Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: Implications for tumor vaccine development

Journal of Immunology

Volumn 160, Issue 5, 1998, Pages 2099-2106

  Kittlesen, David J ^a   Thompson, Lee W ^a   Gulden, Pamela H ^a   Skipper, Jonathan C A ^a,b   Colella, Teresa A ^a   Shabanowitz, Jeffrey A ^a   Hunt, Donald F ^a   Engelhard, Victor H ^a   Slingluff Jr , Craig L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYSTEINE; EPITOPE; MONOPHENOL MONOOXYGENASE; SERINE; TUMOR VACCINE; TYROSINE; VIRUS VECTOR;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ARTICLE; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MELANOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; TARGET CELL; VACCINIA VIRUS;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CANCER VACCINES; CYSTEINE; CYTOTOXICITY, IMMUNOLOGIC; HLA-A1 ANTIGEN; HUMANS; IMMUNODOMINANT EPITOPES; MELANOMA; MONOPHENOL MONOOXYGENASE; PEPTIDE FRAGMENTS; SERINE; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

EID: 0032030641     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Scalzo, A. A., S. L. Elliott, J. Cox, J. Gardner, D. J. Moss, and A. Suhrbier. 1995. Induction of protective cytotoxic T cells to murine cytomegalovirus by using a nonapeptide and a human-compatible adjuvant (Montanide ISA 720). J. Virol. 69:1306.
2. Ada, G. 1991. Strategies for exploiting the immune system in the design of vaccines. Mol. Immunol. 28:225.
3. Feltkamp, M. C., H. L. Smits, M. P. Vierboom, R. P. Minnaar, B. M. deJongh, J. W. Drijfhout, J. ter Schegget, C. J. Melief, and W. M. Kast. 1993. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells. Eur. J. Immunol. 23:2242.
4. Darrow, T. L., C. L. Slingluff, and H. F. Seigler. 1989. The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes: evidence for shared tumor antigens. J. Immunol. 142:3329.
5. Traversari, C., P. van der Bruggen, I. F. Luescher, C. Lurquin, P. Chomez, A. Van Pel, E. De Plaen, A. Amar-Costesec, and T. Boon. 1992. A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E. J. Exp. Med. 176:1453.
6. Van den Eynde, B., O. Peeters, O. De Backer, B. Gaugler, S. Lucas, and T. Boon. 1995. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. J. Exp. Med. 182:689.
7. Brichard, V., A. Van Pel, T. Wolfel, C. Wolfel, E. De Plaen, B. Lethe, P. Coulie, and T. Boon. 1993. The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 178: 489.
8. Coulie, P. G., V. Brichard, A. Van Pel, T. Wolfel, J. Schenider, C. Traversari, E. DePlaen, C. Lurquin, J.-P. Szikora, J.-C. Renauld, and T. Boon. 1994. A new gene encoding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 180:35.
9. Bakker, A. B., M. W. Schreurs, A. J. de Boer, Y. Kawakami, S. A. Rosenberg, G. J. Adema, and C. G. Figdor. 1994. Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes. J. Exp. Med. 179:1005.
10. Cox, A. L., J. Skipper, Y. Chen, R. Henderson, T. L. Darrow, J. Shabanowitz, V. H. Engelhard, D. F. Hunt, and C. L. Slingluff, Jr. 1994. Identification of a peptide recognized by five melanoma-specific human cytotoxic T-cell lines. Science 264:716.
11. Wolfel, T., A. Van Pel, V. Brichard, J. Schneider, B. Seliger, K. H. Meyer zum Buschenfelde, and T. Boon. 1994. Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes. Eur. J. Immunol. 24:759.
12. Skipper, J. C. A., R. C. Hendrickson, P. H. Gulden, V. Brichard, A. VanPel, Y. Chen, J. Shabanowitz, T. Wolfel, C. L. Slingluff, Jr., T. Boon, D. F. Hunt, and V. H. Engelhard. 1996. An HLA-A2 restricted tyrosinase antigen on melanoma cells results from post-translational modification. J. Exp. Med. 183:527.
13. Brichard, V. G., J. Herman, A. Van Pel, C. Wildmann, B. Gaugler, T. Wolfel, T. Boon, and B. Lethe. 1996. A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes. Eur. J. Immunol. 26:224.
14. + T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene. Proc. Natl. Acad. Sci. USA 91:9461.
15. Tiwari, J. L., and P. I. Terasaki. 1985. The HLA complex. In HLA and Disease Associations. J. L. Tiwari and P. I. Terasaki, eds. Springer-Verlag, New York, p. 10.
16. Elliott, B. E., D. A. Carlow, A. M. Rodricks, and A. Wade. 1989. Perspectives on the role of MHC antigens in normal and malignant cell development. Adv. Cancer Res. 53:181 (Rev.).
17. Doyle, A., W. J. Martin, K. Funa, A. Gazdar, D. Carney, S. E. Martin, I. Linnoila, F. Cuttitta, J. Mulshine, P. Bunn, and J. Minna. 1985. Markedly decreased expression of class I histocompatibility antigens, protein, and mRNA in human small-cell lung cancer. J. Exp. Med. 161:1135.
