Regulation of gene expression by natural antisense RNA transcripts

Neurochemistry International

Volumn 31, Issue 3, 1997, Pages 379-392

  Knee, Rai ^a   Murphy, Paul R ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BASIC FIBROBLAST GROWTH FACTOR; COMPLEMENTARY RNA; DOUBLE STRANDED RNA; GONADORELIN; MESSENGER RNA; RNA BINDING PROTEIN; SOMATOMEDIN B; THYROID HORMONE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EUKARYOTIC CELL; GENE EXPRESSION REGULATION; HOMEOBOX; NONHUMAN; ONCOGENE C ERB; ONCOGENE C MYC; OPEN READING FRAME; PRIORITY JOURNAL; PROKARYOTE; PROTO ONCOGENE; REVIEW; RNA DEGRADATION; RNA EDITING; RNA PROCESSING; RNA TRANSLATION; RNA TRANSPORT; SIGNAL TRANSDUCTION;

EUKARYOTA; PROKARYOTA;

EID: 0030757318     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(96)00108-8     Document Type: Article

References (119)

1. Adelman, J. P., Bond, C. T., Douglass, J. and Herbert, E. (1987) Two mammalian genes transcribed from opposite strands of the same DNA Locus. Science 235, 1514-1717.
2. Adelman, J. P., Mason, A. J., Hayflick, J. S. and Seeburg, P. H. (1986) Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat. Proc. Natl. Acad. Sci. U.S.A. 83, 179-183.
3. Armstrong, B. C. and Krystal, G. W. (1992) Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc. Cell. Growth Diff. 3, 385-390.
4. Arrigo, S. J. and Chen, I. S. Y. (1991) Rev is necessary for translation but cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs. Genes Devl. 3, 808-819.
5. Baccarini, P., Fiorentino, M., D'Errico, A., Mancini, A. M. and Grigioni, W. F. (1993) Detection of anti-sense transcripts of the insulin-like growth factor-2 gene in Wilms' tumor. Am. J. Pathol. 143(6), 1535-1542.
6. Basilico, C. and Moscatelli, D. (1992) The FGF family of growth factors and oncogenes. Adv. Cancer Res. 59, 115-165.
7. Bass, B. L. and Weintraub, H. (1987) A developmentally regulated activity that unwinds RNA duplexes. Cell 48, 607-613.
8. Bass, B. L. and Weintraub, H. (1988) An unwinding activity that covalently modifies its double stranded RNA substrate. Cell 55, 1089-1098.
9. Bedford, M., Arman, E., Orr-Urtreger, A. and Lonai, P. (1995) Analysis of the Hoxd-3 gene: structure and localization of its sense and natural antisense transcripts. DNA Cell Biol. 14(4), 295-304.
10. Bentley, D. L. and Groudine, M. (1986) A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells. Nature 321, 702-706.
11. Bond, C. T., Hayflick, J. S., Seeburg, P. H. and Adelman, J. P. (1989) The rat gonadotropin-releasing hormone: SH locus: structure and hypothalamic expression. Mol. Endocrinol. 3(8), 1257-1262.
12. Borja, A. Z. M., Meijers, C. and Zeller, L. (1993) Expression of alternatively spliced bFGF first coding exons and antisense mRNAs during chicken embryogenesis. Devl. Biol. 157, 110-118.
13. Burbelo, P. B., Martin, G. R. and Yamada, Y. (1988) α(IV) and α2(IV) collagen genes are regulated by a bidirectional promoter and shared enhancer. Proc. Natl. Acad. Sci. U.S.A. 85, 9679-9682.
14. Burglin, T. R. (1988) The yeast regulatory gene PHO2 encodes a homeobox. Cell 53, 339-340.
15. Celano, P., Baylin, S. B. and Casero, J. R. A. (1989) Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells. J. Biol. Chem. 264(15), 8922-8927.
16. Celano, P., Baylin, S. B., Giardiello, F. M., Nelkin, B. D. and Casero, J. R. A. (1988) Effect of polyamine depletion on c-myc expression in human colon carcinoma cells. J. Biol. Chem. 263(12), 5491-5494.
17. Celano, P., Berchtold, C., Kizer, D., Weeraratna, A., Nelkin, B., Baylin, S. and Casero, R. (1992) Characterization of an endogenous RNA transcript with homology to the antisense strand of the human c-myc gene. J. Biol. Chem. 267(21), 15092-15096.
