Bone marrow stromal cell cytochrome P4501B1 is required for pre-B cell apoptosis induced by 7,12-dimethylbenz[a]anthracene

Molecular Pharmacology

Volumn 56, Issue 6, 1999, Pages 1317-1323

  Heidel, Shawn M ^a   Holston, Karrie ^a   Buters, Jeroen T M ^b   Gonzalez, Frank J ^c   Jefcoate, Colin R ^a   Czupyrynski, Charles J ^a,d  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c NATIONAL CANCER INSTITUTE   (United States)

^d Dept of Pathobiological Sciences ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 7,12 DIMETHYLBENZ[A]ANTHRACENE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 ISOENZYME;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; COCULTURE; DNA ADDUCT; DRUG METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; STROMA CELL;

EID: 0032755065     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.6.1317     Document Type: Article

References (40)

1. Ashkenazi A, Dixit VM, Evan G and Littlewood T (1998) A matter of life and cell death. Science (Wash DC) 281:1305-1308.
2. Bertrand R, Solary E, Kohn KW and Pommier Y (1994) Induction of a common pathway of apoptosis by staurosporine. Exp Cell Res 211:314-321.
3. Buters JT, Sakai S, Richter T, Pineau T, Alexander DL, Savas U, Doehmer J, Ward JM, Jefcoate CR and Gonzalez FJ (1999) Cytochrome P4501B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induce lymphomas. Proc Natl Acad Sci USA 98:1977-1982.
4. Cui YF, Zhou PK, Woolford LB, Lord BI, Hendry JH and Wang DW (1995) Apoptosis in bone marrow cells of mice with different p53 genotypes after gamma-ray irradiation in vitro. J Environ Pathol Toxicol Oncol 14:159-163.
5. Dassi C, Signorini S, Gerthoux P, Cazzaniga M and Brambilla P (1998) Cytochrome P450 1B1 mRNA measured in blood mononuclear cells by quantitative reverse transcription. Clin Chem 44:2416-2421.
6. Fine JS, Gasiewicz TA and Silverstone AE (1989) Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol Pharmacol 35:18-25.
7. Hardin JA, Hinoshita F and Sherr DH (1992) Mechanisms by which benzo[a] pyrene, an environmental carcinogen, suppresses B cell lymphopoiesis. Toxicol Appl Pharmacol 117:155-164.
8. Harvey RG (1991) Polycyclic Aromatic Hydrocarbons: Chemistry and Carcinogenicity, Cambridge University Press, Cambridge, UK.
9. Heidel SM, Czuprynski CJ and Jefcoate CR (1998) Bone marrow stromal cells constitutively express high levels of cytochrome P4501B1 that metabolize 7,12-dimethylbenz[a]anthracene. Mol Pharmacol 54:1000-1006.
10. Huberman E and Sachs L (1977) DNA binding and its relationship to carcinogenesis by different polycyclic hydrocarbons. Int J Cancer 19:122-127.
11. Kawabata TT and White KL Jr (1989) Metabolism of 7,12-dimethylbenz[a]anthracene by splenic microsomes. FASEB J 1:2199.
12. Ladics GS, Kawabata TT and White KL Jr (1991) Suppression of the in vitro humoral immune response of mouse splenocytes by 7,12-dimethylbenz[a]anthracene metabolites and inhibition of immunosuppression by alpha-naphthoflavone. Toxicol Appl Pharmacol 110:31-44.
13. Lavin AL, Hahn DJ and Gasiewicz TA (1998) Expression of functional aromatic hydrocarbon receptor and aromatic hydrocarbon nuclear translocator proteins in murine bone marrow stromal cells. Arch Biochim Biophys 352:9-18.
14. Lotem J and Sachs L (1992) Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells. Blood 80:1750-1757.
15. Lowe SW, Ruley HE, Jacks T and Housman DE (1993) p53-Dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967.
16. Lutz CT, Browne G and Petzold CR (1998) Methylcholanthrene causes increased thymocyte apoptosis. Toxicology 128:151-167.
17. Melendez-Colon VJ, Smith CA, Seidel A, Luch A, Platt KL and Baird WM (1997) Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo[a,l]pyrene or its diol epoxides. Proc Natl Acad Sci USA 94:13542-13547.
18. Pietrangeli CE, Hayashi S and Kincade PW (1988) Stromal cell lines which support lymphocyte growth: Characterization, sensitivity to radiation and responsiveness to growth factors. Eur J Immunol 18:863-872.
