Anti-inflammatory activities of hypocretenolides from Leontodon hispidus

Planta Medica

Volumn 65, Issue 8, 1999, Pages 704-708

  Zidorn, Christian ^a   Dirsch, Verena M ^b   Rüngeler, Peter ^c   Sosa, Silvio ^d   Della Loggia, Roberto ^d   Merfort, Irmgard ^c   Pahl, Heike L ^e   Vollmar, Angelika M ^c   Stuppner, Hermann ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF TRIESTE   (Italy)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Anti inflammatory activity; Asteraceae; Croton oil induced mouse ear edema; Inducible nitric oxide synthase; Leontodon hispidus L.; NF B; Sesquiterpene lactones

Indexed keywords

ACHILLICIN; CROTON OIL; HYPOCRETENOLIDE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; LIPOPOLYSACCHARIDE; MATRICIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; SESQUITERPENE LACTONE DERIVATIVE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTERACEAE; BIOASSAY; CONTROLLED STUDY; DNA BINDING; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; EDEMA; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MACROPHAGE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; DNA; HUMANS; JURKAT CELLS; MICE; NF-KAPPA B; NITRITES; PLANTS, MEDICINAL; SESQUITERPENES;

ANIMALIA; ASTERACEAE; CICHORIEAE; CROTON; LEONTODON HISPIDUS;

EID: 0032715084     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-14046     Document Type: Article

References (15)

1. Wagenitz G. Hegi Flora von Mitteleuropa, Parey, Berlin, Hamburg 1987; Vol. VI/4, 2nd Ed.: p. 1483
2. Hausen BM. Allergiepflanzen - Pflanzenallergene. Ecomed, Landsberg/Lech 1988: 352 pp.
3. Willuhn G. Radix Taraxaci. Teedrogen und Phytopharmaka, Wichtl M, ed., Wissenschaftliche Verlagsgesellschaft, Stuttgart 1997; 3rd edn.: p. 571-574
4. Zidorn C, Ellmerer-Mueller EP, Stuppner H. Phytochemistry 1998; 49: 797-800
5. Rüngeler P, Lyss G, Castro V, Mora G, Pahl HL, Merfort I. Planta Med. 1998; 64: 588-593
6. Lyss G, Schmidt TJ, Merfort I, Pahl HL. Biol. Chem. 1997; 378: 951-961
7. Lyss G, Knorre A, Schmidt TJ, Pahl H, Merfort I. J. Biol. Chem. 1998; 273: 33508-33516
8. Baeuerle P, Henkel T. Annu. Rev. Immunol. 1994; 12: 141-179
9. Baeuerle P, Baltimore D. Cell 1996; 87: 13-20
10. Barnes PJ, Karin M. N. Engl. J. Med. 1997; 336: 1066-1071
11. Tubaro A, Dri P, Delbello G, Zilli C, Della Loggia R. Agents Actions 1985; 17: 347-349
12. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Anal. Biochem. 1982; 126: 131-138
13. Mosmann T. J. Immunol. Methods 1983; 65: 55-63
14. Xie Q-W, Kashiwabara Y, Nathan C. J. Biol. Chem. 1994; 269: 4705-4708
15. Park H-J, Jung W-T, Basnet P, Kadota S, Namba T. J. Nat. Prod. 1996; 59: 1128-1130