Up-regulation of the tumor suppressor gene p53 and WAF1 gene expression by IP6 in HT-29 human colon carcinoma cell line

Anticancer Research

Volumn 18, Issue 3 A, 1998, Pages 1479-1484

  Saied, Ihab T ^a   Shamsuddin, Abulkalam M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Chemoprevention; Chemotherapy; Inositol hexaphosphate; Phytate

Indexed keywords

ANTIBODY; ANTINEOPLASTIC AGENT; PHYTIC ACID; PROTEIN P21; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G1 PHASE; COLON CARCINOMA; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MITOSIS INHIBITION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; CELL LINE; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; KINETICS; PHYTIC ACID; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031858807     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Parker SL, Tong T, Bolden S, and Wingo PA: Cancer Statistics. CA Cancer J Clin 47: 5-25, 1997
2. 6 a novel anticancer agent Life Sciences 61: 343-354, 1997.
3. 6. TIBS 18: 53-56, 1993.
4. Shamsuddin AM: Inositol phosphates have a novel anticancer function. J Nutr 125: 7258-7328, 1995.
5. Shamsuddin AM, Baten A, Lalwani N D: Effect of inositol hexaphosphate on growth and differentiation in K-562 erythro-leukemia cell line. Cancer Letters 64: 195-202, 1992.
6. 6 induced growth inhibition and differentiation of HT-29 human colon cancer cells: Involvement of intracellular inositol phosphates. Anticancer Res 15: 2479-2488, 1995.
7. 6. growth inhibition and differentiation of human mammary cancer cell lines in vitro. Anticancer Res 16: 3287-3292, 1996.
8. Shamsuddin AM and Yang G: Inositol hexaphosphate inhibits growth and induces differentiation of PC-3 human prostate cancer cells. Carcinogenesis 16: 1975-1979, 1995.
9. Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
10. WAF1/CIP1 mutations in superficial and invasive transtional cell carcinomas. Oncogene 13: 1831-1837, 1996.
11. Lowe SW, Ruley HE, Jacks T And Housman DE: p53 dependent apoptosis modulates the cytotoxocity of anticancer agents. Cell 74: 957-967, 1993.
12. Low SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE and Jacks T: p53 status and the efficacy of cancer therapy in vivo. Science 266: 807-810, 1994.
13. Kinzler KW and Vogelstein B: Cancer therapy meets p53. New England J Medicine 331: 49-50, 1994.
14. Hamada M, Fujiwara T, Hizuta A, Gochi A, Naomoto Y, Takakura N, Takahashi K, Roth JA Tanaka N, and Orita KC: The p53 gene is potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers. J Cancer Res Clin One 122: 360-365, 1996.
15. Symonds H, Krall L, Remington L, Saenz-Robles M, Lowe S, Jacks T and Van Dyke T: p53 dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78: 703-711, 1994.
16. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, and Beach D: p21 cdk interacting protein is potent inhibitor of G1 cyclin dependent kinases. Nature 366: 701-704, 1993.
17. Yang B, Eshleman R, Berger NA and Markowitz SD: Wild type p53 protein potentiates cytotoxicity of therapeutic agents in human colon cancer cells. Clin Cancer Res 2: 1649-1657, 1996.
18. Fujiwara T, Grimm EA, Mukhopadhyay T, Zhang W, Owen-Schaub LB, and Roth JA: Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res 54: 2287-2291, 1994.
19. Roth JA et al: Retrovirus mediated wild type p53 gene transfer to tumors of patients with lung cancer. Nature(Med) 2: 985-991, 1996.
20. Shamsuddin AM: Reduction of cell proliferation and enhancement of NK cell activity. US patent # 5082833, 1992.
21. Sakamoto K, Vucenik I, Shamsuddin AM: Phytic acid (Inositol hexaphosphate) is absorbed and distributed to various tissues in rats. J Nutr 123: 713-720, 1993.
22. 3]-Inositol hexaphosphate is rapidly absorbed and metabolized by murine and human malignant cells in vitro. J Nutr 124: 861-868, 1994.
23. Waga S, Hannon GJ, Beach D and Stillman B: The p21 inhibitor of cyclin dependent kinases controls DNA replication by interaction with PCNA. Nature 369: 574-578, 1994.
24. Williams GT and Smith CA: Molecular regulations of apoptosis: genetic controls on cell death. Cell 74: 777-779, 1993.