Increased radiosensitivity of p16 gene-deleted human glioma cells after transfection with wild-type p16 gene

Japanese Journal of Cancer Research

Volumn 88, Issue 1, 1997, Pages 34-38

  Miyakoshi, Junji ^a   Kitagawa, Kaori ^a,c   Yamagishi, Nobuyuki ^a   Ohtsu, Shuji ^a   Day III, Rufus S ^b   Takebe, Hiraku ^a  

^a KYOTO UNIVERSITY   (Japan)

^b CROSS CANCER INSTITUTE   (Canada)

^c KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Human glioma cell line; Radiosensitivity; Wild type p16

Indexed keywords

COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P16;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DNA TRANSFECTION; GENE DELETION; GLIOMA CELL; HUMAN; HUMAN CELL; PLASMID; PRIORITY JOURNAL; RADIOSENSITIVITY;

EID: 0031050047     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1997.tb00298.x     Document Type: Article

References (25)

1. INK4 in human cancer. Proc. Natl. Acad. Sci. USA, 91, 11045-11049 (1994).
2. Olopade, O. I., Jenkins, R. B., Ransom, D. T., Malik, K., Pomykala, H., Nobori, T., Cowan, J. M., Rowley, J. D. and Dias, M. O. Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas. Cancer Res., 52, 2523-2529 (1992).
3. James, C. D., He, J., Carlbom, E., Nordenskjold, M., Cavenee, W. K. and Collins, V. P. Chromosome 9 deletion mapping reveals interferon α and Interferon β-1 gene deletions in human glial tumors. Cancer Res., 51, 1684-1688 (1991).
4. Serrano, M., Hannon, G. J. and Beach, D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature, 366, 704-707 (1993).
5. Matsushime, H., Quelle, D. E., Shurtleff, S. A., Shibuya, M., Sherr, C. J. and Kato, J. D-Type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol., 14, 2066-2076 (1994).
6. Meyerson, M. and Harlow, E. Identification of G1 kinase activity for cdk6, a novel cyclin D partner, Mol. Cell. Biol., 14, 2077-2086 (1994).
7. INK4 gene mediated by an adenovirus vector. Cancer Res., 55, 3250-3253 (1995).
8. Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., III, Johnson, B. E. and Skolnick, M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science, 264, 436-440 (1994).
9. Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashi, K. and Carson, D. A. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature, 368, 753-756 (1994).
10. Mori, T., Miura, K., Aoki, T., Nishihira, T., Mori, S. and Nakamura, Y. Frequent somatic mutation of the MTS1/ CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res., 54, 3396-3397 (1994).
11. Karlsson, U. L., Leibel, S. A., Wallner, K., Davis, L. W. and Brady, L. W. "Principles and Practice of Radiation Oncology," 2nd Ed., ed. C. A. Ferez and L. W. Brady, pp. 515-552 (1992). J. B. Lippincott Co., Philadelphia.
12. He, J., Allen, J. R., Collin, V. P., Allalunis-Turner, J., Godbout, R., Day, R.S., III. and James, C. D. CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines. Cancer Res., 54, 5804-5807 (1994).
13. Nishikawa, R., Furnari, F. B., Lin, H., Arap, W., Berger, M. S., Cavennee, W. K. and Huang, H.-J. S. Loss of p16-INK4 expression is frequent in high grade gliomas. Cancer Res., 55, 1941-1945 (1995).
14. Yamagishi, N., Miyakoshi, J., Ohtsu, S., Day, R. S., III. and Takebe, H. Modification of the radiosensitivity of human cells to which simian virus 40 T-antigen was transfected. J. Radiat. Res., 36, 239-247 (1995).
15. Miyakoshi, J., Ohtsu, S., Tatsumi-Miyajima, J. and Takebe, H. A newly designed experimental system for exposure of mammalian cells to extremely low frequency magnetic fields. J. Radiat. Res., 35, 26-34 (1994).
16. Shung, B., Miyakoshi, J. and Takebe, H. X-ray-induced transcriptional activation of c-myc and XRCC1 genes in ataxia telangiectasia cells. Mutat. Res., 307, 43-51 (1994).
17. Miyakoshi, J., Scudiero, D. A., Allalunis-Turner, J. and Day, R. S., III. The sensitivities of SV40-transformed human fibroblasts to monofunctional and DNA-crosslinking alkylation agents. Mutat. Res., 254, 55-64 (1991).
18. Nakajima-Iijima, S., Hamada, H., Reddy, P. and Kakunaga, T. Molecular structure of the human cytoplasmic β-actin gene: interspecies homology of sequences in the introns. Proc. Natl. Acad. Sci. USA, 82, 6133-6137 (1985).
19. INK4B/MTS2related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev., 8, 2939-2952 (1994).
20. Lukas, J., Parry, D., Aagaard, L., Mann, D. J., Bartkova, J., Strauss, M., Peters, G. and Bartek, J. Retinoblastoma-protein-dependent cell cycle inhibition by the tumour suppressor p16. Nature, 375, 503-506 (1995).
21. Arap, W., Nishikawa, R., Furnari, F. B., Cavenee, W. K. and Huang, H.-J. S. Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Res., 55, 1351-1354 (1995).
22. Pardo, F. S., Bristow, R. G., Taghian, A., Ong, A. and Borek, C. Role of transfection and clonal selection in mediating radioresistance. Proc. Natl. Acad. Sci. USA, 88, 10652-10656 (1991).
23. Miyakoshi, J., Dobler, K. D., Allalunis-Turner, J., McKean, J. D. S., Petruk, K., Allen, P. B. R., Aronyk, K. N., Weir, B., Huyser-Wierenga, D., Fulton, D., Urtasun, R. C. and Day, R. S. III. Absence of IFNA and IFNB genes from human malignant glioma cell lines and lack of correlation with cellular sensitivity to interferon. Cancer Res., 50, 278-283 (1990).
24. Terasima, R. and Tolmach, L. J. X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells. Science, 140, 490-492 (1963).
25. Sinclair, W. K. and Morton, R. A. X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Radiat. Res., 29, 450-474 (1966).