Characterization of cerebral blood oxygenation and flow changes during prolonged brain activation

Human Brain Mapping

Volumn 5, Issue 2, 1997, Pages 93-109

  Bandettini, P A ^a,e   Kwong, K K ^a   Davis, T L ^a,b   Tootell, R B H ^a   Wong, E C ^c   Fox, P T ^d   Belliveau, J W ^a   Weisskoff, R M ^a   Rosen, B R ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

BOLD contrast; Brain function; Deoxyhemoglobin; fMRI; Human brain mapping; Neuronal habituation; Neuronal metabolism; PET; Photic stimulation; Visual cortex

Indexed keywords

DEOXYHEMOGLOBIN;

ARTICLE; BLOOD OXYGENATION; BRAIN CELL; BRAIN CIRCULATION; BRAIN FUNCTION; BRAIN MAPPING; FLOW RATE; HEMODYNAMICS; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN CONSUMPTION; OXYGENATION; PHOTOSTIMULATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TACTILE STIMULATION; VISUAL CORTEX; VISUAL STIMULATION;

BLOOD FLOW VELOCITY; BRAIN MAPPING; CEREBROVASCULAR CIRCULATION; HUMANS; MAGNETIC RESONANCE IMAGING; OXYGEN; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030974702     PISSN: 10659471     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0193(1997)5:2<93::AID-HBM3>3.0.CO;2-H     Document Type: Article

References (68)

