Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis

Journal of Immunology

Volumn 163, Issue 12, 1999, Pages 6785-6793

  Raeder, Evelin M B ^a   Mansfield, Pamela J ^a   Hinkovska Galcheva, Vania ^a   Shayman, James A ^b   Boxer, Laurence A ^b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; WORTMANNIN;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME INHIBITION; GENE ACTIVATION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CELL MIGRATION INHIBITION; DIGLYCERIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME PRECURSORS; ERYTHROCYTES; HUMANS; IMMUNOGLOBULIN G; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEUTROPHILS; OPSONIN PROTEINS; PHAGOCYTOSIS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; PROTEIN-TYROSINE KINASES; RECEPTORS, IGG; SHEEP; SIGNAL TRANSDUCTION; STILBENES;

EID: 0032742014     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Indik, Z. K., J. G. Park, S. Hunter, and A. D. Schreiber. 1995. The molecular dissection of Fcγ receptor mediated phagocytosis. Blood 86:4389.
2. de Haas, M., P. J. Vossebeld, A. E. von dem Borne, and D. Roos. 1995. Fcγ receptors of phagocytes. J. Lab. Clin. Med. 126:330.
3. Kinet, J. P. 1989. Antibody-cell interactions: Fc receptors. Cell 57:351.
4. Buckle, A. M., and N. Hogg. 1989. The effect of IFN-gamma and colony-stimulating factors on the expression of neutrophil cell membrane receptors. J. Immunol. 143:2295.
5. Ibarrola, I., P. J. Vossebeld, C. H. Homburg, M. Thelen, D. Roos, and A. J. Verhoeven. 1997. Influence of tyrosine phosphorylation on protein interaction with FcγRIIa. Biochim. Biophys. Acta 1357:348.
6. Indik, Z. K., J. G. Park, X. Q. Pan, and A. D. Schreiber. 1995. Induction of phagocytosis by a protein tyrosine kinase. Blood 85:1175.
7. Birge, R. B., and H. Hanafusa. 1993. Closing in on SH2 specificity. Science 262:1522.
8. Songyang, Z., S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Lechleider, et al. 1993. SH2 domains recognize specific phosphopeptide sequences. Cell 72:767.
9. Kiefer, F., J. Brumell, N. Al-Alawi, S. Latour, A. Cheng, A. Veillette, S. Grinstein, and T. Pawson. 1998. The Syk protein tyrosine kinase is essential for Fcγ receptor signaling in macrophages and neutrophils. Mol. Cell. Biol. 18: 4209.
10. Rowley, R. B., A. L. Burkhardt, H. G. Chao, G. R. Matsueda, and J. B. Bolen. 1995. Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig α/Ig β immunoreceptor tyrosine activation motif binding and autophosphorylation. J. Biol. Chem. 270:11590.
11. Greenberg, S., P. Chang, and S. C. Silverstein. 1994. Tyrosine phosphorylation of the γ subunit of Fcγ receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages. J. Biol. Chem. 269:3897.
12. Indik, Z. K., S. Hunter, M. M, Huang, X. Q. Pan, P. Chien, C. Kelly, A. I. Levinson, R. P. Kimberly, and A. D. Schreiber. 1994. The high affinity Fcγ receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fcγ RIIIA imparts phagocytic function to FcγRI. Exp. Hematol 22:599.
13. Indik, Z., C. Kelly, P. Chien, A. I. Levinson, and A. D. Schreiber. 1991. Human Fcγ RII, in the absence of other Fcγ receptors, mediates a phagocytic signal. J. Clin. Invest. 88:1766.
14. Park, J. G., R. K. Murray, P. Chien, C. Darby, and A. D. Schreiber. 1993. Conserved cytoplasmic tyrosine residues of the γ subunit are required for a phagocytic signal mediated by Fcγ RIIIA. J. Clin. Invest. 92:2073.
15. Greenberg, S., P. Chang, D. C. Wang, R. Xavier, and B. Seed. 1996. Clustered Syk tyrosine kinase domains trigger phagocytosis. Proc. Natl. Acad. Sci. USA 93:1103.
16. Matsuda, M., J. G. Park, D. C. Wang, S. Hunter, P. Chien, and A. D. Schreiber. 1996. Abrogation of the Fcγ receptor IIA-mediated phagocytic signal by stemloop Syk antisense oligonucleotides. Mol. Biol. Cell 7:1095.
17. Suchard, S. J., P. J. Mansfield, L. A. Boxer, and J. A. Shayman. 1997. Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide. J. Immunol. 158:4961.
18. Knall, C., S. Young, J. A. Nick, A. M. Buhl, G. S. Worthen, and G. L. Johnson. 1996. Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils. J. Biol. Chem. 271:2832.
19. Pawson, T. 1995. Protein modules and signalling networks. Nature 373:573.
20. Ueda, Y., S. Hirai, S. Osada, A. Suzuki, K. Mizuno, and S. Ohno. 1996. Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 271:23512.
21. Raeder, E., P. Mansfield, V. Hinkosvka-Galcheva, L. Kjeldsen, J. Shayman, and L. Boxer. 1999. Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen activated protein kinase activation. Blood 93:686.
22. 2+ signalling induced by Fcγ receptor cross-linking in human neutrophils. Biochem. J. 323:87.
