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Volumn 7, Issue 5, 1996, Pages 295-304

Role of E6 and E7 oncoproteins anogenital malignancies

Author keywords

E6; E7; HPV induced malignancies; Viral oncoproteins

Indexed keywords

CELL PROTEIN; ONCOPROTEIN; PROTEIN P53; RETINOBLASTOMA PROTEIN; VIRUS DNA; VIRUS PROTEIN;

EID: 0030267239     PISSN: 10445773     EISSN: None     Source Type: Journal    
DOI: 10.1006/smvy.1996.0037     Document Type: Review
Times cited : (38)

References (113)
  • 1
    • 0023902853 scopus 로고
    • Estimates of the worldwide frequency of sixteen major cancers in 1980
    • 1. Parkin DM, Laara E, Muir CS (1988) Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer 41:184-197
    • (1988) Int J Cancer , vol.41 , pp. 184-197
    • Parkin, D.M.1    Laara, E.2    Muir, C.S.3
  • 2
    • 0025886714 scopus 로고
    • Human papillomaviruses in the pathogenesis of anogenital cancer
    • 2. zur Hausen H (1991) Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9-13
    • (1991) Virology , vol.184 , pp. 9-13
    • Zur Hausen, H.1
  • 3
    • 0028926716 scopus 로고
    • Analysis of genomic sequences of 95 papillomavirus types - Uniting typing, phylogeny, and taxonomy
    • 3. Chan SY, Delius H, Halpern AL, Bernard HU (1995) Analysis of genomic sequences of 95 papillomavirus types - uniting typing, phylogeny, and taxonomy. J Virol 69:3074-3083
    • (1995) J Virol , vol.69 , pp. 3074-3083
    • Chan, S.Y.1    Delius, H.2    Halpern, A.L.3    Bernard, H.U.4
  • 4
    • 0025964888 scopus 로고
    • Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm
    • 4. Cullen AP, Reid R, Campion M, Lorincz AT (1991) Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm. J Virol 65:606-612
    • (1991) J Virol , vol.65 , pp. 606-612
    • Cullen, A.P.1    Reid, R.2    Campion, M.3    Lorincz, A.T.4
  • 5
    • 0024423584 scopus 로고
    • Both episomal and integrated forms of human papillomavirus type 16 are involved in invasive cervical cancers
    • 5. Matsukura T, Koi S, Sugase M (1989) Both episomal and integrated forms of human papillomavirus type 16 are involved in invasive cervical cancers. Virology 172:63-72
    • (1989) Virology , vol.172 , pp. 63-72
    • Matsukura, T.1    Koi, S.2    Sugase, M.3
  • 7
    • 0023491478 scopus 로고
    • Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: Implications for cervical carcinogenesis
    • 7. Cripe TP, Haugen TH, Turk JP, Tabatabai F, Schmid PGd, Durst M, Gissmann L, Roman A, Turek LP (1987) Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis. EMBO J 6:3745-3753
    • (1987) EMBO J , vol.6 , pp. 3745-3753
    • Cripe, T.P.1    Haugen, T.H.2    Turk, J.P.3    Tabatabai, F.4    Schmid, P.Gd.5    Durst, M.6    Gissmann, L.7    Roman, A.8    Turek, L.P.9
  • 8
    • 0028900490 scopus 로고
    • Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: Implications for cervical carcinogenesis
    • 8. Jeon S, Lambert PF (1995) Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc Natl Acad Sci USA 92:1654-1658
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1654-1658
    • Jeon, S.1    Lambert, P.F.2
  • 9
    • 0024804363 scopus 로고
    • HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratin ocytes
    • 9. Hawley-Nelson P, Vousden KH, Hubbert NL, Lowy DR, Schiller JT (1989) HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratin ocytes. EMBO J 8:3905-3910
    • (1989) EMBO J , vol.8 , pp. 3905-3910
    • Hawley-Nelson, P.1    Vousden, K.H.2    Hubbert, N.L.3    Lowy, D.R.4    Schiller, J.T.5
  • 10
    • 0024428508 scopus 로고
    • The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratin ocytes
    • 10. Munger K, Phelps WC, Bubb V, Howley PM, Schlegel R (1989) The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratin ocytes. J Virol 63:4417-4421
    • (1989) J Virol , vol.63 , pp. 4417-4421
    • Munger, K.1    Phelps, W.C.2    Bubb, V.3    Howley, P.M.4    Schlegel, R.5
  • 11
    • 0025191335 scopus 로고
    • Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18
    • 11. Hudson JB, Bedell MA, McCance DJ, Laiminis LA (1990) Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18. J Virol 64:519-526
    • (1990) J Virol , vol.64 , pp. 519-526
    • Hudson, J.B.1    Bedell, M.A.2    McCance, D.J.3    Laiminis, L.A.4
  • 12
    • 0026322149 scopus 로고
