Selective killing of cancer cells based on loss of heterozygosity and normal variation in the human genome: A new paradigm for anticancer drug therapy

Molecular Pharmacology

Volumn 56, Issue 2, 1999, Pages 359-369

  Basilion, James P ^a   Schievella, Andrea R ^a   Burns, Erica ^a   Rioux, Patrice ^a   Olson, Jeffrey C ^a   Monia, Brett P ^b   Lemonidis, Kristina M ^b   Stanton Jr , Vincent P ^a   Housman, David E ^c  

^a Variagenics Inc   (United States)

^b ISIS PHARMACEUTICALS   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; REPLICATION PROTEIN A;

ARTICLE; CANCER CELL DESTRUCTION; CANCER CHEMOTHERAPY; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; CYTOTOXICITY; DRUG SPECIFICITY; GENE SEQUENCE; GENE TARGETING; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0032811658     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.2.359     Document Type: Article

References (39)

1. Bennett CF, Chiang MY, Chan H, Shoemaker JEE and Mirabelli CK (1992) Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol Pharmacol 41:1023-1033.
2. Bennett CF, Dean N, Ecker DJ and Monia BP (1996) Pharmacology of antisense therapeutic agents, in Antisense Therapeutics (Agrawal S ed) pp. 13-46, Humana Press, Totowa.
3. Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M, Ng L, Nye JA, Sampson-Johannes A, Fattaey A and McCormick F (1996) An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (Wash DC) 274:373-376.
4. Brill SJ and Stillman B (1991) Replication factor-A from Saccharomyces cerevisiae is encoded by three essential genes coordinately expressed at S phase. Genes Dev 5:1589-1600.
5. Brown T and Mackey K (1987) Analysis of RNA by Northern and slot blot hybridization, in Current Protocols in Molecular Biology (Ausbel F ed) vol 1, pp. 4.9.1-4.9.12, Greene Publishing, New York.
6. Cavenee WK, Scrable HJ and James CD (1991) Molecular genetics of human cancer predisposition and progression. Mutat Res 247:199-202.
7. Chiang MY, Chan H, Zounes MA, Freier SM, Lima WF and Bennett CF (1991) Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J Biol Chem 266:18162-18171.
8. Cooper DN, Smith BA, Cooke HJ, Niemann S and Schmidtke J (1985) An estimate of unique DNA sequence heterozygosity in the human genome. Hum Genet 69: 201-205.
9. Duroux I, Godard G, Boidot-Forget M, Schwab G, Helene C and Saison-Behmoaras T (1995) Rational desing of point mutation-selective antisense DNA targeted to codon 12 of Ha-ras mRNA in human cells. Nucleic Acids Res 23:3411-3418.
10. Erdile LF, Heyer WD, Kolodner R and Kelly TJ (1991) Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication. J Biol Chem 266:12090-12098.
11. Eynde BJVd and Boon T (1997) Tumor antigens recognized by T lymphocytes. Int J Clin Lab Res 27:81-86.
12. Fairman MP and Stillman B (1988) Cellular factors required for multiple stages of SV40 DNA replication in vitro. EMBO J 7:1211-1218.
13. He Z, Henricksen LA, Wold MS and Ingles CJ (1995) RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature (Lond) 374:566-569.
14. Heise C, Sampson-Johannes A, Williams A, McCormick F, Hoff DDV and Kirn DH (1997) ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med 3:639-645.
15. Hodges PE, Payne WE and Garrels JI (1998) The Yeast Protein Database (YPD): A curated proteome database for Saccharoyces cerevisiae. Nucleic Acids Res 26:68-72.
16. Iwahana H, Yoshimoto K and Itakura M (1992) Detection of point mutations by SSCP of PCR-amplified DNA after endonuclease digestion. Biotechniques 12:64-66.
17. Karpel RL (1990) in The Biology of Non-Specific DNA-Protein Interactions (Revzin A ed) pp 103-126, CRC, Boca Raton, FL.
18. Kenny MK, Lee SH and Hurwitz J (1989) Multiple functions of human single-stranded-DNA binding protein in simian virus 40 DNA replication: Single-stranded stabilization and stimulation of DNA polymerases a and d. Proc Natl Acad Sci USA 86:9757-9761.
