Immune responses to antigens of human endogenous retroviruses in patients with acute or stable multiple sclerosis

Journal of Neuroimmunology

Volumn 99, Issue 2, 1999, Pages 173-182

  Clerici, Mario ^a   Fusi, Maria Luisa ^a   Caputo, Domenico ^a   Guerini, Franca R ^a   Trabattoni, Daria ^a   Salvaggio, Antonino ^a   Cazzullo, Carlo L ^b   Arienti, Donatella ^a   Villa, Maria Luisa ^a   Urnovitz, Howard B ^c   Ferrante, Pasquale ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Assoc Ricerca Schizofrenia ARS   (Italy)

^c Calypte Biomedical Corporation   (United States)

Author keywords

Cell mediated immunity; Cytokines; Multiple sclerosis; Retroviruses

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; TETANUS TOXOID;

ADULT; ARTICLE; CELLULAR IMMUNITY; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; FEMALE; HLA SYSTEM; HUMAN; IMMUNE RESPONSE; MALE; MULTIPLE SCLEROSIS; PATHOGENESIS; PRIORITY JOURNAL; RETROVIRUS;

ACUTE DISEASE; ADULT; ANTIGENS, VIRAL; AUTOANTIBODIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CROSS REACTIONS; ENDOGENOUS RETROVIRUSES; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNITY, CELLULAR; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; MALE; MULTIPLE SCLEROSIS; SEVERITY OF ILLNESS INDEX; TETANUS TOXOID;

EID: 0032731171     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00123-X     Document Type: Article

References (58)