    • Viruses in human cancer
    • 12. zur Hausen H (1991) Viruses in human cancer. Science 254:1167-1172
    • (1991) Science , vol.254 , pp. 1167-1172
    • Zur Hausen, H.1
  • 13
    • 0025271203 scopus 로고
    • Association of human papillomavirus types 16 and 18 E6 proteins with p53
    • 13. Werness BA, Levine AJ, Howley PM (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76-79
    • (1990) Science , vol.248 , pp. 76-79
    • Werness, B.A.1    Levine, A.J.2    Howley, P.M.3
  • 14
    • 0024535228 scopus 로고
    • The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    • 14. Dyson N, Howley PM, Munger K, Harlow E (1989) The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934-937
    • (1989) Science , vol.243 , pp. 934-937
    • Dyson, N.1    Howley, P.M.2    Munger, K.3    Harlow, E.4
  • 16
    • 0024968181 scopus 로고
    • Cellular targets for transformation by the adenovirus E1A proteins
    • 16. Whyte P, Williamson NM, Harlow E (1989) Cellular targets for transformation by the adenovirus E1A proteins. Cell 56:67-75
    • (1989) Cell , vol.56 , pp. 67-75
    • Whyte, P.1    Williamson, N.M.2    Harlow, E.3
  • 17
    • 0018348655 scopus 로고
    • T-antigen is bound to host protein in SV40-transformed cells
    • 17. Lane DP, Crawford LV (1979) T-antigen is bound to host protein in SV40-transformed cells. Nature 278:261-263
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 18
    • 0025022381 scopus 로고
    • The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation
    • 18. Barbosa MS, Edmonds C, Fisher C, Schiller JT, Lowy DR, Vousden KH (1990) The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation. EMBO J 9:153-160
    • (1990) EMBO J , vol.9 , pp. 153-160
    • Barbosa, M.S.1    Edmonds, C.2    Fisher, C.3    Schiller, J.T.4    Lowy, D.R.5    Vousden, K.H.6
  • 19
    • 0024809865 scopus 로고
    • Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
    • 19. Munger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley PM (1989) Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J 8:4099-4105
    • (1989) EMBO J , vol.8 , pp. 4099-4105
    • Munger, K.1    Werness, B.A.2    Dyson, N.3    Phelps, W.C.4    Harlow, E.5    Howley, P.M.6
  • 21
    • 0030058803 scopus 로고    scopus 로고
    • Human papillomavirus E7 oncoproteins bind a single form of cyclin E in a complex with cdk2 and p107
    • 21. McIntyre MC, Ruesch MN, Laimins LA (1996) Human papillomavirus E7 oncoproteins bind a single form of cyclin E in a complex with cdk2 and p107. Virology 215:73-82
    • (1996) Virology , vol.215 , pp. 73-82
    • McIntyre, M.C.1    Ruesch, M.N.2    Laimins, L.A.3
  • 22
    • 0027523439 scopus 로고
    • Human papillomavirus type 16 E7 associates with a histone H 1 kinase and with p107 through sequences necessary for transformation
    • 22. Davies R, Hicks R, Crook T, Morris J, Vousden KH (1993) Human papillomavirus type 16 E7 associates with a histone H 1 kinase and with p107 through sequences necessary for transformation. J Virol 67:2521-2528
    • (1993) J Virol , vol.67 , pp. 2521-2528
    • Davies, R.1    Hicks, R.2    Crook, T.3    Morris, J.4    Vousden, K.H.5
  • 24
    • 0029936515 scopus 로고    scopus 로고
    • The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors
    • 24. Antinore MJ, Birrer MJ, Patel D, Nader L, McCance DJ (1996) The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors. EMBO J 15:1950-1960
    • (1996) EMBO J , vol.15 , pp. 1950-1960
    • Antinore, M.J.1    Birrer, M.J.2    Patel, D.3    Nader, L.4    McCance, D.J.5
  • 25
    • 0028223147 scopus 로고
    • Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains
    • 25. Liu F, Green MR (1994) Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains. Nature 368:520-525
    • (1994) Nature , vol.368 , pp. 520-525
    • Liu, F.1    Green, M.R.2
  • 26
    • 0030033730 scopus 로고    scopus 로고
    • Identification of domains required for transcriptional activation and protein dimerization in the human papillomavirus type-16 E7 protein
    • 26. Zwerschke W, Joswig S, Jansen Durr P (1996) Identification of domains required for transcriptional activation and protein dimerization in the human papillomavirus type-16 E7 protein. Oncogene 12:213-220
    • (1996) Oncogene , vol.12 , pp. 213-220