19. Pietrangeli CE and Kincade PW (1987) In vivo localization and growth of the 70Z/3 pre-B-cell line. Cell Immunol 107:358-371.
20. Qing, WG, Conti CJ, Labate M, Johnson D, Slaga TJ and MacLeod MC (1997) Induction of mammary cancer and lymphoma by multiple, low oral doses of 7,12-dimethylbenz[a]anthracene in SENCAR mice. Carcinogenesis 18:553-559.
21. Rajewsky K (1996) Clonal selection and learning in the antibody system. Nature (Lond) 381:751-758.
22. Rowlands JC and Gustafsson JA (1997) Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 27:109-134.
23. Salas VM and Burchiel SW (1998) Apoptosis in Daudi human B cells in response to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol. Toxicol Appl Pharmacol 151: 367-376.
24. Sallmann FR, Bourassa S, Saint-Cyr J and Poirier GG (1997) Characterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose) polymerase: Specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose) polymerase. Biochem Cell Biol 75:451-456.
25. Schmidt JV and Bradfield CA (1996) Ah receptor signaling pathways. Annu Rev Cell Dev Biol 12:55-89.
26. Schmidt JV, Su GH, Reddy JK, Simon MC and Bradfield CA (1996) Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development. Proc Natl Acad Sci USA 93:6731-6736.
27. Shimada T, Hayes CL, Yamazaki H, Amin in S, Hecht SS, Geungerich FP and Sutter TR (1996) Activation of chemically diverse procarcinogens by human cytochrome P4501B1. Cancer Res 56:2979-2984.
28. Spencer DL, Masten SA, Lanier KM, Yang XP, Grassman JA, Miller CR, Sutter TR, Lucier GW and Walker NJ (1999) Quantitative analysis of constitutive and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1B1 expression in human lymphocytes. Cancer Epidemiol Biomarker Prev 8:139-146.
29. Thurmond LM, Lauer LD, House RV, Cook JC and Dean JH (1987) Immunosuppression following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) in Ah-responsive and Ah-nonresponsive mice. Toxicol Appl Pharmacol 91:450-460.
30. Thurmond LM, Tucker AN, Rickert DE, Lauer LD and Dean JH (1989) Functional and biochemical disposition of 7,12-dimethylbenz[a]anthracene in murine lymphoid cells. Chem Biol Interact 72:93-104.
31. Vaziri C and Faller DV (1997) A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts. J Biol Chem 272:2762-2769.
32. Ward EC, Murray MJ, Lauer LD, House RV, Irons R and Dean JH (1984) Immunosuppression following 7,12-dimethylbenz[a]anthracene exposure in B6C3F1 mice. I. Effects on humoral immunity and host resistance. Toxicol Appl Pharmacol 75:299-308.
33. White KL, Kawabata TT and Ladics GS (1994) Mechanisms of polycyclic aromatic hydrocarbon immunotoxicity, in Immunotoxicology and Immunopharmacology (Dean JH and Luster MI eds.) pp 123-142, Raven Press, New York.
34. White KL Jr, Lysy HH and Holsapple MP (1985) Immunosuppression by polycyclic aromatic hydrocarbons: A structure-activity relationship in B6C3F1 and DBA/2 mice. Immunopharmacology 9:155-164.
35. Whitlock CA, Robertson D and Witte ON (1984) Murine B cell lymphopoiesis in long term culture. J Immunol Methods 67:353-369.
36. Williams GT, Smith CA, Spooncer E, Dexter TM and Taylor DR (1990) Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature (Lond) 343:76-79.
37. Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (Lond) 284:555-556.
38. Yamaguchi K, Matulka RA, Shneider AM, Tosselli P, Trombino AF, Yang S, Hafer LJ, Mann KK, Tao X, Tilly JL, Near RI and Sherr DH (1997a) Induction of preB cell apoptosis by 7,12-dimethylbenz[a]anthracene in long-term primary murine bone marrow cultures. Toxicol Appl Pharmacol 147:190-203.
39. Yamaguchi K, Near R, Shneider A, Cui H, Ju ST and Sherr DH (1996) Fluoranthene-induced apoptosis in murine T cell hybridomas is independent of the aromatic hydrocarbon receptor. Toxicol Appl Pharmacol 139:144-152.
40. Yamaguchi K, Near RI, Matulka RA, Shneider A, Tosselli P, Trombino AF and Sherr DH (1997b) Activation of the aryl hydrocarbon receptor/transcription factor and bone marrow stromal cell-dependent preB cell apoptosis. J Immunol 158:2165-2173.