IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/j mice infected with Schistosoma mansoni

Parasite Immunology

Volumn 19, Issue 8, 1997, Pages 347-353

  Bosshardt, Stephen C ^b,c   Freeman Jr , George L ^a   Evan Secor, W ^a   Colley, Daniel G ^a  

^a NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Cytokine; Immunopathogenesis; Immunoregulation; Interleukin 10; S. mansoni; Schistosomiasis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MONOCLONAL ANTIBODY CD3; PARASITE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IMMUNOREGULATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SPLEEN CELL; SPLENOMEGALY;

ANIMALIA; SCHISTOSOMA; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI;

EID: 0030851727     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1997.d01-224.x     Document Type: Article

References (24)

1. Adewusi O.I., Nix N.A., Lu X., Colley D.G. & Secor W.E. (1996) Schistosoma mansoni: Relationship of tumor necrosis factor-alpha to morbidity and collagen deposition in chronic experimental infection. Experimental Parasitology 84, 115-123
2. Amiri P., Locksley R.M., Parslow T.G., Sadick M., Rector E., Ritter D. & McKerrow J.H. (1992) Tumour necrosis factor alpha restores grunulomati und induces parasite egg-laying in schistosome-infected SCID mice. Nature 356, 604-607
3. Bursoum I.S., Colley D.G. & Kamal K.A. (1990) Schistosoma mansoni: Detection of circulating antigens in murine schistosomiasis by antigen-capture sandwich ELISA using a monoclonal antibody. Experimental Parasitology 71, 107-113
4. Berg D.J., Kühn R., Rajewsky K. et al. (1995) Interleukin-10 is a central regulator of the response to LPS in murinc models of endotoxic shock and the Shwartzman reaction but nol endotoxin tolerance, Journal of Clinical Investigation 96, 2339-2347
5. Bogen S.A., Flores Villanueva P.O., McCusker M.E. et al. (1995) In situ analysis of cytokine responses in experimental murine schistosomiasis. Laboratory Investigation 73, 252-258
6. Bosshardt S.C., Nix N.A. & Colley D.G. (1996) Early development and progression of lymphocyte stimulatory cross-reactive idiotypes expressed on antibodies to soluble egg antigens during Schistosoma mansoni infections of mice. European Journal of Immunology 26, 272-275
7. Colley D.G. (1975) Immune responses to a soluble schistosomal egg antigen preparation during chronic primary infection with Schistosoma mansoni. Journal of Immunology 115, 150-156
8. Colley D.G. (1987) Dynamics of the human immune response to schistosomes. In Baillière's Clinical Tropical Medicine and Communicable Diseases, vol. 2, no. 2, Schistosomiasis, A.A.F.Mahmoud, ed. p. 315, Baillière Tindal, London.
9. Colley D.G., Cook J.A., Freeman G.L. Jr., Bartholomew R.K. & Jordan P. (1977) Immune responses during human schistosomiasis mansoni. 1. In vitro lymphocyte blastogenetic responses to heterogeneous antigenic preparations from schistosome eggs, worms and cercariac. International Archives of Allergy and Applied Immunology 53, 420-433
10. Colley D.G., Garcia A.A., Labertucci J.R. et al. (1986) Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease. American Journal of Tropical Medicine and Hygiene 35, 793-802
11. Damian R.T. (1987) Presidential address. The exploitation of host immune responses by parasites. Journal of Parasitology 73, 3-13
12. Doenhoff M.J., Hassounah O., Murare H., Bain J. & Lucas S. (1986) The schistosome egg granuloma: Immunopathology in the cause of host protection or parasite survival? Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 503-514
13. Freeman G.L. Jr., Montesano M.A., Secor W.E., Colley D.G., Howard M.J. & Bosshardt S.C. (1996) Immunopathogenesis and immune-regulation in schistosomiasis: Distinct chronic pathologic syndrome in CBA/J mice. Annals of the New York Academy of Science 797, 151-165
14. Grzyeh J.M., Pearce E.J., Cheever A.W. et al. (1991) Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. Journal of Immunology 146, 1322-1327
15. Harrison D.G., Carter C.E. & Colley D.G. (1979) Immunoaffinity purification of Schistosoma mansoni soluble egg antigen using Con-A-Sepharose chromatography. Journal of Immunology 122, 2210-2217
16. Henderson G.S., Lu X., McCurley T.L. & Colley D.G. (1992) In vivo molecular analysis of lymphokines involved in the murine immune response during Schistosoma mansoni infection. II. Quantification of IL-4 mRNA, IFN-γ mRNA, and IL-2 mRNA levels in the granulomatous livers, mesenteric lymph nodes and spleens during the course of modulation. Journal of Immunology 148, 2261-2269
17. Henderson G.S., Nix N.A., Montesano M.A. et al (1993) Two distinct pathological syndromes in male CBA/J mice with chronic Schistosoma mansoni infections. American Journal of Pathology 142, 703714
18. Ho M., Sexton M.M., Tongtawe P., Looareesuwan S., Suntharasamai P. & Webster H.K. (1995) Interleukin-10 inhibits tumor necrosis factor production but not antigen-specific lymphoproliferation in acute Plasmodium falciparum malaria. Jorunal of Infectious Disease, 172, 838-844
19. Howard M., O'Garra A., Ishida H., De Waal Malefyt R. & DeVries J. (1992) Biological properties of interleukin 10. Journal of Clinical Immunology 12, 239-247
20. Karanja D.M.S., Colley D.G., Nahlen B.L., Ouma J.H. & Secor W.E. Studies on schistosomiasis in western Kenya. I. Evidence for immune-facilitated excretion of schistosome eggs from patients with high intensity Schistosoma mansoni and human immunodeficiency virus co-infections. American Journal of Tropical Medicine and Hygiene (In press)
21. Lenzi H.L., Lenzi J.A. & Sobral A.C.L. (1987) Eosinophils favor the passage of eggs to the intestinal lumen in schistosomiasis. Brazilian Journal of Medical and Biolgical Reserach 20, 433-435
22. + T lymphocytes correlates with down-regulation of Thl cytokine synthesis in helminth infection. Journal of Immunology 147, 2713-2716
23. Tsang V.C.W., Wilson B.C. & Maddison S.E. (1980) Kinetic studies of a quantitative single-tube enzyme-linked immunosorbed assay. Clinical Chemistry 26, 1255-1260
24. ε, receptor-positive cells are a major source of antigen-induced interleukin-4 in spleens of mice infected with Schistosoma mansoni. European Journal of Immunology 23, 1910-1916