23. Duckworth, B. C., and L. C. Cantley. 1997. Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin: dependence on signal strength. J. Biol. Chem. 272:27665.
24. Stephens, L. R., T. R. Jackson, and P. T. Hawkins. 1993. Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? Biochim. Biophys. Acta 1179:27.
25. Dhand, R., K. Hara, I. Hiles, B. Bax, I. Gout, G. Panayotou, M. J. Fry, K. Yonezawa, M. Kasuga, and M. D. Waterfield. 1994. Pl 3-kinase: structural and functional analysis of intersubunit interactions. EMBO J. 13:511.
26. Hu, P., and J. Schlessinger. 1994. Direct association of p110β phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 β. Mol. Cell. Biol. 4:2577.
27. Thelen, M., M. P. Wymann, and H. Langen. 1994. Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes. Proc. Natl. Acad. Sci. USA 91:4960.
28. Curnutte, J. T., and B. M. Babior. 1974. Biological defense mechanisms: the effect of bacteria and serum on superoxide production by granulocytes. J. Clin. Invest. 53:1662.
29. Suchard, S. J., V. Hinkovska-Galcheva, P. J. Mansfield, L. A. Boxer, and J. A. Shayman. 1997. Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes. Blood 89:2139.
30. Pommier, C. G., S. Inada, L. F. Fries, T. Takahashi, M. M. Frank, and E. J. Brown. 1983. Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes. J. Exp. Med. 157:1844.
31. Van Veldhoven, P. P., and R. M. Bell. 1988. Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells. Biochim. Biophys. Acta 959:185.
32. 2 and lactoferrin release in adherent human neutrophils. J. Biol. Chem. 269:8063.
33. Crowley, M. T., P. S. Costello, C. J. Fitzer-Attas, M. Turner, F. Meng, C. Lowell, V. L. Tybulewicz, and A. L. DeFranco. 1997. A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages. J. Exp. Med. 186:1027.
34. syk noncovalently associate with the low affinity Fcγ receptor on human platelets through an immunoreceptor tyrosine-based activation motif: reconstitution with synthetic phosphopeptides. J. Biol. Chem. 271:10775.
35. Ninomiya, N., K. Hazeki, Y. Fukui, T. Seya, T. Okada, O. Hazeki, and M. Ui. 1994. Involvement of phosphatidylinositol 3-kinase in Fc γ receptor signaling. J. Biol. Chem. 269:22732.
36. Zhou, M.-J., D. M. Lublin, D. C. Link, and E. J. Brown. 1995. Distinct tyrosine kinase activation and Triton X-100 insolubility upon FcγRII or FcγRIIIB ligation in human polymorphonuclear leukocytes. J. Biol. Chem. 270:13553.
37. Fialkow, L., C. K. Chan, D. Rotin, S. Grinstein, and G. P. Downey. 1994. Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. J. Biol. Chem. 269:31234.
38. Carey, S. S., P. J. Mansfield, J. A. Shayman, and L. A. Boxer. 1999. The role of ceramide in regulation of the respiratory burst and phagocytosis in polymorphonuclear leukocytes. Blood (Abstr.). In press.
39. Sergeant, S., and L. C. McPhail. 1997. Opsonized zymosan stimulates the redistribution of protein kinase C isoforms in human neutrophils. J. Immunol. 159: 2877.
40. Kiener, P. A., B. M. Rankin, A. L. Burkhardt, G. L. Schieven, L. K. Gilliland, R. B. Rowley, J. B. Bolen, and J. A. Ledbetter. 1993. Cross-linking of Fcγ receptor 1 (FcγRI) and receptor II (FcγRII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase. J. Biol. Chem. 268:24442.
41. syk a protein-tyrosine kinase, in Fcγ receptor signaling. J. Biol. Chem. 268:15900.
42. Della Bianca, V., M. Grzeskowiak, S. Dusi, and F. Rossi. 1993. Transmembrane signaling pathways involved in phagocytosis and associated activation of NADPH oxidase mediated by FcγRs in human neutrophils. J. Leukocyte Biol. 53:427.
43. Capodici, C., S. Hanft, M. Feoktistov, and M. H. Pillinger. 1998. Phosphatidylinositol 3-kinase mediates chemoattractant-stimulated. CD11b/CD18-dependent cell-cell adhesion of human neutrophils: evidence for an ERK-independent pathway. J. Immunol. 160:1901.
44. Sue, A. Q. A. K., L. Fialkow, C. J. Vlahos, J. A. Schelm, S. Grinstein, J. Butler, and G. P. Downey. 1997. Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases. J. Cell. Physiol. 172:94.
45. Araki, N., M. T. Johnson, and J. A. Swanson. 1996. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J. Cell Biol. 135:1249.
46. Gerrard, J. M., L. L. Beattie, J. Park. S. J. Israels, A. McNicol, D. Lint, and H. J. Cragoe. Jr. 1989. A role for protein kinase C in the membrane fusion necessary for platelet granule secretion. Blood 74:2405.
47. Ruiz-Arguello, M. B., F. M. Goni, and A. Alonso. 1998. Vesicle membrane fusion induced by the concerted activities of sphingomyelinase and phospholipase C. J. Biol. Chem. 273:22977.