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Volumn 165, Issue SUPPL. 1, 1999, Pages

Biological markers in the diagnosis and treatment of ALS

Author keywords

Amyotrophic lateral sclerosis; Positron emission tomography; Survival

Indexed keywords

2 AMINO 3 METHYLAMINOPROPIONIC ACID; 3 OXALYLAMINOALANINE; BIOLOGICAL MARKER; CREATINE; DOMOIC ACID; GLUTAMIC ACID; MESSENGER RNA; N ACETYLASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RADIOISOTOPE; REACTIVE OXYGEN METABOLITE; RILUZOLE; ZIDOVUDINE;

EID: 0032788061     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(99)00023-4     Document Type: Conference Paper
Times cited : (38)

References (78)
  • 1
    • 0027477946 scopus 로고
    • Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
    • Beal MF, Hyman BT, Koroshetz W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci 1993;16:125-31.
    • (1993) Trends Neurosci , vol.16 , pp. 125-131
    • Beal, M.F.1    Hyman, B.T.2    Koroshetz, W.3
  • 2
    • 0029732866 scopus 로고    scopus 로고
    • Excitotoxicity in ALS
    • Leigh PN, Meldrum BS. Excitotoxicity in ALS. Neurology 1996;47(Suppl 4):221-7.
    • (1996) Neurology , vol.47 , Issue.4 SUPPL. , pp. 221-227
    • Leigh, P.N.1    Meldrum, B.S.2
  • 3
    • 0029441620 scopus 로고
    • Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis
    • Rothstein ID. Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis. Adv Neurol 1995;68:7-20.
    • (1995) Adv Neurol , vol.68 , pp. 7-20
    • Rothstein, I.D.1
  • 4
    • 0025299819 scopus 로고
    • Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis
    • Rothstein JD, Tsai G, Kuncl RW et al. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol 1990;28:18-25.
    • (1990) Ann Neurol , vol.28 , pp. 18-25
    • Rothstein, J.D.1    Tsai, G.2    Kuncl, R.W.3
  • 5
    • 0029067210 scopus 로고
    • CSF and plasma amino acid levels in motor neuron disease: Elevation of CSF glutamate in a subset of patients
    • Shaw PJ, Forrest V, Ince PG, Richardson JP, Wastell HJ. CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients. Neurodegeneration 1995;4:209-16.
    • (1995) Neurodegeneration , vol.4 , pp. 209-216
    • Shaw, P.J.1    Forrest, V.2    Ince, P.G.3    Richardson, J.P.4    Wastell, H.J.5
  • 6
    • 0030296379 scopus 로고    scopus 로고
    • Muscarinic, N-methyl-D-aspartate (NMDA) and benzodiazepine receptor binding sites in cortical membranes from amyotrophic lateral sclerosis patients
    • Gredal O, Pakkenberg B, Nielsen M. Muscarinic, N-methyl-D-aspartate (NMDA) and benzodiazepine receptor binding sites in cortical membranes from amyotrophic lateral sclerosis patients. J Neurol Sci 1996;143:121-5.
    • (1996) J Neurol Sci , vol.143 , pp. 121-125
    • Gredal, O.1    Pakkenberg, B.2    Nielsen, M.3
  • 7
    • 0028903269 scopus 로고
    • Induction of the immediate early gene c-jun in human spinal cord in amyotrophic lateral sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA
    • Virgo L, de BJ. Induction of the immediate early gene c-jun in human spinal cord in amyotrophic lateral sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA. Brain Res 1995;676:196-204.
    • (1995) Brain Res , vol.676 , pp. 196-204
    • De Virgo, L.B.J.1
  • 8
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein JD, Martin U, Kuncl RW. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. New Eng J Med 1992;326:1464-8.
    • (1992) New Eng J Med , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, U.2    Kuncl, R.W.3
  • 9
    • 0029030610 scopus 로고
    • Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
    • Rothstein JD, Van Kammen M, Levey AI, Martin U, Kunel RW. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 1995;38:73-84.
    • (1995) Ann Neurol , vol.38 , pp. 73-84
    • Rothstein, J.D.1    Van Kammen, M.2    Levey, A.I.3    Martin, U.4    Kunel, R.W.5
  • 10
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • Rothstein JD, Jin L, Dykes-Hoberg M, Kuncl RW. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Nat Acad Sci USA 1993;90:6591-5.
