:20415-20421
7. Riond J, Mattei MG, Kaghad M, Dumont X, Guillemot JC, Le Fur G, Caput D, Ferrara P 1991 Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. Eur J Biochem 195:305-311
8. Garnier M, Dimchev A, Boujrad N, Price MJ, Musto NA, Papadopoulos V 1994 In vitro reconstitution of a functional peripheral-type benzodiazepine receptor. Mol Pharmacol 45:201-211
9. Yanagibashi K, Ohno Y, Nakamichi N, Matsui T, Hayashida K, Takamura M, Yamada K, Tou S, Kawamura M 1989 Peripheral-type benzodiazepine receptors are involved in the regulation of cholesterol side chain cleavage in adrenocortical mitochondria. J Biochem (Tokyo) 106:1026-1029
10. Mukhin AG, Papadopoulos V, Costa E, Krueger KE 1989 Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. Proc Natl Acad Sci USA 86:9813-9816
11. Papadopoulos V, Mukhin AG, Costa E, Krueger KE 1990 The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J Biol Chem 265:3772-3779
12. Amsterdam A, Suh BS 1991 An inducible functional peripheral benzodiazepine receptor in mitochondria of steroidogenic granulosa cells. Endocrinology 128:503-510
13. Papadopoulos V, Nowzari FB, Krueger KE 1991 Hormone-stimulated steroidogenesis is coupled to mitochondrial benzodiazepine receptors. J Biol Chem 266:3682-3687
14. Krueger KE, Papadopoulos V 1990 Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells. J Biol Chem 265:15015-15022
15. Krueger RJ, Orme-Johnson NR 1983 Acute adrenocorticotropic hormone stimulation of adrenal corticosteroidogenesis. J Biol Chem 256:10159-10167
16. Clark BJ, Wells J, King SR, Stocco DM 1994 The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. J Biol Chem 269:28314-28322
17. Stocco DM, Clark BJ 1997 The role of the steroidogenic acute regulatory protein in steroidogenesis. Steroids 62:29-36
18. Munck A, Naray-Fejes-Toth A 1994 Glucocorticoids and stress: permissive and suppressive actions. Ann NY Acad Sci 746:115-133
19. Sapolsky RM 1994 The physiological relevance of glucocorticoid endangerment of the hippocampus. Ann NY Acad Sci 746:294-307
20. McEwen BS 1994 Corticosteroids and hippocampal plasticity. Ann NY Acad Sci 746:134-144
21. deKloet ER, Azmitia EC, Landfield PW 1994 Brain corticosteroid receptors. Studies on the mechanism, function, and neurotoxicity of corticosteroid action. Ann NY Acad Sci 746:000-000
22. Orrell MW, O'Dwyer A-M 1995 Dementia, ageing, and the stress control system. Lancet 345:666-667
23. Kirschbaum C, Wolf OT, May M, Wippich W, Hellhammer DH 1996 Stress-and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sci 58:1475-1483
24. DeFeudis FV 1991 Ginkgo biloba Extract (EGb 761): Pharmacological Activities and Clinical Applications. Elsevier, Paris
25. Christen Y, Courtois Y, Droy-Lefaix MT 1995 Effects of Gingko biloba Extract (EGb 761) on Aging and Age-Related Disorders. Elsevier, Paris
26. Kanowski S, Herrmann WM, Stephan K, Wierich W, Horr R 1996 Proof of efficacy of the Ginkgo biloba extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 29:47-56
27. Christen Y, Costendin J, Lacour M 1991 Effects of Gingko biloba Extract (EGb 761) on the Central Nervous System. Elsevier, Paris
28. Porsolt RD, Martin P, Lenegere A, Fromage S, Drieu K 1990 Effects of an extract of Ginkgo biloba (EGb 761) on "learned helplessness" and other models of stress in rodents. Pharmacol Biochem Behav 36:963-971
29. Rapin JR, Lamproglou I, Drieu K, DeFeudis FV 1994 Demonstration of the "anti-stress" activity of an extract of Ginkgo biloba (EGb 761) using a discrimination learning task. Gen Pharmacol 25:1009-1016
30. Amri H, Ogwuegbu SO, Boujrad N, Drieu K, Papadopoulos V 1996 In vivo regulation of the peripheral-type benzodiazepine receptor and glucocorticoid synthesis by the Ginkgo biloba extract EGb 761 and isolated ginkgolides. Endocrinology 137:5707-5718