1. Bandettini PA, Wong EC (1995): Effects of biophysical and physiologic parameters on brain activation-induced R2* and R2 changes: Simulations using a deterministic diffusion model. Int J Imaging Systems Technol 6:134-152.
2. Bandettini PA, Wong EC, Hinks RS, Tikofsky RS, Hyde JS (1992): Time course EPI of human brain function during task activation. Magn Reson Med 25:390-397.
3. Bandettini PA, Jesmanowicz A, Wong EC, Hyde JS (1993a): Processing strategies for time-course data sets in functional MRI of the human brain. Magn Reson Med 30:161-173.
4. Bandettini PA, Wong EC, DeYoe EA, Binder JR, Rao SM, Birzer D, et al. (1993b): The functional dynamics of blood oxygen level dependent contrast in the motor cortex. In: Proceedings of the SMRM 12th Annual Meeting, New York, p 1382.
5. Bandettini PA, Wong EC, Jesmanowicz A, Hinks RS, Hyde JS (1993c): Simultaneous mapping of activation-induced ΔR2* and ΔR2 in the human brain using a combined gradient-echo and spin-echo EPI pulse sequence. In: Proceedings of the SMRM 12th Annual Meeting, New York, p 169.
6. Bandettini PA, Davis TL, Kwong KK, Fox PT, Jiang A, Baker JR, et al. (1995a): FMRI and PET demonstrate sustained blood oxygenation and flow enhancement during extended visual stimulation durations. In: Proceedings of the SMR 3rd Annual Meeting, Nice, France, p 453.
7. Bandettini PA, Kwong KK, Davis TL, Jiang A, Baker JR, Belliveau JW, et al. (1995b): FMRI demonstrates sustained blood oxygenation and flow enhancement during extended duration visual and motor cortex activation. In: Book of Abstracts, Society for Neuroscience 25th Annual Meeting, San Diego, CA, p 1209.
8. Bandettini PA, Wong EC, Binder JR, Rao SM, Jesmanowicz A, Aaron EA, et al. (1995c): Functional MRI using the BOLD approach: Dynamic characteristics and data analysis methods. In LeBihan D (ed): Diffusion and Perfusion: Magnetic Resonance Imaging. New York: Raven Press, pp 335-349.
9. Bandettini PA, Kwong KK, Wong EC, Tootel RB, Rosen BR (1996): Direct R2* measurements and flow insensitive T2* weighted studies indicate a sustained elevation of blood oxygenation during long term activation. In: Proceedings of the ISMRM 4th Annual Meeting, New York, p 1888.
10. Belliveau JW, Kennedy DN, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, et al. (1991): Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254:716-719.
11. Blamire AM, Ogawa S, Ugurbil K, Rothman D, McCarthy G, Ellermann JM, et al. (1992): Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging. Proc Natl Acad Sci USA 89:11069-11073.
12. Boxerman JL, Hamberg LM, Rosen BR, Weisskoff RM (1995): MR contrast due to mtravascular magnetic susceptibility perturbations. Magn Reson Med 34:555-566.
13. Buxton RB, Frank LR (1997): A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J Cereb Blood Flow Metab 17:64-72.
14. Buxton RB, Wong EC, Frank LR (1997): A biomechanical interpretation of the BOLD signal time course: the balloon model. In: Proceedings of the ISMRM 5th Annual Meeting, Vancouver p 743.
15. Davis TL, Weisskoff RM, Kwong KK, Boxerman JL, Rosen BR (1994): Temporal aspects of fMRI task activation: dynamic modeling of oxygen delivery. In: Proceedings of the SMR 2nd Annual Meeting, San Francisco, p 69.
16. DeYoe EA, Neitz J, Bandettini PA, Wong EC, Hyde JS (1992): Time course of event-related MR signal enhancement in visual and motor cortex. In: Proceedings of the SMRM 11th Annual Meeting, Berlin, p 1824.
17. Edelman R, Sievert B, Darby D (1994a): Qualitative mapping of cerebral blood flow and functional localization with echo planar MR imaging and signal targeting with alternating radiofrequency (EPISTAR). Radiology 192:1-8
18. Edelman R, Wielopolski P, Schmitt F (1994b): Echo-planar MR imaging. Radiology 192:600-612.
19. Edelman RR, Sievert B, Wielopolski P, Pearlman J, Warach S (1994c): Noninvasive mapping of cerebral perfusion by using EPISTAR MR angiography. JMRI 4(P):68, abstract.
20. Ernst T, Hennig J (1994): Observation of a fast response in functional MR. Magn Reson Med 32:146-149.
21. Fox PT, Raichle ME (1986): Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 83:1140-1144.
22. Frahm J, Bruhn H, Merboldt K-D, Hanicke W, Math D (1992): Dynamic MR imaging of human brain oxygenation during rest and photic stimulation. JMRI 2:501-505.
