Expression of sialylated or paragloboside-like lipooligosaccharides are not required for pustule formation by Haemophilus ducreyi in human volunteers

Infection and Immunity

Volumn 67, Issue 12, 1999, Pages 6335-6340

  Young, Royden S ^a   Fortney, Kate ^a   Haley, Jennifer C ^a   Hood, Antoinette F ^a   Campagnari, Anthony A ^b   Wang, Jing ^c   Bozue, Joel A ^c   Munson Jr , Robert S ^c   Spinola, Stanley M ^a  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 DEOXY MANNO OCTULOSONIC ACID; GLYCOSPHINGOLIPID; HEPTOSE; N ACETYLLACTOSAMINE SYNTHASE; OLIGOSACCHARIDE; PARAGLOBOSIDE; TRANSFERASE;

ARTICLE; BACTERIUM MUTANT; COLONY FORMING UNIT; DOSE RESPONSE; HAEMOPHILUS DUCREYI; HISTOPATHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUSTULE; ULCUS MOLLE;

ADULT; CHANCROID; FEMALE; GLOBOSIDES; HAEMOPHILUS DUCREYI; HUMANS; LIPOPOLYSACCHARIDES; MALE; MUTATION; SIALYLTRANSFERASES; SKIN; VIRULENCE;

EID: 0032702581     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Al-Tawfiq, J., J. Harezlak, B. P. Katz, and S. M. Spinola. Cumulative experience with Haemophilus ducreyi in the human model of experimental infection. Sexually Trans. Dis., in press.
2. Al-Tawfiq, J. A., A. C. Thornton, B. P. Katz, K. R. Fortney, K. D. Todd, A. F. Hood, and S. M. Spinola. 1998. Standardization of the experimental model of Haemophilus ducreyi infection in human subjects. J. Infect. Dis. 178:1684-1687.
3. Al-Tawfiq, J. A., M. E. Bauer, K. R. Fortney, B. P. Katz, A. F. Hood, M. Ketterer, M. A. Apicella, and S. M. Spinola. Submitted for publication.
4. 2b. Al-Tawfiq, J. A., K. R. Fortney, B. P. Katz, C. Elkins, and S. M. Spinola. Submitted for publication.
5. Bauer, B. A., S. R. Lumbley, and E. J. Hansen. 1999. Characterization of a waaF (RfaF) homolog expressed by Haemophilus ducreyi. Infect. Immun. 67:899-907.
6. Bauer, B. A., M. K. Stevens, and E. J. Hansen. 1998. Involvement of the Haemophilus ducreyi gmhA gene product in lipooligosaccharide expression and virulence. Infect Immun. 66:4290-4298.
7. Bozue, J. A., M. V. Tullius, J. Wang, B. W. Gibson, and R. S. Munson, Jr. 1999. Haemophilus ducreyi produces a novel sialyltransferase: identification of the sialyltransferase gene and construction of mutants deficient in the production of the sialic acid-containing glycoform of the lipooligosaccharide. J. Biol. Chem. 274:4106-4114.
8. Campagnari, A. A., R. Karalus, M. Apicella, W. Melaugh, A. J. Lesse, and B. W. Gibson. 1994. Use of pyocin to select a Haemophilus ducreyi variant defective in lipooligosaccharide biosynthesis. Infect. Immun. 62:2379-2386.
9. Campagnari, A. A., S. M. Spinola, A. J. Lesse, Y. Abu Kwaik, R. E. Mandrell, and M. A. Apicella. 1990. Lipooligosaccharide epitopes shared among gram-negative non-enteric mucosal pathogens. Microb. Pathog. 8:353-362.
10. Campagnari, A. A., L. M. Wild, G. E. Griffiths, R. J. Karalus, M. A. Wirth, and S. M. Spinola. 1991. Role of lipooligosaccharides in experimental dermal lesions caused by Haemophilus ducreyi. Infect. Immun. 59:2601-2608.
11. Gibson, B. W., A. A. Campagnari, W. Melaugh, N. J. Phillips, M. A. Apicella, S. Grass, J. Wang, K. L. Palmer, and R. S. Munson, Jr. 1997. Characterization of a transposon Tn916-generated mutant of Haemophilus ducreyi 35000 defective in lipooligosaccharide biosynthesis. J. Bacteriol. 179:5062-5071.
12. Gibson, B. W., W. Melaugh, N. J. Phillips, M. A. Apicella, A. A. Campagnari, and J. M. Griffiss. 1993. Investigation of the structural heterogeneity of lipooligosaccharides from pathogenic Haemophilus and Neisseria species and of R-type lipopolysacchardies from Salmonella typhimurium by electrospray mass spectrometry. J. Bacteriol. 175:2702-2712.
