The superantigenic activity of streptococcal pyrogenic exotoxin B is independent of the protease activity

FEMS Immunology and Medical Microbiology

Volumn 25, Issue 4, 1999, Pages 355-363

  Eriksson, Anna ^a   Norgren, Mari ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Cysteine protease; Group A streptococcus; Streptococcal exotoxin B; Superantigen

Indexed keywords

CYSTEINE PROTEINASE; EXOTOXIN; HLA DQ ANTIGEN; INTERLEUKIN 1BETA; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ARTICLE; BACTERIAL VIRULENCE; CELL PROLIFERATION; CYTOKINE RELEASE; ENZYME ACTIVITY; IMMUNOBLOTTING; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STREPTOCOCCUS AGALACTIAE; T LYMPHOCYTE;

ANTIGEN-PRESENTING CELLS; BACTERIAL PROTEINS; CELL DIVISION; CYSTEINE ENDOPEPTIDASES; EXOTOXINS; HUMANS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MITOGENS; SUPERANTIGENS; T-LYMPHOCYTES;

EID: 0032767699     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(99)00108-X     Document Type: Article

References (48)

1. Abe J., Forrester J., Nakahara T., Lafferty J.A., Kotzin B.L., Leung D.Y. Selective stimulation of human T cells with streptococcal erythrogenic toxins A and B. J. Immunol. 146:1991;3747-3750.
2. Barry W., Hudgins L., Donta S.T., Pesanti E.L. Intravenous immunoglobulin therapy for toxic shock syndrome. JAMA. 267:1992;3315-3316.
3. Björck L., Åkesson P., Bohus M., Trojnar J., Abrahamson M., Olafson I., Grubb A. Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor. Nature (London). 337:1989;385-386.
4. Bohach G.A., Hauser A.R., Schlievert P.M. Cloning of the gene, speB, for streptococcal pyrogenic exotoxin type B in Escherichia coli. Infect. Immun. 56:1988;1665-1667.
5. Braun M.A., Gerlach D., Hartwig U.F., Ozegowski J.-H., Romangé F., Carrel S., Köhler W., Fleischer B. Stimulation of human T cells by streptococcal 'superantigen' erythrogenic toxins (scarlet fever toxins). J. Immunol. 150:1993;2457-2466.
6. Eriksson A., Eriksson B., Holm S.E., Norgren M. Streptococcal DNaseB is immunological identical to superantigen SpeF but involves separate domains. Clin. Diagn. Lab. Immunol. 6:1999;133-136.
7. Fleisher B., Gerlach D., Fuhrmann A., Schmidt K.H. Superantigen and pseudosuperantigens of gram-positive cocci. Med. Microbiol. Immunol. (Berlin). 184:1995;1-8.
8. Gerlach D., Günther E., Köhler W., Vettermann S., Fleischer B., Schmidt K.H. Isolation and characterization of a mitogen characteristic of Group A Streptococci (Streptococcus pyogenes). Zbl. Bakt. 282:1995;67-82.
9. Gerlach D., Reichardt W., Fleisher B., Schmidt K.-H. Separation of mitogenic and pyrogenic activities from so-called erythrogenic toxin type B (Streptococcal proteinase). Zbl. Bakt. 280:1994;507-514.
10. Gubba S., Low D.E., Musser J. Expression and characterization of group A streptococcus extracellular cystein protease recombinant mutant proteins and documentation of seroconversion during human invasive disease episodes. Infect. Immun. 66:1998;765-770.
11. Hauser A.R., Schlievert P.M. Nucleotide sequence of the streptococcal pyrogenic exotoxine type B gene and relationship between the toxin and the streptococcal proteinase. J. Bacteriol. 172:1990;4536-4542.
12. Herwald H., Collin M., Muller-Esterl W., Björck L. Streptococcal cysteine proteinase releases kinins: a virulence mechanism. J. Exp. Med. 184:1996;665-673.
13. Holm S.E., Falsen E. An antigen-free-medium for cultivation of β-hemolytic streptococci. Acta Pathol. Microbiol. Scand. 69:1967;264-276.