    • Zwerschke, W.1    Joswig, S.2    Jansen Durr, P.3
  • 27
    • 0029955561 scopus 로고    scopus 로고
    • HPV-16 E7 and adenovirus E1a complex formation with TATA box binding protein is enhanced by casein kinase II phosphorylation
    • 27. Massimi P, Pim D, Storey A, Banks L (1996) HPV-16 E7 and adenovirus E1a complex formation with TATA box binding protein is enhanced by casein kinase II phosphorylation. Oncogene 12:2325-2330
    • (1996) Oncogene , vol.12 , pp. 2325-2330
    • Massimi, P.1    Pim, D.2    Storey, A.3    Banks, L.4
  • 28
    • 0026597152 scopus 로고
    • Structure - Function analysis of the human papillomavirus type 16 E7 oncoprotein
    • 28. Phelps WC, Munger K, Yee CL, Barnes JA, Howley PM (1992) Structure - function analysis of the human papillomavirus type 16 E7 oncoprotein. J Virol 66:2418-2427
    • (1992) J Virol , vol.66 , pp. 2418-2427
    • Phelps, W.C.1    Munger, K.2    Yee, C.L.3    Barnes, J.A.4    Howley, P.M.5
  • 29
    • 0025058437 scopus 로고
    • Mutational analysis of human papillomavirus type 16 E7 functions
    • 29. Watanabe S, Kanda T, Sato H, Furuno A, Yoshiike K (1990) Mutational analysis of human papillomavirus type 16 E7 functions. J Virol 64:207-214
    • (1990) J Virol , vol.64 , pp. 207-214
    • Watanabe, S.1    Kanda, T.2    Sato, H.3    Furuno, A.4    Yoshiike, K.5
  • 30
    • 0024321239 scopus 로고
    • A point mutational analysis of human papillomavirus type 16 E7 protein
    • 30. Edmonds C, Vousden KH (1989) A point mutational analysis of human papillomavirus type 16 E7 protein. J Virol 63:2650-2656
    • (1989) J Virol , vol.63 , pp. 2650-2656
    • Edmonds, C.1    Vousden, K.H.2
  • 31
    • 0027210449 scopus 로고
    • Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding
    • 31. McIntyre MC, Frattini MG, Grossman SR, Laimins LA (1993) Human papillomavirus type 18 E7 protein requires intact Cys-X-X-Cys motifs for zinc binding, dimerization, and transformation but not for Rb binding. J Virol 67:3142-3150
    • (1993) J Virol , vol.67 , pp. 3142-3150
    • McIntyre, M.C.1    Frattini, M.G.2    Grossman, S.R.3    Laimins, L.A.4
  • 32
    • 0028018268 scopus 로고
    • The ubiquitin-proteasome proteolytic pathway
    • 32. Ciechanover A (1994) The ubiquitin-proteasome proteolytic pathway. Cell 79:13-21
    • (1994) Cell , vol.79 , pp. 13-21
    • Ciechanover, A.1
  • 33
    • 0028935165 scopus 로고
    • Ubiquitin, proteasomes, and the regulation of intracellular protein degradation
    • 33. Hochstrasser M (1995) Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr Opin Cell Biol 7:215-223
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 215-223
    • Hochstrasser, M.1
  • 34
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • 34. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 35
    • 0025932933 scopus 로고
    • A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18
    • 35. Huibregtse JM, Scheffner M, Howley PM (1991) A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J 10:4129-4135
    • (1991) EMBO J , vol.10 , pp. 4129-4135
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 36
    • 0027396829 scopus 로고
    • Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53
    • 36. Huibregtse JM, Scheffner M, Howley PM (1993) Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol Cell Biol 13:775-784
    • (1993) Mol Cell Biol , vol.13 , pp. 775-784
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 37
    • 0028939392 scopus 로고
    • Reconstitution of p53-ubiquitinylation reactions from purified components: The role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)
    • 37. Rolfe M, Beer Romero P, Glass S, Eckstein J, Berdo I, Theodoras A, Pagano M, Draetta G (1995) Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP). Proc Natl Acad Sci USA 92:3264-3268
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3264-3268
    • Rolfe, M.1    Beer Romero, P.2    Glass, S.3    Eckstein, J.4    Berdo, I.5    Theodoras, A.6    Pagano, M.7    Draetta, G.8
  • 38
    • 0028898424 scopus 로고
    • Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade
    • 38. Scheffner M, Nuber U, Huibregtse JM (1995) Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature 373:81-83
    • (1995) Nature , vol.373 , pp. 81-83
    • Scheffner, M.1    Nuber, U.2    Huibregtse, J.M.3
