Modulation of amyloid β protein precursor processing as a means of retarding progression of Alzheimer's disease

Journal of Clinical Investigation

Volumn 104, Issue 10, 1999, Pages 1329-1332

  Wagner, Steven L ^a   Munoz, Benito ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; PROTEIN PRECURSOR;

ALZHEIMER DISEASE; BASEMENT MEMBRANE; DISEASE COURSE; HUMAN; NERVE DEGENERATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW;

EID: 0032727896     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8729     Document Type: Review

References (23)

1. Goate, A., et al. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349:704-706.
2. Sherrington, R., et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:754-760.
3. Price, D.L., and Sisodia, S.S. 1998. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21:479-505.
4. Levy-Lahad, E., et al. 1995. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 269:973-977.
5. Shoji, M., et al. 1992. Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science. 258:126-129.
6. Hardy, J. 1992. Framing β-amyloid. Nat. Genet. 1:233-234.
7. Cai, X.D., Golde, T.E., and Younkin, S.G. 1993. Release of excess amyloid β protein from a mutant amyloid β protein precursor. Science. 259:514-516.
8. Iwatsubo, T., et al. 1994. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence char an initially deposited species is Aβ42(43). Neuron. 13:45-53.
9. Jarrett, J.T., and Lansbury, P.T., Jr. 1993. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell. 73:1055-1058.
10. Scheuner, D., et al. 1996. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 8:864-870.
11. Loo, D.T., et al. 1993. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. USA. 90:7951-7955.
12. Behl, C., Davis, J.B., Lesley, R., and Schubert, D. 1994. Hydrogen peroxide mediates amyloid β protein toxicity. Cell. 77:817-827.
13. Akama, K.T., Albanese, C., Pestell, R.G., and Van Eldik, L.J. 1998. Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism. Proc. Nat. Acad. Sci. USA 95:5795-5800.
14. Hensley, K., et al. 1994. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 91:3270-3274.
15. Rogers, J., et al. 1992. Complement activation by β-amyloid in Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 89:10016-10020.
16. Kingston, I.B., Castro, M.J., and Anderson, S. 1995. In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid β-pepride analogues. Nat. Med. 2:138-142.
17. Boggs, L.N., et al. 1996. Clusterin (Apo J) protects against in vitro amyloid-β (1-40) neurotoxicity. J. Neurochem. 67:1324-1327.
18. Chen, S., Frederickson, C.A., and Brunden, K.R. 1996. Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: complement activation and therapeutic approaches. Neurobiol. Aging. 17:781-787.
19. Tjernberg, L.O., et al. 1997. Controlling amyloid β-peptide fibril formation with protease-stable ligands. J. Biol. Chem. 272:12601-12605.
20. Solomon, B., Koppel, R., Frankel, D., and Hanan-Aharon, E. 1997. Disaggregation of Alzheimer β-amyloid by site-directed mAb. Proc. Natl. Acad. Sci. USA. 94:4109-4112.
21. Esler, W.P., et al. 1997. A beta deposition inhibitor screen using synthetic amyloid. Nat. Biotechnol. 15:258-263.
22. Caporaso, G.L., Gandy, S.E., Buxbaum, J.D., Ramabhadran, T.V., and Greengard, P. 1992. Protein phosphorylation regulates secretion of Alzheimer β/A4 amyloid precursor protein. Proc. Natl. Acad. Sci. USA. 89:3055-3059.
23. Lamb, B.T., et al. 1999. Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. Nat. Neurosci. 2:695-697.