Identification of the immunodominant T cell epitope of p38, a major egg antigen, and characterization of the epitope-specific th responsiveness during murine schistosomiasis mansoni

Journal of Immunology

Volumn 160, Issue 11, 1998, Pages 5420-5427

  Chen, Yiguang ^a   Boros, Dov L ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EGG ANTIGEN; EPITOPE; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CELL PROLIFERATION; CYTOKINE PRODUCTION; EPITOPE MAPPING; FEMALE; HAPLOTYPE; HISTOPATHOLOGY; LUNG GRANULOMA; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, HELMINTH; CYTOKINES; EPITOPES, T-LYMPHOCYTE; FEMALE; GRANULOMA, RESPIRATORY TRACT; IMMUNODOMINANT EPITOPES; IMMUNOGLOBULIN ISOTYPES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED CBA; MOLECULAR SEQUENCE DATA; OVUM; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0032103941     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Boros, D. L. 1989. Immunopathology of Schistosoma mansoni infection. Clin. Microbiol. Rev. 2:250.
2. McKerrow, J. H., and E. Sun. 1994. Hepatic schistosomiasis. Prog. Liver Dis. 12:121.
3. Matthew, R. C., and D. L. Boros. 1986. Anti-L3T4 antibody treatment suppresses granuloma formation and abrogates antigen-induced interleukin-2 production in Schistosoma mansoni infection. Infect. Immun. 54:820.
4. Hemandez, H. J., Y. Wang, N. Tzellas, and M. J. Stadecker. 1997. Expression of class II, but not class I. major histocompatibility complex molecules is required for granuloma formation in infection with Schistosoma mansoni. Eur. J. Immunol. 27:1170.
5. Boros, D. L., and K. S. Warren. 1970. Delayed hypersensitivity granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs. J. Exp. Med. 132:488.
6. Boros, D. L., R. Tomford, and K. S. Warren. 1977. Induction of granulomatous and elicitation of cutaneous sensitivity by partially purified SEA of Schistosoma mansoni. J. Immunol. 118:373.
7. Brown, A. P., H. G. Remold, K. S, Warren, and J. R. David. 1977. Partial purification of antigens from eggs of Schistosoma mansoni that elicit delayed hypersensitivity. J. Immunol 119:1275.
8. Harn, D. A., K. Danko, J. J. Quinn, and M. J. Stadecker. 1989. Schistosoma mansoni: the host immune response to egg antigens: partial characterization of cellular and humoral responses to pi fractions of soluble egg antigen. J. Immunol. 142:2061.
9. Lukacs, N. W., and D. L. Boros. 1991. Splenic and granuloma T-lymphocyte responses to fractionated soluble egg antigens of Schistosoma mansoni-infected mice. Infect. Immun. 59:941.
10. Lukacs, N. W., and D. L. Boros. 1991. Identification of larval cross-reactive and egg-specific antigens involved in granuloma formation in murine schistosomiasis mansoni. Infect. Immun. 59:3237.
11. Lukacs, N. W., and D. L. Boros. 1992. utilization of fractionated soluble egg antigens reveals selectively modulated granulomatous and lymphokine responses during schistosomiasis mansoni. infect. Immun. 60:3209.
12. Contigli, C., B. L. Doughty, J. C. Cone, and A. M. Goes. 1994. Recognition of different Schistosoma mansoni antigens by specific human T cell clones. Cell. Immunol. 154:77.
13. Nene, V., D. W. Dunne, K. S. Johnson, D. W. Taylor, and J. S. Cordingley. 1986. Sequence and expression of a major egg antigen from Schistosoma mansoni: homologies to heat shock proteins and alpha-crystallins. Mol. Biochem. Parasitol. 21:179.
14. Cao, M., H. Chao, and B. L. Doughty. 1993. Cloning of acDNA encoding an egg antigen homologue from Schistosoma mansoni. Mol. Biochem. Parasitol. 58:169.
15. Trzyna, W. C., and J. S. Cordingley. 1993. Schistosoma mansoni: genetic nonresponse to p40, the major protein antigen of the egg, reveals a novel mechanism enhancing IgM production during infection. Parasite Immunol. 15:601.
16. + Thl-type lymphocytes. J. Immunol. 150:1413.
17. Cai, Y., J. G. Langley, D. I. Smith, and D. L. Boros. 1996. A cloned major Schistosoma mansoni egg antigen with homologies to small heat shock proteins elicits Thl responsive ness. Infect. Immun. 64:1750.
18. Hernandez, H. J., W. C. Trzyna, J. S. Cordingley, P. H. Brodeur, and M. J. Stadecker. 1997. Differential antigen recognition by T cell populations from strains of mice developing polar forms of granulomatous inflammation in response to eggs of Schistosoma mansoni. Eur. J. Immunol. 27:666.
