메뉴 건너뛰기




Volumn 19, Issue 5 B, 1999, Pages 4353-4356

Molecular 'rehabilitation' by rational drug targeting: The challenge of p53 in cancer treatment

Author keywords

Cancer treatment; p53 targeting; Rational drug design; Tumor suppressor

Indexed keywords

PROTEIN P53;

EID: 0032806386     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (23)
  • 1
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper of growth and division
    • Levine AJ: p53, the cellular gatekeeper of growth and division. Cell 88: 323-331, 1997.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 2
    • 0031928772 scopus 로고    scopus 로고
    • The challenge of p53: Linking biochemistry, biology, and patient management
    • Bray SE, Schorl C and Hall PA: The challenge of p53: linking biochemistry, biology, and patient management. Stem Cells 16(4): 248-260, 1998.
    • (1998) Stem Cells , vol.16 , Issue.4 , pp. 248-260
    • Bray, S.E.1    Schorl, C.2    Hall, P.A.3
  • 5
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumour suppressor-DNa complex: Understanding tumorigenic mutations
    • Cho Y, Gorina S, Jeffrey PD and Pavletich NP: Crystal structure of a p53 tumour suppressor-DNA complex: understanding tumorigenic mutations. Science 265: 346-355, 1994.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 6
    • 0005642319 scopus 로고    scopus 로고
    • Rational design of bioactive molecules
    • (Gubernator K and Böhm HJ, eds). Weinheim, Wiley-VCH
    • Gubernator K and Böhm HJ: Rational design of bioactive molecules. In: Structure-based ligand design (Gubernator K and Böhm HJ, eds). Weinheim, Wiley-VCH, 1998, pp 1-13.
    • (1998) Structure-based Ligand Design , pp. 1-13
    • Gubernator, K.1    Böhm, H.J.2
  • 8
    • 0028899283 scopus 로고
    • Biochemical properties and biological effects of p53
    • Haffner R and Oren M: Biochemical properties and biological effects of p53. Curr Opin Genet Dev 5: 84-90, 1995.
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 84-90
    • Haffner, R.1    Oren, M.2
  • 10
    • 0030722137 scopus 로고    scopus 로고
    • Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain
    • McCoy M, Stavridi ES, Waterman JL, Wieczorek AM, Opella SJ and Halazonetis TD: Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain. EMBO J 16: 6230-6236, 1997.
    • (1997) EMBO J , vol.16 , pp. 6230-6236
    • McCoy, M.1    Stavridi, E.S.2    Waterman, J.L.3    Wieczorek, A.M.4    Opella, S.J.5    Halazonetis, T.D.6
  • 11
    • 0031870368 scopus 로고    scopus 로고
    • Transcription-factor-modulating agents: Precision and selectivity in drug design
    • Papavassiliou AG: Transcription-factor-modulating agents: precision and selectivity in drug design. Mol Med Today 4: 358-366, 1998.
    • (1998) Mol Med Today , vol.4 , pp. 358-366
    • Papavassiliou, A.G.1
  • 12
    • 0028845158 scopus 로고
    • Small peptides activate the latent sequence-specific DNA binding function of p53
    • Hupp TR, Sparks A and Lane DP: Small peptides activate the latent sequence-specific DNA binding function of p53. Cell 83: 237-245, 1995.
    • (1995) Cell , vol.83 , pp. 237-245
    • Hupp, T.R.1    Sparks, A.2    Lane, D.P.3
  • 13
    • 0030961889 scopus 로고    scopus 로고
    • Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
    • Selivanova G, Iotsova V, Okan I, Fritsche M, Strom M, Groner B, Grafstrom RC and Wiman KG: Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nat Med 3: 632-638, 1997.
    • (1997) Nat Med , vol.3 , pp. 632-638
    • Selivanova, G.1    Iotsova, V.2    Okan, I.3    Fritsche, M.4    Strom, M.5    Groner, B.6    Grafstrom, R.C.7    Wiman, K.G.8
  • 14
    • 0030153890 scopus 로고    scopus 로고
    • Peptide mimetic drugs: A comment on progress and prospects
    • Kauvar LM: Peptide mimetic drugs: a comment on progress and prospects. Nat Biotechnol 14: 709, 1996.
    • (1996) Nat Biotechnol , vol.14 , pp. 709
    • Kauvar, L.M.1
  • 15
    • 0026694826 scopus 로고
    • Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion
    • Moll UM, Riou G and Levine AJ: Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci USA 89: 7262-7266, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7262-7266
    • Moll, U.M.1    Riou, G.2    Levine, A.J.3
  • 16
    • 0029049828 scopus 로고
    • Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors
    • Moll UM, LaQuaglia M, Benard J and Riou G: Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci USA 92: 4407-4411, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4407-4411
    • Moll, U.M.1    LaQuaglia, M.2    Benard, J.3    Riou, G.4
  • 17
    • 0030828488 scopus 로고    scopus 로고
    • Apoptosis induced in mammalian cells by small peptides that functionally antagonize the Rb-regulated E2F transcription factor
    • Bandara LR, Girling R and La Thangue NB: Apoptosis induced in mammalian cells by small peptides that functionally antagonize the Rb-regulated E2F transcription factor. Nat Biotechnol 15: 896-901, 1997.
    • (1997) Nat Biotechnol , vol.15 , pp. 896-901
    • Bandara, L.R.1    Girling, R.2    La Thangue, N.B.3
  • 18
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner JD, Kinzler KW, Meltzer PS, George DL and Vogelstein B: Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358: 80-83, 1992.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 19
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D and Levine AJ: The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69: 1237-1245, 1992.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 20
    • 0031802921 scopus 로고    scopus 로고
    • Keeping an old friend under control: Regulation of p53 stability
    • Kubbutat MHG and Vousden KH: Keeping an old friend under control: regulation of p53 stability. Mol Med Today 4: 250-256, 1998.
    • (1998) Mol Med Today , vol.4 , pp. 250-256
    • Kubbutat, M.H.G.1    Vousden, K.H.2
  • 21
    • 0030267239 scopus 로고    scopus 로고
    • Role of E6 and E7 oncoproteins in HPV-induced anogenital malignancies
    • Kubbutat MHG and Vousden KH: Role of E6 and E7 oncoproteins in HPV-induced anogenital malignancies. Semin Virol 7: 295-304, 1996.
    • (1996) Semin Virol , vol.7 , pp. 295-304
    • Kubbutat, M.H.G.1    Vousden, K.H.2
  • 22
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh SY, Ikeda M, Taya Y and Prives C: DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91: 325-334, 1997.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 23
    • 0032952004 scopus 로고    scopus 로고
    • Mdm2: The ups and downs
    • Juven-Gershon T and Oren M: Mdm2: the ups and downs. Mol Med 5: 71-83, 1999.
    • (1999) Mol Med , vol.5 , pp. 71-83
    • Juven-Gershon, T.1    Oren, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.