Antazoline increases insulin secretion and improves glucose tolerance in rats and dogs

European Journal of Pharmacology

Volumn 324, Issue 2-3, 1997, Pages 233-239

  Berdeu, Daniel ^a   Puech, Raymond ^b   Ribes, Gérard ^c   Loubatières Mariani, Marie Madeleine ^a   Bertrand, Gyslaine ^b  

^a Institute of Biology   (France)

^b INSERM   (France)

^c UMR 9921 du CNRS   (France)

Author keywords

Antazoline; Dog; Glucose tolerance; Imidazoline; Insulin secretion; Pancreas; Rat; Somatostatin secretion

Indexed keywords

ANTAZOLINE;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DOG; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; INTRAVENOUS DRUG ADMINISTRATION; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RAT;

EID: 0030908947     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00126-X     Document Type: Article

References (29)

1. Ahrén, B., Lundquist, I., 1985. Effects of α-adrenoceptor blockade by phentolamine on basal and stimulated insulin secretion in the mouse. Acta Physiol. Scand. 125, 211-217.
2. Ahrén, B., Paquette, T.L., Taborsky, G.J., 1986. Effect and mechanism of vagal nerve stimulation on somatostatin secretion in dogs. Am. J. Physiol. 250, E212-217.
3. Berdeu, D., Gross, R., Ribes, G., Loubatières-Mariani, M.M., Bertrand, G., 1994. Effects of imidazolines and derivatives on insulin secretion and vascular resistance in perfused rat pancreas. Eur. J. Pharmacol. 254, 119-125.
4. Berdeu, D., Gross, R., Puech, R., Loubatières-Mariani, M.M., Bertrand, G., 1995. Evidence for different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur. J. Pharmacol. 275, 91-98.
5. Broadstone, V.L., Pfeifer, M.A., Bajaj, V., Stagner, J.I., Samols, E., 1987. Alpha-adrenergic blockade improves glucose-potentiated insulin secretion in non-insulin-dependent diabetes mellitus. Diabetes 36, 932-937.
6. Cerasi, E., Efendic, S., Luft, R., 1969. Role of adrenergic receptors in glucose-induced insulin secretion in man. Lancet ii, 301-302.
7. Chan, S.L.F., Morgan, N.G., 1990. Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels. Eur. J. Pharmacol. 176, 97-101.
8. +ATP channels in insulin-secreting cells. Eur. J. Pharmacol. 204, 41-48.
9. Chan, S.L.F., Stillings, M.R., Morgan, N.G., 1991b. Mechanisms involved in stimulation of insulin secretion by the hypoglycaemic alpha-adrenergic antagonist, DG-5128. Biochem. Biophys. Res. Commun. 176, 1545-1551.
10. Herbert, V., Law, K.S., Gottlieb, C.W., Bleicher, S.J., 1965. Coated charcoal immunoassay of insulin. J. Clin. Endocrinol. 25, 1375-1384.
11. Hermansen, K., 1980. Secretion of somatostatin from the normal and diabetic pancreas. Studies in vitro. Diabetologia 19, 492-504.
12. 2-adrenoceptors on endogenous adrenaline-induced inhibition of insulin release. Eur. J. Pharmacol. 294, 117-123.
13. 2-adrenoceptor blockade does not enhance glucose-evoked insulin release. Eur. J. Pharmacol. 187, 531-536.
14. + channels in pancreatic β-cells. Br. J. Pharmacol. 107, 8-14.
15. Kawazu, S., Suzuki, M., Negishi, K., Watanabe, T., Ishii, J., 1987. Studies of midaglizole (DG-5128). A new type of oral hypoglycaemic drug in healthy subjects. Diabetes 36, 216-220.
16. Michel, M.C., Ernsberger, P., 1992. Keeping an eye on the I site: imidazoline-preferring receptors. Trends Pharmacol. Sci. 13, 369-370.
17. Morgan, N.G., Chan, S.L.F., Brown, C.A., Tsoli, E., 1995. Characterization of the imidazoline binding site involved in regulation of insulin secretion. Ann. NY Acad. Sci. 763, 361-373.
18. 2-Adrenoceptors modulating insulin release from isolated pancreatic islets. Naunyn-Schmiedeberg's Arch. Pharmacol. 313, 151-153.
19. 2-Adrenoceptor blockade does not enhance glucose-induced insulin release in normal subjects or patients with non insulin-dependent diabetes. J. Clin. Endocrinol. Metab. 67, 1054-1059.
20. + channels in mouse pancreatic β-cells. Br. J. Pharmacol. 101, 115-120.
21. Ribes, G., Blayac, J.P., Loubatières-Mariani, M.M., 1983. Differences between the effects of adrenaline and noradrenaline on insulin secretion in dog. Diabetologia 24, 107-112.
22. Ribes, G., Trimble, E.R., Blayac, J.P., Wollheim, C.B., Loubatières-Mariani, M.M., 1984. In vivo stimulation of pancreatic hormone secretion by norepinephrine infusion in the dog. Am. J. Physiol. 246, E339-E343.
23. Robertson, R.P., Halter, J.B., Porte, D., 1976. A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus. J. Clin. Invest. 57, 791-795.
24. Schulz, A., Hasselblatt, A., 1988. Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release. Naunyn-Schmiedeberg's Arch. Pharmacol. 337, 637-643.
25. Schulz, A., Hasselblatt, A., 1989. An insulin-releasing property of imidazoline derivatives is not limited to compounds that block α-adrenoceptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 321-327.
26. Taborsky, G.J., Ensinck, J.W., 1984. Contribution of the pancreas to circulating somatostatin-like immunoreactivity in the normal dog. J. Clin. Invest. 73, 216-223.
27. Unger, R.H., Aguilar-Parada, E., Müller, W., Eisentraut, A.M., 1970. Studies of pancreatic alpha cell function in normal and diabetic subjects. J. Clin. Invest. 49, 837-848.
28. Wang, X., Rondu, F., Laouri, A., Dokhan, R., Marc, S., Touboul, E., Pfeiffer, B., Manechez, D., Renard, P., Guardiola-Lemaitre, B., Godfroid, J.J., Ktorza, A., Penicaud, L., 1996. Effect of S-21663 (PMS 812), an imidazoline derivative, on glucose tolerance and insulin secretion in a rat model of type II diabetes. J. Pharmacol. Exp. Ther. 278, 82-89.
29. Weir, G.C., Samols, E., Day, J.A., Patel, Y.C., 1978. Glucose and glucagon stimulate the secretion of somatostatin from the perfused canine pancreas. Metabolism (Suppl. 1), 1223-1226.