An antisense Bcr-Abl phosphodiester-tailed methylphosphonate oligonucleotide reduces the growth of chronic myeloid leukaemia patient cells by a non-antisense mechanism

British Journal of Haematology

Volumn 96, Issue 2, 1997, Pages 377-381

  Smetsers, Toon F C M ^a   Linders, Ellen H P ^a   Van De Locht, Louis T F ^a   De Witte, Theo M ^a   Mensink, Ewald J B M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

antisense; apoptosis; Bcr Abl; methylphosphonate; oligonucleotides

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BCR ABL PROTEIN; METHYLPHOSPHONIC ACID;

APOPTOSIS; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

EID: 0031054863     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.d01-2035.x     Document Type: Article

References (11)

1. Bi, S.C., Hughes, T., Bungey, J., Chase, A., Defabritiis, P. & Goldman, J.M. (1992) p53 in chronic myeloid leukemia cell lines. Leukemia, 6, 839-842.
2. Kirkland, M.A., Obrien, S.G. & Goldman, J.M. (1994) Antisense therapeutics in haematological malignancies. British Journal of Haematology, 87, 447-452.
3. Kirkland, M.A., Obrien, S.G., Mcdonald, C., Davidson, R.J., Cross, N.C.P. & Goldman, J.M. (1993) BCR-ABL antisense purging in chronic myeloid leukaemia. Lancet, 342, 614.
4. Meijerink, J.P.P., Smetsers, T.F.C.M., Sloetjes, A.W., Linders, E.H.P. & Mensink, E.J.B.M. (1995) Bax mutations in cell lines derived from hematological malignancies. Leukemia, 9, 1828-1832.
5. Obrien, S.G., Kirkland, M.A., Melo, J.V., Rao, M.H., Davidson, R.J., Mcdonald, C. & Goldman, J.M. (1994) Antisense BCR-ABL oligomers cause non-specific inhibition of chronic myeloid leukemia cell lines. Leukemia, 8, 2156-2162.
6. Smetsers, T.F.C.M., Skorski, T., van de Locht, L.T.F., Wessels, H.M.C., Pennings, A.H.M., de Witte, T., Calabretta, B. & Mensink, E.J.B.M. (1994) Antisense BCR-ABL oligonucleotides induce apoptosis in the Philadelphia chromosome-positive cell line BV173. Leukemia, 8, 129-140.
7. Smetsers, T.F.C.M., van-de-Locht, L.T.F., Pennings, A.H.M., Wessels, H.M., de-Witte, T.M. & Mensink, E.J.B.M. (1995) Phosphorothioate BCR-ABL antisense oligonucleotides induce cell death, but fail to reduce cellular bcr-abl protein levels. Leukemia, 9, 118-130.
8. Stein, C.A. (1995) Does antisense exist? Nature Medicine, 1, 1119-1121.
9. Tari, A.M., Tucker, S.D., Deisseroth, A. & Lopezberestein. G. (1994) Liposomal delivery of methylphosphonate antisense oligodeoxy-nucleotides in chronic myelogenous leukemia. Blood, 84, 601-607.
10. + myeloma cells. British Journal of Haematology, 93, 613-622.
11. Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A. & Oren, M. (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature, 353, 345-347.