Ontogeny of synonymous T cell populations with specificity for a self MHC epitope mimicked by a bacterial homologoue: An antigen-specific T cell analysis in a non-transgenic system

European Journal of Immunology

Volumn 29, Issue 12, 1999, Pages 3826-3836

  Bonnin, Dustan ^a   Prakken, Berent ^b   Samodal, Rodrigo ^b   La Cava, Antonio ^a   Carson, Dennis A ^a   Albani, Salvatore ^b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c Androclus Therapeutics   (Italy)

Author keywords

Autoimmunity; Host defense; Ontogeny; T lymphocyte; Thymus

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOLECULAR MIMICRY; MOUSE; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; EPITOPES; GENE TRANSFER TECHNIQUES; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MOLECULAR MIMICRY; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS;

EID: 0032711465     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199912)29:12<3826::AID-IMMU3826>3.0.CO;2-S     Document Type: Article

References (48)

1. + T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J. Exp. Med. 1993. 177: 1469-1476.
2. Allen, P. M., Peptides in positive and negative selection: a delicate balance. Cell 1994. 76: 593-607.
3. Sebzda, E., Wallace, V. A., Mayer, J., Yeung, R. S. M., Mak, T. O. and Ohashi, P. S., Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 1994. 263: 1615-1618.
4. Guery, J. C., Sette, A., Appella, E. and Adorini, L., Constitutive presentation of dominant epitopes from endogenous naturally processed self-beta 2-microglobulin to class II-restricted T cells leads to self-tolerance. J. Immunol. 1995. 154: 545-552.
5. Falk, I., Biro, J., Kohler, H. and Eichmann, K., Proliferation kinetics associated with T cell receptor β chain selection of fetal murine thymocytes. J. Exp. Med. 1996. 184: 2327-2334.
6. Ohashi, P. S., T cell selection and autoimmunity: flexibility and tuning. Curr. Opin. Immunol. 1996. 8: 808-841.
7. Miyazaki, T., Wolf, P., Tourne, S., Waltzinger, C., Dierich, A., Barois, N., Ploegh, H., Benoist, C. and Mathis, D., Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 1996. 84: 531-542.
8. Ignatowicz, L., Kappler, J. and Marrack, P., The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 1996. 84: 521-530.
9. Martin, W. D., Hicks, G. G., Mendiratta, S. K., Leva, H. I., Ruley, H. E. and Van Kaer, L., H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 1996. 84: 543-550.
10. Barton, G. M. and Rudensky, A. Y., Requirement for diverse, low-abundance peptides in positive selection of T cells. Science 1999. 283: 67-70.
11. Garcia, K. C., Degano, M., Pease, L. R., Huang, M., Peterson, P. A., Teyton, L. and Wilson, I. A., Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science 1998. 279: 1166-1170.
12. Falb, D., Briner, T. J., Sunshine, G. H., Bourque, C. R., Luqman, M., Gefter, M. L. and Kamradt, T., Peripheral tolerance in T cell receptor-transgenic mice: evidence for T cell anergy. Eur. J. Immunol. 1996. 26: 130-137.
13. Bode, U., Wonigeit, K., Pabst, R. and Westermann, J., The fate of activated T cells migrating through the body: rescue from apoptosis in the tissue of origin. Eur. J. Immunol. 1997. 27: 2087-2092.
14. d. Science 1992. 256: 1817-1820.
15. Rudensky, A. Y., Preston-Gurlburt, P., Hong, S.-C., Balow, A. and Janeway, C. A., Jr., Sequence analysis of peptides bound to MHC class II molecules. Nature 1991. 353: 622-625.
16. Albani, S. and Carson, D. A., A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis. Immunol. Today 1996. 17: 466-471.
17. La Cava, A., Nelson, J. L., Ollier, W. E. R., MacGregor, A., Keystone, E. C., Thorne, J. C., Scavulli, J. F., Berry, C. C., Carson, D. A. and Albani, S., Genetic bias in immune response to a cassette by different microorganisms in patients with rheumatoid arthritis. J. Clin. Invest. 1997. 100: 658-662.
18. Baum, H., Davies, H. and Peakman, M., Molecular mimicry in the MHC: hidden clues to autoimmunity? Immunol. Today 1996. 17: 64-68.
19. Zhao, Z. S., Granucci, F., Yeh, L., Schaffer, P. A. and Cantor, H., Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection. Science 1998. 279: 1344-1346.
20. van Eden, W., Anderton, S. M., van der Zee, R., Prakken, B. J., Broeren, C. P. and Wauben, M. H., (Altered) self peptides and the regulation of self reactivity in the peripheral T cell pool. Immunol. Rev. 1996. 149: 55-72.
21. Roudier, J., Peterson, J., Rhodes, G. H., Luka, J. and Carson, D. A., Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110. Proc. Natl. Acad. Sci. USA 1989. 86: 5104-5108.
22. Batliwalla, F., Monteiro, J., Serrano, D. and Gegersen, P. K., Oligoclonality of CD8+ T cells in health and disease: aging, infection, or immune regulation? Hum. Immunol. 1996. 48: 68-73.
