A lack of evidence for down-modulation of CD3 ζ expression in colorectal carcinoma and pregnancy using multiple detection methods

Clinical and Experimental Immunology

Volumn 118, Issue 2, 1999, Pages 197-204

  Deakin, A M ^b   Singh, K ^b   Crowe, J S ^b   Ellis, J H ^b   Dalgleish, A ^a   Leicester, R J ^a   Finlayson, C J ^a   Miles, W F A ^a,c   Life, P F ^b  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UK   (United Kingdom)

Author keywords

Carcinoma; CD3; Immunosuppression; Pregnancy; Zeta

Indexed keywords

CD3 ANTIGEN;

ADULT; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; COLORECTAL CARCINOMA; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; PREGNANCY; PRIORITY JOURNAL;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD3; BLOTTING, WESTERN; COLORECTAL NEOPLASMS; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PREGNANCY; RECEPTORS, ANTIGEN, T-CELL;

EID: 0032707489     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.01044.x     Document Type: Article

References (27)

1. 1 Maccubbin DL, Mace KF, Ehrke MJ, Mihich E. Modification of host antitumor defense mechanisms in mice by progressively growing tumor. Cancer Res 1989; 49:4216-24.
2. 2 Miescher S, Whiteside TL, Carrel S, Von Fliedner V. Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes. J Immunol 1986; 136:1899-907.
3. 3 Oliver RT, Nouri A. T-cell immune response to cancer in humans and its relevance for immunodiagnosis and therapy. Cancer Surv 1992; 13:173-204.
4. 4 Mizoguchi H, O'Shea JJ, Longo DL, Loeffler CM, McVicar DW, Ochoa AC. Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science 1992; 258:1795-8.
5. 5 Salvadori S, Gansbacher B, Pizziment AM, Ziers KS. Abnormal signal transduction by T cells of mice with parental tumours is not seen in mice bearing IL-2-secreting tumors. J Immunol 1994; 153:5176-81.
6. lck in T-cells infiltrating human renal cell carcinoma. Cancer Res 1993; 53:5613-6.
7. 7 Nakagomi H, Petersson M, Magnusson I et al. Decreased expression of the signal-transducing ζ chains in tumour-infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res 1993; 53:5610-2.
8. 8 Matsuda M, Pettersson M, Lenkei R et al. Alterations in the signal-transducing molecules of T cells and NK cells in colorectal tumor-infiltrating gut mucosal and peripheral lymphocytes: correlation with the stage of disease. Int J Cancer 1995; 61:765-72.
9. 9 Zea AH, Curti BD, Longo DL et al. Alterations in T cell receptor and signal transduction molecules in melanoma patients. Clin Cancer Res 1995; 1:1327-35.
10. fyn, ZAP-70, and CD3ζ despite suppressed cytolytic activity. J Exp Med 1995; 182:1029-36.
11. 11 Tartour E, Latour S, Mathiot C et al. Variable expression of CD3ζ chain in tumor-infiltrating lymphocytes (TIL) derived from renal-cell carcinoma: relationship with TIL phenotype and function. Int J Cancer 1995; 63:205-12.
12. 12 Cardi G, Haeney JA, Schned AR, Phillips DM, Branda MT, Ernstoff MS. T-cell receptor ζ-chain expression on tumour infiltrating lymphocytes from renal cell carcinoma. Cancer Res 1997; 57:3517-9.
13. 13 Wang Q, Stanley J, Kudoh S et al. T cells infiltrating non-Hodgkins lymphoma show altered tyrosine phosporylation pattern even though T cell receptor/CD3-associated kinases are present. J Immunol 1995; 155:1382-92.
14. 14 Stefanova I, Saville MW, Peters C et al. HIV infection-induced posttranslational modification of T cell signalling molecules associated with disease progression. J Clin Invest 1996; 98:1290-7.
15. 15 Simpson E. Immunology: why baby isn't thrown out. Curr Biol 1996; 6:43-4.
16. 16 Franco JL, Ghosh P, Wiltrout RH et al. Partial degradation of T-cell signal transduction molecules by contaminating granulocytes during protein extraction of splenic T cells from tumour bearing mice. Cancer Res 1995; 55:3840-6.
17. 17 Noda S, Nagata-Narumija T, Kosugi A, Narumija S, Ra C, Fujiwara H, Hamaoka T. Do structural changes of T cell receptor complex occur in tumor-bearing state? Jpn J Cancer Res 1995; 86:383-94.
18. 18 Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-5.
19. 19 Kono K, Salazar-Onfray F, Petersson M et al. Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell and natural killer cell-mediated cytotoxicity. Eur J Immunol 1996; 26:1308-13.
20. 20 Otsuji M, Kimura Y, Aoe T, Okamoto Y, Saito T. Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T cell receptor complex and antigen-specific T-cell responses. Proc Natl Acad Sci USA 1996; 93:13119-24.
21. 21 Pellegrini P, Berghella AM, Del Beato T, Cicia S, Adorno D, Casciani CU. Disregulation in TH1 and TH2 subsets of CD4+ T cells in periperheral blood of colorectal cancer patients and involvement in cancer establishment and progression. Cancer Immunol Immunother 1996; 42:1-8.
22. 22 Mosmann TR, Sad S. The expanding universe of T-cell subsets. Th1, Th2 and more. Immunol Today 1996; 17:138-46.
23. 23 Taupin JL, Anderson P. Activation-induced proteolysis of the cytoplasmic domain of ζ in T cell receptors and Fc receptors. Eur J Immunol 1994; 24:3000-4.
24. 24 Mulder WMC, Bloemena E, Stukart MJ, Kummer JA, Wagstaff J, Scheper RJ. T cell receptor-ζ and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma. Gut 1997; 40:113-9.
25. 25 Levey DL, Srivastava PK. Alterations in T cells of cancer-bearers: whence specificity? Immunol Today 1996; 17:365-8.
26. 26 Choi SB, Chung EJ, Wang DY, Lee SS, Jang Y-S, Kim CW. Alterations of signal-transducing molecules in tumour-infiltrating lymphocytes and peripheral blood T lymphocytes from human colorectal carcinoma patients. Cancer Immunol Immunother 1998; 45:229-305.
27. 27 Kolenko V, Wang Q, Riedy MC et al. Tumour-induced suppression of T-lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signalling. Role of soluble products from human renal cell carcinoma. J Immunol 1997; 159:3057-67.