18. Chen, C., Malone, T., Beckendorf, S. K. and Davus, R. L. (1987) A least two genes reside within a large intron of the dunce gene of Drosophilia. Nature 329, 712-724.
19. Cochrane, A. W., Jones, K. S., Beidas, S., Dillon, P. J., Skalka, A. M. and Rosen, C. A. (1991) Identification and characterization of intragenic sequences which repress human immunodeficency virus structural gene expression. J. Virol. 65, 5305-5313.
20. Condie, B. G. and Capecchi, M. R. (1993) Mice homozygous for a targeted disruptions of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development 119, 579-595.
21. Coulier, F., Ollendorf, V., Marics, I., Rosnet, O., Batoz, M., Planche, J., Marchetto, S., Pebusque, M.-J., DeLapeyriere, O. and Birnbaum, D. (1991) The FGF6 gene within the FGF multigene family. Ann. NY Acad. Sci. 638, 53-61.
22. Denhardt, D. T. (1992) Mechanism of action of antisense RNA: sometime inhibition of transcription, processing, transport, or translation. Ann. NY Acad. Sci. 660, 70-76.
23. DePinho, R. A., Hatton, K. S., Tesfaye, A., Yancopoulos, G. D. and Alt, F. W. (1987) The human myc gene family: stucture and activity of L-myc and an L-myc pseudogene. Genes Devl. 1, 1311-1326.
24. Dolle, P., Izpisua-Belmonte, J.-C., Falkenstein, H., Renucci, A. and Duboule, D. (1989) Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation. Nature 342, 767-772.
25. van Duin, M., de Wit, M. J., Odijk, H., Westerveld, A., Yasui, A., Koken, M. H. M., Hoeijmakers, J. H. J. and Bootsma, D. (1986) Molecular characterization of the human excision repair gene ERCC-1; cDNA cloning and amino acid homology with the yeast DNA repair gene RAD 10. Cell 44, 913-923.
26. van Duin, M., Koken, M. H. M., van den Tol, J., ten Dijke, P., Odijk, H., Westerveld, A., Bootsma, D., Hoeijmakers, J. H. J. (1987) Genomic characterization of the human excision repair gene ERCC-1. Nucl. Acids Res. 22, 9195-9213.
27. van Duin, M., van den Tol, J., Hoeijmakers, J. H. J., Bootsma, D., Rupp, I. P., Reynolds, P., Prakash, L. and Prakash, S. (1989) Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair region. Mol. Cell. Biol. 9(4), 1794-1798.
28. Eguchi, Y., Itoh, T. and Tomizawa, J. (1991) Antisense RNA. Annu. Rev. Biochem. 60, 631-652.
29. Ellerbrok, H., Serpente, N., Pancino, G., Vanhee, C., D'Auriol, L., Sitbon, M. and Vaquero, C. (1993) Sequences in the rev-responsive element responsible for premature translational arrest in the human-immunodeficiency-virus-type-1 envelope. Eur. J. Biochem. 216, 459-467.
30. Haines, D. S., Strauss, K. I. and Gillespie, D. H. (1991) Cellular response to double-stranded RNA. J. Cell. Biochem. 46(1), 9-20.
31. Han, K. and Manly, J. L. (1993) Functional domains of the Drosophila engrailed protein. EMBO J. 12, 2723-2733.
32. Harding, H. P. and Lazar, M. A. (1993) The orphan receptor Rev-ErbAa activates transcription via a novel response element. Mol. Cell. Biol. 13(5), 3113-3121.
33. Haselbacher, G. K., Irminger, J. C., Zapf, J., Ziegler, W. H. and Humbel, R. E. (1987) Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms' tumors: expression at the mRNA and protein level. Proc. Natl. Acad. Sci. U.S.A. 84, 1104-1106.
34. Hatano, M., Roberts, C. W. M., Minden, M., Crist, V. W. and Korsmeyer, S. J. (1991) Deregulation of a homeobox gene, Hox11, by the t(10;14) in T cell leukemia. Science 253, 79-82.
35. Henikoff, S., Keene, M. A., Fechtel, K. and Fristrom, J. W. (1986) Gene within a gene: nested Drosophila genes encode unrelated proteins on opposite DNA strands. Cell 44, 33-42.
36. Heywood, S. M. (1986) tcRNA as a naturally occurring antisense RNA in eukaryotes. Nucl. Acids Res. 14, 6771.
37. Higuchi, M., Single, F. N., Kohler, M., Sommer, B., Sprengel, R. and Seeburg, P. H. (1993) RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell 75, 1361-1370.
