Nigral neurons are likely to die of a mechanism other than classical apoptosis in Parkinson's disease

Parkinsonism and Related Disorders

Volumn 5, Issue 4, 1999, Pages 187-192

  Graeber, M B ^a   Grasbon Frodl, E ^b   Abell Aleff, P ^c   Kosel S ^b  

^a Molecular Neuropathology Laboratory   (Germany)

^b Institute of Neuropathology   (Germany)

^c MAYO CLINIC   (United States)

Author keywords

Aposklesis; Cell death; Mitochondria; Neurodegeneration; Sequencing

Indexed keywords

CELL DEATH; CHROMATIN CONDENSATION; HUMAN; HUMAN CELL; LEWY BODY; MICROGLIA; MITOCHONDRION; MORPHOLOGY; NERVE DEGENERATION; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; SUBSTANTIA NIGRA;

EID: 0032819663     PISSN: 13538020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1353-8020(99)00036-X     Document Type: Article

References (38)

1. Wyllie A.H., Kerr J.F.R., Currie A.R. Cell death: the significance of apoptosis. Intl Rev Cytol. 68:1980;251-306.
2. Dragunow M., Faull R.L.M., Lawlor P., Beilharz E.J., Singleton K., Walker E.B., Mee E. In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. Neuroreport. 6:1995;1053-1057.
3. Mochizuki H., Goto K., Mori H., Mizuno Y. Histochemical detection of apoptosis in Parkinson's disease. J Neurol Sci. 137:1996;120-123.
4. Kösel S., Egensperger R., von Eitzen U., Mehraein P., Graeber M.B. On the question of apoptosis in the parkinsonian substantia nigra. Acta Neuropathol. 93:1997;105-108.
5. Anglade P., Vyas S., Javoy-Agid F., Herrero M.T., Michel P.P., Marquez J., Mouatt-Prigent A., Ruberg M., Hirsch E.C., Agid Y. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol. 12:1997;25-31.
6. Tompkins M.M., Basgall E.J., Zamrini E., Hill W.D. Apoptotic-like changes in Lewy body-associated disorders and normal aging in substantia nigral neurons. Am J Pathol. 150:1997;119-131.
7. Banati R.B., Daniel S.E., Blunt S.B. Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease. Mov Disord. 13:1998;221-227.
8. Tatton N.A., Macleanfraser A., Tatton W.G., Perl D.P., Olanow C.W. A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease. Ann Neurol. 44:1998;S142-S148.
9. Kingsbury A.E., Mardsen C.D., Foster O.J.F. DNA fragmentation in human substantia nigra: apoptosis or perimortem effect? Mov Disord. 13:1998;877-884.
10. De la Monte S.M., Sohn Y.K., Ganju N., Wands J.R. P53- and CD95-associated apoptosis in neurodegenerative diseases. Lab Invest. 78:1998;401-411.
11. Burke R.E., Kholodilov N.G. Programmed cell death: does it play a role in Parkinson's disease? Ann Neurol. 44:1998;S126-S133.
12. Hockenbery D. Defining apoptosis. Am J Pathol. 146:1995;16-19.
13. Banati R.B., Blunt S., Graeber M.B. What does apoptosis have to do with Parkinson's disease? Movement Disord. 00:1999;000. in press.
14. Lowe J., Lennox G., Leigh P.N. Disorders of movement and system degenerations. Graham D.I., Lantos P. Greenfield's neuropathology. 6 :1997;281-366 Arnold, London.
15. McGeer P.L., Itagaki S., Boyes B.E., McGeer E.G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology. 38:1988;1285-1291.
16. Banati R.B., Graeber M.B. Surveillance, intervention and cytotoxicity: is there a protective role of microglia? Dev Neurosci. 16:1994;114-127.
17. Online Mendelian Inheritance in Man. http://www.ncbi.nlm.nih.gov/Omim/.
18. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., Nussbaum R.L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 276:1997;2045-2047.