19. Komberg A and Baker T (1992) DNA Replication. Freeman, New York.
20. Lengauer C, Kinzler K and Vogelstein B (1998) Genetic instabilities in human cancers. Nature (Lond) 396:643-649.
21. Liu Q and Sommer SS (1995) Restriction endonuclease fingerprinting (REF): A sensitive method for screening mutations in long, contiguous segments of DNA. Biotechniques 18:470-477.
22. Monia BP, Johnston JF, Ecker DJ, Zounes MA, Lima WF and Freier SM (1992) Selective inhibition of mutant Ha-ras mRNA expression by antisense Oligonucleotides. J Biol Chem 267:19954-19962.
23. Monia BP, Johnston JF, Geiger T, Muller M and Fabbro D (1996a) Antitumor activity of a phosphorothioate antisense oligonucleotide targeted against C-raf kinase. Nat Med 2:668-674.
24. Monia BP, Lesnik EA, Gonzalez C, Lima WF, McGee D, Guinosso CJ, Kawasaki AM, Cook PD and Freier S (1993) Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression. J Biol Chem 268:14514-14522.
25. Monia BP, Sasmor H, Johnston JF, Freier SM, Lesnik EA, Muller M, Geiger T, Altman KH, Moser H and Fabbro D (1996b) Sequence-specific antitumor activity of a phosphorothioate oligodeoxynucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo. Proc Natl Acad Sci USA 93:15481-15484.
26. O'Donnell M, Onrust R, Dean FB, Chen M and Hurwitz J (1993) Homology in accessory proteins of replicative polymerases - E. coli to humans. Nucleic Acids Res 21:1-3.
27. Ozawa K Dean FB, Chen M, Lee SH, Shiratori A, Murakami Y, Sakakura T, Hurwitz J and Eki T (1993) Mapping of the 70 kDa, 34 kDa, and 11 kDa subunit genes of the human multimeric single-stranded DNA binding protein (hSSB/RPA) to chromosome bands 17p13, 1p35-p36.1, and 7p21-p22. Cell Struct Funct 18: 221-230.
28. Peppel K and Baglioni C (1990) A simple and fast method to extract RNA from tissue culture cells. Biotechniques 9:711-713.
29. Philipova D, Mullen JR, Maniar HS, Lu J, Gu C and Brill S (1996) A heierarchy of SSB promoters in replication protein A. Genes and Development 10:2222-2233.
30. Rodriguez E, Sreekantaiah C and Chaganti RS (1994) Genetic changes in epihelial solid neoplasia. Cancer Res 54:3398-3406.
31. Schwab G, Chavany C, Duroux I, Goubin G, Lebeau J, Helene C and Saison-Behmoaras T (1994) Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorgenicity in nude mice. Proc Natl Acad Sci USA 91:10460-10464.
32. Schwechheimer K and Cavenee KW (1993) Genetics of cancer predisposition and progression. Clin Investig 71:488-502.
33. Sjogren S, Inganas M, Norberg T, Lindgren A, Nordgren H, Holmberg L and Bergh J (1996) The p53 gene in breast cancer: Prognostic value of complementary DNA sequencing versus immunohistochemistry. J Natl Cancer Inst 88:173-182.
34. Smetsers TF, Linders EH, Locht LTvd, Witte TMd and Mensink EJ (1997) An antisense Bcr-Abl phosphodiester-tailed methylphosphonate oligonucleotide reducess the growth of chronic myeloid leukaemia patient cells by a non-antisense mechanism. Br J Hoematol 96:377-381.
35. Umbricht CB, Griffin CA, Hawkins AL, Grzeschik KH, O'Connell P, Leach R, Green ED and Kelly TJ (1993) High-resolution genomic mapping of the three human replication protein A genes (RPA1, RPA2, and RPA3). Genomics 20:249-257.
36. Webb A, Cunningham D, Cotter F, Clarke PA, di Stefano F, Ross P, Corbo M and Dziewanowska Z (1997) BCL-2 antisense therapy in patients with non-Hodgkin lymphoma. Lancet 349:1137-1141.
37. Witte ON (1993) Role of the BCR-ABL oncogene in human leukemia: Fifteenth Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res 53:485-489.
38. Wobbe CR, Weissbach L, Borowiec JA, Dean FB, Murakami Y, Bullock P and Hurwitz J (1987) Replication of simian virus 40 origin-containing DNA in vitro with purified proteins. Proc Natl Acad Sci USA 84:1834-1838.
39. Wold MS and Kelly TJ (1988) Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA. Proc Natl Acad Sci USA 85:2523-2527.