    • (1993) Proc Nat Acad Sci USA , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3    Kuncl, R.W.4
  • 11
    • 13344286293 scopus 로고    scopus 로고
    • Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
    • Rothstein JD, Dykes-Hoberg M, Pardo CA et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 1996;16:675-86.
    • (1996) Neuron , vol.16 , pp. 675-686
    • Rothstein, J.D.1    Dykes-Hoberg, M.2    Pardo, C.A.3
  • 12
    • 0030695278 scopus 로고    scopus 로고
    • Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis. Evidence from paired transcranial magnetic stimulation
    • Ziemann U, Winter M, Reimers CD, Reimers K, Tergau F, Paulus W. Impaired motor cortex inhibition in patients with amyotrophic lateral sclerosis. Evidence from paired transcranial magnetic stimulation. Neurology 1997;49:1292-8.
    • (1997) Neurology , vol.49 , pp. 1292-1298
    • Ziemann, U.1    Winter, M.2    Reimers, C.D.3    Reimers, K.4    Tergau, F.5    Paulus, W.6
  • 13
    • 0030789324 scopus 로고    scopus 로고
    • Corticomotor threshold is reduced in early sporadic amyotrophic lateral sclerosis
    • Mills KR, Nithi KA. Corticomotor threshold is reduced in early sporadic amyotrophic lateral sclerosis. Mus Nerv 1997;20:1137-41.
    • (1997) Mus Nerv , vol.20 , pp. 1137-1141
    • Mills, K.R.1    Nithi, K.A.2
  • 14
    • 0028923295 scopus 로고
    • Comparison of single motor unit responses to transcranial magnetic and peroneal nerve stimulation in the tibialis anterior muscle of patients with amyotrophic lateral sclerosis
    • Awiszus F, Feistner H. Comparison of single motor unit responses to transcranial magnetic and peroneal nerve stimulation in the tibialis anterior muscle of patients with amyotrophic lateral sclerosis. Electroenceph Clin Neurophysiol 1995;97:90-5.
    • (1995) Electroenceph Clin Neurophysiol , vol.97 , pp. 90-95
    • Awiszus, F.1    Feistner, H.2
  • 15
    • 0029832232 scopus 로고    scopus 로고
    • Toxic models of upper motor neuron disease
    • Ludolph AC, Spencer P. Toxic models of upper motor neuron disease. J Neurol Sci 1996;139(Suppl):53-9.
    • (1996) J Neurol Sci , vol.139 , Issue.SUPPL. , pp. 53-59
    • Ludolph, A.C.1    Spencer, P.2
  • 16
    • 0028980731 scopus 로고
    • The neurotoxin, beta-N-methylamino-L-alanine (BMAA) interacts with the strychnine-insensitive glycine modulatory site of the N-methyl-D-aspartate receptor
    • Allen CN, Omelchenko I, Ross SM, Spencer P. The neurotoxin, beta-N-methylamino-L-alanine (BMAA) interacts with the strychnine-insensitive glycine modulatory site of the N-methyl-D-aspartate receptor. Neuropharmacology 1995;34:651-8.
    • (1995) Neuropharmacology , vol.34 , pp. 651-658
    • Allen, C.N.1    Omelchenko, I.2    Ross, S.M.3    Spencer, P.4
  • 17
    • 0025194683 scopus 로고
    • Neurological sequelae of domoic acid intoxication due to ingestion of mussels from Prince Edward Island
    • Teitelbaum JS, Zatorre RI, Carpenter S, Gendron D, Cashman NR. Neurological sequelae of domoic acid intoxication due to ingestion of mussels from Prince Edward Island. New Eng J Med 1990;322:1781-7.
    • (1990) New Eng J Med , vol.322 , pp. 1781-1787
    • Teitelbaum, J.S.1    Zatorre, R.I.2    Carpenter, S.3    Gendron, D.4    Cashman, N.R.5
  • 18
    • 0027426169 scopus 로고
    • Amyotrophic lateral sclerosis and structural defects in Cu, Zn superoxide dismutase
    • Deng HX, Hentati A, Tainer JA et al. Amyotrophic lateral sclerosis and structural defects in Cu, Zn superoxide dismutase. Science 1993;261:1047-51.