23. Frahm J, Merboldt K-D, Hanicke W (1993): Functional MRI of human brain activation at high spatial resolution, Magn Reson Med 29:139-144.
24. Frahm J, Krüger G, Merboldt K-D, Kleinschmidt A (1996): Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal activation in man. Magn Reson Med 35:143-148.
25. Frostig RD, Lieke EE, Ts'o DY Grinvald A (1990): Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals. Proc Natl Acad Sci USA 87:6082-6086.
26. Glover GH, Lee AT (1995): Motion artifacts in fMRI: Comparison of 2DFT with PR and spiral scan methods. Magn Reson Med 33:624-635.
27. Glover GH, Lemieux SK, Drangova M, Pauly JM (1996): Decomposition of inflow and blood oxygenation level-dependent (BOLD) effects with dual-echo spiral gradient-recalled echo (GRE) fMRI. Magn Reson Med Vol 35, pp 299-308.
28. Grinvald A, Frostig RD, Siegel RM, Bratfeld E (1991): High-resolution optical imaging of functional brain architecture in the awake monkey. Proc Natl Acad Sci USA 88:11559-11563.
29. Hathout GM, Kirlew KA, So GJK, Hamilton DR, Zhang JX, Sinha U, et al. (1994): MR imaging signal response to sustained stimulation in human visual cortex. JMRI 4:537-543.
30. Hathout GM, Gambhir SS, Gopi RK, Kirlew KAT, Choi Y, So G, et al. (1995): A quantitative physiologic model of blood oxygenation for functional magnetic resonance imaging. Invest Radiol 30:669-682.
31. Hennig J, Janz C, Speck O, Ernst T (1995): Functional spectroscopy of brain activation following a single light pulse: Examinations of the mechanism of the fast initial response. Int J Imaging Systems Technol 6:203-208.
32. Howseman AM, Josephs O, Muller E, Carroll A, Brennan A, Frackowiak RSJ, et al. (1996): Sustained activation in visual cortex: A comparison between echo-planar and FLASH fMRI methods. In: Proceedings of the ISMRM 4th Annual Meeting, New York, p 1855.
33. Jezzard P, Heinmann F, Taylor J, Despres D, Wen H, Balaban RS, et al. (1994): Comparison of EPI gradient-echo contrast changes in cat brain caused by respiratory challenges with direct simultaneous evaluation of cerebral oxygenation via a cranial window. NMR Biomed 7:35-44.
34. Karczmar GS, Kuperman VY, River JN, Lewis MZ, Lipton MJ (1994): Magnetic resonance measurement of response to hypoxia differentiates tumors from normal tissue and may be sensitive to oxygen consumption. Invest Radiol 29(S2):S161-S163.
35. Kennan RP, Zhong J, Gore JC (1994): Intravascular susceptibility contrast mechanisms in tissues. Magn Reson Med 31:9-21.
36. Kim S-G (1995): Quantification of relative cerebral blood flow change by flow-sensitive alternating inversion recovery (FAIR) technique: Application to functional mapping. Magn Reson Med 34:293-301.
37. Kollias S, Golay X, Meier D, Boesinger P, Valavanis A (1996): Blood oxygenation level dependent (BOLD) signal response to progressive shortening of the rest period between constant activated phases at high temporal resolution. In: Proceedings of the ISMRM 4th Annual Meeting, New York, p 1758.
38. Kwong KK (1995): Functional magnetic resonance imaging with echo planar imaging. Magn Reson Q 11:1-20.
39. Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, et al. (1992a): Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89:5675-5679.
40. Kwong KK, Beiliveau JW, Stern CE, Chesler DA, Goldberg IE, Poncelet BP, et al. (1992b): Functional MR imaging of primary visual and motor cortex. JMRI 2(P):76, abstract
41. Kwong KK, Chesler DA, Weisskoff RM, Donahue KM, Davis TL, Ostergaard L, et al. (1995). MR perfusion studies with T1-weighted echo planar imaging. Magn Reson Med 34:878-887.
42. Le TH, Hu X (1996): Evaluation of the early response in individual subjects using short stimulus duration. In: Proceedings of the ISMRM 4th Annual Meeting, New York, p 285.
43. Livingstone MS, Hubel DH (1984): Anatomy and physiology of a color system in the primate visual cortex. J Neurosci 4:309-356.
44. Madsen PL, Hasselbalch SG, Hagemann LP, Olsen KS, Bülow J, Holm S, et al. (1995): Persistent resetting of the cerebral oxygen/ glucose uptake ratio by brain activation: Evidence obtained with the Kety-Schmidt technique. J Cereb Blood Flow Metab 15:485-491.
