Evidence for the presence of streptococcal-superantigen-neutralizing antibodies in normal polyspecific immunoglobulin G

Infection and Immunity

Volumn 64, Issue 12, 1996, Pages 5395-5398

  Norrby Teglund, Anna ^a   Kaul, Rupert ^b   Low, Donald E ^b   McGeer, Allison ^b   Andersson, Jan ^c   Andersson, Ulf ^c   Kotb, Malak ^a,d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MOUNT SINAI HOSPITAL   (Canada)

^c STOCKHOLM UNIVERSITY   (Sweden)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; EXOTOXIN; IMMUNOGLOBULIN G; MITOGENIC AGENT; NEUTRALIZING ANTIBODY; PENICILLIN G; PHYTOHEMAGGLUTININ; STREPTOCOCCUS ANTIGEN; SUPERANTIGEN;

ADULT; ARTICLE; BACTERIAL ARTHRITIS; CASE REPORT; CELLULITIS; CONTROLLED STUDY; CONVALESCENCE; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOTHERAPY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NECROTIZING FASCIITIS; PRIORITY JOURNAL; STREPTOCOCCUS GROUP A; STREPTOCOCCUS PYOGENES;

EID: 0029846421     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.12.5395-5398.1996     Document Type: Article

References (15)

1. Barry, W., L. Hudgins, S. T. Donta, and E. L. Pesanti. 1992. Intravenous immunoglobulin therapy for toxic shock syndrome. JAMA 267:3315-3316.
2. Kaul, R., A. McGeer, Ontario Streptococcal Study Group, A. Norrby-Teglund, M. Kotb, and D. E. Low. 1995. Intravenous immunoglobulin (IVIG) therapy in Streptococcal toxic shock syndrome (STSS): results of a matched case-control study, abstr. LM 68, p. 339. In Abstracts of the 35th Intcrscicnce Conference of Antimicrobial Agents and Chemotherapy 1995. American Society for Microbiology, Washington, D.C,
3. Kotb, M, 1995. Bacterial pyrogenic exotoxins as superantigcns. Clin. Microbiol. Rev. 8:411-426.
4. Marrack, P., and J. Kappler. 1990. The staphylococcal entcrotoxins and their relatives. Science 248:705-711.
5. McGeer, A., K. Green, D. Cann, B. Schwarte, R. Kaul, A. Fletcher, S. Matsumura, Ontario Group A Streptococcal Study Group, and D. E, Low. 1995. Changing epidemiology of invasive group A Streptococcal infectionspopulation based surveillance, Ontario, Canada, 1992-5, ahstr. K135, p. 312. In Abstracts of the 35th Interscience Conference of Antimicrobial Agents and Chemotherapy 1995. American Society for Microbiology, Washington, D.C.
6. Molllck, J. A., G. G. Miller, R. G, Cook, D. Grossman, and R. R. Rich. 1993. A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C. J. Clin. Invest. 92:710-719.
7. Nadal, D., R. P. Lauener, C. P. Braegger, A. Kaufhold, B. Slmma, R. Lutticken, and R. A. Seger. 1993. T cell activation and cytokine release in Streptococcal toxic shock-like syndrome. J. Pediatr. 122:727-729.
8. Norrby-Teglund, A., R Kaul, D. E. Low, A. McGeer, D. W. Newton, J. Andersson, U. Andersson, and M. Kotb. 1996, Plasma from patients with severe invasive group A Streptococcal infections treated with normal polyspecific IgG (IVIG) inhibits Streptococcal supcrantigen-induced T cell proliferation and cytokine production. J. Immunol. 156:3057-3064.
9. Norrby-Teglund, A., D. Newton, M. Kolb, S. E. Holm, and M. Norgren. 1994. Superantigenic properties of the group A Streptococcal exotoxin, SpeF (MF). Infect. Immun, 62:5227-5233,
10. Norrby-Teglund, A., K. Pauksens, S. E. Holm, and M. Norgren. 1994. Relation between low capacity of human sera to inhibit streplococcal mitogcm and serious manifestation of disease. J. Infect. Dis. 170:585-591.
11. Schlievert, P. M. 1993. Role of superantigens In human diseases, J. Infect. Dis. 167:997-1002.
12. Skansen-Saphir, U., J. Andersson, L. Björk, and U. Andersson. 1994. Lymphokine production induced by Streptococcal pyrogenic exotoxin-A is selectively down-regulated by pooled human IgG. Eur. J. Immunol. 24:916-922.
13. Stevens, D. L. 1992. Invasive group A streptococcus infections. Clin. Infect. Dis. 14:2-13.
14. Takei, S., Y. K. Arura, and S. M. Walker. 1993. Intravenous immunoglobulin contains specific antibodies inhibitory to activation of T cells by staphylococcal toxin superantigens. J. Clin. Invest. 91:602-607.
15. Watanabe-Ohnishi, R., D. E. Low, A. McGeer, D. L. Stevens, P. M. Schllevert, D. Newton, B. Schwartz, B. Kreiswirth, and M. Kotb. 1995. Selective depletion of Vβ-bearing T cells in patients with severe invasive group A Streptococcal infections and streptncoccal toxic shock syndrome. J. Infect. Dis. 171:74-84.