Transepithelial paracellular leakiness induced by chronic phorbol ester exposure correlates with polyp-like foci and redistribution of protein kinase C-α

Carcinogenesis

Volumn 18, Issue 12, 1997, Pages 2339-2345

  Mullin, James M ^a   Kampherstein, Jennifer A ^a   Laughlin, Kathleen V ^a   Saladik, Douglas T ^a   Soler, Alejandro Peralta ^a  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MANNITOL; PHORBOL ESTER; PROTEIN KINASE C; RUTHENIUM RED;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; ELECTRIC RESISTANCE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; INTERCELLULAR SPACE; NONHUMAN; PRIORITY JOURNAL; TIGHT JUNCTION;

ANIMALS; CELL COMPARTMENTATION; CELLS, CULTURED; ELECTROPHYSIOLOGY; EPITHELIAL CELLS; INTERCELLULAR JUNCTIONS; ISOENZYMES; KIDNEY; MANNITOL; PERMEABILITY; POLYPS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; SWINE; TETRADECANOYLPHORBOL ACETATE;

EID: 0031419675     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.12.2339     Document Type: Article

References (32)

1. Schneeberger, E.E. and Lynch, R.D. (1992) Structure, function and regulation of cellular tight junctions. Am. J. Physiol., 262, L647-L661.
2. Ernst, S.A. (1972) Transport adenosine triphosphatase cytochemistry. II. Cytochemical localization of ouabain-sensitive, potassium dependent phosphatase activity in the secretory epithelium of the avian salt gland. J. Histochem. Cytochem., 20, 23-38.
3. Kinne, R., Murer, H., Kinne-Saffran, E., Thees, M. and Sachs, G. (1975) Sugar transport by renal plasma membrane vesicles: Characterization of the systems in the brush border microvilli and basal-lateral plasma membranes. J. Memb. Biol., 21, 375-395.
4. Murer, H., Hopfer, U., Kinne-Saffran, E. and Kinne, R. (1974) Glucose transport in isolated brush-border and lateral-basal plasma membrane vesicles from intestinal epithelial cells. Biochim. Biophys. Acta, 345, 170-179.
5. Martinez-Palomo, A. (1970) Ultrastructural modifications of intercellular junctions between tumor cells. In Vitro, 6, 15-20.
6. Saito, T. (1970) Ultrastructural changes in the junctional complexes in the human urinary bladder carcinoma by thin sectioning and freeze fracture. J. Clin. Electron Microsc., 17, 201-209.
7. Hollander, D. (1988) Crohn's disease - a permeability disorder of the tight junction. Gut, 29, 1621-1624.
8. 1 renal epithelial tight junctions and transepithelial fluxes. Am. J. Physiol., 251, C597-C602.
9. Mullin, J.M. and McGinn, M.T. (1987) The phorbol ester, TPA, increases transepithelial epidermal growth factor flux. FEBS Lett., 221, 359-364.
10. 1 renal epithelia: Similarity to phorbol ester tumor promoters. J. Cell Physiol., 134, 357-366.
11. Mullin, J.M., McGinn, M.T., Snock, K.V. and Imaizumi, S. (1990) The effects of teleocidin and aplysiatoxin tumor promoters on epithelial tight junctions and transepithelial permeability: Comparison to phorbol esters. Carcinogenesis, 11, 377-385.
12. 1 transepithelial permeability. Biochem. Biophys. Res. Commun., 209, 669-676.
13. Blobe, G.C., Obeid, L.M. and Hannun, Y.A. (1994) Regulation of protein kinase C and role in cancer biology. Cancer Metast. Rev., 13, 411-131.
14. Weinstein, I.B. (1990) The role of protein kinase C in growth control and the concept of carcinogenesis as a progressive disorder in signal transduction. Adv. Second Messenger Phosphoprotein Res., 24, 307-316.
15. 1 epithelia to the phorbol ester, TPA, produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization. Expt. Cell Res., 227, 12-22.
16. 1. In Vitro, 12, 670-677.
17. Chen, T.R. (1977) In-situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Expt. Cell Res., 104, 255-261.
18. 1 renal epithelial cells in culture. Carcinogenesis, 3, 1165-1169.
19. 1) tight junction permeability and cell division. Exp. Cell Res., 207, 398-406.
20. Jaken, S., Leach, K. and Klauck, T. (1990) Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts. J. Cell Biol., 697, 704-1989.
21. Boutwell, R.K. (1974) The function and mechanism of promoters of carcinogenesis. CRC Crit. Rev. Toxicol., 2, 419-443.
22. Diamond, L., O'Brien, T.G. and Baird, W.M. (1980) Tumor promoters and the mechanism of tumor promotion. Advan.Cancer Res., 32, 1-63.
23. Mroczkowski, B. and Reich, M. (1993) Identification of biologically active epidermal growth factor in human fluids and secretions. Endocrinology, 132, 417-125.
24. Saeki, T., Stromberg, K., Qi, C.-F., Gullick, W.J., Tahara, E., Normanno, N., Ciardiello, F., Kenney, N., Johnson, G.R. and Salomon, D.S. (1992) Differential immunohistochemical detection of amphiregulin and Cripto in human normal colon and colorectal tumors. Cancer Res., 52, 3467-3473.
25. Barnard, J.A., Beauchamp, R.D., Russell, W.E., DuBois, R.N. and Coffey, R.J. (1995) Epidermal growth factor related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology, 108, 564-580.
26. Mullin, J.M., Snock, K.V., Shurina, R.D., Noe, J., George, K., Misner, L., Imaizumi, S. and O'Brien, T.G. (1992) Effects of acute vs chronic phorbol ester exposure on transepithelial permeability and epithelial morphology. J. Cell Physiol., 152, 35-47.
27. Mullin, J.M., Marano, C.W., Laughlin, K.V., Nuciglio, M. and Peralta Soler, A. (1997) Different size limitations for increased transepithelial paracellular solute flux across phorbol ester and tumor necrosis factor-treated epithelial cell sheets. J. Cell Physiol., 171, 226-233.
28. Ellis, B., Schneeberger, E.E. and Rabito, C.A. (1992) Cellular variability in the development of tight junctions after activation of protein kinase C. Am. J. Physiol., 263, F293-F300.
29. Lee, H.-W., Smith, L., Pettit, G.R., Vinitsky, A. and Smith, J. B. (1996) Ubiquitination of protein kinase C-α an degradation by the proteasome. J. Biol. Chem., 271, 20973-20976.
30. 1 epithelial cell line. J. Biol. Chem., 272, 14950-14953.
31. Wrenn, R.W. and Herman, L.E. (1995) Integrin-linked tyrosine phosphorylation increases membrane association of protein kinase Cα in pancreatic acinar cells. Biochem. Biophys. Res. Commun., 208, 978-984.
32. Craven, P.A. and DeRubertis, F.R. (1992) Alterations in protein kinase in 1,2-dimethylhydrazine induced colonic carcinogenesis. Cancer Res., 52, 2216-2221.