    • (1993) Science , vol.261 , pp. 1047-1051
    • Deng, H.X.1    Hentati, A.2    Tainer, J.A.3
  • 19
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • [published erratum appears in Nature 1993;364(6435):362]
    • Rosen DR, Siddique T, Patterson D et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis [published erratum appears in Nature 1993;364(6435):362]. Nature 1993;362:59-62.
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3
  • 20
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
    • Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD et al. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science 1994;264(5166):1772-5.
    • (1994) Science , vol.264 , Issue.5166 , pp. 1772-1775
    • Gurney, M.E.1    Pu, H.2    Chiu, A.Y.3    Dal Canto, M.C.4    Polchow, C.Y.5    Alexander, D.D.6
  • 21
    • 0030813067 scopus 로고    scopus 로고
    • Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis
    • Ferrante RJ, Browne SE, Shinobu LA, Bowling AC, Baik MJ, MacGarvey U et al. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem 1997;69:2064-74.
    • (1997) J Neurochem , vol.69 , pp. 2064-2074
    • Ferrante, R.J.1    Browne, S.E.2    Shinobu, L.A.3    Bowling, A.C.4    Baik, M.J.5    MacGarvey, U.6
  • 22
    • 0032127330 scopus 로고    scopus 로고
    • Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS
    • Hall ED, Andrus PK, Oostveen JA, Fleck TJ, Gurney ME. Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS. J Neurosci Res 1998;53:66-77.
    • (1998) J Neurosci Res , vol.53 , pp. 66-77
    • Hall, E.D.1    Andrus, P.K.2    Oostveen, J.A.3    Fleck, T.J.4    Gurney, M.E.5
  • 23
    • 0030767498 scopus 로고    scopus 로고
    • Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation
    • Ferrante RJ, Shinobu LA, Schulz JB, Matthews RT, Thomas CE, Kowall NW et al. Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation. Ann Neurol 1997;42:326-34.
    • (1997) Ann Neurol , vol.42 , pp. 326-334
    • Ferrante, R.J.1    Shinobu, L.A.2    Schulz, J.B.3    Matthews, R.T.4    Thomas, C.E.5    Kowall, N.W.6
  • 24
    • 0030927075 scopus 로고    scopus 로고
    • Glutamate, excitotoxicity and amyotrophic lateral sclerosis
    • Shaw PJ, Ince PG. Glutamate, excitotoxicity and amyotrophic lateral sclerosis. J Neurol 1997;244(Suppl 2):S3-14.
    • (1997) J Neurol , vol.244 , Issue.2 SUPPL.
    • Shaw, P.J.1    Ince, P.G.2
  • 26
    • 0030050727 scopus 로고    scopus 로고
    • Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
    • Gurney ME, Cutting FB, Zhai P et al. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol 1996;39:147-57.
    • (1996) Ann Neurol , vol.39 , pp. 147-157
    • Gurney, M.E.1    Cutting, F.B.2    Zhai, P.3
  • 28
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group
    • Bensimon G, Lacomblez L, Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. New Eng J Med 1994;330:585-91.
    • (1994) New Eng J Med , vol.330 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 29
    • 0029977337 scopus 로고    scopus 로고
    • Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II
    • Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet 1996;347:1425-31.
    • (1996) Lancet , vol.347 , pp. 1425-1431
    • Lacomblez, L.1    Bensimon, G.2    Leigh, P.N.3    Guillet, P.4    Meininger, V.5
  • 30
    • 10544254257 scopus 로고    scopus 로고
    • Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. WALS Study Group. Western Amyotrophic Lateral Sclerosis Study Group
    • Miller RG, Moore D, Young LA et al. Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. WALS Study Group. Western Amyotrophic Lateral Sclerosis Study Group. Neurology 1996;47:1383-8.
    • (1996) Neurology , vol.47 , pp. 1383-1388
    • Miller, R.G.1    Moore, D.2    Young, L.A.3
  • 32
    • 0001163277 scopus 로고    scopus 로고
    • The amyotrophic lateral sclerosis functional rating scale. Assessment of activities of daily living in patients with amyotrophic lateral sclerosis. The ALS CNTF treatment study (ACTS) phase I-II study group
    • The ALS CNTF Treatment Study (ACTS) Phase I-II Study Group. The amyotrophic lateral sclerosis functional rating scale. Assessment of activities of daily living in patients with amyotrophic lateral sclerosis. The ALS CNTF treatment study (ACTS) phase I-II study group. Arch Neurol 1996;53:141-7.