38. Hill, D. J. (1990) Relative abundance and molecular size of immunoreactive insulin-like growth factor I and II in human fetal tissues. Early Human Devl. 21, 49-58.
39. Hirling, H., Scheffner, M., Restle, T. and Stahl, H. (1989) RNA helicase activity associated with the human p68 protein. Nature 339, 562-564.
40. Hjalt, T. A. and Wagner, E. G. H. (1995) Bulged-out nucleotides in antisense RNA are required for rapid target RNA binding in vitro and inhibition in vivo. Nucl. Acids Res. 23(4), 580-587.
41. Hodin, R. A., Lazar, M. A., Wintman, B. I., Darting, D. S., Koenig, R. J., Larsen, P. R., Moore, D. D. and Chin, W. W. (1989) Identification of a thyroid hormone receptor that is pituitary-specific. Science 244, 76-79.
42. Hsieh-Li, H. M., Witte, D. P., Weinstein, M., Branford, W., Li, H., Small, K. and Potter, S. S. (1995) Hoxa11 structure, extensive antisense transcription, and function in male and female fertility. Development 121, 1373-1385.
43. Huang, J. X., Potts, J. D., Vincent, E. B., Weeks, D. L. and Runyan, R. B. (1995) Mechanisms of cell transformation in the embryonic heart. Ann. NY Acad. Sci. 752, 317-330.
44. Irminger, J. C., Schoenle, E. J., Briner, J. and Humbel, R. E. (1989) Structural alteration of the insulin-like factor II gene in Wilms' tumor. Eur. J. Pediatr. 148, 620-623.
45. Jakubowski, M. and Roberts, J. L. (1994) Processing of gonadotropin-releasing hormone gene transcripts in the rat brain. J. Biol. Chem. 269(6), 4078-4083.
46. Kelly, A. C., Rodgers, A., Dong, K. W., Barrezueta, N. X., Blum, M. and Roberts, J. L. (1991) Gonadotropin-releasing hormone and chorionic gonadotropin gene expression in human placental development. DNA Cell Biol. 10, 411-421.
47. Khokha, R., Waterhouse, P., Yagel, S., Lala, P. K., Overall, C. A., Norton, G. and Denhardt, D. T. (1989) Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells. Science 243, 947-950.
48. Kim, U. and Nishikura, K. (1993) Double-stranded RNA adenosine deaminase as a potential mammalian editing factor. Semin. Cell. Biol. 4, 285-293.
49. Kimelman, D. and Kirschner, M. (1987) Synergistic induction of mesoderm by FGF and TGF-b and the identification of an mRNA coding for FGF in the early Xenopus embryo. Cell 51, 869-877.
50. Kimelman, D., Abraham, J., Haaparanta, T., Palisi, T. and Kirschner, M. (1988) The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer. Science 242, 1053-1056.
51. Kimelman, D. and Kirschner, M. W. (1989) An antisense messenger RNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes. Cell 59, 687-696.
52. Kindy, M. S., McCormack, J. E., Buckler, A. J., Levine, R. A. and Sonenshein, G. E. (1987) Independent regulation of the transcription of the two strands of the c-myc gene. Mol. Cell. Biol. 7, 2857-2862.
53. Knee, R. S., Pitcher, S. E. and Murphy, P. R. (1994) Basic fibroblast growth factor sense (FGF) and antisense (gfg) RNA transcripts are expressed in unfertilized human oocytes and in differentiated adult tissues. Biochem, Biophys. Res. Commun. 205, 577-583.
54. Knee R., Li A. W. and Murphy P. R. (1996) Isolation and characterization of the rat FGF-2 antisense cDNA. 78th Annual Meeting of the Endocrine Society, San Francisco, CA, June 12-15.
55. Kohl, N. E., Kanda, N., Schreck, R., Bruns, G., Latt, S. and Gilbert, F. (1983) Transposition and amplification of oncogene related sequence in human neuroblastomas. Cell 35, 359-367.
56. Konarska, M. M., Padgett, R. A. and Sharp, P. A. (1985) Trans splicing of mRNA precursors in vitro. Cell 42, 165-171.
57. Koonin, E. V. (1993) A highly conserved sequence motif defining the family of MutT-related proteins from eubacteria, eukaryotes and viruses. Nucl. Acids Res. 21(20), 4847.
58. Krinke, L. and Wulff, D. L. (1987) OOP RNA, produced from multicopy plasmid, inhibits 1 cII gene expression through an RNase III-dependent mechanism. Genes Devl. 1, 1005-1013.
