Methylcholanthrene causes increased thymocyte apoptosis

Toxicology

Volumn 128, Issue 2, 1998, Pages 151-167

  Lutz, Charles T ^a   Browne, Garvan ^a,b   Petzold, C Rosemarie ^a  

^a UNIVERSITY OF IOWA   (United States)

^b Monread Clinic   (Ireland)

Author keywords

Apoptosis; Methylcholanthrene; Ontogeny; T cell; Thymus

Indexed keywords

3 METHYLCHOLANTHRENE; AROMATIC HYDROCARBON RECEPTOR; GLUCOCORTICOID; POLYCYCLIC AROMATIC HYDROCARBON;

ADRENALECTOMY; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOSE RESPONSE; ELECTRON MICROSCOPY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAINING; THYMOCYTE; THYMUS ATROPHY;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CARCINOGENS; DNA; FEMALE; FLOW CYTOMETRY; GENETIC TECHNIQUES; METHYLCHOLANTHRENE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; MICROSCOPY, ELECTRON; PHAGOCYTOSIS; RECEPTORS, ARYL HYDROCARBON; SPECIES SPECIFICITY; T-LYMPHOCYTES; THYMUS GLAND;

ANIMALIA;

EID: 0032479558     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(98)00043-2     Document Type: Article

References (55)