    • (1996) Arch Neurol , vol.53 , pp. 141-147
  • 33
    • 0023195073 scopus 로고
    • A rating scale for amyotrophic lateral sclerosis: Description and preliminary experience
    • Appel V, Stewart SS, Smith G, Appel SLI. A rating scale for amyotrophic lateral sclerosis: description and preliminary experience. Ann Neurol 1987;22:328-33.
    • (1987) Ann Neurol , vol.22 , pp. 328-333
    • Appel, V.1    Stewart, S.S.2    Smith, G.3    Appel, S.L.I.4
  • 34
    • 6844266272 scopus 로고    scopus 로고
    • Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group
    • Lai EC, Felice KJ, Festoff BW, Gawel MJ, Gelinas DF, Kratz R et al. Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group. Neurology 1997;49:1621-30.
    • (1997) Neurology , vol.49 , pp. 1621-1630
    • Lai, E.C.1    Felice, K.J.2    Festoff, B.W.3    Gawel, M.J.4    Gelinas, D.F.5    Kratz, R.6
  • 35
    • 0026342465 scopus 로고
    • The extent and time course of motor neuron involvement in amyotrophic lateral sclerosis
    • Dantes MI, McComas A. The extent and time course of motor neuron involvement in amyotrophic lateral sclerosis. Mus Nerv 1991;14:416-21.
    • (1991) Mus Nerv , vol.14 , pp. 416-421
    • Dantes, M.I.1    McComas, A.2
  • 36
    • 0029891795 scopus 로고    scopus 로고
    • Cortical projections to spinal motoneurons: Changes with aging and amyotrophic lateral sclerosis
    • Eisen A, Entezari-Taher MI, Stewart H. Cortical projections to spinal motoneurons: changes with aging and amyotrophic lateral sclerosis. Neurology 1996;46:1396-404.
    • (1996) Neurology , vol.46 , pp. 1396-1404
    • Eisen, A.1    Entezari-Taher, M.I.2    Stewart, H.3
  • 37
    • 0029061319 scopus 로고
    • Transcranial magnetic stimulation as a diagnostic and prognostic test in amyotrophic lateral sclerosis
    • Claus D, Brunholzl C, Kerling FP, Henschel S. Transcranial magnetic stimulation as a diagnostic and prognostic test in amyotrophic lateral sclerosis. J Neurol Sci 1995;129(Suppl):30-4.
    • (1995) J Neurol Sci , vol.129 , Issue.SUPPL. , pp. 30-34
    • Claus, D.1    Brunholzl, C.2    Kerling, F.P.3    Henschel, S.4
  • 38
    • 0028924742 scopus 로고
    • Amyotrophic lateral sclerosis: Correlation of clinical and MR imaging findings
    • Cheung G, Gawel MJ, Cooper PW, Farb RI, Ang LC, Gawal MJ. Amyotrophic lateral sclerosis: correlation of clinical and MR imaging findings. Radiology 1995;194:263-70.
    • (1995) Radiology , vol.194 , pp. 263-270
    • Cheung, G.1    Gawel, M.J.2    Cooper, P.W.3    Farb, R.I.4    Ang, L.C.5    Gawal, M.J.6
  • 39
    • 0024351849 scopus 로고
    • Focal signal-intensity variations in the posterior internal capsule: Normal MR findings and distinction from pathologic findings
    • Mirowitz S, Sartor K, Gado MI, Torack R. Focal signal-intensity variations in the posterior internal capsule: normal MR findings and distinction from pathologic findings. Radiology 1989;172:535-9.
    • (1989) Radiology , vol.172 , pp. 535-539
    • Mirowitz, S.1    Sartor, K.2    Gado, M.I.3    Torack, R.4
  • 40
    • 0027136233 scopus 로고
    • MR findings of the pyramidal tract in amyotrophic lateral sclerosis
    • Segawa F. MR findings of the pyramidal tract in amyotrophic lateral sclerosis. Rinsho Shinkeigaku-Clin Neurol 1993;33:835-44.