59. Krystal, G., Birrer, M., Way, J., Nau, M., Sausville, E., Thompson, C., Minna, J. and Battey, J. (1988) Multiple mechanisms of transcriptional regulation of the myc gene family in small-cell lung cancer. Mol. Cell. Biol. 8(8), 3373-3381.
60. Krystal, G. W., Armstrong, B. C. and Battey, J. F. (1990) N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts. Mol. Cell. Biol. 10(8), 4180-4191.
61. Lacatena, R. M. and Cesareni, G. (1981) Base pairing of RNA I with its complementary sequence in the primer precursor inhibits Co1E1 replication. Nature 294, 623-626.
62. Lazar, M. A., Hodin, R. A., Darling, D. S. and Chin, W. W. (1989) A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbAa transcriptional unit. Mol. Cell. Biol. 9(3), 1128-1136.
63. Levinson, B., Kenwrick, S., Lakich, D., Hammonds, G. J. and Gitschier, J. (1990) A transcribed gene in an intron of the human factor VIII gene. Genomics 7(1), 1-11.
64. Li, A. W., Seyoum, G., Shiu, R. P. C. and Murphy, P. R. (1996a) Expression of the rat bFGF antisense RNA transcript is tissue-specific and developmentally regulated. Mo. Cell. Endocrinol. 118, 113-123.
65. Li, A. W., Too, C. K. L. and Murphy, P. R. (1996b) The basic fibroblast growth factor (FGF-2) antisense RNA (GFG) is translated into a MutT-related protein in vivo. Biochem. Biophys. Res. Commun. 223, 19-23.
66. Linton, J. P., Yen, J.-Y. J., Selby, E., Chen, Z., Chinsky, J. M., Liu, K., Kellems, R. E. and Crouse, G. F. (1989) Dual bidirectional promoters at the mouse dhfr locus: cloning and characterization of two mRNA classes of the divergently transcribed Rep-1 gene. Mol. Cell. Biol. 9, 3058-3072.
67. Lisziewicz, J., Sun, D., Weichold, F. F., Thierry, A. R., Lusso, P., Tang, J., Gallo, R. C. and Agrawal, S. (1994) Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells. Proc. Natl. Acad. Sci. U.S.A. 91(17), 7942-7946.
68. Makela, T. P., Saksela, K. and Alitalo, K. (1989) Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene. Mol. Cell. Biol. 9, 1545-1552.
69. Manche, L., Green, S. R., Schmedt, C. and Matthews, M. B. (1992) Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol. Cell. Biol. 12(11), 5238-5248.
70. Masters, M., March, J. B., Oliver, I. R. and Collins, J. F. (1990) A possible role for the pcnB gene product of Escherichia coli in modulating RNA:RNA interactions, Mol. Gen. Genet. 220(2), 341-344.
71. McGinnis, W. and Krumlauf, R. (1992) Homeobox genes and axial patterning. Cell 68, 283-302.
72. Melcher, T., Maas, S., Higuchi, M., Keller, W. and Seeburg, P. H. (1995) Editing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR-B pre-mRNA in vitro reveals site-selective adenosine to inosine conversion. J. Biol. Chem. 270(15), 8566-8570.
73. Merino, E., Balbas, P., Puente, J. L. and Bolivar, F. (1994) Antisense overlapping open reading frames in genes from bacteria to humans. Nucl. Acids Res. 22, 1903-1908.
74. Micheal, N. L., Vahey, M. T., d'Arcy, L., Ehrenberg, P. K., Mosca, J. D., Pappaport, J. and Redfield, R. R. (1994) Negative-strand RNA transcripts are produced in human immunodeficiency virus type 1-infected cells and patients by a novel promoter downregulated by Tat. J. Virol. 68(2), 979-987.
75. Miller, R. H. (1988) Human immunodeficiency virus may encode a novel protein on the genomic DNA plus strand. Science 239, 1420-1422.
76. Mitchell, P. J., Carothers, M., Han, J. H., Harding, J. D., Kas, E., Venolia, L. and Chasin, L. A. (1986) Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5′ region of the CHO dhfr gene. Mol. Cell. Biol. 6, 425-440.
77. Mitchell, P. J. and Tjian, R. (1989) Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245, 371-378.
78. Miyajima, N., Horiuchi, R., Shibuya, Y., Fukushige, S., Mutsubara, K., Toyoshima, K. and Yamamoto, T. (1989) Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 57, 31-39.
79. Munroe, S. H. and Lazar, M. A. (1991) Inhibition of c-erbA mRNA splicing by a naturally occurring antisense RNA. J. Biol. Chem. 266(33), 22083-22086.
