Nociceptin (1-7) antagonizes nociceptin-induced hyperalgesia in mice

British Journal of Pharmacology

Volumn 128, Issue 5, 1999, Pages 941-944

  Sakurada, Tsukasa ^a   Sakurada, Shinobu ^b   Katsuyama, Sou ^b   Sakurada, Chikai ^a   Koichi, Tan No ^b   Terenius, Lars ^c  

^a DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Hyperalgesia; Intrathecal injection; Nociceptin; Nociceptin (1 7); Spinal cord

Indexed keywords

NOCICEPTIN; NOCICEPTIN[1-7]; PEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; HYPERALGESIA; INTRATHECAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TAIL FLICK TEST; WITHDRAWAL REFLEX;

AMINO ACID SEQUENCE; ANIMALS; HYPERALGESIA; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SPINAL; MALE; MICE; MOLECULAR SEQUENCE DATA; OPIOID PEPTIDES; PAIN MEASUREMENT; PEPTIDE FRAGMENTS; REACTION TIME; RECEPTORS, OPIOID; SPINAL CORD;

EID: 0032732401     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702898     Document Type: Article

References (14)

1. 1 receptor by nociceptin, nociceptin analogs and opioids. Eur. J. Pharmacol., 321, 97-103.
2. GRISEL, J., MOGIL, J.S., BELKNAP, J.K. & GRANDY, D.K. (1996). Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide. Neuro Report, 7, 2125-2129.
3. HARA, N., MINAMI, T., OKUDA-ASHITAKA, E., SUGIMOTO, T., SAKAI, M., ONAKA, M., MORI, H., IMANISHI, T., SHINGU, K. & ITO, S. (1997). Characterization of nociceptin hyperalgesia and allodynia in conscious mice. Br. J. Pharmacol., 121, 401-408.
4. HYLDEN, J.L.K. & WILCOX, G.L. (1980). Intrathecal morphine in mice, a new technique. Eur. J. Pharmacol., 67, 313-316.
5. KING, M.A., ROSSI, G.C., CHANG, A.H., WILLIAMS, L. & PASTERNAK, G.W. (1997). Spinal analgesic activity of orphanin FQ/ nociceptin and its fragments. Neurosci. Lett., 223, 113-116.
6. MATHIS, J.P., RYAN-MORO, J., CHANG, A., HOM, J.S.H., SCHEINBERG, D.A. & PASTERNAK, G.W. (1997). Biochemical evidence for orphanin FQ/nociceptin receptor heterogeneity in mouse brain. Biochem. Biophy. Res. Commun., 230, 462-465.
7. 1 receptor. Nature, 377, 532-535.
8. MOLLEREAU, C., PARMENTIER, M., MAILLEUX, P., BUTOUR, J.-L., MOISAND, C., CHALON, P., CAPUT, D., VASSART, G. & MEUNIER, J.-C. (1994). ORL1, a novel member of the opioid receptor family. FEBS Lett., 341, 33-38.
9. MONTIEL, J.-L., CORNILLE, F., ROQUES, B.P. & NOBLE, F. (1997). Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15. J. Neurochem., 68, 354-361.
10. REINSCHEID, R.K., NOTHACKER, H.-P., BOURSON, A., ARDATI, A., HENNINGSEN, R.A., BUNZOW, J.R., GRANDY, D.K., LANGEN, H., MONSMA, JR. F.J. & CIVELLI, O. (1995). Orphanin FQ: a neuropeptide that activates an opioid-like G protein-coupled receptor. Science, 270, 792-794.
11. ROSSI, G.C., LEVENTHAL, L., BOLAN, E. & PASTERNAK, G.W. (1997). Pharmacological characterization of orphanin FQ/ nociceptin and its fragments. J. Pharmacol. Exp. Ther., 282, 858-865.
12. 1 receptors. Br. J. Pharmacol., 127, 1712-1718.
13. TIAN, J.-H., XU, W., FANG, Y., MOGIL, J.S., GRISEL, J.E., GRANDY, D.K. & HAN, J.-S. (1997). Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. Br. J. Pharmacol., 120, 676-680.
14. XU, X.-J., HAO, J.-X. & WIESENFELD-HALLIN, Z. (1996). Nociception or antinociceptin: potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat. Neuro Report, 7, 2092-2094.