19. Krüger R., Kuhn W., Müller T., Woitalla D., Graeber M., Kösel S., Przuntek H., Epplen J.T., Schöls L., Riess O. Ala30Pro missense mutation in the alpha-synuclein gene causes autosomal dominant Parkinson's disease. Nat Genet. 18:1998;106-108.
20. Spillantini M.G., Schmidt M.L., Lee V.M.Y., Trojanowski J.Q., Jakes R., Goedert M. Alpha-synuclein in Lewy bodies. Nature. 388:1997;839-840.
21. Kösel S., Grasbon-Frodl E.M., Mautsch U., Egensperger R., von Eitzen U., Frishman D., Hofmann S., Gerbitz K.D., Mehraein P., Graeber M.B. Novel mutations of mitochondrial complex I in pathologically proven Parkinson disease. Neurogenetics. 1:1998;197-204.
22. Schnopp N.M., Kösel S., Egensperger R., Graeber M.B. Regional heterogeneity of mtDNA heteroplasmy in parkinsonian brain. Clin Neuropathol. 15:1996;348-352.
23. Shoffner J.M. Oxidative phosphorylation defects and Alzheimer's disease. Neurogenetics. 1:1997;13-19.
24. Grasbon-Frodl E.M., Kösel S., Sprinzl M., von Eitzen U., Mehraein P., Graeber M.B. Two novel point mutations of mitochondrial tRNA genes in histologically confirmed Parkinson disease. Neurogenetics. 2:1999;123-127. in press.
25. Gu M., Cooper J.M., Taanman J.W., Schapira A.H.V. Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease. Ann Neurol. 44:1998;177-186.
26. Marsden C.D., Olanow C.W. The causes of Parkinson's disease are being unraveled and rational neuroprotective therapy is close to reality. Ann Neurol. 44:1998;S189-S196.
27. Brenner C., Marzo I., Kroemer G. A revolution in apoptosis: from a nucleocentric to a mitochondriocentric perspective. Exp Gerontology. 33:1998;543-553.
28. Susin S.A., Zamzami N., Kroemer G. Mitochondria as regulators of apoptosis: doubt no more. Biochim Biophys Acta-Bioenergetics. 1366:1998;151-165.
29. Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Snow B.E., Brothers G.M., Mangion J., Jacotot E., Costantini P., Loeffler M., Larochette N., Goodlett D.R., Aebersold R., Siderovski D.P., Penninger J.M., Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 397:1999;441-446.
30. Depraetere V., Golstein P. Dismantling in cell death: molecular mechanisms and relationship to caspase activation. Scand J Immunol. 47:1998;523-531.
31. Kihira T., Yoshida S., Hironishi M., Wakayama I., Yase Y. Neuronal degeneration in amyotrophic lateral-sclerosis is mediated by a possible mechanism different from classical apoptosis. Neuropathology. 18:1998;301-308.
32. Stadelmann C., Brück W., Bancher C., Jellinger K., Lassmann H. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J Neuropathol Exp Neurol. 57:1998;456-464.
33. Grasl-Kraupp B., Ruttkay-Nedecky B., Koudelka H., Bukowska K., Bursch W., Schulte H.R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology. 21:1995;1465-1468.
34. Charriaut-Marlangue C., Ben-Ari Y. A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport. 7:1995;61-64.
35. Torres C de, Munell F., Ferrer I., Reventos J., Macaya A. Identification of necrotic cell death by the TUNEL assay in the hypoxic-ischemic neonatal rat brain. Neurosci Lett. 230:1997;1-4.
36. Jones L.L., Banati R.B., Graeber M.B., Bonfanti L., Raivich G., Kreutzberg G.W. Population control of microglia: does apoptosis play a role? J Neurocytol. 26:1997;755-770.
37. Green D., Kroemer G. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol. 8:1998;267-271.
38. Swerdlow R.H., Parks J.K., Davis J.N., Cassarino D.S., Trimmer P.A., Currie L.J., Dougherty J., Bridges W.C., Bennett J.P., Wooten G.F., Parker W.D. Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family. Ann Neurol. 44:1998;873-881.