Alternative treatments for childhood brain tumors

Child's Nervous System

Volumn 15, Issue 11-12, 1999, Pages 789-794

  Packer, Roger J ^a  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

Brain tumor; Gene therapy; Immunotherapy; Toxin therapy

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIBODY CONJUGATE; ARYLBUTYRIC ACID DERIVATIVE; BETA INTERFERON; LEFLUNOMIDE; PHENYLACETIC ACID; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RETINOIC ACID;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN TUMOR; CANCER GROWTH; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CHILDHOOD CANCER; DRUG EFFICACY; GENE THERAPY; HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CHILD; DRUG DELIVERY SYSTEMS; GENE THERAPY; HUMANS; IMMUNOTHERAPY; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION;

EID: 0032703128     PISSN: 02567040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003810050472     Document Type: Article

References (29)

1. Bartus RT, Elliott PJ, Hayward NJ, Dean R, McEwen EL, Fisher SK (1996) Permeability of the blood brain barrier by the bradykinin agonist, Cereport™: evidence for a sensitive, auto-regulated, receptor-mediated system. Immunopharmacology 33:270-278
2. Berger MS, Prados MD, Gilder JC van, Warnick RD, McDermott MW, Marcus SG, Kapcala LP (1997) Phase II trial of GLI 328 HSV-TK gene therapy in recurrent glioblastoma. Cancer Gene Ther 4:S42
3. Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH (1994) Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA 91:2076-2080
4. Bollag W, Hartmann HR (1983) Prevention and therapy of cancer with retinoids in animals and man. Cancer Surv 2:293-314
5. Chen CY, Chang YN, Ryan P, Linscott M, McGarrity GJ, Chiang YL (1995) Effects of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the "bystander effect." Hum Gene Ther 6:1467-1476
6. Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM (1992) In vivo gene transfer with retroviral vector-producing cells for treatment of experimental brain tumors. Science 256:1550-1552
7. D'Amato RJ, Loughnan MS, Flynn E, Folkman J (1994) Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA 92:4082-4085
8. Ewel CH, Urba WJ, Kopp WC, Smith JW II, Steis RG, Rossio JL, Longo DL, Jones MJ, Alvord WG, Pinsky CM, et al (1992) Polyinosinic-polycytidylic acid complexed with poly-L lysine and carboxymethylcellulose in combination with interleukin 2 in patients with cancer: clinical and immunological effects. Cancer Res 52:3005-3010
9. Fathallah-Shaykh H (1999) New molecular strategies to cure brain tumors. Arch Neurol 56:449-453
10. Friden PM: Receptor-mediated transport of therapeutics across the blood-brain barrier. Neurosurgery 35:294-298
11. Gibbs JB, Oliff A (1997) The potential of farnesyltransferase inhibitors as cancer chemotherapeutics. Annu Rev Pharmacol Toxicol 37:143-166
12. Graham S (1995) Inhibitors of protein farnesylation: a new approach to cancer chemotherapy. Exp Opin Ther Patents 5:1269-1285
13. Inamura T, Nomura T, Bartus RT, Black KL (1994) Intracarotid infusion of RMP-7, a bradykinin analog: a method for selective drug delivery to brain tumors. J Neurosurg 81:752-758
14. Johnson VG, Wrobel C, Wilson D, Zovickian J, Greenfield L, Oldfield EH, Youle R (1989) Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia. J Neurosurg 70:240-248
15. Laske DW, Ilercil O, Akbasak A, Youle RJ, Oldfield EH (1994) Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice. J Neurosurg 80:520-526
16. Laske DW, Youle RJ, Oldfield EH (1997) Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nat Med 3:1361-1368
17. Leonard DM (1997) Ras farnesyltransferase: a new therapeutic target. J Med Chem 40:2971-2990
18. Long Z, Li LP, Grooms T, Lockey C, Nader K, Mychkovsky I, Mueller S, Burimski I, Ryan P, Kikuchi G, Ennist D, Marcus S, Otto E, McGarrity G (1998) Biosafety monitoring of patients receiving intracerebral injections of retroviral producer cells. Hum Gene Ther 9:1165-1172
19. Lund EL, Spang Thomsen M, Skovgaard Poulsen H, Kristjansen PE (1998) Tumor angiogenesis - a new therapeutic target in gliomas. Acta Neurol Scand 98:52-62
20. Packer RJ (1996) Alternative therapies of children with brain stem gliomas: immunotherapy and gene therapy. Pediatr Neurosurg 24:217-222
21. Packer RJ (1999) Brain tumors in children. Arch Neurol 56:421-425
22. Packer RJ, Prados M, Phillips P, Nicholson HS, Boyett JM, Goldwein J, Rorke LB, Needle MN, Sutton L, Zimmerman RA, Fitz CR, Vezina LG, Etcubanas E, Wallenberg JC, Reaman G, Wara W (1996) Treatment of children with newly diagnosed brain stem gliomas with intravenous recombinant beta-interferon and hyperfractionated radiation therapy: a Children's Cancer Group phase I/II study. Cancer 77:2150-2156
23. Pluda JM (1997) Tumor-associated angiogenesis: mechanisms, clinical implications, and therapeutic strategies. Semin Oncol 24:203-218
24. Pollack IF, Bredel M, Erff M (1998) Application of signal transduction inhibition as a therapeutic strategy for central nervous system tumors. Pediatr Neurosurg 29:228-244
25. Ram Z, Culver KW, Oshiro EM, Viola JJ, DeVroom HL, Otto E, Long Z, Chiang Y, McGarrity GJ, Muul LM, Katz D, Blaese RM, Oldfield EH (1997) Therapy of malignant brain tumors by intratumoral implantation of retrovirus-producing cells. Nat Med 3:1354-1361
26. Rapoport SI (1988) Osmotic opening of the blood-brain barrier. Ann Neurol 24:677-684
27. Salazar AM, Levy HB, Ondra S, Kende M, Scherokman B, Brown D, Mena H, Martin N, Schwab K, Donovan D, Dougherty D, Pulliam M, Ippolito M, Graves M, Brown H, Ommaya A (1996) Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study. Neurosurgery 38:1096-1103
28. Samid D, Shack S, Sherman L (1992) Phenylacetate: a novel nontoxic inducer of tumor cell differentiation. Cancer Res 52:1988-1992
29. Westermark B, Heldin CH (1993) Platelet-derived growth factor. Structure, function and implications in normal and malignant cell growth. Acta Oncol 32:101-105