Effects of ambroxol on spontaneous or stimulated generation of reactive oxygen species by bronchoalveolar lavage cells harvested from patients with or without chronic obstructive pulmonary diseases

Pharmacology

Volumn 59, Issue 3, 1999, Pages 135-141

  Teramoto, Shinji ^a   Suzuki, Masashi ^a   Ohga, Eijiro ^a   Ishii, Takeo ^a   Matsui, Hirotoshi ^a   Matsuse, Takeshi ^a   Ouchi, Yasuyoshi ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

Ambroxol; Bronchoalveolar lavage; Chemiluminescence; Chronic obstructive pulmonary disease; Oxygen radicals

Indexed keywords

AMBROXOL; ANTIOXIDANT; REACTIVE OXYGEN METABOLITE;

ANTIOXIDANT ACTIVITY; ARTICLE; CHEMOLUMINESCENCE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; HUMAN; HUMAN CELL; LUNG LAVAGE; MALE; PRIORITY JOURNAL;

AGED; AMBROXOL; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; EXPECTORANTS; FEMALE; FREE RADICALS; HUMANS; INDICATORS AND REAGENTS; LUNG DISEASES, OBSTRUCTIVE; MALE; MIDDLE AGED; REACTIVE OXYGEN SPECIES;

EID: 0032766309     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028313     Document Type: Article

References (37)