31. Schultz R, Pelto-Huikko M, Alho H 1992 Expression of diazepam binding inhibitor-like immunoreactivity in rat testis is dependent on pituitary hormones. Endocrinology 130:3200-3206
32. Dibartolomeis MJ, Jefcoate CR 1984 The interrelationship of polycyclic hydrocarbon metabolism and steroidogenesis in primary cultures of bovine adrenal cortical cells. Mol Pharmacol 25:476-486
33. Arai M, Widmaier EP 1993 Steroidogenesis in isolated adrenocortical cells during development in rats. Mol Cell Endocrinol 92:91-97
34. Pon LA, Roberts Orme-Johnson N 1986 Acute stimulation of steroidogenesis in corpus luteum and adrenal cortex by peptide hormones. J Biol Chem 261:6594-6599
35. O'Farrell PH 1975 High resolution two-dimensional electrophoresis of proteins. J Biol Chem 250:4007-4021
36. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 72:248-254
37. Chrousos GP, Gold PW 1992 The concepts of stress and stress system disorders. JAMA 267:1244-1252
38. Itil T, Martorano D 1995 Natural substances on psychiatry (Ginkgo biloba in dementia). Psychopharmcol Bull 31:147-158
39. Kant GJ, Mougey EH, Meyerhoff JL 1989 ACTH, prolactin, corticosterone and pituitary cyclic AMP responses to repeated stress. Pharmacol Biochem Behav 32:557-561
40. Holmes PV, Stringer AP, Drugan RC 1992 Impact of psychological dynamics of stress on the peripheral benzodiazepine receptor. Pharmacol Biochem Behav 42:437-444
41. Drugan RC, Holmes PV, Scher DM, Luczak S, Oh H, Ferland RJ 1995 Environmentally induced changes in peripheral benzodiazepine receptors are stressors and tissue specific. Pharmacol Biochem Behav 50:551-562
42. Stocco DM, Kilgore MW 1988 Induction of mitochondrial proteins in MA-10 Leydig tumor cells with human choriogonadotropin. Biochem J 249:95-103
43. Mittre H, Aunai P, Benhaim A, Leymarie P 1990 Acute stimulation by lutropin of mitochondrial protein synthesis in small luteal cells. EurJ Biochem 187:721-726
44. McEnery MW, Snowman AM, Trifiletri RR, Snyder SH 1992 Isolation of the mitochondrial benzodia/epine receptor association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA 89:3170-3174
45. Bernassau JM, Reversat JL, Ferrara P, Caput D, Lefur G 1993 A 3D model of the peripheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport. J Mol Graph 11:236-245
46. Epstein LF, Orme-Johnson NR 1991 Acute action of luteinizing hormone on mouse Leydig cells: accumulation of mitochondrial phosphoproteins and stimulation of testosterone synthesis. Mol Cell Endocrinol 81:113-126
47. Elliott ME, Goodfriend TL, Jefcoate CR 1993 Bovine adrenal glomerulosa and fasciculata cells exhibit 28.5-kilodalton proteins sensitive to angiotensin, other agonists, and atrial natriuretic peptide. Endocrinology 133:1669-1677
48. Boujrad N, Gaillard J-L, Gamier M, Papadopoulos V 1994 Acute action of choriogonadotropin on Leydig tumor cells: induction of a higher affinity benzodiazepine binding site related to steroid biosynthesis. Endocrinology 135:1576-1583
49. Boujrad N, Vidic B, Papadopoulos V 1996 Acute action of choriogonadotropin on Leydig tumor cells: changes in the topography of the mitochondrial peripheral-type benzodiazepine receptor. Endocrinology 137:5727-5730
50. Stocco DM, Sodeman TC 1991 The 30-kDa mitochondrial proteins induced by hormone stimulation in MA-10 mouse Leydig tumor cells are processed from larger precursors. J Biol Chem 266:19731-19738
51. Epstein LF, Orme-Johnson NR 1991 Regulation of steroid hormone biosynthesis. Identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells. J Biol Chem 266:19739-19745
52. Arakane F, Sugawara T, Nishino H, Liu Z, Holt JA, Pain D, Stocco DM, Miller WL, Strauss III JF 1996 Steroiodgenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import sequence: implications for the mechanism of StAR action. Proc Natl Acad Sci USA 93:13731-13736
53. Sapolsky RM 1996 Why stress is bad for your brain. Science 273:749-750