14. Imanishi K., Igarashi H., Uchiyama T. Relative abilities of distinct isotypes of human major histocompatibility complex class II molecules to bind streptococcal pyrogenic exotoxin type A and B. Infect. Immun. 60:1992;5025-5029.
15. Iwasaki M., Igarashi H., Hinuma Y., Yutsuda T. Cloning, characterization and over-expression of a Streptococcus pyogenes gene encoding a new type of mitogenic factor. FEMS Lett. 331:1993;87-192.
16. Iwasaki M., Igarashi H., Yutsudo T. Mitogenic factor secreted by Streptococcus pyogenes is a heat-stable nuclease requiring His122 for activity. Microbiology. 143:1997;2449-2455.
17. Kamezawa Y., Nakahara T., Nakano S., Abe Y., Nozaki-Renard J., Isono T. Streptococcal mitogenic exotoxin Z, a novel acidic superantigenic Toxin produced by a T1 strain of Streptococcus pyogenes. Infect. Immun. 65:1997;3828-3833.
18. Kaplan E., Clark C. Improved rosetting assay for detection of human T lymphocytes. J. Immunol. Methods. 5:1974;131-135.
19. Kapur V., Majesky M.W., Ling-Ling L., Black R.A., Musser J.M. Cleavage of interleukin 1β(IL-1β) precursor to produce active IL-1β by a conserved extracellular cysteine protease from Streptococcus pyogenes. Proc. Natl. Acad. Sci. USA. 90:1993;7676-7680.
20. Kapur V., Topouzis S., Majesky M.W., Ling-Ling L., Hamrick M.R., Hamill R.J., Patti J.M., Musser J.M. A conserved Streptococcus pyogenes cysteine protease cleaves human fibronectin and degrades vitronectin. Microb. Pathog. 15:1993;327-346.
21. Kotb M., Watanabe-Ohnishi R., Wang B., Tomai M.A., Le Gros L., Schlievert P.M., El Demellawy M., Geller A.M. Analysis of the TcR Vβ specificities of bacterial superantigens using PCR. Immunomethods. 2:1993;33-40.
22. Kuo C.-F., Wu J.-J., Tsai P.-J., Kao F.-J., Lei H.-Y., Lin M.T., Lin Y.-S. Streptococcal pyrogenic exotoxin B induces apoptosis and reduces phagocytic activity in U937 cells. Infect. Immun. 67:1999;126-130.
23. Li P.-L., Tiedemann R.E., Moffat S.L., Fraser J.D. The superantigen streptococcal pyrogenic exotoxin C (SPE-C) exhibits a novel mode of action. J. Exp. Med. 186:1997;375-383.
24. Lukomski S., Burns E.H. Jr., Wyde P.R., Podbielski A., Rurangirwa J., Moore-Poveda D.K., Musser J.M. Genetic inactivation of an extracelleular cystein protease (SpeB) expressed by Streptococcus pyogenes decreases resistance to phagocytosis and dissemination to organs. Infect. Immun. 66:1998;771-776.
25. Lyon W.R., Gibson C.M., Caparon M.G. A role for trigger factor and an Rgg-like regulator in the transcription, secretion and processing of the cystein proteinase of Streptococcus pyogenes. EMBO J. 17:1998;6263-6275.
26. Mollick J.A., Miller G.G., Musser J.M., Cook R.G., Grossman D., Rich R.R. A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C. J. Clin. Invest. 92:1993;710-719.
27. Montecucco C., Schiavo G. Tetanus toxin and botulinum neurotoxins a new group of zinc protease. Trends. Biochem. Sci. 18:1993;324-327.
28. Musser J.M. Steptococcal superantigen, mitogenic factor, and pyrogenic exotoxin B expressed by Streptococcus pyogenes. Prep. Biochem. Biotech. 27:1997;143-172.
29. Nemoto E., Rikiishi H., Sugawara S., Okamoto S., Tamura K., Maruyama Y., Kumagai K. Isolation of a new superantigen with potent mitogenic activity to murine T cells from Streptococcus pyogenes. FEMS Immunol. Med. Microbiol. 15:1996;81-91.
30. Norrby-Teglund A., Basma H., Andersson J., McGeer A., Low D.E., Kotb M. Varying titers of neutralizing antibodies to streptococcal superantigens in different preparations of normal polyspecific immunoglobulin G: implications for therapeutic efficacy. Clin. Infect. Dis. 26:1998;631-638.