  • 39
    • 0028607435 scopus 로고
    • Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53
    • 39. Scheffner M, Huibregtse JM, Howley PM (1994) Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc Natl Acad Sci USA 91:8797-8801
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8797-8801
    • Scheffner, M.1    Huibregtse, J.M.2    Howley, P.M.3
  • 40
    • 0028276554 scopus 로고
    • Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2
    • 40. Ciechanover A, Shkedy D, Oren M, Bercovich B (1994) Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2. J Biol Chem 269:9582-9589
    • (1994) J Biol Chem , vol.269 , pp. 9582-9589
    • Ciechanover, A.1    Shkedy, D.2    Oren, M.3    Bercovich, B.4
  • 41
    • 0030043724 scopus 로고    scopus 로고
    • Cloning of human ubiquitin-conjugating enzymes Ubch6 and Ubch7 (E2-F1) and characterization of their interaction with E6-Ap and Rsp5
    • 41. Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (1996) Cloning of human ubiquitin-conjugating enzymes Ubch6 and Ubch7 (E2-F1) and characterization of their interaction with E6-Ap and Rsp5. J Biol Chem 271:2795-2800
    • (1996) J Biol Chem , vol.271 , pp. 2795-2800
    • Nuber, U.1    Schwarz, S.2    Kaiser, P.3    Schneider, R.4    Scheffner, M.5
  • 42
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • 42. Scheffner M, Huibregtse JM, Vierstra RD, Howley PM (1993) The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75:495-505
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 43
    • 0027169680 scopus 로고
    • Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins
    • 43. Huibregtse JM, Scheffner M, Howley PM (1993) Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins. Mol Cell Biol 13:4918-4927
    • (1993) Mol Cell Biol , vol.13 , pp. 4918-4927
    • Huibregtse, J.M.1    Scheffner, M.2    Howley, P.M.3
  • 44
    • 0025988293 scopus 로고
    • Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation
    • 44. Crook T, Tidy JA, Vousden KH (1991) Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation. Cell 67:547-556
    • (1991) Cell , vol.67 , pp. 547-556
    • Crook, T.1    Tidy, J.A.2    Vousden, K.H.3
  • 45
    • 0030050770 scopus 로고    scopus 로고
    • Mutational analysis of human papillomavirus type-16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial-cells
    • 45. Dalal S, Gao QS, Androphy EJ, Band V (1996) Mutational analysis of human papillomavirus type-16 E6 demonstrates that p53 degradation is necessary for immortalization of mammary epithelial-cells. J Virol 70:683-688
    • (1996) J Virol , vol.70 , pp. 683-688
    • Dalal, S.1    Gao, Q.S.2    Androphy, E.J.3    Band, V.4
  • 46
    • 0028358885 scopus 로고
    • Mutational analysis of HPV-18 E6 identifies domains required for p53 degradation in vitro, abolition of p53 transactivation in vivo and immortalisation of primary BMK cells
    • 46. Pim D, Storey A, Thomas M, Massimi P, Banks L (1994) Mutational analysis of HPV-18 E6 identifies domains required for p53 degradation in vitro, abolition of p53 transactivation in vivo and immortalisation of primary BMK cells. Oncogene 9:1869-1876
    • (1994) Oncogene , vol.9 , pp. 1869-1876
    • Pim, D.1    Storey, A.2    Thomas, M.3    Massimi, P.4    Banks, L.5
  • 47
    • 0028199891 scopus 로고
    • Inhibition of p53 DNA binding by human papillomavirus E6 proteins
    • 47. Lechner MS, Laimins LA (1994) Inhibition of p53 DNA binding by human papillomavirus E6 proteins. J Virol 68:4262-4273
    • (1994) J Virol , vol.68 , pp. 4262-4273
    • Lechner, M.S.1    Laimins, L.A.2
  • 49
    • 0027522365 scopus 로고
    • The p53 protein is an unusually shaped tetramer that binds directly to DNA
    • 49. Friedman PN, Chen X, Bargonetti J, Prives C (1993) The p53 protein is an unusually shaped tetramer that binds directly to DNA. Proc Natl Acad Sci USA 90:3319-3323
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3319-3323
    • Friedman, P.N.1    Chen, X.2    Bargonetti, J.3    Prives, C.4
  • 50
    • 0029031942 scopus 로고
    • Oligomerisation of full length p53 contributes to the interaction with mdm2 but not HPV E6
    • 50. Marston NJ, Jenkins JR, Vousden KH (1995) Oligomerisation of full length p53 contributes to the interaction with mdm2 but not HPV E6. Oncogene 10:1709-1715