45. Malonek D, Grinvald A (1996): Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: Implications for functional brain mapping. Science 272:551-554.
46. Menon RS, Ogawa S, Tank DW, Ugurbil K (1993): 4 Tesla gradient recalled echo characteristics of photic stimulation-induced signal changes in the human primary visual cortex. Magn Reson Med 30:380-386.
47. Menon RS, Ogawa S, Strupp JP, Anderson P, Ugurbil K (1995a): BOLD based functional MRI at 4 Tesla includes a capillary bed contribution: Echo-planar imaging correlates with previous optical imaging using intrinsic signals. Magn Reson Med 33:453-459.
48. Menon RS, Ogawa S, Ugurbil K (1995b): High-temporal-resolution studies of the human primary visual cortex at 4T: Teasing out the oxygenation contribution in FMRI. Int J Imaging Systems Technol 6:209-215.
49. Noll DC (1995): Methodologic considerations for spiral k-space functional MRI. Int J Imaging Systems Technol 6:175-183.
50. Noll DC, Cohen JD, Meyer CH, Schneider W (1995): Spiral k-space MR imaging of cortical activation. JMRI 5:49-56.
51. Ogawa S, Lee T-M (1990): Magnetic resonance imaging of blood vessels at high fields: In vivo and in vitro measurements and image simulation. Magn Reson Med 16.9-18.
52. Ogawa S, Lee T-M, Nayak AS, Glynn P (1990a): Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14:68-78.
53. Ogawa S, Lee TM, Kay AR, Tank DW (1990b): Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 87:9868-9872.
54. Ogawa S, Tank DW, Menon R, Ellermann JM, Kim S-G, Merkle H, et al. (1992): Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 89:5951-5955.
55. Savoy RL, O'Craven KM, Weisskoff RM, Davis TL, Baker J, Rosen B (1994): Exploring the temporal boundaries of fMRI: Measuring responses to very brief visual stimuli. In: Book of Abstracts, Society for Neuroscience 24th Annual Meeting, Miami, p 1264.
56. Savoy RL, Bandettini PA, Weisskoff RM, Kwong KK, Davis TL, Baker JR, et al. (1995): Pushing the temporal resolution of fMRI: Studies of very brief visual stimuli, onset variability and asynchrony, and stimulus-correlated changes in noise. In: Proceedings of the SMR 3rd Annual Meeting, Nice, France, p 450.
57. Silverman MS, Grosof DH, DeValois RL, Elfar SD (1989): Spatial-frequency organization in primate striate cortex. Proc Natl Acad Sci USA 86:711-715.
58. Stehling MK, Schmitt F, Ladebeck R (1993): Echo-planar MR imaging of human brain oxygenation changes. JMRI 3:471-474.
59. Turner R, LeBihan D, Moonen CTW, Despres D, Frank J (1991): Echo-planar time course MRI of cat brain oxygenation changes. Magn Reson Med 27:159-166.
60. Turner R, Jezzard P, Wen H, Kwong KK, Bihan DL, Zeffiro T, et al. (1993): Functional mapping of the human visual cortex at 4 and 1.5 Tesla using deoxygenation contrast EPI. Magn Reson Med 29:277-279.
61. Villringer A, Dirnagle U (1995): Coupling of brain activity and cerebral blood flow: Basis of functional neuroimaging. Cereb Brain Metab Rev 7:240-276.
62. Villringer A, Planck J, Hock C, Scheinkofer L, Dirnagl U (1993): Near infrared spectroscopy (NIRS): A new tool to study hemodynamic changes during activation of brain function in human adults. Neurosci Lett 154:101-104.
63. Weisskoff RM, Zuo CS, Boxerman JL, Rosen BR (1994): Microscopic susceptibility variation and transverse relaxation: Theory and experiment. Magn Reson Med 31:601-610.
64. Wong EC, Bandettini PA (1996): Two embedded techniques for simultaneous acquisition of flow and BOLD signals in functional MRI. In: Proceedings of the ISMRM 4th Annual Meeting, New York, p 1816.
65. Wong EC, Bandettini PA, Hyde JS (1992): Echo-planar imaging of the human brain using a three axis local gradient coil. In: Proceedings of the SMRM 11th Annual Meeting, Berlin, p 105.
66. Wong EC, Buxton RB, Frank LR (1996a): Quantitative imaging of perfusion using a single subtraction (QUIPSS). In: Second International Conference of Functional Mapping of the Human Brain, Boston. Neuroimage 3:S5.
67. Wong EC, Buxton RB, Frank LR (1996b): Quantitative perfusion imaging using EPISTAR and FAIR. In: Proceedings of the ISMRM 4th Annual Meeting, New York, p 8.
68. Yablonsky DA, Haacke EM (1994): Theory of NMR signal behavior in magnetically inhomogenous tissues: The static dephasing regime. Magn Reson Med 32:749-763.