1. Benoist C., Mathis D. Retrovirus as trigger, precipitator or marker? Nature. 388:1997;833-834.
2. Benveniste E.N. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J. Mol. Med. 75:1997;165-173.
3. Blomberg J., Nived O., Pipkorn R., Bengtsson A., Erlinge D., Sturfelt G. Increased antiretroviral antibody reactivity in sera from a defined population of patients with systemic lupus erythematosus. Arthritis Rheum. 37:1994;57-66.
4. Cianciolo G.J., Copeland T.D., Oroszlan S., Snyderman R. Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science. 223:1985;364-370.
5. Clerici M., Giorgi J.V., Chou C.C., Gudeman V.K., Zack J.A., Gupta P., Ho H.-N., Nishanian P.G., Berzofsky J.A., Shearer G.M. Cell mediated immune response to human immunodeficiency virus type 1 (HIV-1) in seronegative homosexuals with recent sexual exposure to HIV-1. J. Infect. Dis. 165:1992;1012-1019.
6. Conrad B., Weissmahr R.N., Boni J., Arcari R., Schupbach J., Mach B. A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes. Cell. 90:1997;303-313.
7. Dalgleish A.G. Viruses and multiple sclerosis. Acta Neurol. Scand. S. 169:1987;8-15.
8. Dekaban G.A., Rice G.P.A. Retroviruses and multiple sclerosis: II. Failure of gene amplification techniques to detect viral sequences unique to the disease. Neurology. 40:1990;1254-1258.
9. Doolitle R.F., Feng D.-F., Johnson M.S., McClure M.A. Origins and evolutionary relationships of retroviruses. Q. Rev. Biol. 64:1989;1-30.
10. Ferrante P., Caputo D., Mori L. Detection of HTLV-I DNA sequences in multiple sclerosis patients. J. Trop. Geogr. Neurol. 2:1992;97-101.
11. Ferrante P., Fusi M.L., Saresella M., Caputo D., Biasin M., Trabattoni D., Salvaggio A., Clerici E., de Vries J.E., Aversa G., Cazzullo C.L., Clerici M. Cytokine production and surface markers expression in acute and stable multiple sclerosis. Dysregulated IL-12 production and augmented SLAM-expressing lymphocytes in acute multiple sclerosis. J. Immunol. 160:1998;1514-1521.
12. Fugger L., Morling N., Ryder L.P., Sandberg-Wollheim P., Svejgaard A. Failure to demonstrate human T cell lymphotropic virus type 1 in multiple sclerosis patients. J. Gentile. Virol. 71:1990;1103-1107.
13. Garfinkel, D.J., 1992. Retroelements in microorganisms. In: Levy, J.A. (Ed.), The Retroviridae, Vol. 3, Plenum, New York, NY, pp. 103-158.
14. Garry R.F. New evidence for involvement of retroviruses in sjogren syndrome and other autoimmune diseases. Arthritis Rheum. 37:1994;465-469.
15. Gebickehaerter P.J., Vancalker D., Norenberg W., Illes P. Molecular mechanisms of microglial activation: a. Implications for regeneration and neurodegenerative diseases. Neurochem. Int. 29:1996;1-12.
16. Gessain A., Abel L., De Thé G. Lack of antibodies to HTLV-I-1 and HIV in patients with multiple sclerosis from France and French West Indies. B.M.J. 293:1986;424-425.
17. Giovannoni G., Hartung P. The immunopathogenesis of multiple sclerosis and Guillain-Barré syndrome. Curr. Opin. Neurol. 9:1996;165-174.
18. Haar S., Sommerlund M., Christensen T., Jensen A.W., Hansen H.A., Moller-Larsen A. A putative new retrovirus associated with multiple sclerosis and the possible involvement of Epstein-Barr virus in this disease. Ann. N. Y. Acad. Sci. 724:1994;148-152.
19. Hackett J., Swanson P., Leahy D., Anderson E.L., Sato S., Roos R.P., Decker R., Devare S.G. Search for retrovirus in patients with multiple sclerosis. Ann. Neurol. 40:1996;805-809.
20. Haraguchi S., Good R.A., Day N.K. Immunosuppressive retroviral peptides: cAMP and cytokine patterns. Immunol. Today. 16:1995;595-601.
21. Hohlfeld R., Lucas K. Cytokines networks in multiple sclerosis. Neurology. 45:1994;S1-S8. suppl. 6.
22. Hull R., Will H. Molecular biology of viral and nonviral retroelements. Trends Genet. 5:1989;357-359.
23. Koprowski H., DeFreitas E.C., Harper M.E., Sandberg-Wollheim M., Sheremata W.A., Robert-Guroff M., Saxinger C.W., Feinberg M.B., Wong-Staal F., Gallo R.C. Multiple sclerosis and human T-cell lymphotropic retroviruses. Nature. 318:1985;154-160.
24. Krieg A.M., Gourley M.F., Perl A. Endogenous retroviruses: potential etiologic agents in autoimmunity. FASEB J. 6:1992;2537-2544.
25. Kurtzke J.F. Epidemiological evidence for multiple sclerosis as an infection. Clin. Microbiol. Rev. 6:1987;382-427.
26. Li H., Cuzner M.L., Newcombe J. Microglia-derived macrophages in early multiple sclerosis plaques. Neuropathol. Appl. Neurobiol. 22:1996;207-215.
27. Link J., Soderstrom M., Olsson T., Hojeberg B. Increased TGFb, IL-4, and IFNa in multiple sclerosis. Ann. Neurol. 36:1994;379-389.
28. Martin R., McFarland H.F. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit. Rev. Clin. Lab. Sci. 32:1995;121-128.
29. Murray P.D., Mcgavern D.B., Lin X.Q., Njenga M.K., Leibowitz J., Pease L.R., Rodriguez M. Perforin-dependent neurologic injury in a viral model of multiple sclerosis. J. Neurosci. 18:1998;7306-7314.
