Discovery of α1a-Adrenergic Receptor Antagonists Based on the L-Type Ca2+ Channel Antagonist Niguldipine

Journal of Medicinal Chemistry

Volumn 38, Issue 10, 1995, Pages 1579-1581

  Wetzel, John M ^a   Miao, Shou Wu ^a   Forray, Carlos ^a   Borden, Laurence A ^b   Branchek, Theresa A ^a   Gluchowski, Charles ^a  

^a H LUNDBECK A S   (Denmark)

^b Trophix Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 4 (4 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLIC ACID 3 (4,4 DIPHENYL 1 PIPERIDINYL)PROPYL METHYL ESTER; 1,4 DIHYDRO 2,6 DIMETHYL 4 (4 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLIC ACID [3 (4,4 DIPHENYL 1 PIPERIDINYL)PROPYL]AMIDE METHYL ESTER; 5 [3 (4,4 DIPHENYL 1 PIPERIDINYL)PROPYLCARBAMOYL] 1,4 DIHYDRO 2,6 DIMETHYL 4 (4 NITROPHENYL) 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ABANOQUIL; ALFUZOSIN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; DOXAZOSIN; GUANINE NUCLEOTIDE BINDING PROTEIN; NIFEDIPINE DERIVATIVE; NIGULDIPINE; NORADRENALIN; PRAZOSIN; TERAZOSIN; UNCLASSIFIED DRUG;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ARTICLE; CALCIUM ANTAGONISM; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ANALYSIS;

ADRENERGIC ALPHA-ANTAGONISTS; CALCIUM CHANNEL BLOCKERS; CELL LINE; CLONING, MOLECULAR; DIHYDROPYRIDINES; HUMAN; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 0029065459     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00010a001     Document Type: Article

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