80. Murphy, P. R. and Knee, R. S. (1994) Identification and characterization of an antisense RNA transcript (gfg) from the basic fibroblast growth factor gene in human and rat cells. Mol. Endocrinol. 8(7), 852-859.
81. Murphy, P. R., Guo, J. Z. and Friesen, H. G. (1990) Messenger RNA stabilization accounts for elevated basic fibroblast growth factor transcript levels in a human astrocytoma cell line. Mol. Endocrinol. 4(2), 196-200.
82. Murphy, P. R., Sato, R., Sato, Y. and Friesen, H. G. (1988) Fibroblast growth factor mRNA expression in a human astrocytoma cell line: regulation by serum and cell density. Mol. Endocrinol. 2(7), 591-598.
83. Murray, M. B., Zilz, N. D., McCreary, N. L., MacDonald, M. J. and Towle, H. C. (1988) Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors. J. Biol. Chem. 263(25), 12770-12777.
84. Nakai, A., Sakurai, A., Bell, G. I. and DeGroot, L. J. (1988) Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues. Mol. Endocrinol. 2, 1087-1092.
85. Nau, M. M., Brooks, B. J., Battey, J. F., Sausville, E. A., Gazdar, A. F., Kirsh, I. R., McBride, O. W., Bertness, V., Hollis, G. F. and Minna, J. D. (1985) L-myc, a new wye-related gene amplified and expressed in human small cell lung cancer. Nature 318, 69-73.
86. Nellen, W. and Lichtenstein, C. (1993) What makes an mRNA anti-sense-itive? TIBS 18, 419-423.
87. Nepveu, A. and Marcu, K. B. (1986) Intragenic pausing and anti-sense transcription within the murine c-myc locus. EMBO J. 5, 2859-2865.
88. Novick, R., Jordanescu, S., Projan, S., Kornblum, J. and Edelman, I. (1989) pT181 plasmid replication is regulated by a countertranscript-driven transcriptional attenuator. Cell 59, 395.
89. Patterson, J. B. and Samuel, C. E. (1995) Expression and regulation by interferon of a double-stranded RNA-specific adenosine deaminase from human cells: evidence of two forms of the deaminase. Mol. Cell. Biol. 15(10), 5376-5388.
90. Pontius, B. W. and Berg, P. (1990) Renaturation of complementary DNA strands mediated by purified mammalian heterogeneous nuclear ribonucleoprotein A1 protein: implications for a mechanism for rapid molecular assembly. Proc. Natl. Acad. Sci. U.S.A. 87, 8403-8407.
91. Potts, J. D., Vincent, E. B., Runyan, R. B. and Weeks, D. L. (1992) Sense and antisense TGF beta 3 mRNA levels correlate with cardiac valve induction. Devl. Dynamics 193(4), 340-345.
92. Powell, P. P., Finklestein, S. P., Dionne, C. A., Jaye, M. and Klagsbrun, M. (1991) Temporal, differential and regional expression of messenger RNA for basic fibroblast growth factor in the developing and adult rat brain. Mol. Brain Res. 11(1), 71-77.
93. Ray, B. K., Lawson, T. G., Kramer, J. C., Cladaras, M. H., Grifo, J. A., Abramson, R. D., Merrick, W. C. and Thach, R. E. (1985) ATP-dependent onwinding of messenger RNA structure by eukaryotic. J. Biol. Chem. 260, 7651-7658.
94. Rebagliati, M. R. and Melton, D. A. (1987) Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity. Cell 48, 599-605.
95. Rivkin, M., Rosen, K. M. and Villa-Komaroff, L. (1993) Identification of an antisense transcript from the IGF-II locus in mouse. Mol. Reprod. Devl. 35, 394-397.
96. Rotwein, P. and Hall, L. (1990) Evolution of insulin-like growth factor II: characterization of the mouse IGF-II gene and identification of two pseudo-exons. DNA Cell Biol. 9, 725-735.
97. Runyan, R. B., Potts, J. D. and Weeks, D. L. (1992) TGF-beta 3-mediated tissue interaction during embryonic heart development. Mol. Reprod. Devl. 32(2), 152-159.
98. Saccomanno, L. and Bass, B. L. (1994) The cytoplasm of Xenopus oocytes contains a factor that protects double-stranded RNA from adenosine-to-inosine modification. Mol. Cell. Biol. 14(8), 5425-5432.
