Tumor-induced suppression of T lymphocyte proliferation coincides with inhibition of Jak3 expression and IL-2 receptor signaling: Role of soluble products from human renal cell carcinomas

Journal of Immunology

Volumn 159, Issue 6, 1997, Pages 3057-3067

  Kolenko, Vladimir ^a   Wang, Qiu ^a   Riedy, M C ^b   O'Shea, John ^b   Ritz, Jerome ^c   Cathcart, Martha K ^a   Rayman, Patricia ^a   Tubbs, Raymond ^a   Edinger, Mark ^a   Novick, Andrew ^a   Bukowski, Ronald ^a   Finke, James ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2 RECEPTOR; JAK3 PROTEIN, HUMAN; JANUS KINASE 3; PROTEIN TYROSINE KINASE;

ARTICLE; CELL CULTURE; CELL DIVISION; CYTOTOXICITY; DRUG ANTAGONISM; HUMAN; IMMUNOLOGY; KIDNEY CARCINOMA; KIDNEY TUMOR; LYMPHOCYTE ACTIVATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR ESCAPE;

CARCINOMA, RENAL CELL; CELL DIVISION; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; JANUS KINASE 3; KIDNEY NEOPLASMS; LYMPHOCYTE ACTIVATION; PROTEIN-TYROSINE KINASES; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TUMOR CELLS, CULTURED; TUMOR ESCAPE;

EID: 0031571785     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Altraan, A., K. M. Coggeshall, and T. Mustelin. 1990. Molecular events mediating T cell activation. Adv. Immunol. 48:227.
2. Ullman, K. S., J. P. Northrop, C. L. Verweij, and G. R. Crabtree. 1990. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu. Rev. Immunol. 8:421.
3. Minami, Y., T. Kono, K. Yamada, and T. Taniguchi. 1993. The interleukin-2 receptors: insights into a complex signaling mechanism. Annu. Rev. Immunol. 11:245.
4. Taniguchi, T., and Y. Minami. 1993. The IL2/IL2 receptor system: a current overview. Cell 73:5.
5. Nakarai, T., M. J. Robertson, M. Streuli, Z. Wu, T. L. Ciardelli, K. A. Smith, and J. Ritz. 1994. Interleukin 2 receptor γ chain expression on resting and activated lymphoid cells. J. Exp. Med. 180:241.
6. Nelson, B. H., J. D. Lord, and P. D. Greenberg. 1994. Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation. Nature 369:333.
7. Nakamura, Y. S., S. M. Russell, S. A. Mess, M. Friedmann, M. Erdos, C. Francois, Y. Jacques, S. Adelstein, and W. J. Leonard. 1994. Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signaling. Nature 369:330.
8. Johnston, J. A., M. Kawamura, R. A. Kirken, Y-Q. Chen, T. B. Blake, K. Shibuya, J. R. Ortaldo, D. W. McVicar, and J. J. O'Shea. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151.
9. Witthuhn, B. A., O. Silvennoinen, O. Miura, K. S. Lal, C. Cwik, E. T. Liu, and J. N. Ihle. 1994. Involvement of the Jak-3 Janus kinase in signaling by interleukin 2 and 4 in lymphoid and myeloid cells. Nature 370:153.
10. Beading, C., D. Guschin, B. A. Whithuh, A. Ziemiecki, J. N. Me, I. M. Kerr, and D. A. Cantrell. 1994. Activation of JAK kinases and STAT proteins by interleukin-2 and interferon α, but not the T cell antigen receptor, in human T lymphocytes. EMBO J. 13:5605.
11. lck: identification of novel intermolecular association. Science 252:1523.
12. c chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042.
13. Miyasaki, T., A. Kawahara, H. Fujii, Y. Nakagawa, Y. Minami, Z.-J. Liu, I. Oishi, O. Silvennoinen, B. A. Witthuhn, J. N. Ihle, and T. Taniguchi. 1994. Functional activation of Jakl and Jak3 by selective association with IL2 receptor subunits. Science 266:1045.
14. Hatakeyema, M., H. Don, and T. Taniguchi. 1989. A restricted cytoplasmic region of 1L2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization. Cell 59:837.
15. Kirken, R. A., H. Rui, M. G. Malabarba, and W. L. Farrar. 1994. Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase. J. Biol. Chem. 269:19136.
16. Hersh, E. M., and J. J. Oppenheim. 1965. Impaired in vitro lymphocyte transformation in Hodgkin's disease. N. Engl. J. Med. 273:1006.
17. Roszman, T., L. Elliott, and V. V. Brooks. 1991. Modulation of T-cell function by gliomas. Immunol. Today 12:370.
18. Ikemoto, S., S. Wada, M. Kamizuru, N. Hayahara, T. Kishimoto, and M. Maekawa. 1992. Clinical studies on cell-mediated immunity in patients with renal cell carcinoma: interleukin-2 and interferon-γ production of lymphocytes. Cancer Immuno. Immunother. 34:289.
19. Miescher, S., T. L. Whiteside, C. Carrel, and V. Von Fliedner. 1986. Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supematants on proliferative responses of lymphocytes. J. Immunol. 136:1899.
20. Miescher, S., M. Stoeck, L. Qiao, C. Barras, L. Barrelet, and V. Von Fliedner. 1988. Proliferative and cytolytic potentials of purified human tumor-infiltrating T lymphocytes: impaired response to mitogen-driven stimulation despite T-cell receptor expression. Int. J. Cancer 42:659.
21. Yoshino, I., T. Yuno, M. Murata, T. Ishida, K. Sugimachi, G. Kimura, and K. Nomoto. 1992. Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor. Cancer Res. 52:775.