    • (1995) Oncogene , vol.10 , pp. 1709-1715
    • Marston, N.J.1    Jenkins, J.R.2    Vousden, K.H.3
  • 51
    • 0028821580 scopus 로고
    • The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain
    • 51. Mansur CP, Marcus B, Dalal S, Androphy EJ (1995) The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain. Oncogene 10:457-465
    • (1995) Oncogene , vol.10 , pp. 457-465
    • Mansur, C.P.1    Marcus, B.2    Dalal, S.3    Androphy, E.J.4
  • 52
    • 0026740294 scopus 로고
    • Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins
    • 52. Scheffner M, Takahashi T, Huibregtse JM, Minna JD, Howley PM (1992) Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins. J Virol 66:5100-5105
    • (1992) J Virol , vol.66 , pp. 5100-5105
    • Scheffner, M.1    Takahashi, T.2    Huibregtse, J.M.3    Minna, J.D.4    Howley, P.M.5
  • 53
    • 0027185055 scopus 로고
    • Targeting and degradation of p53 by E6 of human papillomavirus type 16 is preferential for the 1620+ p53 conformation
    • 53. Medcalf EA, Milner J (1993) Targeting and degradation of p53 by E6 of human papillomavirus type 16 is preferential for the 1620+ p53 conformation. Oncogene 8:2847-2851
    • (1993) Oncogene , vol.8 , pp. 2847-2851
    • Medcalf, E.A.1    Milner, J.2
  • 54
    • 0027980357 scopus 로고
    • Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function
    • 54. Marston NJ, Crook T, Vousden KH (1994) Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function. Oncogene 9:2707-2716
    • (1994) Oncogene , vol.9 , pp. 2707-2716
    • Marston, N.J.1    Crook, T.2    Vousden, K.H.3
  • 55
    • 0029048405 scopus 로고
    • Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein
    • 55. Chen JJ, Reid CE, Band V, Androphy EJ (1995) Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. Science 269:529-531
    • (1995) Science , vol.269 , pp. 529-531
    • Chen, J.J.1    Reid, C.E.2    Band, V.3    Androphy, E.J.4
  • 56
    • 0028339802 scopus 로고
    • The endoplasmic reticulum calcium-binding protein of 55kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif
    • 56. Weis K, Griffiths G, Lamond AI (1994) The endoplasmic reticulum calcium-binding protein of 55kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif. J Biol Chem 269:19142-19150
    • (1994) J Biol Chem , vol.269 , pp. 19142-19150
    • Weis, K.1    Griffiths, G.2    Lamond, A.I.3
  • 57
    • 0030008177 scopus 로고    scopus 로고
    • Telomerase activation by the E6 gene product of human papillomavirus type 16
    • 57. Klingelhutz AJ, Foster SA, McDougall JK (1996) Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380:79-82
    • (1996) Nature , vol.380 , pp. 79-82
    • Klingelhutz, A.J.1    Foster, S.A.2    McDougall, J.K.3
  • 59
    • 0026012525 scopus 로고
    • The full-length E6 protein of human papillomavirus type 16 has transforming and transactivating activities and cooperates with E7 to immortalize keratinocytes in culture
    • 59. Sedman SA, Barbosa MS, Vass WC, Hubbert NL, Haas JA, Lowy DR, Schiller JT (1991) The full-length E6 protein of human papillomavirus type 16 has transforming and transactivating activities and cooperates with E7 to immortalize keratinocytes in culture. J Virol 65:4860-4866
    • (1991) J Virol , vol.65 , pp. 4860-4866
    • Sedman, S.A.1    Barbosa, M.S.2    Vass, W.C.3    Hubbert, N.L.4    Haas, J.A.5    Lowy, D.R.6    Schiller, J.T.7
  • 60
    • 0027513556 scopus 로고
    • Human papillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells
    • 60. Storey A, Banks L (1993) Human papillomavirus type 16 E6 gene cooperates with EJ-ras to immortalize primary mouse cells. Oncogene 8:919-924
    • (1993) Oncogene , vol.8 , pp. 919-924
    • Storey, A.1    Banks, L.2
  • 61
    • 0028865982 scopus 로고
    • Mutational analysis of human papillomavirus type 16 E6 protein: Transforming function for human cells and degradation of p53 in vitro
    • 61. Nakagawa S, Watanabe S, Yoshikawa H, Taketani Y, Yoshiike K, Kanda T (1995) Mutational analysis of human papillomavirus type 16 E6 protein: transforming function for human cells and degradation of p53 in vitro. Virology 212:535-542
    • (1995) Virology , vol.212 , pp. 535-542
    • Nakagawa, S.1    Watanabe, S.2    Yoshikawa, H.3    Taketani, Y.4    Yoshiike, K.5    Kanda, T.6