31. Norrby-Teglund A., Kaul R., Low D.E., McGeer A., Andersson J., Andersson U., Kotb M. Evidence for the presence of streptococcal-superantigen-neutralizing antibodies in normal polyspecific immunoglobulin G. Infect. Immun. 64:1996;5395-5398.
32. Norrby-Teglund A., Newton D., Kotb M., Holm S.E., Norgren M. Superantigenic properties of the group A streptococcal exotoxin, SpeF (MF). Infect. Immun. 62:1994;5227-5233.
33. Norrby-Teglund A., Pauksens K., Holm S.E., Norgren M. Relation between low capacity of human sera to inhibit streptococcal mitogens and serious manifestation of disease. J. Infect. Dis. 170:1994;585-591.
34. Norgren M., Eriksson A. Streptococcal superantigens and their role in the pathogenesis of severe infections. J. Toxicol. Toxin Rev. 16:1997;1-32.
35. Ohara-Nemoto Y., Sasaki M., Kaneko M., Nemoto T., Ota M. Cysteine protease activity of streptococcal pyrogenic exotoxin B. Can. J. Microbiol. 40:1994;930-936.
36. Papageorgiou A.C., Acharya K.R., Shapiro R., Passalacqua E.F., Brehm R.D., Tranter H.S. Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site. Structure. 3:1995;769-779.
37. Proft T., Moffatt L.S., Berkhan C.J., Fraser J.D. Identification and characterization of novel superantigens from Streptococcus pyogenes. J. Exp. Med. 189:1999;89-102.
38. Reichardt, W., Fleischer, B., Gerlach, D. (1998) Mitogenic activity hitherto attributed to erythrogenic toxin type B is caused by a common group A streptococcal mitogen. In: Bacterial Protein Toxins (Hacker et al., Eds.), pp. 212-213, Zbl. Bakteriol. Suppl. 29.
39. Roggiani M., Stoehr J.A., Leonard B.A., Schlievert P.M. Analysis of toxicity of streptococcal pyrogenic exotoxin A mutants. Infect. Immun. 65:1997;2868-2875.
40. Roussel A., Anderson B.F., Baker H.M., Fraser J.D., Baker E.N. Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of action with MHC class II molecules. Nat. Struct. Biol. 4:1997;635-643.
41. Schlievert P.M. Role of superantigens in human disease. Curr. Opin. Infect. Dis. 8:1995;170-174.
42. Schmidt K.H., Gerlach D., Wollweber L., Reichardt W., Mann K., Ozegowski J.H., Fleischer B. Mitogenicity of M5 protein extracted from Streptococcus pyogenes cells is due to streptococcal pyrogenic exotoxin C and mitogenic factor MF. Infect. Immun. 63:1995;4569-4575.
43. Stevens K.R., Van M., Lamphear J.G., Orkiszewski R.S., Ballard K.D., Cook R.G., Rich R.R. Species-dependent post-translational modifications and position 2 allelism: effects on streptococcal superantigen SSA structure and V beta specificity. J. Immunol. 157:1996;2479-2487.
44. 2+-mediated homodimerization. EMBO J. 15:1996;6832-6840.
45. Thompson G.A., Carpenter F.H. Leucine amino peptidase (bovine lens). The relative binding of cobalt and zinc to leucine amino peptidase and the effect of cobalt substitution on specific activity. J. Biol. Chem. 251:1976;1618-1624.
46. Tomai M.A., Schlievert P.M., Kotb M. Distinct T cell receptor Vβ gene usage by human T lymphocytes stimulated with the streptococcal pyrogenic exotoxins and pep M5 protein. Infect. Immun. 60:1992;701-705.
47. Toyosaki T., Yoshioka T., Tsuruta Y., Yutsudo T., Iwasaki M., Suzuki R. Definition of the mitogenic factor (MF) as a novel streptococcal superantigen that is different from streptococcal pyrogenic exotoxins A, B, and C. Eur. J. Immunol. 26:1996;2693-2701.
48. Wang B., Schlievert P.M., Gaber A.O., Kotb M. Localization of an immunologically functional region of the streptococcal superantigen pepsin-extracted fragment of type 5 M protein. J. Immunol. 151:1993;1419-1429.