99. Savage, M. P. and Fallon, J. F. (1995) FGF-2 mRNA and its antisense message are expressed in a developmentally specific manner in the chick limb bud and mesonephros. Devl. Dynamics 202(4), 343-353.
100. Savage, M. P., Hart, C. E., Riley, B. B., Sasse, J., Olwin, B. B. and Fallon, J. F. (1993) Distribution of FGF-2 suggests it has a role in chick limb bud growth. Devl. Dynamics 198(3), 159-170.
101. Schwab, M., Alitalo, K., Klempnauer, L., Varmus, H., Bishop, J., Gilbert, F., Brodeur, G., Goldstein, M. and Trent, J. (1983) Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumor. Nature 305, 245-248.
102. Simons, R. W. (1993) The control of prokaryotic and eukaryotic gene expression by naturally occurring antisense RNA. In Antisense Research and Applications (Crooke S. T. and LeBlew B. Eds), pp. 97-124. CRC Press Inc., Boca Raton.
103. Small, K. M. and Potter, S. S. (1993) Homeotic transformation and limb defects in Hoxa11 mutant mice. Genes Devl. 7, 2318-2328.
104. Sommer, B., Kohler, M., Sprengel, R. and Seeburg, P. H. (1991) RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67, 11-19.
105. Stolt, P. and Zillig, W. (1993) Antisense RNA mediates transcriptional processing in an archaebacterium, indicating a novel kind of RNase activity. Mol. Microbiol. 7(6), 875-882.
106. Sussenbach, J. S. (1989) The gene structure of the insulin-like growth factor family. Prog. Growth Fact. Res. 1, 33-48.
107. Swiatek, P. J. and Gridley, T. (1993) Perinatal lethality and defects in hindbrain development in mice homozygous for a targetted mutation of the zinc finger gene Krox20. Genes Devl. 7, 2071-2084.
108. Taylor, E. R., Seleiro, E. A. P. and Brickell, P. M. (1991) Identification of antisense transcripts of the chicken insulin-like growth factor-II gene. J. Mol. Endocrinol. 7, 145-154.
109. Tetart, F. and Bouche, J.-P. (1992) Regulation of the expression of the cell-cycle gene ftsZ by DicF antisense RNA: division does not require a fixed number of FtsZ molecules. Mol. Microbiol. 6, 615-620.
110. Tosic, M., Roach, A., de Rivaz, J. C., Dolivo, M. and Matthieu, J. M. (1990) Post-transcriptional events are responsible for low expression of myelin basic protein in myelin deficient mice: role of natural antisense RNA. EMBO J. 9(2), 401-406.
111. + individuals. Virology 206, 196-202.
112. Volk, R., Koster, M., Poting, A., Hartmann, L. and Knochel, W. (1989) An antisense transcript from the Xenopus laevis bFGF gene coding for an evolutionarily conserved 24 kd protein. EMBO J. 8(10), 2983-2988.
113. Wagner, E. G. H. and Simons, R. S. (1994) Antisense RNA control in bacteria, phages, and plasmids. Annu. Rev. Microbiol. 48, 713-742.
114. Wallace, M. R., Marchuk, D. A., Adensen, L. B., Letcher, R., Odeh, H. M., Saulino, A. M., Fountain, J. W., Brereton, A., Nicholson, J., Mitchell, A. L., Brownstein, B. H. and Collins, P. S. (1990) Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science 249, 181-186.
115. Weinberger, C., Thompson, C. C., Ong, E. S., Lebo, R., Gruol, D. J. and Evans, R. M. (1986) The c-erb-A gene encodes a thyroid hormone receptor. Nature 324, 641-646.
116. Williams, T. and Fried, M. (1986) A mouse locus at which transcription from both DNA strands produces mRNAs complementary at their 3′ ends. Nature 322, 275-279.
117. Wilson, T. M., Yu-Lee, L. and Kelley, M. R. (1995) Coordinate gene expression of luteinizing hormone-releasing hormone (LHRH) and the LHRH-receptor after prolactin stimulation in the rat Nb2 T-cell line: implications for a role in immunomodulation and cell cycle gene expression. Mol. Endocrinol. 9(1), 44-53.
118. Woolf, T. M., Melton, D. A. and Jennings, C. G. B. (1992) Specificity of antisense oligonucleotides in vivo. Proc. Natl. Acad. Sci. U.S.A. 89, 7305-7309.
119. Yokouchi, Y., Sasaki, H. and Kuroiwa, A. (1991) Homeobox expression correlated with the process of limb cartilage development. Nature 353, 443-445.