  • 62
    • 0027308761 scopus 로고
    • Molecular characterization of the retinoblastoma susceptibility gene
    • 62. Goodrich DW, Lee WH (1993) Molecular characterization of the retinoblastoma susceptibility gene. Biochim Biophys Acta 1155:43-61
    • (1993) Biochim Biophys Acta , vol.1155 , pp. 43-61
    • Goodrich, D.W.1    Lee, W.H.2
  • 63
    • 0029281412 scopus 로고
    • The retinoblastoma protein and its relatives
    • 63. Whyte P (1995) The retinoblastoma protein and its relatives. Semin Cancer Biol 6:83-90
    • (1995) Semin Cancer Biol , vol.6 , pp. 83-90
    • Whyte, P.1
  • 68
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • 68. Lane DP (1992) p53, guardian of the genome. Nature 358:15-16
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 71
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • 71. Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 72
    • 0027459198 scopus 로고
    • mdm2 expression is induced by wild type p53 activity
    • 72. Barak Y, Juven T, Haffner R, Oren M (1993) mdm2 expression is induced by wild type p53 activity. EMBO J 12:461-468
    • (1993) EMBO J , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 73
    • 0027944251 scopus 로고
    • Cyclin G is a transcriptional target of the p53 tumor suppression protein
    • 73. Okamoto K, Beach D (1994) Cyclin G is a transcriptional target of the p53 tumor suppression protein. EMBO J 13:4816-4822
    • (1994) EMBO J , vol.13 , pp. 4816-4822
    • Okamoto, K.1    Beach, D.2
  • 75
    • 0028131554 scopus 로고
    • Transcriptional activation by p53 correlates with suppression of growth but not transformation
    • 75. Crook T, Marston NJ, Sara EA, Vousden KH (1994) Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell 79:817-827
    • (1994) Cell , vol.79 , pp. 817-827
    • Crook, T.1    Marston, N.J.2    Sara, E.A.3    Vousden, K.H.4
  • 77
    • 0030046508 scopus 로고    scopus 로고
    • Life, death, and the pursuit of apoptosis
    • 77. White E (1996) Life, death, and the pursuit of apoptosis. Genes Dev 10:1-15
    • (1996) Genes Dev , vol.10 , pp. 1-15
    • White, E.1
  • 79
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • 79. Caelles C, Helmberg A, Karin M (1994) p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370:220-223
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 80
    • 0028034199 scopus 로고
    • Mye-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21 waf1/ cip1
    • 80. Wagner AJ, Kokontis JM, Hay N (1994) Mye-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21 waf1/ cip1. Genes Dev 8:2817-2830
    • (1994) Genes Dev , vol.8 , pp. 2817-2830
    • Wagner, A.J.1    Kokontis, J.M.2    Hay, N.3
  • 81
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by trans-activation-deficient p53
    • 81. Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M (1995) Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev 9:2170-2183
    • (1995) Genes Dev , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.H.4    Oren, M.5
  • 82
    • 0025838393 scopus 로고
    • Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism
    • 82. Phelps WC, Bagchi S, Barnes JA, Raychaudhuri P, Kraus V, Munger K, Howley PM, Nevins JR (1991) Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. J Virol 65:6922-6930
    • (1991) J Virol , vol.65 , pp. 6922-6930
    • Phelps, W.C.1    Bagchi, S.2    Barnes, J.A.3    Raychaudhuri, P.4    Kraus, V.5    Munger, K.6    Howley, P.M.7    Nevins, J.R.8
  • 83
    • 0026568793 scopus 로고
    • Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product
    • 83. Chellappan S, Kraus VB, Kroger B, Munger K, Howley PM, Phelps WC, Nevins JR (1992) Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Natl Acad Sci USA 89:4549-4553
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4549-4553
    • Chellappan, S.1    Kraus, V.B.2    Kroger, B.3    Munger, K.4    Howley, P.M.5    Phelps, W.C.6    Nevins, J.R.7
  • 86
    • 0028826881 scopus 로고
    • E2F-1 Accumulation bypasses a G(1) arrest resulting from the inhibition of G(1) cyclin-dependent kinase-activity
    • 86. Degregori J, Leone G, Ohtani K, Miron A, Nevins JR (1995) E2F-1 Accumulation bypasses a G(1) arrest resulting from the inhibition of G(1) cyclin-dependent kinase-activity. Gene Dev 9:2873-2887