    • (1993) Rinsho Shinkeigaku-Clin Neurol , vol.33 , pp. 835-844
    • Segawa, F.1
  • 41
    • 0026806491 scopus 로고
    • MRI and SPECT findings in amyotrophic lateral sclerosis. Demonstration of upper motor neurone involvement by clinical neuroimaging
    • Udaka F, Sawada H, Seriu N, Shindou K, Nishitani N, Kameyama MI. MRI and SPECT findings in amyotrophic lateral sclerosis. Demonstration of upper motor neurone involvement by clinical neuroimaging. Neuroradiology 1992;34:389-93.
    • (1992) Neuroradiology , vol.34 , pp. 389-393
    • Udaka, F.1    Sawada, H.2    Seriu, N.3    Shindou, K.4    Nishitani, N.5    Kameyama, M.I.6
  • 42
    • 0029550868 scopus 로고
    • MR imaging of the brain of amyotrophic lateral sclerosis
    • Yagishita A. MR imaging of the brain of amyotrophic lateral sclerosis. Rinsho Shinkeigaku-Clin Neurol 1995;35:1554-6.
    • (1995) Rinsho Shinkeigaku-Clin Neurol , vol.35 , pp. 1554-1556
    • Yagishita, A.1
  • 43
    • 0027429573 scopus 로고
    • Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging
    • Oba H, Araki T, Ohtomo K et al. Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging. Radiology 1993;189:843-6.
    • (1993) Radiology , vol.189 , pp. 843-846
    • Oba, H.1    Araki, T.2    Ohtomo, K.3
  • 44
    • 0028264024 scopus 로고
    • Cortical function in progressive lower motor neuron disorders and amyotrophic lateral sclerosis: A comparative PET study
    • Kew JJ, Brooks DJ, Passingham RE, Rothwell JC, Frackowiak RS, Leigh PN. Cortical function in progressive lower motor neuron disorders and amyotrophic lateral sclerosis: a comparative PET study. Neurology 1994;44:1101-10.
    • (1994) Neurology , vol.44 , pp. 1101-1110
    • Kew, J.J.1    Brooks, D.J.2    Passingham, R.E.3    Rothwell, J.C.4    Frackowiak, R.S.5    Leigh, P.N.6
  • 45
    • 0027240698 scopus 로고
    • Reduced isotope uptake restricted to the motor area in patients with amyotrophic lateral sclerosis
    • Abe K, Yorifuji S, Nishikawa Y Reduced isotope uptake restricted to the motor area in patients with amyotrophic lateral sclerosis. Neuroradiology 1993;35:410-1.
    • (1993) Neuroradiology , vol.35 , pp. 410-411
    • Abe, K.1    Yorifuji, S.2    Nishikawa, Y.3
  • 46
    • 0344550566 scopus 로고    scopus 로고
    • Detection of pyramidal tract lesions in ALS by using magnetization-transfer measurements
    • Kato Y, Matsumura K, Kinosada Y, NaritaY, Kuzuhara S, Nakagawa T. Detection of pyramidal tract lesions in ALS by using magnetization-transfer measurements [abstract]. Neurology 1997;48(Suppl. 2):128.
    • (1997) Neurology , vol.48 , Issue.2 SUPPL. , pp. 128
    • Kato, Y.1    Matsumura, K.2    Kinosada, Y.3    Narita, Y.4    Kuzuhara, S.5    Nakagawa, T.6
  • 47
    • 0021231872 scopus 로고
    • N-acetyl-aspartyl-glutamate: Regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method
    • Koller KJ, Zaczek R, Coyle JT. N-acetyl-aspartyl-glutamate: regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method. J Neurochem 1984;43:1136-42.
    • (1984) J Neurochem , vol.43 , pp. 1136-1142
    • Koller, K.J.1    Zaczek, R.2    Coyle, J.T.3
  • 48
  • 49
    • 0026000851 scopus 로고
    • Immunocytochemical localization of N-acetylaspartate with monoclonal antibodies
    • Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetylaspartate with monoclonal antibodies. Neuroscience 1991;45:37-45.
    • (1991) Neuroscience , vol.45 , pp. 37-45
    • Simmons, M.L.1    Frondoza, C.G.2    Coyle, J.T.3
  • 50
    • 0018622817 scopus 로고
    • Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport
    • Patel TB, Clark JB. Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport. Biochem J 1979;184:539-46.
