The effect of caspase-inhibitors on radiation induced apoptosis in human peripheral blood lymphocytes: An electron microscopic approach

Apoptosis

Volumn 4, Issue 6, 1999, Pages 449-454

  Cornelissen, M ^b   Vral, A ^c   Thierens, H ^a   De Ridder, L ^c  

^a GHENT UNIVERSITY   (Belgium)

^b Laboratory of Histology   (Belgium)

^c NONE

Author keywords

Apoptosis; Caspase inhibitors; Electron microscopy; Ionizing radiation; Lymphocytes

Indexed keywords

CASPASE; CASPASE INHIBITOR; COBALT;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL ULTRASTRUCTURE; CHROMATIN CONDENSATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; GAMMA RADIATION; HUMAN; HUMAN CELL; IONIZING RADIATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

EID: 0032779866     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009652426259     Document Type: Article

References (24)

1. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1974; 26: 239-257.
2. Alnemri ES, Livingston DJ, Nicholson DW, et al. Human ICE/CED-3 protease nomenclature. Cell 1996; 87: 171.
3. Cohen JM. Caspases: the executioners of apoptosis. Biochem J 1997; 326: 1-16.
4. Cryns VL, Yuan J. The cutting edge: caspases in apoptosis and disease. In: Lockshin R, Zaker Z, Tilly J, eds. When Cells Die. New York: Wiley-Liss 1998: 177-210.
5. Darzynkiewicz Z, Juan G, Li X, Corczyca W, Murakami T, Traganos F. Cytometry in cell necrobiology: analysis of apoptotic and accidental cell death (necrosis). Cytometry 27: 1-20.
6. Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980; 98: 251-306.
7. Wyllie AH, Morris RG, Smith AL, Dunlop D. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J of Pathol 1984; 142: 67-77.
8. Cornelissen M, Vral A, Thierens H, Louagie H, de Ridder L. Radiation-induced apoptosis and necrosis in human peripheral blood lymphocytes after moderate and high doses of γ-rays and fast neutrons: an electron microscopic approach. Scanning Microscopy, in press.
9. Louagie H, Cornelissen M, Philippé J, Vral A, Thierens H, de Ridder L. Flow cytometric scoring of apoptosis compared to electron microscopy in γ-irradiated lymphocytes. Cell Biol Int 1988; 2: 277-283.
10. Akagi Y, Ito K, Sawada S. Radiation-induced apoptosis and necrosis in Molt-4 cells: a study of dose-effect relationships and their modification. Int J Radiat Biol 1993; 645: 47-56.
11. Nakano H, Shinohara K. X-ray-induced cell death: apoptosis and necrosis. Rad Res 1994; 140: 1-9.
12. Longthorne V, Williams G. Caspase activity is required for commitment to Fas-mediated apoptosis. EMBO J 1997; 16: 3805-3812.
13. Green D, Kroemer G. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol 1998; 8: 267-271.
14. Brunet C, Gunby R, Benson R, Hickman J, Watson A, Brady G. Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers. Cell Death and Differentiation 1998; 5: 107-115.
15. De Maria R, Lenti L, Malisan F, et al. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. Science 1997; 277: 1652-1655.
16. Amarante-Mendes G, Finucane D, Martin S, Cotter T, Salvesen G, Green D. Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death. Cell Death and Differentiation 1998; 5: 298-306.
17. Trapani JA, Jans DA, Jans PJ, Smyth MJ, Browne KA, Sutton VR . Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent. J Biol Chem 1998; 273: 27934-27938.
18. Hampton MB, Fadeel B, Orenius S. Redox regulation of the caspases during apoptosis. Ann N Y Acad Sci 1988; 854: 328-335.
19. Quignon F, De Bels F, Koken M, Feunteun J, Ameisen JC, de The H. PML induces a novel caspase-independent death process. Nat Genet 1998; 20: 259-265.
20. Berndt C, Mopps B, Angermuller S, Gierschik P, Krammer PH. CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells. Proc Natl Acad Sci USA 1998, 95: 12556-12561.
21. Lavoie JN, Nguyen M, Marcellus RC, Branton PE, Shore GC. E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk. J Cell Biol 1988; 140: 637-645.
22. Ojcius DM, Souque P, Perfettini JL, Dautry-Varsat A. Apoptosis of epithelial cells and macrophages due to infection with the obligate intracellular pathogen Chlamydia psittaci. J Immunol 1998; 161: 4220-4226.
23. Kurokawa H, Nishio K, Fukumoto H, Tomonari A, Suzuki T, Saijo N. Alteration of caspase-3 (CPP32/Yama/apopain) in wild-type MCF-7, breast cancer cells. Oncol Rep 1999; 6: 33-37.
24. Hallan E, Blomhoff H, Smeland E, Lomo L. Involvement of Ice (Caspase) family in γ-radiation-induced apoptosis of normal B lymphocytes. Scand J Immunol 1997; 46: 601-608.