18. Lassam, N., and G. Jay. 1989. Suppression of MHC class I RNA in highly oncogenic cells occurs at the level of transcription initiation. J Immunol. 143: 3792.
19. Lehmann, F., M. Marchand, P. Hainaut, P. Pouillart, X. Sastre, H. Ikeda, T. Boon, and P. G. Coulie. 1995. Differences in the antigens recognized by cytolytic T cells on two successive metastases of a melanoma patient are consistent with immune selection. Eur. J. Immunol. 25:340.
20. Celis, E., V. Tsai, C. Crimi, R. DeMars, P. A. Wentworth, R. W. Chesnut, H. M. Grey, A. Sette, and H. M. Serra. 1994. Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes. Proc. Natl. Acad. Sci. USA 91:2105.
21. Gaugler, B., B. Van den Eynde, P. van der Bruggen, P. Romero, J. J. Gaforio, E. De Plaen, B. Lethe, F. Brasseur, and T. Boon. 1994. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. J. Exp. Med. 179:921.
22. Skipper, J. C. A., D. J. Kittlesen, R. C. Hendrickson, D. D. Deacon, N. L. Harthun, S. N. Wagner, D. F. Hunt, V. H. Engelhard, and C. L. Slingluff, Jr. 1996. Shared epitopes for HLA-A3 restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100. J. Immunol. 157: 5027.
23. Adema, G. J., A. J. de Boer, A. M. Vogel, W. A. Loenen, and C. G. Figdor. 1994. Molecular characterization of the melanocyte lineage-specific antigen gp100. J. Biol. Chem. 269:20126.
24. Chen, Y. T., E. Stockert, S. Tsang, K. A. Coplan, and L. J. Old. 1995. Immunophenotyping of melanomas for tyrosinase: implications for vaccine development. Proc. Natl. Acad. Sci. USA 92:8125.
25. Slingluff, C. L., Jr., A. L. Cox, R. A. Henderson, D. F. Hunt, and V. H. Engelhard. 1993. Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes. J. Immunol. 150:2955.
26. Hahn, Y. S., V. L. Braciale, and T. J. Braciale, 1991. Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocytes: recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product. J. Exp. Med. 174:733.
27. Mackett, M., G. L. Smith, and B. Moss. 1984. General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes. J. Virol. 49:857.
28. Moroder, L., D. Besse, H-J. Musiol, S. Rudolph-Bohner, and F. Siedler. 1996. Oxidative folding of cystine-rich peptides vs. regioselective cysteine pairing strategies. Biopolymers 40:207.
29. Meadows, L., W. Wang, J. M. M. Den Haan, E. Blokland, C. Reinhardus, J. W. Drijfhout, J. Shabanowitz, R. Pierce, A. I. Agulnik, C. E. Bishop, D. F. Hunt, E. Goulmy, and V. H. Engelhard. 1997. The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. Immunity 6:273.
30. DiBrino, M., K. C. Parker, J. Shiloach, R. V. Turner, T. Tsuchida, M. Garfield. W. E. Biddison, and J. E. Coligan. 1994. Endogenous peptides with distinct amino acid anchor residue motifs bind to HLA-A1 and HLA-B8. J. Immunol. 152:620.
31. DiBrino, M., T. Tsuchida, R. V. Turner, K. C. Parker, J. E. Coligan, and W. E. Biddison. 1993. HLA-A1 and HLA-A3 T cell epitopes derived from influenza virus proteins predicted from peptide binding motifs. J. Immunol. 151: 5930.
32. Hobohm, U., and A. Meyerhans. 1993. A pattern search method for putative anchor residues in T cell epitopes. Eur. J. Immunol. 23:1271.
33. Kast, W. M., R. M. P. Brandt, J. Sidney, J.-W. Drijfhout, R. T. Kubo, H. M. Grey, C. J. M. Melief, and A. Sette. 1994. Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins. J. Immunol. 152:3904.
34. Celis, E., J. Fikes, P. Wentworth, J. Sidney, S. Southwood, A. Maewal, M.-F. Del Guercio, A. Sette, and B. Livingston. 1994. Identification of potential CTL epitopes of tumor-associated antigen MAGE-1 for five common HLA-A alleles. Mol. Immunol. 31:1423.
35. Kawakami, Y., S. Eliyahu, K. Sakaguchi, P. F. Robbins, L. Rivoltini, J. R. Yannelli, E. Appella, and S. A. Rosenberg. 1994. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes. J. Exp. Med. 180:147.
36. Stofer-Vogel, B., T. Cerny, A. Kupfer, E. Junker, and B. H. Lauterburg. 1993. Depletion of circulating cyst(e)ine by oral and intravenous mesna. Br. J. Cancer 68:590.
37. Engelhard, V. H. 1994. Structure of peptides associated with MHC class I molecules. Curr. Opin. Immunol. 6:13.
38. Henderson, R. A., H. Michel, K. Sakaguchi, J. Shabanowitz, E. Appella, D. F. Hunt, and V. H. Engelhard. 1992. HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation. Science 255:1264.
39. Hwang, C., A. J. Sinskey, and H. F. Lodish. 1992. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257:1496.
40. Freedman, R. B. 1984. Native disulphide bond formation in protein biosynthesis: evidence for the role of protein disulphide isomerase. Trends Biochem. Sci. 9:438.