    • (1995) Gene Dev , vol.9 , pp. 2873-2887
    • Degregori, J.1    Leone, G.2    Ohtani, K.3    Miron, A.4    Nevins, J.R.5
  • 87
    • 0028239976 scopus 로고
    • Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation
    • 87. Hickman ES, Picksley SM, Vousden KH (1993) Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation. Oncogene 9:2177-2181
    • (1993) Oncogene , vol.9 , pp. 2177-2181
    • Hickman, E.S.1    Picksley, S.M.2    Vousden, K.H.3
  • 88
    • 0028325483 scopus 로고
    • Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7
    • 88. Demers GW, Foster SA, Halbert CL, Galloway DA (1994) Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. Proc Natl Acad Sci USA 91:4382-4386
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4382-4386
    • Demers, G.W.1    Foster, S.A.2    Halbert, C.L.3    Galloway, D.A.4
  • 91
    • 0028040299 scopus 로고
    • HPV16 E7 oncoprotein deregulates E-myb expression: Correlation with targeting of p107/ E2F complexes
    • 91. Lam EW-F, Morris JDH, Davies R, Crook T, Watson RJ, Vousden K (1994) HPV16 E7 oncoprotein deregulates E-myb expression: correlation with targeting of p107/ E2F complexes. EMBO J 13:871-878
    • (1994) EMBO J , vol.13 , pp. 871-878
    • Lam, E.W.-F.1    Morris, J.D.H.2    Davies, R.3    Crook, T.4    Watson, R.J.5    Vousden, K.6
  • 93
    • 0029134617 scopus 로고
    • Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation
    • 93. Zerfass K, Schulze A, Spitkovsky D, Friedman V, Henglein B, Jansen Durr P (1995) Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation. J Virol 69:6389-6399
    • (1995) J Virol , vol.69 , pp. 6389-6399
    • Zerfass, K.1    Schulze, A.2    Spitkovsky, D.3    Friedman, V.4    Henglein, B.5    Jansen Durr, P.6
  • 94
    • 0027380708 scopus 로고
    • Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex
    • 94. Arroyo M, Bagchi S, Raychaudhuri P (1993) Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex. Mol Cell Biol 13:6537-6546
    • (1993) Mol Cell Biol , vol.13 , pp. 6537-6546
    • Arroyo, M.1    Bagchi, S.2    Raychaudhuri, P.3
  • 95
    • 0029670376 scopus 로고    scopus 로고
    • Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFbeta-treated cells
    • 95. Mal A, Poon RY, Howe PH, Toyoshima H, Hunter T, Harter ML (1996) Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFbeta-treated cells. Nature 380:262-265
    • (1996) Nature , vol.380 , pp. 262-265
    • Mal, A.1    Poon, R.Y.2    Howe, P.H.3    Toyoshima, H.4    Hunter, T.5    Harter, M.L.6
  • 96
    • 0026660339 scopus 로고
    • Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens
    • 96. Crook T, Vousden KH (1992) Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens. EMBO J 11:3935-3940
    • (1992) EMBO J , vol.11 , pp. 3935-3940
    • Crook, T.1    Vousden, K.H.2
  • 97
    • 0026530432 scopus 로고
    • Clonal p53 mutation in primary cervical cancer: Association with human-papillomavirus-negative tumours
    • 97. Crook T, Wrede D, Tidy JA, Mason WP, Evans DJ, Vousden KH (1992) Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours. Lancet 339:1070-1073
    • (1992) Lancet , vol.339 , pp. 1070-1073
    • Crook, T.1    Wrede, D.2    Tidy, J.A.3    Mason, W.P.4    Evans, D.J.5    Vousden, K.H.6
  • 98
    • 0025832211 scopus 로고
    • Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines
    • 98. Wrede D, Tidy JA, Crook T, Lane D, Vousden KH (1991) Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines. Mol Carcinogen 4:171-175
    • (1991) Mol Carcinogen , vol.4 , pp. 171-175
    • Wrede, D.1    Tidy, J.A.2    Crook, T.3    Lane, D.4    Vousden, K.H.5
  • 99
    • 0025953696 scopus 로고
    • The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines
    • 99. Scheffner M, Munger K, Byrne JC, Howley PM (1991) The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc Natl Acad Sci USA 88:5523-5527
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5523-5527
    • Scheffner, M.1    Munger, K.2    Byrne, J.C.3    Howley, P.M.4
  • 100
    • 0026660417 scopus 로고
    • Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes
    • 100. Hubbert NL, Sedman SA, Schiller JT (1992) Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes. J Virol 66:6237-6241
    • (1992) J Virol , vol.66 , pp. 6237-6241
    • Hubbert, N.L.1    Sedman, S.A.2    Schiller, J.T.3