1. Bemelmans, M.H.A., van Tits, L.J.H., Buurman, W.A., 1996. Tumor necrosis factor: function, release and clearance. Crit. Rev. Immunol. 16, 1-11.
2. Brown, D.G., Sun, X.-M., Cohen, G.M., 1993. Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation. J. Biol. Chem. 268, 3037-3039.
3. Burchiel, S.W., Davis, D.A.P., Ray, S.D., Archuleta, M.M., Thilsted, J.P., Corcoran, G.B., 1992. DMBA-induced cytotoxicity in lymphoid and non-lymphoid organs of B6C3F1 mice: Relation of cell death to target cell intracellular calcium and DNA damage. Toxicol. Appl. Pharmacol. 113, 126-132.
4. Burchiel, S.W., Davis, D.A.P., Ray, S.D., Barton, S.L., 1993. DMBA induces programmed cell death (apoptosis) in the A20.1 murine B cell lymphoma. Fundam. Appl. Toxicol. 21, 120-124.
5. Carlstedt-Duke, J.M.B., 1979. Tissue distribution of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Cancer Res. 39, 3172-3176.
6. Cavalieri, E.L., Rogan, E.G., 1992. The approach to understanding aromatic hydrocarbon carcinogenesis. The central role of radical cations in metabolic activation. Pharmacol. Ther. 55, 183-199.
7. Cho, H.Y., Arnstein, P., Rhim, J.S., 1978. Chemical transformation of human revertant induced by murine sarcoma virus. Int. J. Cancer 21, 22-26.
8. Cohen, G.M., Sun, X.-M., Snowden, R.T., Ormerod, M.G., Dinsdale, D., 1993. Identification of a transitional preapoptotic population of thymocytes. J. Immunol. 151, 566-574.
9. 2+-associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons. J. Toxicol. Environ. Health 45, 101-126.
10. DiGiovanni, J., 1989. Metabolism of polycyclic aromatic hydrocarbons and phorbol esters by mouse skin: relevance to mechanisms of action and trans-species/strain carcinogenesis. Prog. Clin. Biol. Res. 298, 167-199.
11. Dudley, M.E., Roopenian, D.C., 1996. Loss of a unique tumor antigen by cytotoxic T lymphocyte immunoselection from a 3-methylcholanthrene-induced mouse sarcoma reveals secondary unique and shared antigens. J. Exp. Med. 184, 441-447.
12. Egerton, M., Scollay, R., Shortman, K., 1990. Kinetics of mature T-cell development in the thymus. Proc. Natl. Acad. Sci. USA 87, 2579-2582.
13. Esser, C., Welzel, M., 1993. Ontogenic development of murine fetal thymocytes is accelerated by 3,3′,4,4′-tetrachlorobiphenyl. Int. J. Immunopharmacol. 15, 841-852.
14. Fadok, V.A., Savill, J.S., Haslett, C., Bratton, D.L., Doherty, D.E., Campbell, P.A., Henson, P.M., 1992a. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J. Immunol. 149, 4029-4035.
15. Fadok, V.A., Voelker, D.R., Campbell, P.A., Cohen, J.J., Bratton, D.L., Henson, P.M., 1992b. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148, 2207-2216.
16. Fernandez-Salguero, P., Pineau, T., Hilbert, D.M., McPhail, T., Lee, S.S.T., Kimura, S., Nebert, D.W., Rudikoff, S., Ward, J.M., Gonzalez, F.J., 1995. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268, 722-726.
17. Fine, J.S., Silverstone, A.E., Gasiewicz, T.A., 1990. Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Immunol. 144, 1169-1176.
18. Grell, M., Douni, E., Wajant, H., Löhden, M., Clauss, M., Maxeiner, B., Georgopoulos, S., Lessiauer, W., Kollias, G., Pfizenmaier, K., Scheurich, P., 1995. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 83, 793-802.
19. Hinoshita, F., Hardin, J.A., Sherr, D.H., 1992. Fluoranthene induces programmed cell death and alters growth of immature B cell populations in bone marrow cultures. Toxicology 73, 203-218.
20. Holladay, S.D., Lindstrom, P., Blaylock, B.L., Comment, C.E., Germolec, D.R., Heindell, J.J., Luster, M.I., 1991. Perinatal thymocyte antigen expression and postnatal immune development altered by gestational exposure to tetrachlorodibenzo-p-dioxin (TCDD). Teratology 44, 385-393.
21. Holsapple, M.P., Snyder, N.K., Wood, S.C., Morris, D.L., 1991. A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: 1991 update. Toxicology 69, 219-255.
22. King, L.B., Ashwell, J.D., 1993. Signaling for death of lymphoid cells. Curr. Opin. Immunol. 5, 368-373.
23. Kremer, J., Gleichmann, E., Esser, C., 1994. Thymic stroma exposed to arylhydrocarbon receptor-binding xenobiotics fails to support proliferation of early thymocytes but induces differentiation. J. Immunol. 153, 2778-2786.
24. Kuroda, K., Yamashina, K., Kitatani, N., Kagishima, A., Hamaoka, T., Hosaka, Y., 1995. Characterization of defectiveness in endogenous antigen presentation of novel murine cells established from methylcholanthrene-induced fibrosarcomas. Immunology 84, 153-158.
25. Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A., Jacks, T., 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.