13. Hiltke, T. J., A. A. Campagnari, and S. M. Spinola. 1996. Characterization of a novel lipoprotein expressed by Haemophilus ducreyi. Infect. Immun. 64: 5047-5052.
14. Hobbs, M. M., L. R. SanMateo, P. E. Orndorff, G. Almond, and T. H. Kawula. 1995. Swine model of Haemophilus ducreyi infection. Infect. Immun. 63:3094-3100.
15. Mandrell, R. E., J. M. Griffiss, and B. A. Macher. 1988. Lipooligosaccharides (LOS) of Neisseria gonorrhoeae and Neisseria meningitidis have components that are immunochemically similar to precursors of human blood group antigens. Carbohydrate sequence specificity of the mouse monoclonal antibodies that recognize crossreacting antigens on LOS and human erythrocytes. J. Exp. Med 168:107-126.
16. Melaugh, W., A. A. Campagnari, and B. W. Gibson. 1996. The lipooligosaccharides of Haemophilus ducreyi are highly sialylated. J. Bacteriol. 178:564-570.
17. Melaugh, W., N. J. Phillips, A. A. Campagnari, M. V. Tullius, and B. W. Gibson. 1994. Structure of the major oligosaccharide from the lipooligosaccharide of Haemophilus ducreyi strain 35000 and evidence for additional glycoforms. Biochemistry 33:13070-13078.
18. Palmer, K. L., W. E. Goldman, and R. S. Munson, Jr. 1996. An isogenic hemolysin-deficient mutant of Haemophilus ducreyi lacks the ability to produce cytopathic effects on human foreskin fibroblasts. Mol. Microbiol. 21: 13-19.
19. Palmer, K. L., C. T. Schnizlein-Bick, A. Orazi, K. John, C.-Y. Chen, A. F. Hood, and S. M. Spinola. 1998. The immune response to Haemophilus ducreyi resembles a delayed-type hypersensitivity reaction throughout experimental infection of human subjects. J. Infect. Dis. 178:1688-1697.
20. Palmer, K. L., A. C. Thornton, K. A. Fortney, A. F. Hood, R. S. Munson, Jr., and S. M. Spinola. 1998. Evaluation of an isogenic hemolysin-deficient mutant in the human model of Haemophilus ducreyi infection. J. Infect. Dis. 178:191-199.
21. Perez-Casal, J., M. G. Caparon, and J. R. Scott. 1991. Mry, a trans-acting positive regulator of the M protein gene of Streptococcus pyogenes with similarity to the receptor proteins of two-component regulatory systems. J. Bacteriol. 173:2617-2624.
22. Schneider, H., J. M. Griffiss, J. W. Boslego, P. J. Hitchcock, K. M. Zahos, and M. A. Apicella. 1991. Expression of paragloboside-like lipooligosaccharides may be a necessary component of gonococcal pathogenesis in men. J. Exp. Med. 174:1601-1605.
23. Schweda, E. K. H., A. C. Sundstrom, L. M. Eriksson, J. A. Jonasson, and A. A. Lindberg. 1994. Structural studies of the cell envelope lipopolysaccharides from Haemophilus ducreyi strains ITM 2665 and ITM 4747. J. Biol. Chem. 269:12040-12048.
24. Spinola, S. M., A. Orazi, J. N. Arno, K. Fortney, P. Kotylo, C.-Y. Chen, A. A. Campagnari, and A. F. Hood. 1996. Haemophilus ducreyi elicits a cutaneous infiltrate of CD4 cells during experimental human infection. J. Infect. Dis. 173:394-402.
25. Spinola, S. M., L. M. Wild, M. A. Apicella, A. A. Caspari, and A. A. Campagnari. 1994. Experimental human infection with Haemophilus ducreyi. J. Infect. Dis. 169:1146-1150.
26. Stevens, M. K., J. Klesney-Tait, S. Lumbley, K. A. Walters, A. M. Joffe, J. D. Radolf, and E. J. Hansen. 1997. Identification of tandem genes involved in lipooligosaccharide expression by Haemophilus ducreyi. Infect. Immun. 65: 651-660.
27. Tullius, M. V., R. S. Munson, Jr., J. Wang, and B. W. Gibson. 1996 Purification, cloning, and expression of a cytidine 5′-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi. J. Biol. Chem. 271: 15373-15380.