    • (1979) Biochem J , vol.184 , pp. 539-546
    • Patel, T.B.1    Clark, J.B.2
  • 51
    • 0022196667 scopus 로고
    • N-Acetylation of L-aspartate in the nervous system: Differential distribution of a specific enzyme
    • Truckenmiller ME, Namboodiri MA, Brownstein MJ, Neale JH. N-Acetylation of L-aspartate in the nervous system: differential distribution of a specific enzyme. J Neurochem 1985;45:1658-62.
    • (1985) J Neurochem , vol.45 , pp. 1658-1662
    • Truckenmiller, M.E.1    Namboodiri, M.A.2    Brownstein, M.J.3    Neale, J.H.4
  • 52
    • 0025367229 scopus 로고
    • Effects of hypernatremia on organic brain osmoles
    • Lien YH, Shapiro JI, Chan L. Effects of hypernatremia on organic brain osmoles. J Clin Invest 1990;85:1427-35.
    • (1990) J Clin Invest , vol.85 , pp. 1427-1435
    • Lien, Y.H.1    Shapiro, J.I.2    Chan, L.3
  • 53
    • 0028001019 scopus 로고
    • Brief report: Organic osmolytes in the brain of an infant with hypernatremia
    • Lee JH, Arcinue E, Ross BD. Brief report: organic osmolytes in the brain of an infant with hypernatremia. N Eng J Med 1994;331:439-42.
    • (1994) N Eng J Med , vol.331 , pp. 439-442
    • Lee, J.H.1    Arcinue, E.2    Ross, B.D.3
  • 55
    • 0016609552 scopus 로고
    • A relationship of N-acetylaspartate biosynthesis to neuronal protein synthesis
    • Clarke DD, Greenfield S, Dicker E, Tirri U, Ronan EJ. A relationship of N-acetylaspartate biosynthesis to neuronal protein synthesis. J Neurochem 1975;24:479-85.
    • (1975) J Neurochem , vol.24 , pp. 479-485
    • Clarke, D.D.1    Greenfield, S.2    Dicker, E.3    Tirri, U.4    Ronan, E.J.5
  • 56
    • 0014378844 scopus 로고
    • Acetyl transport mechanisms. Involvement of N-acetyl aspartic acid in de novo fatty acid biosynthesis in the developing rat brain
    • D'Adamo AJ, Gidez LI, Yatsu FM. Acetyl transport mechanisms. Involvement of N-acetyl aspartic acid in de novo fatty acid biosynthesis in the developing rat brain. Exp Brain Res 1968;5:267-73.
    • (1968) Exp Brain Res , vol.5 , pp. 267-273
    • D'Adamo, A.J.1    Gidez, L.I.2    Yatsu, F.M.3
  • 57
    • 0023616046 scopus 로고
    • Immunohistochemistry and biosynthesis of N-acetylaspartylglutamate in spinal sensory ganglia
    • Cangro CB, Namboodiri MA, Sklar LA, Corigliano-Murphy A, Neale JH. Immunohistochemistry and biosynthesis of N-acetylaspartylglutamate in spinal sensory ganglia. J Neurochem 1987;49:1579-88.
    • (1987) J Neurochem , vol.49 , pp. 1579-1588
    • Cangro, C.B.1    Namboodiri, M.A.2    Sklar, L.A.3    Corigliano-Murphy, A.4    Neale, J.H.5
  • 58
    • 0027948962 scopus 로고
    • Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo
    • Pioro EP, Antel JP, Cashman NR, Arnold DL. Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo. Neurology 1994;44:1933-8.
    • (1994) Neurology , vol.44 , pp. 1933-1938
    • Pioro, E.P.1    Antel, J.P.2    Cashman, N.R.3    Arnold, D.L.4
  • 59
    • 0345412756 scopus 로고    scopus 로고
    • Monitoring benefit to upper motor neurons from riluzole therapy in ALS using proton magnetic resonance spectroscopic imaging
    • Kalra S, Genge A, Cashman N, Antel JP, Arnold DL. Monitoring benefit to upper motor neurons from riluzole therapy in ALS using proton magnetic resonance spectroscopic imaging [abstract]. Neurology 1997;48(Suppl 2):129.
