Overexpression of bax in human glioma cell lines

Journal of Neurosurgery

Volumn 91, Issue 3, 1999, Pages 483-489

  Vogelbaum, Michael A ^a   Tong, Jianxin X ^a   Perugu, Rajashri ^a   Gutmann, David H ^a   Rich, Keith M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl 2 gene family; Brain neoplasm; Chemotherapy; Gene therapy; P53 gene

Indexed keywords

CYTARABINE; PROTEIN BAX; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CHEMOSENSITIVITY; DNA DAMAGE; GENE INDUCTION; GENE OVEREXPRESSION; GENOTYPE; GLIOMA; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL;

EID: 0032782588     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.1999.91.3.0483     Document Type: Article

References (43)

1. Alderson LM, Castleberg RL, Harsh GR IV, et al: Human gliomas with wild-type p53 express bcl-2. Cancer Res 55: 999-1001, 1995
2. Allan DJ: Radiation-induced apoptosis: its role in a MADCaT (mitosis-apoptosis-differentiation-calcium toxicity) scheme of cytotoxicity mechanisms. Int J Radiat Biol 62:145-152, 1992
3. Anker L, Ohgaki H, Ludeke BI, et al: p53 protein accumulation and gene mutations in human glioma cell lines. Int J Cancer 55:982-987, 1993
4. Bargou RC, Wagener C, Bommert K, et al: Overexpression of the death-promoting gene bax-α which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J Clin Invest 97: 2651-2659, 1996
5. Boise LH, Gonzàlez-Garcia M, Postema CE, et al: bcl-x, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608, 1993
6. Brimmell M, Mendiola R, Mangion J, et al: BAX frameshift mutations in cell lines derived from human heamopoietic malignancies are associated with resistance to apoptosis and microsatellite instability. Oncogene 16:1803-1812, 1998
7. Chiou SK, Rao L, White E: bcl-2 blocks p53-dependent apoptosis. Mol Cell Biol 14:2556-2563, 1994
8. Chou D, Miyashita T, Mohrenweiser HW, et al: The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas. Cancer Genet Cytogenet 88: 136-140, 1996
9. Chresta CM, Masters JRW, Hickman JA: Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. Cancer Res 56:1834-1841, 1996
10. D'Amico AV, McKenna WG: Apoptosis and a re-investigation of the biologic basis for cancer therapy. Radiother Oncol 33: 3-10, 1994
11. Dole M, Nuñez G, Merchant AK, et al: bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma. Cancer Res 54: 3253-3259, 1994
12. Frankel RH, Bayona W, Koslow M, et al: p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency. Cancer Res 52:1427-1433, 1992
13. Gomez-Manzano C, Fueyo J, Kyritsis AP, et al: Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 56:694-699, 1996
14. 1-phase checkpoint. Radiat Res 145:289-298, 1996
15. Hickman JA, Potten CS, Merritt AJ, et al: Apoptosis and cancer chemotherapy. Phil Trans R Soc Lond B Biol Sci 345: 319-325, 1994
16. Hockenbery DM: bcl-2 in cancer, development and apoptosis. J Cell Sci 18 (Suppl):51-55, 1994
17. Ikemoto H, Tani E, Matsumoto T, et al: Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor. J Neurosurg 83:1008-1016, 1995
18. Iwadate Y, Fujimoto S, Tagawa M, et al: Association of p53 gene mutation with decreased chemosensitivity in human malignant gliomas. Int J Cancer 69:236-240, 1996
19. Kerr JFR, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257, 1972
20. Knudson CM, Tung KSK, Tourtellotte WG, et al: Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96-99, 1995
21. Kondo S, Barnett GH, Hara H, et al: MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis. Oncogene 10:2001-2006, 1995
22. Lowe SW, Ruley HE, Jacks T, et al: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967, 1993
23. Meijerink JPP, Mensink EJBM, Wang K, et al: Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood 91:2991-2997, 1998
24. Merritt AJ, Potten CS, Kemp CJ, et al: The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 54: 614-617, 1994
25. Miyashita T, Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299, 1995
26. Motoyama N, Wang F, Roth KA, et al: Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267:1506-1510, 1995
27. Murai N, Ueba T, Takahashi JA, et al: Apoptosis of human glioma cells in vitro and in vivo induced by a neutralizing antibody against human basic fibroblast growth factor. J Neurosurg 85:1072-1077, 1996
28. Oltvai ZN, Korsmeyer SJ: Checkpoints of dueling dimers foil death wishes. Cell 79:189-192, 1994
29. Oltvai ZN, Milliman CL, Korsmeyer SJ: bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programed cell death. Cell 74:609-619, 1993
30. Rubio MP, von Deimling A, Yandell DW, et al: Accumulation of wild type p53 protein in human astrocytomas. Cancer Res 53:3465-3467, 1993
31. Ryan KM, Vousden KH: Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest. Mol Cell Biol 18:3692-3698, 1998
32. Sakakura C, Sweeney EA, Shirahama T, et al: Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis. Int J Cancer 67:101-105, 1996
33. Strobel T, Swanson L, Korsmeyer S, et al: BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc Natl Acad Sci USA 93:14094-14099, 1996
34. Tsujimoto Y, Finger LR, Yunis J, et al: Cloning of the chromosome breakpoint of neoplastic B cells with the t(1;18) chromosome translocation. Science 226:1097-1099, 1984
35. Van Meir EG, Kikuchi T, Tada M, et al: Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res 54:649-652, 1994
36. Vaux DL, Cory S, Adams JM: Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442, 1988
37. Vogelbaum MA, Tong JX, Higashikubo R, et al: Transfection of C6 glioma cells with the bax gene and increased sensitivity to treatment with cytosine arabinoside. J Neurosurg 88: 99-105, 1998
38. Vogelbaum MA, Tong JX, Rich KM: Developmental regulation of apoptosis in dorsal root ganglion neurons. J Neurosci 18:8928-8935, 1998
39. von Deimling A, Louis DN, Wiestler OD: Molecular pathways in the formation of gliomas. Glia 15:328-338, 1995
40. Wagener C, Bargou RC, Daniel PT, et al: Induction of the death-promoting gene bax-α sensitizes cultured breast-cancer cells to drug-induced apoptosis. Int J Cancer 67:138-141, 1996
41. Weller M, Malipiero U, Aguzzi A, et al: Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. J Clin Invest 95:2633-2643, 1995
42. Wolter KG, Hsu YT, Smith CL, et al: Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139: 1281-1292, 1997
43. Yount GL, Haas-Kogan DA, Vidair CA, et al: Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells. Cancer Res 56:500-506, 1996