1. Wong HR, Wispe JR: The stress response and the lung. Am J Physiol 1997;273:L1-L9.
2. Rahman I, Morisson D, Donaldson K, MacNee W: Systemic oxidant stress in asthma, COPD and smokers. Am J Respir Crit Care Med 1996;154:1055-1060.
3. Praticö D, Basili S, Vieri M, Cordova C, Violi F, Fitzgerald GA: Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2 alpha-III, an index of oxidant stress. Am J Respir Crit Care Med 1998; 158:1709-1714.
4. Strausz J, Muller-Quernheim J, Steppling H, Ferlinz R: Oxygen radical production by alveolar inflammatory cells in idiopathic pulmonary fibrosis. Am Rev Respir Dis 1990;141:124-128.
5. Teramoto S, Fukuchi V, Uejima Y, Chu CY, Orimo H: Superoxide anion formation and glutathione metabolism of blood in patients with idiopathic pulmonary fibrosis. Biochem Mol Med 1995;55:66-70.
6. Teramoto S, Chu CY, Ouchi Y, Fukuchi Y: Increased spontaneous production and generation of superoxide anion by blood neutrophils in patients with asthma. J Asthma 1996;33:149-155.
7. Repine JE, Bast A, Lankhorst L, and The Oxidative Stress Study Group: Oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997;156:341-357.
8. Teramoto S, Fukuchi Y, Uejima Y, Teramoto K, Orimo H: Age-related changes in antioxidant screen of distal lung in mice. Lung 1994;172: 223-230.
9. Weiss T, Dorow P, Felix R: Effects of beta-adrenergic drug and a secretolytic agent on regional mucociliary clearance in patients with COPD. Chest 1981;80:881-885.
10. Wiemeyer JC: Influence of ambroxol on the bronchopulmonary level of antibiotics. Arzneimittelforschung 1981;31:974-976.
11. Nowak D, Antczak A, Krol M, Bialasiewicz P, Pietras T: Antioxidant properties of ambroxol. Free Radic Biol Med 1994;16:517-522.
12. Nowak D, Pietras T, Antczak A, Krol M, Piasecka G: Ambroxol inhibits endotoxin-induced lipid peroxidation in mice. Pol J Pharmacol 1993;45:317-322.
13. Suzuki M, Teramoto S, Matsuse T et al: Inhibitory effect of ambroxol on superoxide anion production and generation by murine alveolar macrophages. J Asthma 1998;35:267-272.
14. Teramoto S, Suzuki M, Matsuse T, Ouchi Y: Effect of ambroxol on oxygen radical production and generation by bronchoalveolar lavage cells in young and aged guinea pigs. Jpn J Pharmacol 1998;78:429-433.
15. Nowak D, Antczak A, Pietras T, Bialasiewicz P, Krol M: Protective effect of ambroxol against heat-and hydrogen peroxide-induced damage to lung lipids in mice. Eur Respir J 1994;7:1629-1634.
16. Felix K, Pairet M, Zimmermann R: The antioxidative activity of the mucoregulatory agents: Ambroxol, bromhexine and N-acetyl-L-cysteine. A pulse radiolysis study. Life Sci 1996;59:1141-1147.
17. Gllissen A, Nowak D: Characterization of N-acetylcysteine and ambroxol in antioxidant therapy. Respir Med 1998;82:609-623.
18. Teramoto S, Fukuchi Y, Orimo H: Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in chronic obstructive pulmonary disease. Chest 1993; 103:1774-1782.
19. Teramoto S, Fukuchi Y: Improvements in exercise capacity and dyspnoea by inhaled anticholinergic drug in elderly patients with chronic obstructive pulmonary disease. Age Ageing 1995;24:278-282.
20. Baldwin E de F, Cournand A, Richards DW: Pulmonary insufficiency. I. Physiologic classification, clinical methods of analysis. Standard values in normal subjects. Medicine 1948;27:243-278.
21. Burrows B, Kasik JE, Niden AH, Barclay WR: Clinical usefulness of the single-breath pulmonary diffusing capacity test. Am Rev Respir Dis 1961;84:789-806.
22. Teramoto S, Fukuchi Y, Shu CY, Orimo H: Influences of cisplatin combination chemotherapy on oxygen radical generation by blood in elderly and adult patients with lung cancer. Chemotherapy 1995;41: 222-228.
23. Teramoto S, Fukuchi Y, Uejima Y, Teramoto K, Orimo H: Biochemical characteristics of lungs in senescence-accelerated mouse (SAM). Eur Respir J 1995;8:450-456.
24. Dekhuijzen PN, Aben KK, Dekker I et al: Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996;154:813-816.
25. Teramoto S, Fukuchi Y: Bullous emphysema. Curr Opin Pulm Med 1996;2:90-96.
26. Horvath I, Donnelly LE, Kiss A et al: Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am J Respir Crit Care Med 1998;158:1042-1046.
27. Clement A, Chadelat K, Masliah J et al: A controlled study of oxygen metabolite release by alveolar macrophages from children with interstitial lung disease. Am Rev Respir Dis 1987;136:1424-1428.
28. Magnan A, Mege JL, Escallier JC et al: Balance between alveolar macrophage IL-6 and TGF-β in lung-transplant recipients. Marseille and Montreal Lung Transplantation Group. Am J Respir Crit Care Med 1996; 153:1431-1436.
29. Takei K, Tokuyama K, Kato M, Morikawa A: Role of cyclic adenosine monophosphate in reducing superoxide anion generation in guinea pig alveolar macrophages. Pharmacology 1998;57:1-7.
30. Lasuardi M, Capelli A, Cerutti CG, Spada EL, Donner CF: Airways inflammation in subjects with chronic bronchitis who have never smoked. Thorax 1994;49:1211-1216.
31. 1-proteinase inhibitor by alveolar inflammatory cells from smoking patients with or without emphysema. Am Rev Respir Dis 1993;147:1537-1543.
32. Lusuardi M, Capelli A, Cardi S et al: Local airways immune modifications induced by oral bacterial extracts in chronic bronchitis. Chest 1993;103:1783-1791.
33. Winsel K: Antioxidant and anti-inflammatory properties of ambroxol. Pneumologie 1992;46:461-475.
34. 14C-labelled Bisolvon in the rat and mouse. Arzneimittelforschung 1971;21:914-918.
35. Mezzetti M, Colombo L, Marini MG, Crusi V, Pierfedirici P, Mussini E: A pharmacokinetics study on pulmonary tropism of ambroxol on patients under thoracic surgery. Surg Intensive Care 1990;13:179-185.
36. Fegiz G: Prevention by ambroxol of bronchopulmonary complications after upper abdominal surgery: Double-blind Italian multicenter clinical study. Lung 1991;169:69-76.
37. Marini A, Franzetti M, Gios G et al: Ambroxol in the treatment of idiopathic respiratory distress syndrome. An interim report on a controlled double-blind multicenter study versus placebo. Respiration 1987;51:60-67.