23. Merkenschlager, M., Graf, D., Lovatt, M., Bommhardt, U., Zamoyska, R. and Fisher, A. G., How many thymocytes audition for selection. J. Exp. Med. 1997. 186: 1149-1153.
24. Hough, M. R., Takei, F., Humphries, R. K. and Kay, R., Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen. J. Exp. Med. 1994. 179: 177-184.
25. Jameson, S. C., Hogquist, K. A. and Bevan, M. J., Positive selection of thymocytes. Annu. Rev. Immunol. 1994. 13: 93-118.
26. Surh, C. D., Lee, D.-S., Fung-Lueng, W., Karlsson, L. and Sprent, J., Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells. Immunity 1997. 7: 209-215.
27. 0/0 mice. Immunity 1997. 7: 187-195.
28. Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J. and Davis, M. M., Phenotypic analysis of antigen-specific T lymphocytes. Science 1996. 274: 94-97.
29. Crawford, F., Kozono, H., Kozono, W. J. M. P. K. J., White, H. J., Marrack, P. and Kappler, J., Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 1998. 8: 675-686.
30. Davis, M. M., Ligand recognition by alpha-beta T cell receptors. Annu. Rev. Immunol. 1998. 16: 52345-52372.
31. Kozono, H., White, J., Clements, J., Marrack, P. and Kappler, J., Production of soluble MHC class II proteins with covalently bound single peptides. Nature 1994. 369: 151-153.
32. Rudensky, A. Y., Rath, S., Preston-Gurlburt, P., Murphy, D. B. and Janeway, C. A., Jr., On the complexity of self. Nature 1991. 353: 660-662.
33. Garboczi, D. N., Ghosh, P., Utz, U., Fan, Q. R., Biddison, W. E. and Wiley, D. C., Structure of the complex between human T cell receptor, viral peptide and HLA-A2. Nature 1996. 384: 134-140.
34. Bjorkman, P. J., MHC restriction in three dimensions: a view of T cell receptor/ligand interactions. Cell 1997. 89: 167-175.
35. Fields, B. A. and Mariuzza, R. A., Structure and function of the T-cell receptor: insights from X-ray crystallography. Immunol. Today 1996. 17: 330-334.
36. Loftus, D. J., Chen, Y., Covell, D. G., Engelhard, V. H. and Appella, E., Differential contact of disparate class I/ peptide complexes as the basis for epitope cross-recognition by a single T cell receptor. J. Immunol. 1997. 158: 3651-3660.
37. Ding, Y.-H., Smith, K. J., Garboczi, D. N., Utz, U., Biddison, W. E. and Wiley, D. C., Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/tax peptide complex using different TCR amino acids. Immunity 1998. 8: 403-414.
38. Albani, S., Keystone, E. C., Nelson, J. L., Ollier, W. E. R., La Cava, A., Montemayor, A. C., Weber, D. A., Montecucco, C., Martini, A. and Carson, D. A., Positive selection in autoimmunity: abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis. Nat. Med. 1995. 1: 448-451.
39. Albani, S., Ravelli, A., Massa, M., De Benedetti, F., Andree, G., Roudier, J., Martini, A. and Carson, D. A., Immune responses to the Escherichia coli dnaJ heat shock protein in juvenile rheumatoid arthritis and their correlation with disease activity. J. Pediatr. 1994. 124: 561-564.
40. Wucherpfennig, K. W. and Strominger, J. L., Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995. 80: 695-703.
41. Janeway, C. A., A tale of two T cells. Immunity 1998. 8: 391-392.
42. Bonnin, D. and Albani, S., Mucosal modulation of immune responses to heat shock proteins in autoimmune arthritis. Biotherapy 1998. 10: 213-218.
43. Altschul, S. F., Madden, T. L., Schaffer, A. A, Zhang, J., Zhang, Z., Miller, W. and Lipman, D. J., Gapped BLAST and PSI-BLAST: a new generation of protein data base search programs. Nucleic Acids Res. 1997. 25: 3389-3395.
44. Sette, A., Adorini, L., Appella, E., Colon, S. M., Miles, C., Tanaka, S., Ehrhardt, C., Doria, G., Nagy, Z. A. and Buus, S., Structural requirements for the interaction between peptide antigens and I-Ed molecules. J. Immunol. 1989. 143: 3289-3293.
45. Coeshott, C. M., Chesnut, W. W., Kubo, R. T., Grammer, S. F., Jenis, D. M. and Gray, H. M., la-specific mixed leukocyte reactive T cell hybridomas: analysis of their specificity by using purified class II MHC molecules in synthetic membrane system. J. Immunol. 1986. 136: 2832-2841.
46. Brian, A. A. and McConnell, H. M., Allogenic stimulation of cytotoxic T cells by supported planar membranes. Proc. Natl. Acad. Sci. USA 1984. 81: 6159-6164.
47. Buus, S., Sette, A., Colon, S. M, Jenis, D. M. and Grey, H. M., Isolation and characterization of antigen-la complexes involved in T cell recognition. Cell 1986. 47: 1071-1080.
48. Lessin, S. R., Rook, A. H. and Rovera, G., Molecular diagnosis of cutaneous T-cell lymphoma: polymerase chain reaction amplification of T-cell antigen receptor beta-chain gene rearrangements. J. Invest. Dermatol. 1991. 96: 299-305.