    • (1997) Neurology , vol.48 , Issue.2 SUPPL. , pp. 129
    • Kalra, S.1    Genge, A.2    Cashman, N.3    Antel, J.P.4    Arnold, D.L.5
  • 60
    • 15144347054 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease. Subgroup analysis and follow-up measurements
    • Wolfgang B, Karitzky J et al. Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease. Subgroup analysis and follow-up measurements. Arch Neurol 1998;55:931-6.
    • (1998) Arch Neurol , vol.55 , pp. 931-936
    • Wolfgang, B.1    Karitzky, J.2
  • 61
    • 0024528020 scopus 로고
    • Cerebral metabolism in man after acute stroke: New observations using localized proton NMR spectroscopy
    • Bruhn H, Frahm J, Gyngell ML, Merboldt KD, Hanicke W, Sauter R. Cerebral metabolism in man after acute stroke: new observations using localized proton NMR spectroscopy. Mag Res Med 1989;9:126-31.
    • (1989) Mag Res Med , vol.9 , pp. 126-131
    • Bruhn, H.1    Frahm, J.2    Gyngell, M.L.3    Merboldt, K.D.4    Hanicke, W.5    Sauter, R.6
  • 62
    • 0025152028 scopus 로고
    • Proton MR spectroscopy and imaging of the brain in AIDS: Evidence of neuronal loss in regions that appear normal with imaging
    • Menon DK, Baudouin CJ, Tomlinson D, Hoyle C. Proton MR spectroscopy and imaging of the brain in AIDS: evidence of neuronal loss in regions that appear normal with imaging. J Comp Ass Tomog 1990;14:882-5.
    • (1990) J Comp Ass Tomog , vol.14 , pp. 882-885
    • Menon, D.K.1    Baudouin, C.J.2    Tomlinson, D.3    Hoyle, C.4
  • 63
    • 0026694238 scopus 로고
    • Decreased brain N-acetylaspartate in Huntington's disease
    • Dunlop DS, Mc Hale DM, Lajtha A. Decreased brain N-acetylaspartate in Huntington's disease. Brain Res 1992;580:44-8.
    • (1992) Brain Res , vol.580 , pp. 44-48
    • Dunlop, D.S.1    Mc Hale, D.M.2    Lajtha, A.3
  • 64
    • 0027722281 scopus 로고
    • Proton MR spectroscopic characterization of differences in regional brain metabolic abnormalities in mitochondrial encephalomyopathies
    • Matthews PM, Andermann F, Silver K, Karpati G, Arnold DL. Proton MR spectroscopic characterization of differences in regional brain metabolic abnormalities in mitochondrial encephalomyopathies. Neurology 1993;43:2484-90.
    • (1993) Neurology , vol.43 , pp. 2484-2490
    • Matthews, P.M.1    Andermann, F.2    Silver, K.3    Karpati, G.4    Arnold, D.L.5
  • 65
    • 0027952561 scopus 로고
    • Lateralization of temporal lobe epilepsy based on regional metabolic abnormalities in proton magnetic resonance spectroscopic images
    • Cendes F, Andermann F, Preul MC, Arnold DL. Lateralization of temporal lobe epilepsy based on regional metabolic abnormalities in proton magnetic resonance spectroscopic images. Ann Neurol 1994;35:211-6.
    • (1994) Ann Neurol , vol.35 , pp. 211-216
    • Cendes, F.1    Andermann, F.2    Preul, M.C.3    Arnold, D.L.4
  • 66
    • 0025472002 scopus 로고
    • Proton and phosphorus magnetic resonance spectroscopy of human astrocytomas in vivo. Preliminary observations on tumor grading
    • Arnold DL, Shoubridge EA, Villemure JG, Feindel W. Proton and phosphorus magnetic resonance spectroscopy of human astrocytomas in vivo. Preliminary observations on tumor grading. NMR Biomed 1990;3:184-9.
    • (1990) NMR Biomed , vol.3 , pp. 184-189
    • Arnold, D.L.1    Shoubridge, E.A.2    Villemure, J.G.3    Feindel, W.4
  • 67
    • 0028792005 scopus 로고
    • Reversible decreases in N-acetylaspartate after acute brain injury
    • De Stefano N, Matthews PM, Arnold DL. Reversible decreases in N-acetylaspartate after acute brain injury. Mag Res Med 1995;34:721-7.
    • (1995) Mag Res Med , vol.34 , pp. 721-727
    • De Stefano, N.1    Matthews, P.M.2    Arnold, D.L.3
  • 68
    • 0028265609 scopus 로고
    • Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions
    • Davie CA, Hawkins CP, Barker GJ et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994;117:49-58.