19. Karplus, T. E., R. J. Ulevitch, and C. B. Wilson. 1987. A new method for reduction of endotoxin contamination from protein solutions. J. Immunol. Methods 105:211.
20. Ragheb, S., and D. L. Boros. 1989. Characterization of granuloma T lymphocyte function from Schistosoma mansoni-infected mice. J. Immunol. 142:3239.
21. Morag, E., E. A. Bayer, and M. Wilchek. 1996. Reversibility of biotin-binding by selective modification of tyrosine in avidin. Biochem. J. 316:193.
22. Gammon, G., N. Shastri, J. Cogswell, S. Wilbur, S. Sadegh-Nasseri, U. Krzych, A. Miller, and E. Sercarz. 1987. The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site. Immunol. Rev. 98:53.
23. Pearce, S. L., and S. L. Reiner. 1995. Induction of Th2 responses in infectious diseases. Curr. Opin. Immunol. 7:497.
24. Remick, D. G., S. W. Chensue, J. C. Hiserodt, G. I. Higashi, and S. L. Kunkel. 1988. Flow-cytometrie evaluation of lymphocyte subpopulations in synchronously developing Schistosoma mansoni egg and Sephadex bead pulmonary granulomas. Am. J. Pathol. 131:298.
25. Weinstock, J. V., S. W. Chensue, and D. L. Boros. 1983. Modulation of granulomatous hypersensitivity: participation of histamine receptor positive and negative lymphocytes in the granulomatous response of Schistosoma mansom-infected mice. J. Immunol. 130:423.
26. Sabin, E. A., M. A. Kopf, and E. J. Pearce. 1996. Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils. J. Exp. Med. 184:1871.
27. Wynn, T. A., I. Eltoum, I. P. Oswald, A. W. Cheever, and A. Sher. 1994. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J. Exp. Med. 179:1551.
28. Gryzch, J. M., E. J. Pearce, Z. A. Caulada, P. Caspar, S. Hieny, F. Lewis, and A. Sher. 1991. Egg deposition is the major stimuli for the production of Th2 cytokines in murine schistosomiasis. J. Immunol. 146:1322.
29. Pearce, E. J., P. Caspar, J. M. Gryzch, F. A. Lewis, and A. Sher. 1991. Down-regulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 173:159.
30. Wynn, T. A., I. Eltoum, A. W. Cheever, F. A. Lewis, W. C. Cause, and A. Sher. 1993. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunoi 151:1430.
31. Everson, M. P., D. S. McDuftie, D. G. Lemak, W. J. Koopman, J. R. McGhee, and K. W. Beagley. 1996. Dendritic cells from different tissues induce production of different T cell cytokine profiles. J. Leukocyte Biol. 59:494.
32. Mosmann, T. R., and R. L. Coffman. 1989. Th-1 and Th-2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
33. Boros, D. L., R. P. Pelley, and K. S. Warren. 1975. Spontaneous modulation of granulomatous hypersensitivity in schistosomiasis mansoni. J. Immunol. 114: 1437.
34. Colley, D. G. 1975. Immune responses to a soluble schistosomal egg antigen preparation during chronic primary infection with Schistosoma mansoni. J. Immunol. 115:150.
35. Parish, C. R. 1972. The relationship between humoral and cell-mediated immunity. Transplant. Rev. 13:35.
36. Ledermann, F., C. Heusser, C. Schlienger, and G. LeGros. 1992. Interleukin-3-treated non-B, non-T cells switch activated B cells to IgGl/IgE synthesis. Eur. J. Immunol 22:2783.
37. Kullberg, M. C., J. A. Berzofsky, D. L. Jankovic, S. Barbieri, M. E. William, P. Perlmann, A. Sher, and M. Troye-Blomberg. 1996. T cell-derived IL-3 induces the production of IL-4 by non-B, non-T cells to amplify the Th2-cytokine response to a nonparasite antigen in Schistosoma mansoni-infected mice. J. Immunol. 156:1482.
38. Chaturvedi, P., Q. Yu, S. Scouthwood, A. Sette, and B. Singh. 1996. Peptide analogs with different affinities for MHC alter the cytokine profile of T helper cells. Int. Immunol. 8:745.
39. Schountz, T., J. P. Kasselman, F. A. Martinson, L. Brown, and J. S. Murray. 1996. MHC genotype controls the capacity of ligand density to switch T helper (Th)-l/Th-2 priming in vivo. J. Immunol. 157:3893.
40. + T cell responses: the alternative approaches. Annu. Rev. Immunol 15:297.
41. Matsuoka, T., H. Kohrogi, M. Ando, Y. Nishimura, and S. Matsushita. 1996. Altered TCR ligands affect antigen-presenting cell responses: up-regulation of IL-12 by an analogue peptide. J. Immunol. 157:4837.