30. Nakagawa K., Harrison L.C. The potential roles of endogenous retroviruses in autoimmunity. Immunol. Rev. 152:1997;193-236.
31. Navikas V., He B., Link J., Haglund M., Sodderstrom M., Fredrickson S., Link H. Augmented expression of tumor necrosis a and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis. Brain. 119:1996;213-220.
32. Nelson M., Nelson D.S., Cianciolo G.J., Snyderman R. Effect of CKS-17, a synthetic retroviral envelop peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. Cancer Immunol. Immunother. 30:1989;113-118.
33. Ohta M., Ohta K., Mori F., Nishitani H., Saida T. Sera from patients with multiple sclerosis react with human T-cell lymphotropic virus-I gag proteins but not env proteins - western blotting analysis. J. Immunol. 11:1986;3440-3444.
34. Olsson T., Wang W.Z., Hojeberg B., Link J. Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon gamma. J. Clin. Invest. 86:1990;981-992.
35. Olsson T., Sun J., Hiller J.et al. Increased numbers of T cells recognizing multiple myelin basic proteins epitopes in multiple sclerosis. Eur. J. Immunol. 22:1992;1083-1092.
36. Oostendorp R.A., Meijer C.J., Scheper R.J. Immunosuppression by retroviral-envelope-related proteins, and their role in non-retroviral human disease. Crit. Rev. Oncol.-Hematol. 14:1993;189-206.
37. Panitch H.S., Heracl R.I., Schindler J., Johnson K.P. Treatment of MS with gamma interferon: exacerbation associated with activation of the immune system. Neurology. 37:1987;1097-1110.
38. Perron H., Lalande B., Gratacap B., Laurent A., Genoulaz O., Geny C., Mallaret M., Schuller E., Stoebner P., Seigneurin J.M. Isolation of retrovirus from patients with multiple sclerosis. Lancet. 337:1991;862-863.
39. Perron H., Geny C., Genoulaz O., Pellat J., Perret J., Seigneurin J.M. Antibody to reverse transcriptase of human retroviruses in multiple sclerosis. Acta. Neurol. Scand. 84:1991;507-511.
40. Perron H., Gaerson J.A., Bedin F., Beseme F., Paranhos-Baccala G., Komurian-Pradel F., Mallet F., Tuke P.W., Voisset C., Blond J.L., Lalande L., Seigneurin J.M., Mandrand B. Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. Proc. Natl. Acad. Sci. USA. 94:1997;7583-7588.
41. Poser C.M. The pathogenesis of multiple sclerosis. Additional consideration. J. Neurol. Sci. 115:1993;S3-S8. suppl.
42. Rasmussen H.B., Perron H., Clausen J. Do endogenous retroviruses have etiologic implications in inflammatory and degenerative nervous system diseases? Acta Neurol. Scand. 88:1993;190-198.
43. Rasmussen H.B., Geny C., Deforges L., Perron H., Tuortelotte W., Helberg A., Clausen J. Expression of endogenous retroviruses in blood mononuclear cells and brain tissue from multiple sclerosis patients. Multiple Sclerosis. 1:1997;82-89.
44. Rice G.P.A., Armstrong H.A., Bulman D.E., Paty D.W., Ebers G.C. Absence of antibody to HTLV-I and HTLV-II in sera of Canadian patients with multiple sclerosis and chronic myelopathy. Ann. Neurol. 20:1986;533-534.
45. Richardson J.H., Wucherpfenning K.W., Endo N., Rudge P., Dalgleish A.G., Hafler D.A. PCR analysis of DNA from multiple sclerosis patients. Science. 246:1989;821-823.
46. Rieckmann P., Albrecht M., Kitze B. Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology. 44:1994;1523-1531.
47. Rieckmann P., Albrecht M., Kitze B., Weber T., Tumani H., Broocks A., Luer W., Helwig A., Poser S. Tumor necrosis factor-a messenger RNA expression in patients with multiple sclerosis is associated with disease activity. Ann. Neurol. 32:1995;82.
48. Rudge P. Does a retrovirally encoded superantigen cause multiple sclerosis? J. Neurol. Neurosurg. Psychiatry. 54:1991;853-855.
49. Sarrowa J., Dau-Yin C., Maraja R.J. The decline in human Alu retroposition was accompanied by an asymmetric decrease in SRP9/14 binding to dimeric Alu RNA and increased expression of small cytoplasmic Alu RNA. Mol. Cell. Biol. 17:1997;1144-1151.
50. Sriram S., Rodriguez M. Indictment of the microglia as the villain in multiple sclerosis. Neurology. 48:1997;464-470.
51. Steinman L. Multiple Sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell. 85:1996;299-302.
52. Sun J.B., Olsson T., Wang W.Z., HIller J. Autoreactive T and B cell cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur. J. Immunol. 21:1991;1461-1469.
53. Sun J.B., Link J., Xiao B.G. Autoreactive T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J. Immunol. 46:1991;1490-1499.
54. The IFNβ Multiple Sclerosis Group Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. Neurology. 43:1993;655-662.
55. Urnovitz H.B. Urine-based diagnostic technologies. Trends Biotechnol. 152:1996;361-364.
56. Urnovitz H.B., Murphy W.B. Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease. Clin. Microbiol. Rev. 9:1996;72-99.
57. Weinshenker B.G., Debakan G., Rice G.P.A. Multiple sclerosis: I. Analysis of seroreactivity by Western blot and radioimmune assay. Neurology. 40:1990;1251-1253.
58. Wucherpfenning K., Strominger J.L. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:1995;695-700.