HNPCC syndrome, microsatellite instability and NF1 gene alteration;Syndrome HNPCC, instabilite des microsatellites et alteration du gene NF1

Bulletin du Cancer

Volumn 86, Issue 10, 1999, Pages 812-814

  Puisieux, Alain ^a  

^a CENTRE LÉON BÉRARD   (France)

Author keywords

A venir

Indexed keywords

BASE MISPAIRING; CANCER GROWTH; CANCER SUSCEPTIBILITY; COLORECTAL CANCER; GENE MUTATION; GENETIC PREDISPOSITION; HEMATOPOIETIC SYSTEM TUMOR; HETEROZYGOSITY; MICROSATELLITE INSTABILITY; NEUROFIBROMATOSIS; SHORT SURVEY; B LYMPHOCYTE; CHILD; COLORECTAL TUMOR; DISEASE COURSE; DNA REPAIR; GENETICS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; METABOLISM; MUTATION; REVIEW; TUMOR SUPPRESSOR GENE;

ADENOSINE TRIPHOSPHATASE; CARRIER PROTEIN; DNA BINDING PROTEIN; MICROSATELLITE DNA; MLH1 PROTEIN, HUMAN; MSH2 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN MSH2; TUMOR PROTEIN;

ADENOSINE TRIPHOSPHATASES; B-LYMPHOCYTES; BASE PAIR MISMATCH; CARRIER PROTEINS; CHILD; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DISEASE PROGRESSION; DNA REPAIR; DNA-BINDING PROTEINS; GENES, NEUROFIBROMATOSIS 1; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MICROSATELLITE REPEATS; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NEUROFIBROMATOSIS 1; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS;

EID: 0032734460     PISSN: 00074551     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (11)

1. 1. Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem 1996; 65: 101-33.
2. 2. Prolla TA, Baker SM, Harris AC, Tsao JL, Yao X, Bronner CE, et al. Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nature Genet 1998; 18: 276-9.
3. 3. Lynch HT, Smyrk T, Lynch JF. Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome). Int J Cancer 1996; 69: 38-43.
4. 4. Olschwang S, Hamelin R, Laurent-Puig P, Thuille B, De Rycke Y, Li Y-J, et al. Alternative genetic pathways in colorectal carcinogenesis. Proc Natl Acad Sci USA 1997; 94: 12122-7.
5. 5. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (Washington DC) 1995; 268: 1336-8.
6. 6. Ouyang H, Shiwaku HO, Hagiwara H, Miura K, Abe T, Kato Y, et al. The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum. Cancer Res 1997; 57: 1851-4.
7. 7. Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC, et al. Somatic frameshift mutations in the bax gene in colon cancer of the microsatellite mutator phenotype. Science (Washington DC) 1997; 275: 967-9.
8. 8. Wang Q, Lasset C, Desseigne F, Frappaz D, Bergeton C, Navarro C, et al. Neurofibromatosis and early onset of cancers in hMLH1-deficient children. Cancer Res 1999; 59: 294-7.
9. 9. Ricciardone MD, Özçelik T, Cevher B, Özdag H, Tuncer M, Gürgey A, et al. Human MLH1 deficiency predisposes to hemarological malignancy and neurofibromatosis type I. Cancer Res 1999; 59: 290-3.
10. 10. Riccardi VM. Neurofibromatosis: phenotype, natural history and pathogenesis. 2nd edition. Baltimore: Johns Hopkins University Press, 1992.
11. 11. Rodenhiser DI, Andrews JD, Mancini DN, Jung JH, Singh SM. Homonucleotide tracts, short repeats and CpG/CpNpG motifs are frequent sites for heterogeneous mutations in the neurofibromatosis type I (NF1) tumour-suppressor gene. Mutat Res 1997; 373: 185-95.