    • (1994) Brain , vol.117 , pp. 49-58
    • Davie, C.A.1    Hawkins, C.P.2    Barker, G.J.3
  • 69
    • 0028888923 scopus 로고
    • Human cerebral osmolytes during chronic hyponatremia. A proton magnetic resonance spectroscopy study
    • Videen JS, Michaelis T, Pinto P, Ross BD. Human cerebral osmolytes during chronic hyponatremia. A proton magnetic resonance spectroscopy study. J Clin Invest 1995;95:788-93.
    • (1995) J Clin Invest , vol.95 , pp. 788-793
    • Videen, J.S.1    Michaelis, T.2    Pinto, P.3    Ross, B.D.4
  • 70
    • 0029846238 scopus 로고    scopus 로고
    • Effectiveness of revascularization surgery evaluated by proton magnetic resonance spectroscopy and single photon emission computed tomography
    • Uno MI, Ueda S, Hondo H, Matsumoto K, Harada MI. Effectiveness of revascularization surgery evaluated by proton magnetic resonance spectroscopy and single photon emission computed tomography. Neurol Med-Chir 1996;36:560-6.
    • (1996) Neurol Med-Chir , vol.36 , pp. 560-566
    • Uno, M.I.1    Ueda, S.2    Hondo, H.3    Matsumoto, K.4    Harada, M.I.5
  • 71
    • 0031468302 scopus 로고    scopus 로고
    • Normalization of neuronal metabolic dysfunction after surgery for temporal lobe epilepsy. Evidence from proton MR spectroscopic imaging
    • Cendes F, Andermann F, Dubeau F, Matthews PM, Arnold DL. Normalization of neuronal metabolic dysfunction after surgery for temporal lobe epilepsy. Evidence from proton MR spectroscopic imaging. Neurology 1997;49:1525-33.
    • (1997) Neurology , vol.49 , pp. 1525-1533
    • Cendes, F.1    Andermann, F.2    Dubeau, F.3    Matthews, P.M.4    Arnold, D.L.5
  • 72
    • 0029810095 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is a primary event in glutamate neurotoxicity
    • Schinder AF, Olson EC, Spitzer NC, Montal MI. Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J Neurosci 1996;16:6125-33.
    • (1996) J Neurosci , vol.16 , pp. 6125-6133
    • Schinder, A.F.1    Olson, E.C.2    Spitzer, N.C.3    Montal, M.I.4
  • 73
    • 0029788243 scopus 로고    scopus 로고
    • Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
    • White RJ, Reynolds IJ. Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J Neurosci 1996;16:5688-97.
    • (1996) J Neurosci , vol.16 , pp. 5688-5697
    • White, R.J.1    Reynolds, I.J.2
  • 74
    • 0029827804 scopus 로고    scopus 로고
    • Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells
    • Budd SL, Nicholls DG. Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells. J Neurochem 1996;67:2282-91.
    • (1996) J Neurochem , vol.67 , pp. 2282-2291
    • Budd, S.L.1    Nicholls, D.G.2
  • 75
    • 0032102114 scopus 로고    scopus 로고
    • Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy
    • Kalra S, Cashman N, Genge A, Arnold DL. Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport 1998;9:1757-61.
    • (1998) Neuroreport , vol.9 , pp. 1757-1761
    • Kalra, S.1    Cashman, N.2    Genge, A.3    Arnold, D.L.4
  • 76
    • 0029753270 scopus 로고    scopus 로고
    • The pharmacology and mechanism of action of riluzole
    • Doble A. The pharmacology and mechanism of action of riluzole. Neurology 1996;47(Suppl. 4):233-41.
    • (1996) Neurology , vol.47 , Issue.4 SUPPL. , pp. 233-241
    • Doble, A.1
  • 77
    • 0024270741 scopus 로고
    • A hypothesis for the pathogenesis of amyotrophic lateral sclerosis
    • Karpati G, Carpenter S, Durham H. A hypothesis for the pathogenesis of amyotrophic lateral sclerosis. Rev Neurol 1988;144:672-5.
    • (1988) Rev Neurol , vol.144 , pp. 672-675
    • Karpati, G.1    Carpenter, S.2    Durham, H.3


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