26. Malmgren, R.A., Bennison, B.E., McKinley, T.W. Jr., 1952. Reduced antibody titers in mice treated with carcinogenic and cancer chemotherapeutic agents. Proc. Soc. Exp. Biol. Med. 79, 484-488.
27. McConkey, D.J., Orrenius, S., 1989. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid-sensitive thymocytes in vivo. Biochem. Biophys. Res. Commun. 160, 1003-1008.
28. 2+-mediated endonuclease activation. Science 242, 256-259.
29. Mower, D.A. Jr., Peckham, D.W., Illera, V.A., Fishbaugh, J.K., Stunz, L.L., Ashman, R.F., 1994. Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse B cell apoptosis. J. Immunol. 152, 4832-4842.
30. Park, N.-H., Gujuluva, C.N., Baek, J.-H., Cherrick, H.M., Shin, K.-H., Min, B.-M., 1995. Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: An in vitro multistep carcinogenesis model. Oncogene 10, 2145-2153.
31. Penn, I., 1990. Cancers complicating organ transplantation. N. Engl. J. Med. 323, 1767-1769.
32. Poland, A., Glover, E., 1975. Genetic expression of aryl hydrocarbon hydroxylase by 2,3,7,8-tetrachlorodibenzo-p-dioxin: evidence for a receptor mutation in genetically non-responsive mice. Mol. Pharmacol. 11, 389-398.
33. Poland, A., Glover, E., 1977. Chlorinated biphenyl induction of aryl hydrocarbon hydroxylase activity: a study of the structure-activity relationship. Mol. Pharmacol. 13, 924-938.
34. Poland, A., Glover, E., 1980. 2,3,7,8-tetrachlorodibenzo-p-dioxin: segregation of toxicity with the Ah locus. Mol. Pharmacol. 17, 86-94.
35. Poland, A., Glover, E., Kende, A.S., 1976. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J. Biol. Chem. 251, 4936-4946.
36. Poland, A., Glover, E., Taylor, B.A., 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol. Pharmacol. 32, 471-478.
37. Reed, A.H., Henry, R.J., Mason, W.B., 1971. Influence of statistical method used on the resulting estimate of normal range. Clin. Chem. 17, 275-284.
38. Rhim, J.S., 1993. Neoplastic transformation of human cells in vitro. Crit. Rev. Oncog. 4, 313-335.
39. Robey, E., Fowlkes, B.J., 1994. Selective events in T cell development. Annu. Rev. Immunol. 12, 675-705.
40. Sentman, C.L., Shutter, J.R., Hockenbery, D., Kanagawa, O., Korsmeyer, S.J., 1991. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67, 879-888.
41. Silverstone, A.E., Frazier, D.E. Jr., Fiore, N.C., Soults, J.A., Gasiewicz, T.A., 1994a. Dexamethasone, β-Estradiol, and 2,3,7,8-tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets. Toxicol. Appl. Pharmacol. 126, 248-259.
42. Silverstone, A.E., Frazier, D.E. Jr., Gasiewicz, T.A., 1994b. Alternate immune system targets for TCDD: Lymphocyte stem cells and extrathymic T-cell development. Exp. Clin. Immunogenet. 11, 94-101.
43. Sironi, M., Pesenti, E., Bernasconi, S., Vecchi, A., 1990. 3-methylcholanthrene induces differential inhibition of humoral and cell mediated immune responses in mice of different ages. Toxicology 60, 263-273.
44. Smith, M.L., Fornace, A.J. Jr., 1995. Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis. Mutat. Res. 340, 109-124.
45. Strasser, A., 1995. Life and death during lymphocyte development and function: evidence for two distinct killing mechanisms. Curr. Opin. Immunol. 7, 228-234.
46. Strasser, A., Harris, A.W., Cory, S., 1991. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67, 889-899.
47. Strasser, A., Harris, A.W., Huang, D.C.S., Krammer, P.H., Cory, S., 1995. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14, 6136-6147.
48. Stutman, O., 1969a. Absence of carcinogen-induced immune depression in mice resistant to methylcholanthrene oncogenesis [Abstract]. Proc. Am. Assoc. Cancer Res. 10, 89.
49. Stutman, O., 1969b. Carcinogen-induced immune depression: Absence in mice resistant to chemical oncogenesis. Science 166, 620-621.
50. Surh, C.D., Sprent, J., 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372, 100-103.
51. Talcott, P.A., Exon, J.H., Mather, G.G., Koller, L.D., 1990. Alterations of rat natural killer (NK) cell cytotoxicity and cytokine production by 3-methylcholanthrene (3-MC). Int. J. Immunopharmacol. 12, 917-926.
52. Taylor, M.J., Lucier, G.W., Mahler, J.F., Thompson, M., Lockhart, A.C., Clark, G.C., 1992. Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone. Toxicol. Appl. Pharmacol. 117, 126-132.
53. Wojdani, A., Alfred, L.J., 1984. Alterations in cell-mediated immune functions induced in mouse splenic lymphocytes by polycyclic aromatic hydrocarbons. Cancer Res. 44, 942-945.
54. Yamaguchi, K., Near, R., Shneider, A., Cui, H., Ju, S.-T., Sherr, D.H., 1996. Fluoranthene-induced apoptosis inmurine T cell hybridomas is independent of the aromatic hydrocarbon receptor. Toxicol. Appl. Pharmacol. 139, 144-152.
55. Zedeck, M.S., 1980. Polycyclic aromatic hydrocarbons: a review. J. Environ. Pathol. Toxicol. 3, 537-567.