  • 101
    • 0026680464 scopus 로고
    • Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription
    • 101. Lechner MS, Mack DH, Finicle AB, Crook T, Vousden KH, Laimins LA (1992) Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription. EMBO J 11:3045-3052
    • (1992) EMBO J , vol.11 , pp. 3045-3052
    • Lechner, M.S.1    Mack, D.H.2    Finicle, A.B.3    Crook, T.4    Vousden, K.H.5    Laimins, L.A.6
  • 102
    • 0026504287 scopus 로고
    • Stability of p53 protein in rat cells transformed by various viral transforming genes
    • 102. Inoue H, Kondoh G, Sudiro TM, Hakura A (1992) Stability of p53 protein in rat cells transformed by various viral transforming genes. Virology 187:343-347
    • (1992) Virology , vol.187 , pp. 343-347
    • Inoue, H.1    Kondoh, G.2    Sudiro, T.M.3    Hakura, A.4
  • 103
    • 0028347587 scopus 로고
    • Modulation of transcriptional regulatory properties of p53 by HPV E6
    • 103. Crook T, Fisher C, Masterson PJ, Vousden KH (1994) Modulation of transcriptional regulatory properties of p53 by HPV E6. Oncogene 9:1225-1230
    • (1994) Oncogene , vol.9 , pp. 1225-1230
    • Crook, T.1    Fisher, C.2    Masterson, P.J.3    Vousden, K.H.4
  • 104
    • 0028089004 scopus 로고
    • DNA damage induced p53 mediated transcription is inhibited by human papillomavirus type 18 E6
    • 104. Gu Z, Pim D, Labrecque S, Banks L, Matlashewski G (1994) DNA damage induced p53 mediated transcription is inhibited by human papillomavirus type 18 E6. Oncogene 9:629-633
    • (1994) Oncogene , vol.9 , pp. 629-633
    • Gu, Z.1    Pim, D.2    Labrecque, S.3    Banks, L.4    Matlashewski, G.5
  • 107
    • 0028847870 scopus 로고
    • HPV-18 E6 mediated inhibition of p53 DNA binding activity is independent of E6 induced degradation
    • 107. Thomas M, Massimi P, Jenkins J, Banks L (1995) HPV-18 E6 mediated inhibition of p53 DNA binding activity is independent of E6 induced degradation. Oncogene 10:261-268
    • (1995) Oncogene , vol.10 , pp. 261-268
    • Thomas, M.1    Massimi, P.2    Jenkins, J.3    Banks, L.4
  • 108
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • 108. Wu X, Levine AJ (1994) p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA 91:3602-3606
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 109
    • 0028334011 scopus 로고
    • Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
    • 109. Pan H, Griep AE (1994) Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev 8:1285-1299
    • (1994) Genes Dev , vol.8 , pp. 1285-1299
    • Pan, H.1    Griep, A.E.2
  • 110
    • 0023809597 scopus 로고
    • Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells
    • 110. von Knebel Doeberitz M, Oltersdorf T, Schwarz E, Gissmann L (1988) Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells. Cancer Res 48:3780-3786
    • (1988) Cancer Res , vol.48 , pp. 3780-3786
    • Von Knebel Doeberitz, M.1    Oltersdorf, T.2    Schwarz, E.3    Gissmann, L.4
  • 111
    • 0026737278 scopus 로고
    • Effect on cancer cells of plasmids that express antisense RNA of human papillomavirus type 18
    • 111. Steele C, Sacks PG, Adler Storthz K, Shillitoe EJ (1992) Effect on cancer cells of plasmids that express antisense RNA of human papillomavirus type 18. Cancer Res 52:4706-4711
    • (1992) Cancer Res , vol.52 , pp. 4706-4711
    • Steele, C.1    Sacks, P.G.2    Adler Storthz, K.3    Shillitoe, E.J.4
  • 112
    • 0027286512 scopus 로고
    • Effects of human papillomavirus type 18-specific antisense oligonucleotides on the transformed phenotype of human carcinoma cell lines
    • 112. Steele C, Cowsert LM, Shillitoe EJ (1993) Effects of human papillomavirus type 18-specific antisense oligonucleotides on the transformed phenotype of human carcinoma cell lines. Cancer Res 53:2330-2337
    • (1993) Cancer Res , vol.53 , pp. 2330-2337
    • Steele, C.1    Cowsert, L.M.2    Shillitoe, E.J.3
  • 113
    • 0028823757 scopus 로고
    • In vitro and in vivo inhibition of human papillomavirus type 16 E6 and E7 genes
    • 113. Tan TM, Ting RC (1995) In vitro and in vivo inhibition of human papillomavirus type 16 E6 and E7 genes. Cancer Res 55:4599-4605
    • (1995) Cancer Res , vol.55 , pp. 4599-4605
    • Tan, T.M.1    Ting, R.C.2


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